-
3
-
-
63849325584
-
Ligand based NMR methods for drug discovery
-
Ludwig C., and Guenther U.L. Ligand based NMR methods for drug discovery. Front. Biosci. 14 (2009) 4565-4574
-
(2009)
Front. Biosci.
, vol.14
, pp. 4565-4574
-
-
Ludwig, C.1
Guenther, U.L.2
-
4
-
-
51249121331
-
Perspectives on NMR in drug discovery: a technique comes of age
-
Pellecchia M., Bertini I., Cowburn D., Dalvit C., Giralt E., Jahnke W., James T.L., Homans S.W., Kessler H., Luchinat C., Meyer B., Oschkinat H., Peng J., Schwalbe H., and Siegal G. Perspectives on NMR in drug discovery: a technique comes of age. Nat. Rev. Drug Discov. 7 (2008) 738-745
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 738-745
-
-
Pellecchia, M.1
Bertini, I.2
Cowburn, D.3
Dalvit, C.4
Giralt, E.5
Jahnke, W.6
James, T.L.7
Homans, S.W.8
Kessler, H.9
Luchinat, C.10
Meyer, B.11
Oschkinat, H.12
Peng, J.13
Schwalbe, H.14
Siegal, G.15
-
5
-
-
0032494393
-
NOE pumping: a novel NMR technique for identification of compounds with binding affinity to macromolecules
-
Chen A., and Shapiro M.J. NOE pumping: a novel NMR technique for identification of compounds with binding affinity to macromolecules. J. Am. Chem. Soc. 120 (1998) 10258-10259
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 10258-10259
-
-
Chen, A.1
Shapiro, M.J.2
-
6
-
-
0033963395
-
NOE pumping. 2. A high-throughput method to determine compounds with binding affinity to macromolecules by NMR
-
Chen A., and Shapiro M.J. NOE pumping. 2. A high-throughput method to determine compounds with binding affinity to macromolecules by NMR. J. Am. Chem. Soc. 122 (2000) 414-415
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 414-415
-
-
Chen, A.1
Shapiro, M.J.2
-
7
-
-
0031576702
-
One-dimensional relaxation- and diffusion-edited NMR methods for screening compounds that bind to macromolecules
-
Hajduk P.J., Olejniczak E.T., and Fesik S.W. One-dimensional relaxation- and diffusion-edited NMR methods for screening compounds that bind to macromolecules. J. Am. Chem. Soc. 119 (1997) 12257-12261
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 12257-12261
-
-
Hajduk, P.J.1
Olejniczak, E.T.2
Fesik, S.W.3
-
8
-
-
0034596286
-
Second-site NMR screening with a spin-labeled first ligand
-
Jahnke W., Perez L.B., Paris C.G., Strauss A., Fendrich G., and Nalin C.M. Second-site NMR screening with a spin-labeled first ligand. J. Am. Chem. Soc. 122 (2000) 7394-7395
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 7394-7395
-
-
Jahnke, W.1
Perez, L.B.2
Paris, C.G.3
Strauss, A.4
Fendrich, G.5
Nalin, C.M.6
-
10
-
-
0001174635
-
Diffusion-edited NMR; affinity NMR for direct observation of molecular interactions
-
Lin M., Shapiro M.J., and Wareing J.R. Diffusion-edited NMR; affinity NMR for direct observation of molecular interactions. J. Am. Chem. Soc. 119 (1997) 5249-5250
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 5249-5250
-
-
Lin, M.1
Shapiro, M.J.2
Wareing, J.R.3
-
11
-
-
0037463033
-
NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors
-
Meyer B., and Peters T. NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors. Angew. Chem. Int. Ed. Engl. 42 (2003) 864-890
-
(2003)
Angew. Chem. Int. Ed. Engl.
, vol.42
, pp. 864-890
-
-
Meyer, B.1
Peters, T.2
-
12
-
-
0037010533
-
NMR screening techniques in drug discovery and drug design
-
Stockman B.J., and Dalvit C. NMR screening techniques in drug discovery and drug design. Prog. Nucl. Magn. Reson. Spectrosc. 41 (2002) 187-231
-
(2002)
Prog. Nucl. Magn. Reson. Spectrosc.
, vol.41
, pp. 187-231
-
-
Stockman, B.J.1
Dalvit, C.2
-
13
-
-
0034694684
-
Transferred 13C T1 relaxation at natural isotopic abundance; a practical method for determining site-specific changes in ligand flexibility upon binding to a macromolecule
-
LaPlante S.R., Aubry N., Deziel R., Ni F., and Xu P. Transferred 13C T1 relaxation at natural isotopic abundance; a practical method for determining site-specific changes in ligand flexibility upon binding to a macromolecule. J. Am. Chem. Soc. 122 (2000) 12530-12535
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 12530-12535
-
-
LaPlante, S.R.1
Aubry, N.2
Deziel, R.3
Ni, F.4
Xu, P.5
-
14
-
-
63449101029
-
Time efficient detection of protein-ligand interactions with the polarization optimized PO-WaterLOGSY NMR experiment
-
Gossert A.D., Henry C., Blommers M.J.J., Jahnke W., and Fernandez C. Time efficient detection of protein-ligand interactions with the polarization optimized PO-WaterLOGSY NMR experiment. J. Biomol. NMR 43 (2009) 211-217
-
(2009)
J. Biomol. NMR
, vol.43
, pp. 211-217
-
-
Gossert, A.D.1
Henry, C.2
Blommers, M.J.J.3
Jahnke, W.4
Fernandez, C.5
-
15
-
-
0142184432
-
Studies of protein-ligand interactions by NMR
-
Clarkson J., and Campbell I.D. Studies of protein-ligand interactions by NMR. Biochem. Soc. Trans. 31 (2003) 1006-1009
-
(2003)
Biochem. Soc. Trans.
