Mechanisms of renal injury and progression of renal disease in congenital obstructive nephropathy

Pediatric Nephrology

Volumn 25, Issue 4, 2010, Pages 687-697

  Chevalier, Robert L ^a,b   Thornhill, Barbara A ^a   Forbes, Michael S ^a   Kiley, Susan C ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Apoptosis; Biomarkers; Fibrosis; Growth factors; Inflammation; Recovery

Indexed keywords

ANGIOTENSIN; BIOLOGICAL MARKER; CELL ADHESION MOLECULE; CYTOKINE; ENALAPRIL; EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; LOSARTAN; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ATROPHY; CELL HYPOXIA; CONFERENCE PAPER; DISEASE COURSE; DISEASE EXACERBATION; DISEASE SEVERITY; EXTRACELLULAR MATRIX; FIBROGENESIS; GLOMERULITIS; HUMAN; KIDNEY DEVELOPMENT; KIDNEY FIBROSIS; KIDNEY INJURY; KIDNEY TUBULE CELL; KIDNEY TUBULE DISORDER; NEPHRON; NONHUMAN; OBSTRUCTIVE UROPATHY; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PYELOPLASTY; RENAL PROTECTION; URETER OBSTRUCTION;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BIOLOGICAL MARKERS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; HUMANS; HYDRONEPHROSIS; KIDNEY; KIDNEY FUNCTION TESTS; KIDNEY TUBULES; NEPHRONS; RECOVERY OF FUNCTION; URETERAL OBSTRUCTION;

EID: 77951253854     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-009-1316-5     Document Type: Conference Paper

References (121)

1. RL Chevalier CA Peters 2003 Congenital urinary tract obstruction: Proceedings of the State-Of-The-Art Strategic Planning Workshop - National Institutes of Health, Bethesda, Maryland, USA, 11-12 March 2002. Pediatr Nephrol 18 576 606 12720078
2. R Airik A Kispert 2007 Down the tube of obstructive nephropathies: the importance of tissue interactions during ureter development Kidney Int 72 1459 1467 1:CAS:528:DC%2BD2sXhtlKltLrI 17928823 (Pubitemid 350197957)
3. Y Miyazaki S Tsuchida H Nishimura JC Pope RC Harris JM McKanna T Inagami BM Hogan A Fogo I Ichikawa 1998 Angiotensin induces the urinary peristaltic machinery during the perinatal period J Clin Invest 102 1489 1497 1:CAS:528:DyaK1cXmvVygurc%3D 9788961 (Pubitemid 28492215)
4. Y Miyazaki S Tsuchida A Fogo I Ichikawa 1999 The renal lesions that develop in neonatal mice during angiotensin inhibition mimic obstructive nephropathy Kidney Int 55 1683 1695 1:CAS:528:DyaK1MXjtVOgs74%3D 10231430 (Pubitemid 29197955)
5. CP Chang BW McDill JR Neilson HE Joist JA Epstein GR Crabtree F Chen 2004 Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery J Clin Invest 113 1051 1058 1:CAS:528:DC%2BD2cXivFCqsLg%3D 15057312 (Pubitemid 38544127)
6. JC Pope JW Brock III MC Adams Y Miyazaki FD Stephens I Ichikawa 2001 Congenital anomalies of the kidney and urinary tract-role of the loss of function mutation in the pluripotent angiotensin type 2 receptor gene J Urol 165 196 202 1:CAS:528:DC%2BD3MXhtFOgtg%3D%3D 11125405
7. M Hiraoka T Taniguchi H Nakai M Kino Y Okada A Tanizawa H Tsukahara Y Ohshima I Muramatsu M Mayumi 2001 No evidence for AT2R gene derangement in human urinary tract anomalies Kidney Int 59 1244 1249 1:CAS:528:DC%2BD3MXjtVOhtrc%3D 11260384 (Pubitemid 32281211)
