Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum

British Journal of Pharmacology

Volumn 167, Issue 6, 2012, Pages 1287-1300

  Hsin, I Lun ^a   Sheu, Gwo Tarng ^a   Jan, Ming Shiou ^a   Sun, Hai Lun ^a,b   Wu, Tzu Chin ^a,b   Chiu, Ling Yen ^a   Lue, Ko Huang ^a,b   Ko, Jiunn Liang ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

ATP6V0A1; autophagic cell death; autophagic flux; autophagy; GMI; immunomodulatory protein; lysosome; mTOR; PKB; V ATPases

Indexed keywords

BAFILOMYCIN A1; CHLOROQUINE; IMMUNOMODULATING AGENT; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN GMI; PROTEIN KINASE B; RECOMBINANT PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ATP6V0A1 GENE; AUTOPHAGOSOME; AUTOPHAGY; BIOACCUMULATION; CANCER CELL CULTURE; CELL DEATH; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DEGRADATION KINETICS; DRUG TARGETING; ENZYME INHIBITION; FLOW CYTOMETRY; GANODERMA; GANODERMA MICROSPORUM; GENE; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; LYSOSOME; PRIORITY JOURNAL; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AUTOPHAGY; CELL LINE, TUMOR; CHLOROQUINE; FUNGAL PROTEINS; GANODERMA; GENE SILENCING; HUMANS; IMMUNOLOGIC FACTORS; LYSOSOMES; MACROLIDES; PHAGOSOMES; PROTO-ONCOGENE PROTEINS C-AKT; TOR SERINE-THREONINE KINASES; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84867812810     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02073.x     Document Type: Article

References (40)