, vol.31
, pp. 1006-1009
-
-
Clarkson, J.1
Campbell, I.D.2
-
16
-
-
0038207989
-
Fluorine-NMR experiments for high-throughput screening: theoretical aspects, practical considerations, and range of applicability
-
Dalvit C., Fagerness P.E., Hadden D.T.A., Sarver R.W., and Stockman B.J. Fluorine-NMR experiments for high-throughput screening: theoretical aspects, practical considerations, and range of applicability. J. Am. Chem. Soc. 125 (2003) 7696-7703
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 7696-7703
-
-
Dalvit, C.1
Fagerness, P.E.2
Hadden, D.T.A.3
Sarver, R.W.4
Stockman, B.J.5
-
17
-
-
0036707428
-
Cryogenic probe 13C NMR spectroscopy of urine for metabonomic studies
-
Keun H.C., Beckonert O., Griffin J.L., Richter C., Moskau D., Lindon J.C., and Nicholson J.K. Cryogenic probe 13C NMR spectroscopy of urine for metabonomic studies. Anal. Chem. 74 (2002) 4588-4593
-
(2002)
Anal. Chem.
, vol.74
, pp. 4588-4593
-
-
Keun, H.C.1
Beckonert, O.2
Griffin, J.L.3
Richter, C.4
Moskau, D.5
Lindon, J.C.6
Nicholson, J.K.7
-
18
-
-
0000633163
-
Principles of dynamic nuclear polarisation
-
Abragam A., and Goldman M. Principles of dynamic nuclear polarisation. Rep. Prog. Phys. 41 (1978) 395-467
-
(1978)
Rep. Prog. Phys.
, vol.41
, pp. 395-467
-
-
Abragam, A.1
Goldman, M.2
-
19
-
-
0042763165
-
Increase in signal-to-noise ratio of >10, 000 times in liquid-state NMR
-
Ardenkjær-Larsen J.H., Fridlund B., Gram A., Hansson G., Hansson L., Lerche M.H., Servin R., Thaning M., and Golman K. Increase in signal-to-noise ratio of >10, 000 times in liquid-state NMR. Proc. Natl Acad. Sci. USA 100 (2003) 10158-10163
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 10158-10163
-
-
Ardenkjær-Larsen, J.H.1
Fridlund, B.2
Gram, A.3
Hansson, G.4
Hansson, L.5
Lerche, M.H.6
Servin, R.7
Thaning, M.8
Golman, K.9
-
21
-
-
0028936571
-
An exact mathematical expression for describing competitive binding of two different ligands to a protein molecule
-
Wang Z.-X. An exact mathematical expression for describing competitive binding of two different ligands to a protein molecule. FEBS Lett. 360 (1995) 111-114
-
(1995)
FEBS Lett.
, vol.360
, pp. 111-114
-
-
Wang, Z.-X.1
-
22
-
-
0015241653
-
Conformation and segmental motion of native and denatured ribonuclease A in solution. Application of natural-abundance carbon-13 partially relaxed Fourier transform nuclear magnetic resonance
-
Allerhand A., Doddrell D., Glushko V., Cochran D.W., Wenkert E., Lawson P.J., and Gurd F.R.N. Conformation and segmental motion of native and denatured ribonuclease A in solution. Application of natural-abundance carbon-13 partially relaxed Fourier transform nuclear magnetic resonance. J. Am. Chem. Soc. 93 (1971) 544-546
-
(1971)
J. Am. Chem. Soc.
, vol.93
, pp. 544-546
-
-
Allerhand, A.1
Doddrell, D.2
Glushko, V.3
Cochran, D.W.4
Wenkert, E.5
Lawson, P.J.6
Gurd, F.R.N.7
-
24
-
-
48149098245
-
Time-resolved dynamic nuclear polarization enhanced NMR spectroscopy
-
Bowen S., and Hilty C. Time-resolved dynamic nuclear polarization enhanced NMR spectroscopy. Angew. Chem. Int. Ed. Engl. 47 (2008) 5235-5237
-
(2008)
Angew. Chem. Int. Ed. Engl.