8. CA Peters 1997 Obstruction of the fetal urinary tract J Am Soc Nephrol 8 653 663 1:STN:280:DyaK1MvisFyjsQ%3D%3D 10495796
9. DG Matsell AF Tarantal 2002 Experimental models of fetal obstructive nephropathy Pediatr Nephrol 17 470 476 12172756
10. CA Peters MC Carr A Lais AB Retik J Mandell 1992 The response of the fetal kidney to obstruction J Urol 148 503 509 1:STN:280:DyaK38zkvFCqsA%3D%3D 1640511
11. DG Matsell A Mok AF Tarantal 2002 Altered primate glomerular development due to in utero-urinary tract obstruction Kidney Int 61 1263 1269 11918732 (Pubitemid 34304486)
12. MS MacDonald JL Emery 1959 The late intrauterine and postnatal development of human renal glomeruli J Anat 93 331 340 1:STN:280: DyaF3c7nt1Sjuw%3D%3D 14419327
13. L Larsson A Aperia P Wilton 1980 Effect of normal development on compensatory renal growth Kidney Int 18 29 35 1:STN:280:DyaL3M7ntFWlsQ%3D%3D 7218658 (Pubitemid 10044811)
14. T Gilbert M Lelievre-Pegorier R Malienou A Meulemans C Merlet-Benichou 1987 Effects of prenatal and postnatal exposure to gentamicin on renal differentiation in the rat Toxicology 43 301 313 1:CAS:528:DyaL2sXhvVymsL0%3D 3824397 (Pubitemid 17024454)
15. HA Hartman HL Lai P Patterson 2007 Cessation of renal morphogenesis in mice Dev Biol 310 379 387 1:CAS:528:DC%2BD2sXhtFSksrvJ 17826763
16. RL Chevalier MS Forbes BA Thornhill 2009 Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy Kidney Int 75 1145 1152 19340094
17. L Larsson AB Maunsbach 1980 The ultrastructural development of the glomerular filtration barrier in the rat kidney: a morphometric analysis J Ultrastr Res 72 392 406 1:STN:280:DyaL3M%2FkvFOlug%3D%3D
18. RL Chevalier A Kim BA Thornhill JT Wolstenholme 1999 Recovery following relief of unilateral ureteral obstruction in the neonatal rat Kidney Int 55 793 807 1:STN:280:DyaK1M7lt1ajsQ%3D%3D 10027917 (Pubitemid 29100692)
19. KF Hilgers SK Nagaraj EA Karginova IG Kazakova RL Chevalier RM Carey ES Pentz RA Gomez 1998 Molecular cloning of KS, a novel rat gene expressed exclusively in the kidney Kidney Int 54 1444 1454 1:CAS:528:DyaK1cXnsVeqt78%3D 9844120 (Pubitemid 28502886)
20. S Poucell-Hatton M Huang S Bannykh K Benirschke E Masliah 2000 Fetal obstructive uropathy: patterns of renal pathology Pediatr Dev Pathol 3 223 231 1:STN:280:DC%2BD3c3gvFKisw%3D%3D 10742409 (Pubitemid 30232847)
21. AF Tarantal VKM Han KC Cochrum A Mok M DaSilva DG Matsell 2001 Fetal rhesus monkey model of obstructive renal dysplasia Kidney Int 59 446 456 1:STN:280:DC%2BD3M7ptl2ltQ%3D%3D 11168926 (Pubitemid 32157909)
22. RL Chevalier KH Chung CD Smith M Ficenec RA Gomez 1996 Renal apoptosis and clusterin following ureteral obstruction: the role of maturation J Urol 156 1474 1479 1:STN:280:DyaK28vgsVOksg%3D%3D 8808911 (Pubitemid 26307641)
23. F Cachat B Lange-Sperandio AY Chang SC Kiley BA Thornhill MS Forbes RL Chevalier 2003 Ureteral obstruction in neonatal mice elicits segment-specific tubular cell responses leading to nephron loss Kidney Int 63 564 575 12631121 (Pubitemid 36126802)
