Losartan improves recovery of contraction and inhibits transient inward current in a cellular model of cardiac ischemia and reperfusion

Journal of Pharmacology and Experimental Therapeutics

Volumn 295, Issue 2, 2000, Pages 697-704

  Louch, W E ^a   Ferrier, G R ^a   Howlett, S E ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; LOSARTAN;

ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; GUINEA PIG; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; STUNNED HEART MUSCLE;

ANGIOTENSIN II; ANIMAL; ANTI-ARRHYTHMIA AGENTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, T-TYPE; COMPARATIVE STUDY; GUINEA PIGS; HEART VENTRICLE; LOSARTAN; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIAL STUNNING; PATCH-CLAMP TECHNIQUES; RECEPTORS, ANGIOTENSIN; SUPPORT, NON-U.S. GOV'T;

EID: 0033776284     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Prevention of thrombexane A2 receptor-mediated pulmonary hypertension by a nonpeptide angiotensin II type 1 receptor antagonist
2. Differential regulation of angiotensin II and losartan binding sites in glomeruli and mesangial cells
3. Effects of enalapril in heart failure: A double blind study of effects on exercise performance, renal function, hormones and metabolic state
4. Unblock of the slow inward current induces the arrhythmogenic transient inward current in isolated guinea pig myocytes
5. Simulated ischaemia and reperfusion in isolated guinea pig ventricular myocytes
6. 'Myocardial stunning' remaining questions
7. Lack of involvement of thrombexane A2 in postischemic recovery of stunned canine myocardium
8. Digitalis arrhythmias: Role of oscillatory afterpotentials
9. Ventricular tachycardia in an isolated guinea pig ventricular free wall model of ischemia and reperfusion
10. Possible mechanisms of ventricular arrhythmias elicited by ischemia followed by reperfusion. Studies on isolated canine ventricular tissues
11. Prostacyclin prevents ventricular fibrillation in a canine model of sudden cardiac death
12. Opposite effects of angiotensin AT1 and AT2 receptor antagonists on recovery of mechanical function after ischemia-reperfusion in isolated working rat hearts
13. Intrinsic ANG II type 1 receptor stimulation contributes to recovery of postischemic mechanical function
14. 2+ responsiveness and altered diastolic function in intact ventricular muscle
15. Elevated plasma endothelin concentrations in heart failure; an effect of angiotensin II?
16. The 1996 Merck Frosst Award. The voltage-sensitive release mechanism: A new trigger for cardiac contraction
17. The nonpeptide angiotensin II antagonist DuP 753 is a potent stimulus for prostacyclin synthesis
18. Electrical uncoupling and impulse propagation in isolated sheep Purkinje fibers
19. Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibers
20. Effects of intravenous captopril on inducible sustained ventricular tachycardia one week after experimental infarction in the anesthetized pig
21. Losartan attenuates myocardial ischemia-induced ventricular arrhythmias and reperfusion injury in spontaneously hypertensive rats
22. Influence of local converting enzyme inhibition on angiotensin and bradykinin effects in ischemic rat hearts
23. Tetracaine can inhibit contractions initiated by a voltage-sensitive release mechanism in guinea-pig ventricular myocytes
24. Transient depolarization and spontaneous fluctuations in isolated single cells from guinea pig ventricles. Calcium-mediated membrane potential fluctuations
25. Effects of an angiotensin II antagonist on reperfusion arrhythmias in dogs
26. Reperfusion injury: A review of the pathophysiology, clinical manifestations and therapeutic options
27. Angiotensin II receptor inhibition. A new therapeutic principle
28. Effects of an angiotensin II antagonist on ischemic and nonischemic isolated rat hearts
29. Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE)
30. 'Cardioprotection' by ACE-inhibitors in acute myocardial ischemia and infarction?
31. Short- and long-term neurohormonal activation following acute myocardial infarction
32. Effects of local inhibition of the cardiac renin-angiotensin system with CV-11974 in a canine ischaemia-reperfusion model
33. Losartan exerts antiarrhythmic activity independent of angiotensin II receptor blockade in simulated ventricular ischemia and reperfusion
34. Angiotensin I conversion and coronary constriction by angiotensin II in ischemic and hypoxic isolated rat hearts
35. Effect of enalapril on ventricular arrhythmias in congestive heart failure
36. The actions of ouabain on intercellular coupling and conduction velocity in mammalian ventricular muscle
37. Use of losartan to examine the role of the cardiac renin-angiotensin system in myocardial dysfunction during ischemia and reperfusion
38. 2+ sparks, and local control of excitation-contraction coupling in normal heart muscle
39. Cardioprotective effect of the angiotensin II type 1 receptor antagonist TCV-116 on ischemia-reperfusion injury
40. INaCa and ICI(Ca) contribute to isproterenol-induced delayed after depolarizations in midmyocardial cells