Ranking of high-affinity ligands by NMR spectroscopy

Angewandte Chemie - International Edition

Volumn 48, Issue 36, 2009, Pages 6691-6694

  Zhang, Xiaolu ^a,b   Sänger, Andrea ^a   Hemmig, René ^a   Jahnke, Wolfgang ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Dissociation constants; Lead optimization; NMR spectroscopy; Proteins

Indexed keywords

BINDING LIGANDS; DISSOCIATION CONSTANTS; HIGH AFFINITY LIGANDS; LEAD OPTIMIZATION; NMR SPECTROSCOPY; PROTEIN RECEPTORS; RELATIVE BINDING AFFINITY;

BINDING ENERGY; DISSOCIATION; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS;

LIGANDS;

LIGAND; PROTEIN;

ARTICLE; CHEMISTRY; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING;

LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEINS;

EID: 70349923663     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200902591     Document Type: Article

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