24. BA Thornhill LA Burt C Chen MS Forbes RL Chevalier 2005 Variable chronic partial ureteral obstruction in the neonatal rat: a new model of ureteropelvic junction obstruction Kidney Int 67 42 52 15610226 (Pubitemid 40019224)
25. RL Chevalier BA Thornhill JT Wolstenholme A Kim 1999 Unilateral ureteral obstruction in early development alters renal growth: dependence on the duration of obstruction J Urol 161 309 313 1:STN:280:DyaK1M7lsFSgsQ%3D%3D 10037429 (Pubitemid 29422353)
26. CA Peters RC Gaertner MC Carr J Mandell 1993 Fetal compensatory renal growth due to unilateral ureteral obstruction J Urol 150 597 600 1:STN:280:DyaK3szhs1ChtA%3D%3D 7686988 (Pubitemid 23213697)
27. KH Yoo BA Thornhill MS Forbes RL Chevalier 2006 Compensatory renal growth due to neonatal ureteral obstruction: implications for clinical studies Pediatr Nephrol 21 368 375 16382318
28. B Gasser Y Mauss JP Ghnassia R Favre M Kohler O Yu JL Vonesch 1993 A quantitative study of normal nephrogenesis in the human fetus: its implication in the natural history of kidney changes due to low obstructive uropathies Fetal Diagn Ther 8 371 384 1:STN:280:DyaK2c7hsVSktA%3D%3D 8286028 (Pubitemid 24014267)
29. S Rosen D McClellan WY Huang J Borer C Peters 2003 The morphology of the kidney in ureteropelvic junction obstruction (abstract) Pediatr Nephrol 18 586 587 (Pubitemid 36443525)
30. HM Snyder RL Lebowitz AH Colodny SB Bauer AB Retik 1980 Ureteropelvic junction obstruction in children Urol Clin North Am 7 273 290 7404869
31. J Valayer G Adda 1982 Hydronephrosis due to pelviureteric junction obstruction in infancy Brit J Urol 54 451 454 1:STN:280:DyaL3s%2Fns1WlsQ%3D%3D 7171947 (Pubitemid 13204311)
32. A Eskild-Jensen J Frokiaer JC Djurhuus TM Jorgensen JR Nyengaard 2002 Reduced number of glomeruli in kidneys with neonatally induced partial ureteropelvic obstruction in pigs J Urol 167 1435 1439 11832765 (Pubitemid 34132125)
33. S Josephson 1983 Experimental obstructive hydronephrosis in newborn rats: III. long-term effects on renal function J Urol 129 396 400 1:STN:280:DyaL3s7msVCrsA%3D%3D 6834522 (Pubitemid 13111321)
34. RL Chevalier BA Thornhill AY Chang F Cachat A Lackey 2002 Recovery from release of ureteral obstruction in the rat: relationship to nephrogenesis Kidney Int 61 2033 2043 12028444 (Pubitemid 34539321)
35. BA Thornhill MS Forbes ES Marcinko RL Chevalier 2007 Glomerulotubular disconnection in neonatal mice after relief of partial ureteral obstruction Kidney Int 72 1103 1112 1:STN:280:DC%2BD2snhslWlsA%3D%3D 17728704 (Pubitemid 47609049)
36. CH Garcia K Krueger BH Landing TR Wells 1986 Microdissection demonstration of the lesion of the endocrine kidney in children Pediatr Pathol 5 45 54 1:STN:280:DyaL283lvFCmsg%3D%3D 3725706 (Pubitemid 16020422)
37. R Konda S Orikasa K Sakai S Ota N Kimura 1996 The distribution of renin containing cells in scarred kidneys J Urol 156 1450 1454 1:STN:280: DyaK28vgsVOltg%3D%3D 8808905 (Pubitemid 26307635)
