The 1.85 Å structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity

Biochemistry

Volumn 48, Issue 33, 2009, Pages 7906-7915

  Neau, David B ^a,c   Gilbert, Nathaniel C ^a   Bartlett, Sue G ^a   Boeglin, William ^b   Brash, Alan R ^b   Newcomer, Marcia E ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACIDS; EICOSANOIDS; GENERAL MODEL; LIPOXYGENASES; PRODUCT SPECIFICITY; RESOLUTION STRUCTURE; SPECIFIC INHIBITORS; SUBSTRATE BINDING; SUBSTRATE RECOGNITION; U-SHAPED CHANNELS;

AMINES; AMINO ACIDS; BIOCHEMISTRY; ENZYMES; ORGANIC ACIDS; SUBSTRATES;

ENZYME ACTIVITY;

AMINO ACID; LIPOXYGENASE; HYDROPEROXIDE ISOMERASE; ISOMERASE;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; ANIMAL; ANTHOZOA; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; MOLECULAR GENETICS; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

PLEXAURA HOMOMALLA;

AMINO ACID SEQUENCE; ANIMALS; ANTHOZOA; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; LIPOXYGENASE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 69049086852     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900084m     Document Type: Article

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