Ghrelin inhibits hydrogen peroxide-induced apoptotic cell death of oligodendrocytes via ERK and p38MAPK signaling

Endocrinology

Volumn 152, Issue 6, 2011, Pages 2377-2386

  Lee, Jee Y ^a   Oh, Tae H ^a   Yune, Tae Y ^a  

^a Kyung Hee University Hospital   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE 3; CYTOCHROME C; GHRELIN; GHRELIN RECEPTOR; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FRACTIONATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; NONHUMAN; OLIGODENDROGLIA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GHRELIN; HYDROGEN PEROXIDE; MAP KINASE SIGNALING SYSTEM; OLIGODENDROGLIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79956324625     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2011-0090     Document Type: Article

References (53)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660 (Pubitemid 129516334)
2. Tschöp M, Smiley DL, Heiman ML 2000 Ghrelin induces adiposity in rodents. Nature 407:908-913
3. Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M 2000 Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141:4255-4261
4. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S 2001 A role for ghrelin in the central regulation of feeding. Nature 409:194-198 (Pubitemid 32144284)
5. Inui A 2001 Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat Rev Neurosci 2:551-560 (Pubitemid 33679828)
6. Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka S, Itoh Z, Hosoda H, Kojima M, Kangawa K 2000 Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 276:905-908
7. Shimizu Y, Nagaya N, Teranishi Y, Imazu M, Yamamoto H, Shokawa T, Kangawa K, Kohno N, Yoshizumi M 2003 Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats. Biochem Biophys Res Commun 310:830-835 (Pubitemid 37188697)
8. Nagaya N, Moriya J, Yasumura Y, Uematsu M, Ono F, Shimizu W, Ueno K, Kitakaze M, Miyatake K, Kangawa K 2004 Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation 110:3674-3679 (Pubitemid 39665256)
9. van der Lely AJ, Tschöp M, Heiman ML, Ghigo E 2004 Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25:426-457 (Pubitemid 38780667)
10. Kojima M, Kangawa K 2005 Ghrelin: structure and function. Physiol Rev 85:495-522 (Pubitemid 40404635)
11. Baldanzi G, Filigheddu N, Cutrupi S, Catapano F, Bonissoni S, Fubini A, Malan D, Baj G, Granata R, Broglio F, Papotti M, Surico N, Bussolino F, Isgaard J, Deghenghi R, Sinigaglia F, Prat M, Muccioli G, Ghigo E, Graziani A 2002 Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol 159:1029-1037 (Pubitemid 36055757)
12. Kim SW, Her SJ, Park SJ, Kim D, Park KS, Lee HK, Han BH, Kim MS, Shin CS, Kim SY 2005 Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells. Bone 37:359-369 (Pubitemid 41160494)
13. Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G 2007 Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic β-cells and human islets: involvement of 3′,5′-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling. Endocrinology 148:512-529 (Pubitemid 46143157)
14. Chung H, Kim E, Lee DH, Seo S, Ju S, Lee D, Kim H, Park S 2007 Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation. Endocrinology 148:148-159 (Pubitemid 46021447)
15. Jana M, Pahan K 2005 Redox regulation of cytokine-mediated inhibition of myelin gene expression in human primary oligodendrocytes. Free Radic Biol Med 39:823-831 (Pubitemid 41139895)
16. Yune TY, Lee JY, Jung GY, Kim SJ, Jiang MH, Kim YC, Oh YJ, Markelonis GJ, Oh TH 2007 Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury. J Neurosci 27:7751-7761 (Pubitemid 47093808)
