In vivo gene delivery in the retina using polyethylenimine

BioTechniques

Volumn 42, Issue 3, 2007, Pages 285-288

  Liao, Hsi Wen ^a   Yau, King Wai ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELANOPSIN; OPSIN; POLYETHYLENEIMINE; POLYMER; RNA;

ANIMAL; ARTICLE; CHEMISTRY; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; METABOLISM; METHODOLOGY; MOUSE; RETINA; RNA INTERFERENCE; TRANSGENIC MOUSE;

ANIMALS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; MICE; MICE, TRANSGENIC; OPSIN; POLYETHYLENEIMINE; POLYMERS; RETINA; RNA; RNA INTERFERENCE; TRANSFECTION;

EID: 34248529978     PISSN: 07366205     EISSN: None     Source Type: Journal    
DOI: 10.2144/000112404     Document Type: Article

References (17)

1. Young, L.S., P.F. Searle, D. Onion, and V. Mautner. 2006. Viral gene therapy strategies: from basic science to clinical application. J. Pathol. 208:299-318. (Pubitemid 43126122)
2. Raoul, C., S.D. Barker, and P. Aebischer. 2006. Viral-based modelling and correction of neurodegenerative diseases by RNA interference. Gene Ther. 13:487-495.
3. Reynolds, A., D. Leake, Q. Boese, S. Scaringe, W.S. Marshall, and A. Khvorova. 2004. Rational siRNA design for RNA interference. Nat. Biotechnol. 22:326-330.
4. Dudus, L., V. Anand, G.M. Acland, S.J. Chen, J.M. Wilson, K.J. Fisher, A.M. Maguire, and J. Bennett. 1999. Persistent transgene product in retina, optic nerve and brain after intraocular injection of rAAV. Vision Res. 39:2545-2553. (Pubitemid 29197300)
5. Martin, K.R., R.L. Klein, and H.A. Quigley. 2002. Gene delivery to the eye using adeno-associated viral vectors. Methods 28:267-275. (Pubitemid 35341091)
6. van Adel, B.A., C. Kostic, N. Deglon, A.K. Ball, and Y. Arsenijevic. 2003. Delivery of ciliary neurotrophic factor via lentiviral-mediated transfer protects axotomized retinal ganglion cells for an extended period of time. Hum. Gene Ther. 14:103-115.
7. Lungwitz, U., M. Breunig, T. Blunk, and A. Gopferich. 2005. Polyethyleniminebased non-viral gene delivery systems. Eur. J. Pharm. Biopharm. 60:247-266.
8. Provencio, I., G. Jiang, W.J. De Grip, W.P. Hayes, and M.D. Rollag. 1998. Melanopsin: an opsin in melanophores, brain, and eye. Proc. Natl. Acad. Sci. USA 95:340-345.
9. Lucas, R.J., S. Hattar, M. Takao, D.M. Berson, R.G. Foster, and K.-W. Yau. 2003. Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice. Science 299:245-247.
10. Fu, Y., H.-W. Liao, M.T. Do, and K.-W. Yau. 2005. Non-image-forming ocular photoreception in vertebrates. Curr. Opin. Neurobiol. 15:415-422.
11. Jeffery, G. 1998. The retinal pigment epithelium as a developmental regulator of the neural retina. Eye 12:499-503. (Pubitemid 28356657)
12. Hattar, S., H.-W. Liao, M. Takao, D.M. Berson, and K.-W. Yau. 2002. Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science 295:1065-1070. (Pubitemid 34132235)
13. Plouffe, L. and R.M. Stelmack. 1979. Neuroticism and the effect of stress on the pupillary light reflex. Percept. Mot. Skills 49:635-642.
14. Bi, A., J. Cui, Y.P. Ma, E. Olshevskava, M. Pu, A.M. Dizhoor, and Z.H. Pan. 2006. Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. Neuron 50:23-33.
15. Dinculescu, A., L. Glushakova, S.H. Min, and W.W. Hauswirth. 2005. Adeno-associated virus-vectored gene therapy for retinal disease. Hum. Gene Ther. 16:649-663.
16. Trejo, L.J. and C.M. Cicerone. 1984. Cells in the pretectal olivary nucleus are in the pathway for the direct light reflex of the pupil in the rat. Brain Res. 300:49-62.
17. Clarke, R.J. and H. Ikeda. 1985. Luminance and darkness detectors in the olivary and posterior pretectal nuclei and their relationship to the pupillary light reflex in the rat. I. Studies with steady luminance levels. Exp. Brain Res. 57:224-232.