1. Bayer MJ, Reese C, Buhler S, Peters C, Mayer A, (2003). Vacuole membrane fusion: V0 functions after trans-SNARE pairing and is coupled to the Ca2+-releasing channel. J Cell Biol 162: 211-222.
2. Boh B, Berovic M, Zhang J, Zhi-Bin L, (2007). Ganoderma lucidum and its pharmaceutically active compounds. Biotechnol Annu Rev 13: 265-301.
3. Decuypere JP, Bultynck G, Parys JB, (2011). A dual role for Ca(2+) in autophagy regulation. Cell Calcium 50: 242-250.
4. Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, et al,. (2010). Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal 3: ra81.
5. Forgac M, (1999). Structure and properties of the vacuolar (H+)-ATPases. J Biol Chem 274: 12951-12954.
6. Fu L, Kim YA, Wang X, Wu X, Yue P, Lonial S, et al,. (2009). Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res 69: 8967-8976.
7. Ganley IG, Wong PM, Gammoh N, Jiang X, (2011). Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest. Mol Cell 42: 731-743.
8. Geng Y, Kohli L, Klocke BJ, Roth KA, (2010). Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent. Neuro Oncol 12: 473-481.
9. Hoyer-Hansen M, Bastholm L, Szyniarowski P, Campanella M, Szabadkai G, Farkas T, et al,. (2007). Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol Cell 25: 193-205.
10. Hsin IL, Ou CC, Wu TC, Jan MS, Wu MF, Chiu LY, et al,. (2011). GMI, an immunomodulatory protein from Ganoderma microsporum, induces autophagy in non-small cell lung cancer cells. Autophagy 7: 873-882.
11. Janku F, McConkey DJ, Hong DS, Kurzrock R, (2011). Autophagy as a target for anticancer therapy. Nat Rev Clin Oncol 8: 528-539.
12. Jinn TR, Wu CM, Tu WC, Ko JL, Tzen JT, (2006). Functional expression of FIP-gts, a fungal immunomodulatory protein from Ganoderma tsugae in Sf21 insect cells. Biosci Biotechnol Biochem 70: 2627-2634.
13. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, et al,. (2008a). Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4: 151-175.
14. Klionsky DJ, Elazar Z, Seglen PO, Rubinsztein DC, (2008b). Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy 4: 849-950.
15. Levine B, (2007). Cell biology: autophagy and cancer. Nature 446: 745-747.
16. Liao CH, Hsiao YM, Hsu CP, Lin MY, Wang JC, Huang YL, et al,. (2006). Transcriptionally mediated inhibition of telomerase of fungal immunomodulatory protein from Ganoderma tsugae in A549 human lung adenocarcinoma cell line. Mol Carcinog 45: 220-229.
17. Liao CH, Hsiao YM, Sheu GT, Chang JT, Wang PH, Wu MF, et al,. (2007). Nuclear translocation of telomerase reverse transcriptase and calcium signaling in repression of telomerase activity in human lung cancer cells by fungal immunomodulatory protein from Ganoderma tsugae. Biochem Pharmacol 74: 1541-1554.
18. Liao CH, Hsiao YM, Lin CH, Yeh CS, Wang JC, Ni CH, et al,. (2008). Induction of premature senescence in human lung cancer by fungal immunomodulatory protein from Ganoderma tsugae. Food Chem Toxicol 46: 1851-1859.
19. Lin CH, Hsiao YM, Ou CC, Lin YW, Chiu YL, Lue KH, et al,. (2010a). GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor alpha-induced expression of matrix metalloproteinase 9 via NF-kappaB pathway in human alveolar epithelial A549 cells. J Agric Food Chem 58: 12014-12021.
20. Lin CH, Sheu GT, Lin YW, Yeh CS, Huang YH, Lai YC, et al,. (2010b). A new immunomodulatory protein from Ganoderma microsporum inhibits epidermal growth factor mediated migration and invasion in A549 lung cancer cells. Process Biochem 45: 1537-1542.
21. Ling YH, Aracil M, Zou Y, Yuan Z, Lu B, Jimeno J, et al,. (2011). PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase. Clin Cancer Res 17: 5353-5366.
22. Maiuri MC, Zalckvar E, Kimchi A, Kroemer G, (2007). Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8: 741-752.
23. Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P, et al,. (2007). FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab 6: 458-471.
24. Mizushima N, Yoshimori T, Levine B, (2010). Methods in mammalian autophagy research. Cell 140: 313-326.
25. Paroutis P, Touret N, Grinstein S, (2004). The pH of the secretory pathway: measurement, determinants, and regulation. Physiology (Bethesda) 19: 207-215.
26. Pena-Llopis S, Vega-Rubin-de-Celis S, Schwartz JC, Wolff NC, Tran TA, Zou L, et al,. (2011). Regulation of TFEB and V-ATPases by mTORC1. EMBO J 30: 3242-3258.
27. Peri F, Nusslein-Volhard C, (2008). Live imaging of neuronal degradation by microglia reveals a role for v0-ATPase a1 in phagosomal fusion in vivo. Cell 133: 916-927.
28. Ramser B, Kokot A, Metze D, Weiss N, Luger TA, Bohm M, (2009). Hydroxychloroquine modulates metabolic activity and proliferation and induces autophagic cell death of human dermal fibroblasts. J Invest Dermatol 129: 2419-2426.
29. Rosenfeldt MT, Ryan KM, (2011). The multiple roles of autophagy in cancer. Carcinogenesis 32: 955-963.
30. Rubinsztein DC, Marino G, Kroemer G, (2011). Autophagy and aging. Cell 146: 682-695.
31. Scott CC, Bissig C, Gruenberg J, (2011). Duelling functions of the V-ATPase. EMBO J 30: 4113-4115.
32. Shen HM, Codogno P, (2011). Autophagic cell death: Loch Ness monster or endangered species? Autophagy 7: 457-465.
33. Shvets E, Fass E, Elazar Z, (2008). Utilizing flow cytometry to monitor autophagy in living mammalian cells. Autophagy 4: 621-628.
34. Smith DM, Patel S, Raffoul F, Haller E, Mills GB, Nanjundan M, (2010). Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells. Cell Death Differ 17: 1867-1881.
35. Strasser B, Iwaszkiewicz J, Michielin O, Mayer A, (2011). The V-ATPase proteolipid cylinder promotes the lipid-mixing stage of SNARE-dependent fusion of yeast vacuoles. EMBO J 30: 4126-4141.
36. Tanida I, Minematsu-Ikeguchi N, Ueno T, Kominami E, (2005). Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 1: 84-91.
37. Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D'Amelio M, et al,. (2008). Regulation of autophagy by cytoplasmic p53. Nat Cell Biol 10: 676-687.
38. Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R, Tashiro Y, (1998). Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct Funct 23: 33-42.
39. Yang PM, Liu YL, Lin YC, Shun CT, Wu MS, Chen CC, (2010). Inhibition of autophagy enhances anticancer effects of atorvastatin in digestive malignancies. Cancer Res 70: 7699-7709.
40. Yang Z, Klionsky DJ, (2010). Eaten alive: a history of macroautophagy. Nat Cell Biol 12: 814-822.