, vol.47
, pp. 5235-5237
-
-
Bowen, S.1
Hilty, C.2
-
25
-
-
70349668768
-
Hyperpolarized amino acids for in vivo assays of transaminase activity
-
Jensen P.R., Karlsson M., Meier S., Duus J.Ø., and Lerche M.H. Hyperpolarized amino acids for in vivo assays of transaminase activity. Chemistry 15 (2009) 10010-10012
-
(2009)
Chemistry
, vol.15
, pp. 10010-10012
-
-
Jensen, P.R.1
Karlsson, M.2
Meier, S.3
Duus, J.Ø.4
Lerche, M.H.5
-
26
-
-
69249137416
-
Detection of low-populated reaction intermediates with hyperpolarized NMR
-
Jensen P.R., Meier S., Ardenkjaer-Larsen J.H., Duus J.O., Karlsson M., and Lerche M.H. Detection of low-populated reaction intermediates with hyperpolarized NMR. Chem. Commun. 34 (2009) 5168-5170
-
(2009)
Chem. Commun.
, vol.34
, pp. 5168-5170
-
-
Jensen, P.R.1
Meier, S.2
Ardenkjaer-Larsen, J.H.3
Duus, J.O.4
Karlsson, M.5
Lerche, M.H.6
-
27
-
-
38049103113
-
Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR
-
Merritt M.E., Harrison C., Storey C., Jeffrey F.M., Sherry A.D., and Malloy C.R. Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. Proc. Natl. Acad. Sci. USA 104 (2007) 19773-19777
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 19773-19777
-
-
Merritt, M.E.1
Harrison, C.2
Storey, C.3
Jeffrey, F.M.4
Sherry, A.D.5
Malloy, C.R.6
-
30
-
-
0033521508
-
The effect of phosphate buffer in the range of pH 5.80-8.07 on jack bean urease activity
-
Krajewska B., and Zaborska W. The effect of phosphate buffer in the range of pH 5.80-8.07 on jack bean urease activity. J. Mol. Catal. B Enzym. 6 (1999) 75-81
-
(1999)
J. Mol. Catal. B Enzym.
, vol.6
, pp. 75-81
-
-
Krajewska, B.1
Zaborska, W.2
-
31
-
-
0015861774
-
i) and the concentration of inhibitor which causes 50 per cent inhibition (IC50) of an enzymatic reaction
-
i) and the concentration of inhibitor which causes 50 per cent inhibition (IC50) of an enzymatic reaction. Biochem. Pharmacol. 22 (1973) 3099-3108
-
(1973)
Biochem. Pharmacol.
, vol.22
, pp. 3099-3108
-
-
Cheng, Y.1
Prusoff, W.H.2
-
32
-
-
0019476084
-
Role of urease in the formation of infection stones: comparison of ureases from different sources
-
Rosenstein I.J., Hamilton-Miller J.M., and Brumfitt W. Role of urease in the formation of infection stones: comparison of ureases from different sources. Infect. Immun. 32 (1981) 32-37
-
(1981)
Infect. Immun.
, vol.32
, pp. 32-37
-
-
Rosenstein, I.J.1
Hamilton-Miller, J.M.2
Brumfitt, W.3
-
33
-
-
0033541040
-
Transferred cross-correlated relaxation complements transferred NOE: structure of an IL-4R-derived peptide bound to STAT-6
-
Blommers M.J.J., Stark W., Jones C.E., Head D., Owen C.E., and Jahnke W. Transferred cross-correlated relaxation complements transferred NOE: structure of an IL-4R-derived peptide bound to STAT-6. J. Am. Chem. Soc. 121 (1999) 1949-1953
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 1949-1953
-
-
Blommers, M.J.J.1
Stark, W.2
Jones, C.E.3
Head, D.4
Owen, C.E.5
Jahnke, W.6
-
34
-
-
0033541092
-
Transferred cross-correlated relaxation: application to the determination of sugar pucker in an aminoacylated tRNA-mimetic weakly bound to EF-Tu
-
Carlomagno T., Felli I.C., Czech M., Fischer R., Sprinzl M., and Griesinger C. Transferred cross-correlated relaxation: application to the determination of sugar pucker in an aminoacylated tRNA-mimetic weakly bound to EF-Tu. J. Am. Chem. Soc. 121 (1999) 1945-1948
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 1945-1948
-
-
Carlomagno, T.1
Felli, I.C.2
Czech, M.3
Fischer, R.4
Sprinzl, M.5
Griesinger, C.6
-
35
-
-
75749084537
-
A closed helium sorption pump system and its use in hyperpolarized 13C metabolic imaging
-
Königstein
-
J.H. Ardenkjaer-Larsen, J. Urbahn, A. Leach, E. Stautner, T. Zhang, N. Clarke, A closed helium sorption pump system and its use in hyperpolarized 13C metabolic imaging, in: 2nd DNP Symposium, Königstein, 2009, p. 38.
-
(2009)
2nd DNP Symposium
, pp. 38
-
-
Ardenkjaer-Larsen, J.H.1
Urbahn, J.2
Leach, A.3
Stautner, E.4
Zhang, T.5
Clarke, N.6
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