Hydroxychloroquine modulates metabolic activity and proliferation and induces autophagic cell death of human dermal fibroblasts

Journal of Investigative Dermatology

Volumn 129, Issue 10, 2009, Pages 2419-2426

  Ramser, Bettina ^a   Kokot, Agatha ^a   Metze, Dieter ^a   Weiß, Nina ^a   Luger, Thomas A ^a   Böhm, Markus ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; BECLIN 1; HYDROXYCHLOROQUINE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLSERINE; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL METABOLISM; CELL PROLIFERATION; CELL STRUCTURE; CELL VACUOLE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INACTIVATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; NEWBORN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; REGULATORY MECHANISM; SKIN FIBROBLAST; TARGET CELL;

ANTIMALARIALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BIOLOGICAL MARKERS; CELL PROLIFERATION; CELLS, CULTURED; DERMIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HUMANS; HYDROXYCHLOROQUINE; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION;

EID: 70349118300     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.80     Document Type: Article

References (43)

1. Balogh E, Nagy-Vezekényi K, Fórizs E (1980) REM syndrome: an immediate therapeutic response to hydroxychloroquine sulphate. Acta Dermatol Venereol 60:173-175
2. Böhm M, Eickelmann M, Li Z, Schneider SW, Oji V, Diederichs S et al. (2005a) Detection of functionally active melanocortin receptors and evidence for an immunoregulatory activity of alpha melanocyte-stimulating hormone in human dermal papilla cells. Endocrinology 146:4635-4646
3. Böhm M, Wolff I, Scholzen TE, Luger TA, Robinson S, Healy E et al. (2005b) a-Melanocyte-stimulating hormone protects from UVB-induced apopto-sis and DNA damage. J Biol Chem 280:5795-5802
4. Bondeson J, Sundler R (1998) Antimalarial drugs inhibit phospholipase A2 activation and induction of interleukin 1beta and tumor necrosis factor alpha in macrophages: implications for their mode of action in rheumatoid arthritis. Gen Pharmacol 30:357-366 (Pubitemid 28046507)
5. Boya P, Gonzalez-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N et al. (2005) Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 25:1025-1040
6. Brownell I, Soter NA, Franks AG (2007) Familial linear scleroderma (en coup de sabre) responsive to antimalarials and narrowband ultraviolet B therapy. Dermatol Online J 13:11 Cho JY (2008) Chloroquine, an anti-malarial agent, acts as a novel regulator of beta 1-integrin-mediated cell-cell adhesion. Biol Pharm Bull 31:726-730
7. Fedorko ME, Hirsch JG, Cohn ZA (1968) Autophagic vacuoles produced in vitro. I. Studies on cultured macrophages exposed to chloroquine. J Cell Biol 38:377-391
8. Ferraris C, Cooklis M, Polakowska RR, Haake AR (1997) Induction of apoptosis through the PKC pathway in cultured dermal fibroblasts. Exp Cell Res 234:37-46
9. Gilman AL, Chan KW, Mogul A, Morris C, Goldman FD, Boyer M et al. (2000) Hydroxychloroquine for the treatment of chronic graft-versus-host disease. Biol Blood Marrow Transplant 6:327-334
10. Hauss WH, Mey J, Schulte H (1979) The effect of pathogenic factors and anti-rheumatic drugs on the proliferation of cultured human fibroblasts. Z Rheumatol 38:220-232
11. Inyang AL, Bikfalvi A, Lu H, Tobelem G (1990) Chloroquine's modulation of endothelial cell activity induced with basic fibroblast growth factor and human serum: effect on mitogenesis, protease production and cell migration. Cell Biol Int Rep 14:35-46
12. Kabeya Y, Kamada Y, Baba M, Takikawa H, Sasaki M, Ohsumi Y (2005) Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy. Mol Biol Cell 16:2544-2553
13. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T et al. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19:5720-5728
14. Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y (2000) Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 150:1507-1513
15. Kim WU, Yoo SA, Min SY, Park SH, Koh HS, Song SW et al. (2006) Hydroxychloroquine potentiates Fas-mediated apoptosis of rheumatoid synoviocytes. Clin Exp Immunol 144:503-511
16. Klionsky DJ, Ohsumi Y (1999) Vacuolar import of proteins and organelles from the cytoplasm. Annu Rev Cell Dev Biol 15:1-32