38. RL Chevalier MS Forbes 2008 Generation and evolution of atubular glomeruli in the progression of renal disorders J Am Soc Nephrol 19 197 206 18199796
39. RL Chevalier 2006 Obstructive nephropathy: towards biomarker discovery and gene therapy Nat Clin Prac Nephrol 2 157 168 1:CAS:528:DC%2BD28XivFCltb8%3D
40. WY Huang CA Peters D Zurakowski JG Borer DA Diamond SB Bauer DL McLellan S Rosen 2006 Renal biopsy in congenital ureteropelvic junction obstruction: evidence for parenchymal maldevelopment Kidney Int 69 137 143 16374434 (Pubitemid 43117749)
41. A Miyajima J Chen C Lawrence S Ledbetter RA Soslow J Stern S Jha J Pigato ML Lemer DP Poppas ED Vaughan Jr D Felsen 2000 Antibody to transforming growth factor-β ameliorates tubular apoptosis in unilateral ureteral obstruction Kidney Int 58 2301 2313 1:CAS:528:DC%2BD3MXitFShsw%3D%3D 11115064
42. R Misseri DR Meldrum CA Dinarello P Dagher KL Hile RC Rink KK Meldrum 2005 TNF-alpha mediates obstruction-induced renal tubular cell apoptosis and proapoptotic signaling Am J Physiol Renal Physiol 288 F406 F411 1:CAS:528:DC%2BD2MXhsFeltLk%3D 15507546 (Pubitemid 40105400)
43. J Hughes RJ Johnson 1999 Role of Fas (CD95) in tubulointerstitial disease induced by unilateral ureteric obstruction Am J Physiol 277 F26 F32 1:CAS:528:DyaK1MXkslKmt7c%3D 10409294 (Pubitemid 29352671)
44. YJ Choi L Mendoza SJ Rha D Sheikh-Hamad E Baranowska-Daca V Nguyen CW Smith G Nassar WN Suki LD Truong 2001 Role of p53-dependent activation of caspases in chronic obstructive uropathy: evidence from p53 null mutant mice J Am Soc Nephrol 12 983 992 1:CAS:528:DC%2BD3MXjvVCgtLk%3D 11316857 (Pubitemid 32378339)
45. RK Malik BA Thornhill AY Chang SC Kiley RL Chevalier 2001 Renal apoptosis parallels ceramide content following chronic ureteral obstruction in the neonatal rat Am J Physiol 281 F56 F61 1:CAS:528:DC%2BD3MXltVynurw%3D
46. KH Chung RL Chevalier 1996 Arrested development of the neonatal kidney following chronic ureteral obstruction J Urol 155 1139 1144 1:STN:280: DyaK287msVKrtg%3D%3D 8583580
47. LE Burt MS Forbes BA Thornhill RL Chevalier 2007 Renal vascular endothelial growth factor (VEGF) in neonatal obstructive nephropathy: I. Endogenous VEGF Am J Physiol 292 F158 F167 1:CAS:528:DC%2BD2sXisFGht78%3D
48. DM Silverstein BR Travis BA Thornhill JS Schurr JK Kolls JC Leung RL Chevalier 2003 Altered expression of immune modulator and structural genes in neonatal unilateral ureteral obstruction Kidney Int 64 25 35 1:CAS:528:DC%2BD3sXlsFelurc%3D 12787392
49. MS Forbes BA Thornhill MH Park RL Chevalier 2007 Lack of endothelial nitric-oxide synthase leads to progressive focal renal injury Am J Pathol 170 87 99 1:CAS:528:DC%2BD2sXhsV2gur4%3D 17200185
50. L Murer E Benetti S Centi VM Della L Artifoni A Capizzi P Zucchetta PD Del C Carasi G Montini W Rigamonti G Zaccello 2006 Clinical and molecular markers of chronic interstitial nephropathy in congenital unilateral ureteropelvic junction obstruction J Urol 176 2668 2673 1:CAS:528: DC%2BD28XhtlantbvI 17085190 (Pubitemid 44755071)