17. Smith KJ, Kapoor R, Felts PA 1999 Demyelination: the role of reactive oxygen and nitrogen species. Brain Pathol 9:69-92 (Pubitemid 29056521)
18. Juurlink BH, Thorburne SK, Hertz L 1998 Peroxide-scavenging deficit underlies oligodendrocyte susceptibility to oxidative stress. Glia 22:371-378 (Pubitemid 28129714)
19. Lee JY, Chung H, Yoo YS, Oh YJ, Oh TH, Park S, Yune TY 2010 Inhibition of apoptotic cell death by ghrelin improves functional recovery after spinal cord injury. Endocrinology 151:3815-3826
20. Liu Y, Chen L, Xu X, Vicaut E, Sercombe R 2009 Both ischemic preconditioning and ghrelin administration protect hippocampus from ischemia/reperfusion and upregulate uncoupling protein-2. BMC Physiol 9:17
21. Obay BD, Taşdemir E, Tümer C, Bilgin HM, Atmaca M 2008 Dose dependent effects of ghrelin on pentylenetetrazole-induced oxidative stress in a rat seizure model. Peptides 29:448-455
22. Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp MH, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S 2008 UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 454:846-851
23. Andrews ZB, Erion D, Beiler R, Liu ZW, Abizaid A, Zigman J, Elsworth JD, Savitt JM, DiMarchi R, Tschoep M, Roth RH, Gao XB, Horvath TL 2009 Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism. J Neurosci 29:14057-14065
24. Hou Y, An J, Hu XR, Sun BB, Lin J, Xu D, Wang T, Wen FQ 2009 Ghrelin inhibits interleukin-8 production induced by hydrogen peroxide in A549 cells via NF-κB pathway. Int Immunopharmacol 9:120-126
25. Li WG, Gavrila D, Liu X, Wang L, Gunnlaugsson S, Stoll LL, McCormick ML, Sigmund CD, Tang C, Weintraub NL 2004 Ghrelin inhibits proinflammatory responses and nuclear factor-κB activation in human endothelial cells. Circulation 109:2221-2226 (Pubitemid 38625400)
26. Yoon SO, Casaccia-Bonnefil P, Carter B, Chao MV 1998 Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival. J Neurosci 18:3273-3281 (Pubitemid 28186020)
27. Vollgraf U, Wegner M, Richter-Landsberg C 1999 Activation of AP-1 and nuclear factor-κB transcription factors is involved in hydrogen peroxide-induced apoptotic cell death of oligodendrocytes. J Neurochem 73:2501-2509
28. Lee SM, Yune TY, Kim SJ, Kim YC, Oh YJ, Markelonis GJ, Oh TH 2004 Minocycline inhibits apoptotic cell death via attenuation of TNF-α expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co-cultures. J Neurochem 91:568-578 (Pubitemid 39431152)
29. Yune TY, Lee SM, Kim SJ, Park HK, Oh YJ, Kim YC, Markelonis GJ, Oh TH 2004 Manganese superoxide dismutase induced by TNF-β is regulated transcriptionally by NF-κB after spinal cord injury in rats. J Neurotrauma 21:1778-1794 (Pubitemid 39587575)
30. Baumann N, Pham-Dinh D 2001 Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol Rev 81:871-927 (Pubitemid 32267079)
31. Perfeito R, Pereira J, Oliveira CR, Bettencourt-Relvas J, Rego AC 2007 Trolox protection of myelin membrane in hydrogen peroxide-treated mature oligodendrocytes. Free Radic Res 41:444-451 (Pubitemid 46470942)
32. Kroemer G, Reed JC 2000 Mitochondrial control of cell death. Nat Med 6:513-519 (Pubitemid 30305900)
33. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJ, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LH 1996 A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273974-977
34. Guan XM, Yu H, Palyha OC, McKee KK, Feighner SD, Sirinathsinghji DJ, Smith RG, Van der Ploeg LH, Howard AD 1997 Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res 48:23-29 (Pubitemid 27298124)