17. Kokot A, Metze D, Mouchet N, Galibert M-D, Luger TA, Böhm M (2009b) a-MSH counteracts the suppressive effect of UVB on Nrf1/2 and Nrf1/2-dependent gene expression in human skin. Endocrinology, in press.
18. Kokot A, Sindrilaru A, Schiller M, Sunderkötter C, Kerkhoff C, Scharffetter-Kochanek K et al. (2009a) a-Melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma. Arthritis Rheum 60:592-603
19. Koranda FC (1981) Antimalarials. J Am Acad Dermatol 4:650-655
20. Lagneaux L, Delforge A, Dejeneffe M, Massy M, Bernier M, Bron D (2002) Hydroxychloroquine-induced apoptosis of chronic lymphocytic leukemia involves activation of caspase-3 and modulation of Bcl-2/bax/ratio. Leuk Lymphoma 43:1087-1095
21. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H et al. (1999) Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402:672-676
22. Liang XH, Yu J, Brown K, Levine B (2001) Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. Cancer Res 61:3443-3449
23. MacIntyre AC, Cutler DJ (1988) Role of lysosomes in hepatic accumulation of chloroquine. J Pharm Sci 77:196-199
24. Marzano AV, Tanzi C, Caputo R, Alessi E (2005) Sclerodermic linear lupus panniculitis: report of two cases. Dermatology 210:329-332
25. Meng XW, Feller JM, Ziegler JB, Pittmann SM, Ireland CM (1997) Induction of apoptosis in peripheral blood lymphocytes following treatment in vitro with hydroxychloroquine. Arhritis Rheum 40: 927-935
26. Miracco C, Cosci E, Oliveti G, Luzi P, Pacenti L, Monciatti I et al. (2006) Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours. Int J Oncol 30:429-436
27. Mizushima N, Ohsumi Y, Yoshimori T (2002) Autophagosome formation in mammalian cells. Cell Struct Funct 27:421-429
28. Nagy E, Ladányi É (1987) Treatment of circumscribed scleroderma in childhood. Z Hautkr 62:547-549
29. Noda T, Ohsumi Y (1998) Tor, a phosphatidylinositol kinase homolog, controls autophagy in yeast. J Biol Chem 273:3963-3966
30. Pattingre S, Espert L, Biard-Piechaczyk M, Codogno P (2008) Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie 90:313-323
31. Potvin F, Petitclerc E, Marceau F, Poubelle PE (1997) Mechanisms of action of antimalarials in inflammation: induction of apoptosis in human endothelial cells. J Immunol 158:1872-1879
32. Raught B, Gingras AC, Sonenberg N (2001) The target of rapamycin (TOR) proteins. Proc Natl Acad Sci USA 98:7037-7044
33. Schultz KR, Gilman AL (1997) The lysosomotropic amines, chloroquine and hydroxychloroquine: a potentially novel therapy for graft-versus-host disease. Leuk Lymphoma 24:201-210
34. Seitz M, Valbracht J, Quach J, Lotz M (2003) Gold sodium thiomalate and chloroquine inhibit cytokine production in monocytic THP-1 cells through distinct transcriptional and posttranslational mechanisms. J Clin Immunol 23:477-484
35. Shaffer B, Cahn MM, Levy EJ (1958) Absorption of antimalarial drugs in human skin; spectroscopic and chemical analysis in epidermis and corium. J Invest Dermatol 30:341-345
36. Sperber K, Quraishi H, Kalb TH, Panja A, Stecher V, Mayer L (1993) Selective regulation of cytokine secretion by hydroxychloroquine: inhibition of interleukin 1 alpha (IL-1-alpha) and IL-6 in human monocytes and T cells. J Rheumatol 20:803-808
37. Su WP, Greene SL (1986) Bullous morphea profunda. Am J Dermatopathol 8:144-147
38. Terheyden P, Becker JC, Lurz C, Kahaly GJ, Bröcker EB (2003) Treatment of scleromyxoedema with hydroxychloroquine. J Dtsch Dermatol Ges 1:30-35
39. Weber SM, Chen JM, Levitz SM (2002) Inhibition of mitogen-activated protein kinase signaling by chloroquine. J Immunol 168:5303-5309
40. Wibo M, Poole B (1974) Protein degradation in cultured cells. II. The uptake of chloroquine by rat fibroblasts and the inhibition of cellular protein degradation and cathepsin B1. J Cell Biol 63:430-440
41. Wolf R, Wolf D, Ruocco V (2000) Antimalarials: unapproved uses or indications. Clin Dermatol 18:17-35
42. Wolf R, Wolf D, Ruocco V (2000) Antimalarials: unapproved uses or indications. Clin Dermatol 18:17-35 Wuthrich RC, Roenigk HH, Steck WD (1975) Localized scleroderma. Arch Dermatol 111:98-100
43. Yoshimori T (2004) Autophagy: a regulated bulk degradation process inside cells. Biochem Biophys Res Commun 313:453-458