51. SW Han SE Lee JH Kim HJ Jeong KH Rha SK Choi 1998 Does delayed operation for pediatric ureteropelvic junction obstruction cause histopathological changes? J Urol 160 984 988 1:STN:280:DyaK1czotlOnsw%3D%3D 9719259
52. P Valles L Pascual W Manucha L Carrizo M Ruttler 2003 Role of endogenous nitric oxide in unilateral ureteropelvic junction obstruction in children Kidney Int 63 1104 1115 1:CAS:528:DC%2BD3sXivV2jtrY%3D 12631094 (Pubitemid 36315590)
53. RM Ward NT Starr BW Snow MF Bellinger TJ Pysher RJ Zaino 1989 Serial renal function in an ovine model of unilateral fetal urinary tract obstruction J Urol 142 652 656 1:STN:280:DyaL1MzhtFOmsQ%3D%3D 2746794
54. RL Chevalier 1984 Chronic partial ureteral obstruction in the neonatal guinea pig. II: pressure gradients affecting glomerular filtration rate Pediatr Res 18 1271 1277 1:STN:280:DyaL2M7ht1artQ%3D%3D 6522141 (Pubitemid 15221475)
55. G Lama F Ferraraccio F Iaccarino I Luongo A Marte PF Rambaldi M Esposito-Salsano 2003 Pelviureteral junction obstruction: correlation of renal cell apoptosis and differential renal function J Urol 169 2335 2338 12771794 (Pubitemid 36576796)
56. PJD Winyard J Nauta DS Lirenman P Hardman VR Sams RA Risdon AS Woolf 1996 Deregulation of cell survival in cystic and dysplastic renal development Kidney Int 49 135 146 1:STN:280:DyaK28zms1yntw%3D%3D 8770959 (Pubitemid 26022835)
57. SC Kiley BA Thornhill SS Tang JR Ingelfinger RL Chevalier 2003 Growth factor-mediated phosphorylation of proapoptotic BAD reduces tubule cell death in vitro and in vivo Kidney Int 63 33 42 1:CAS:528:DC%2BD3sXmtV2isw%3D%3D 12472766
58. B Lange-Sperandio F Cachat BA Thornhill RL Chevalier 2002 Selectins mediate macrophage infiltration in obstructive nephropathy in newborn mice Kidney Int 61 516 524 1:CAS:528:DC%2BD38XhtlWjtL8%3D 11849391 (Pubitemid 34102591)
59. B Lange-Sperandio S Fulda A Vandewalle RL Chevalier 2003 Macrophages induce apoptosis in proximal tubule cells Pediatr Nephrol 18 335 341 12700958 (Pubitemid 36790070)
60. M Stephan S Conrad T Eggert R Heuer S Fernandez H Huland 2002 Urinary concentration and tissue messenger RNA expression of monocyte chemoattractant protein-1 as an indicator of the degree of hydronephrotic atrophy in partial ureteral obstruction J Urol 167 1497 1502 11832777 (Pubitemid 34132139)
61. K Fukuda K Yoshitomi T Yanagida M Tokumoto H Hirakata 2001 Quantification of TGF-β1 mRNA along rat nephron in obstructive nephropathy Am J Physiol 281 F513 F521 1:CAS:528:DC%2BD3MXmvFWis70%3D (Pubitemid 32885135)
62. DW Johnson HJ Saunders RC Baxter MJ Feld CA Pollock 1998 Paracrine stimulation of human renal fibroblasts by proximal tubule cells Kidney Int 54 747 757 1:CAS:528:DyaK1cXlvVCms7o%3D 9734599 (Pubitemid 28397392)
63. F Seseke P Thelen RH Ringert 2004 Characterization of an animal model of spontaneous congenital unilateral obstructive uropathy by cDNA microarray analysis Eur Urol 45 374 381 1:CAS:528:DC%2BD2cXisVWmurY%3D 15036686 (Pubitemid 38221413)
