Nuclear magnetic resonance of hyperpolarized fluorine for characterization of protein-ligand interactions

Journal of the American Chemical Society

Volumn 134, Issue 42, 2012, Pages 17448-17451

  Lee, Youngbok ^a   Zeng, Haifeng ^a   Ruedisser, Simon ^b   Gossert, Alvar D ^b   Hilty, Christian ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DISSOCIATION CONSTANT; DRUG DISCOVERY; DRUG MOLECULES; DRUG SCREENING; DYNAMIC NUCLEAR POLARIZATION; FLUORINE ATOMS; HYPERPOLARIZED; LIGAND CONCENTRATION; NMR ANALYSIS; PROTEIN CONCENTRATIONS; PROTEIN-LIGAND INTERACTIONS; SMALL MOLECULES; SUBMICROMOLAR CONCENTRATIONS;

DISSOCIATION; FLUORINE; LIGANDS; MOLECULES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS;

SIGNAL DETECTION;

FLUORINE; LIGAND; PROTEIN;

ARTICLE; ATOM; HYPERPOLARIZATION; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLARIZATION; PROTEIN INTERACTION;

FLUORINE; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; TRYPSIN;

EID: 84867807912     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja308437h     Document Type: Article

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