35. Kyriakis JM, Avruch J 2001 Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81:807-869 (Pubitemid 32267078)
36. Kim MS, Yoon CY, Jang PG, Park YJ, Shin CS, Park HS, Ryu JW, Pak YK, Park JY, Lee KU, Kim SY, Lee HK, Kim YB, Park KS 2004 The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes. Mol Endocrinol 18:2291-2301
37. Fragoso G, Martinez-Bermudez AK, Liu HN, Khorchid A, Chemtob S, Mushynski WE, Almazan G 2004 Developmental differences in H2O2-induced oligodendrocyte cell death: role of glutathione, mitogen-activated protein kinases and caspase 3. J Neurochem 90:392-404 (Pubitemid 38938225)
38. Seger R, Krebs EG 1995 The MAPK signaling cascade. FASEB J 9:726-735
39. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME 1995 Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326-1331
40. Anderson AJ, Robert S, Huang W, Young W, Cotman CW 2004 Activation of complement pathways after contusion-induced spinal cord injury. J Neurotrauma 21:1831-1846 (Pubitemid 39587578)
41. Mronga T, Stahnke T, Goldbaum O, Richter-Landsberg C 2004 Mitochondrial pathway is involved in hydrogen-peroxide-induced apoptotic cell death of oligodendrocytes. Glia 46:446-455 (Pubitemid 38679202)
42. Malagón MM, Luque RM, Ruiz-Guerrero E, Rodríguez-Pacheco F, García-Navarro S, Casanueva FF, Gracia-Navarro F, Castaño JP 2003 Intracellular signaling mechanisms mediating ghrelin-stimulated growth hormone release in somatotropes. Endocrinology 144: 5372-5380 (Pubitemid 37476066)
43. Carreira MC, Camiña JP, Smith RG, Casanueva FF 2004 Agonist-specific coupling of growth hormone secretagogue receptor type 1a to different intracellular signaling systems. Role of adenosine. Neuroendocrinology 79:13-25 (Pubitemid 38186450)
44. Nanzer AM, Khalaf S, Mozid AM, Fowkes RC, Patel MV, Burrin JM, Grossman AB, Korbonits M 2004 Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol 151:233-240 (Pubitemid 39207019)
45. Kohno D, Gao HZ, Muroya S, Kikuyama S, Yada T 2003 Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 52:948-956 (Pubitemid 36384265)
46. Liu Y, Wang PS, Xie D, Liu K, Chen L 2006 Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion. Chin J Physiol 49:244-250
47. Theil MM, Miyake S, Mizuno M, Tomi C, Croxford JL, Hosoda H, Theil J, von Hörsten S, Yokote H, Chiba A, Lin Y, Oki S, Akamizu T, Kangawa K, Yamamura T 2009 Suppression of experimental autoimmune encephalomyelitis by ghrelin. J Immunol 183:2859-2866
48. Xu J, Wang S, Lin Y, Cao L, Wang R, Chi Z 2009 Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. Neurosci Lett 453:58-61
49. Miao Y, Xia Q, Hou Z, Zheng Y, Pan H, Zhu S 2007 Ghrelin protects cortical neuron against focal ischemia/reperfusion in rats. Biochem Biophys Res Commun 359:795-800 (Pubitemid 46899020)
50. Chung H, Seo S, Moon M, Park S 2008 Phosphatidylinositol-3- kinase/Akt/glycogen synthase kinase-3β and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells. J Endocrinol 198:511-521
51. Moon M, Kim HG, Hwang L Seo JH, Kim S, Hwang S, Kim S, Lee D, Chung H, Oh MS, Lee KT, Park S 2009 Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease by blocking microglial activation. Neurotox Res 15:332-347
52. Zigman JM, Jones JE, Lee CE, Saper CB, Elmquist JK 2006 Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol 494:528-548 (Pubitemid 41791000)
53. Ferens DM, Yin L, Bron R, Hunne B, Ohashi-Doi K, Kitchener PD, Sanger GJ, Witherington J, Shimizu Y, Furness JB 2010 Functional and in situ hybridization evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors. Neuroscience 166:671-679