64. H Liapis RH Doshi MA Watson A Liapis GF Steinhardt 2002 Reduced renin expression and altered gene transcript profiles in multicystic dysplastic kidneys J Urol 168 1816 1820 1:CAS:528:DC%2BD38XotFGqt7w%3D 12352367 (Pubitemid 35034094)
65. M Iwano D Plieth TM Danoff C Xue H Okada EG Neilson 2002 Evidence that fibroblasts derive from epithelium during tissue fibrosis J Clin Invest 110 341 350 1:CAS:528:DC%2BD38XlvFKhtLY%3D 12163453 (Pubitemid 34847966)
66. MJ Butt AF Tarantal DF Jimenez DG Matsell 2007 Collecting duct epithelial-mesenchymal transition in fetal urinary tract obstruction Kidney Int 72 936 944 1:STN:280:DC%2BD2srptFGnug%3D%3D 17667982
67. KH Chung RA Gomez RL Chevalier 1995 Regulation of renal growth factors and clusterin by angiotensin AT1 receptors during neonatal ureteral obstruction Am J Physiol 268 F1117 F1123 1:CAS:528:DyaK2MXmvVyjsrk%3D 7611452
68. VF Norwood RM Carey KM Geary PA Jose RA Gomez RL Chevalier 1994 Neonatal ureteral obstruction stimulates recruitment of renin-secreting renal cortical cells Kidney Int 45 1333 1339 1:STN:280:DyaK2czltF2rtg%3D%3D 8072245
69. N Kawada T Moriyama A Ando M Fukunaga T Miyata K Kurokawa E Imai M Hori 1999 Increased oxidative stress in mouse kidneys with unilateral ureteral obstruction Kidney Int 56 1004 1013 1:CAS:528:DyaK1MXlvF2gurY%3D 10469368 (Pubitemid 29411727)
70. B Pat T Yang C Kong D Watters DW Johnson G Gobe 2005 Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants Kidney Int 67 931 943 1:CAS:528:DC%2BD2MXis1Grtbc%3D 15698432 (Pubitemid 41623317)
71. R Agarwal 2002 Proinflammatory effects of oxidative stress in chronic kidney disease: role of additional angiotensin II blockade Am J Physiol 284 F863 F869 (Pubitemid 36336992)
72. M Kinter JT Wolstenholme BA Thornhill EA Newton ML McCormick RL Chevalier 1999 Unilateral ureteral obstruction impairs renal antioxidant enzyme activation during sodium depletion Kidney Int 55 1327 1334 1:CAS:528: DyaK1MXit1WqtrY%3D 10200997 (Pubitemid 29157131)
73. SD Ricardo G Ding M Eufemio JR Diamond 1997 Antioxidant expression in experimental hydronephrosis: role of mechanical stretch and growth factors Am J Physiol 272 F789 F798 1:CAS:528:DyaK2sXksVSku7c%3D 9227641 (Pubitemid 27382200)
74. RL Chevalier MJ Peach 1985 Hemodynamic effects of enalapril on neonatal chronic partial ureteral obstruction Kidney Int 28 891 898 1:CAS:528: DyaL28Xks1egsQ%3D%3D 3003442
75. A Beharrie J Franc-Guimond MM Rodriguez J Au G Zilleruelo CL Abitbol 2004 A functional immature model of chronic partial ureteral obstruction Kidney Int 65 1155 1161 15086454 (Pubitemid 38406953)
76. WS McDougal 1982 Pharmacologic preservation of renal mass and function in obstructive uropathy J Urol 128 418 421 1:STN:280:DyaL383mvFehug%3D%3D 7050421
77. CO Chen MH Park MS Forbes BA Thornhill SC Kiley KH Yoo RL Chevalier 2007 Angiotensin converting enzyme inhibition aggravates renal interstitial injury resulting from partial unilateral ureteral obstruction in the neonatal rat Am J Physiol Renal Physiol 292 F946 F955 1:CAS:528:DC%2BD2sXjsVyksr8%3D 17107943
78. CM Coleman JJ Minor LE Burt BA Thornhill MS Forbes RL Chevalier 2007 Angiotensin AT1 receptor inhibition exacerbates renal injury resulting from partial unilateral ureteral obstruction in the neonatal rat Am J Physiol 293 F262 F268 1:CAS:528:DC%2BD2sXovVygtLo%3D
79. BG Hanss JE Lewy RC Vari 1994 Alterations in glomerular dynamics in congenital, unilateral hydronephrosis Kidney Int 46 48 57 1:STN:280: DyaK2M%2FhvFCnuw%3D%3D 7933848
80. H Yanagisawa J Morrissey AR Morrison ML Purkerson S Klahr 1990 Role of ANG II in eicosanoid production by isolated glomeruli from rats with bilateral ureteral obstruction Am J Physiol 258 F85 F93 1:CAS:528:DyaK3cXhtFaktrs%3D 2154128 (Pubitemid 20063073)
81. FT Hammad AM Wheatley G Davis 2000 Long-term renal effects of unilateral ureteral obstruction and the role of endothelin Kidney Int 58 242 250 1:CAS:528:DC%2BD3cXltVyjtb0%3D 10886569 (Pubitemid 30429869)
82. AA Reyes D Martin S Settle S Klahr 1992 EDRF role in renal function and blood pressure of normal rats and rats with obstructive uropathy Kidney Int 41 403 413 1:STN:280:DyaK383gtlGqtw%3D%3D 1552713
83. PJD Foxall S Bewley GH Neild CH Rodeck JK Nicholson 1995 Analysis of fetal and neonatal urine using proton nuclear magnetic resonance spectroscopy Arch Dis Child Fetal Neonatal 73 F153 F157 1:STN:280:DyaK287jslyguw%3D%3D
84. L Murer F Addabbo M Carmosino G Procino G Tamma G Montini W Rigamonti P Zucchetta M della Vella A Venturini G Zacchello M Svelto G Valenti 2004 Selective decrease in urinary aquaporin 2 and increase in prostaglandin E2 excretion is associated with postobstructive polyuria in human congenital hydronephrosis J Am Soc Nephrol 15 2705 2712 1:CAS:528:DC%2BD2cXnslOntLk%3D 15466275 (Pubitemid 41103377)
85. G Claesson L Svensson B Robertson S Josephson T Cederlund 1989 Experimental obstructive hydronephrosis in newborn rats. XI. A one-year follow-up study of renal function and morphology J Urol 142 1602 1607 1:STN:280:DyaK3c%2FmsVyrtA%3D%3D 2555574 (Pubitemid 20012000)
86. C Li W Wang TH Kwon L Isikay JG Wen D Marples JC Djurhuus A Stockwell MA Knepper S Nielsen J Frokiaer 2001 Downregulation of AQP1, -2, and -3 after ureteral obstruction is associated with a long-term urine-concentrating defect Am J Physiol 281 F163 F171 1:CAS:528:DC%2BD3MXltVynu70%3D (Pubitemid 32911882)
87. A Boubaker JO Prior B Meyrat AB Delaloye 2003 Unilateral ureteropelvic junction obstruction in children: long-term followup after unilateral pyeloplasty J Urol 170 575 579 12853834 (Pubitemid 36870260)
88. B Chertin A Pollack D Koulikov R Rabinowitz D Hain I Hadas-Halperin A Farkas 2006 Conservative treatment of ureteropelvic junction obstruction in children with antenatal diagnosis of hydronephrosis: lessons learned after 16 years of follow-up Eur Urol 49 734 739 16504374 (Pubitemid 43374742)
89. A Eskild-Jensen TM Jorgensen LH Olsen JC Djurhuus J Frokiær 2003 Renal function may not be restored when using decreasing differential function as the criterion for surgery in unilateral hydronephrosis BJU Int 92 779 782 1:STN:280:DC%2BD3srmtVGhuw%3D%3D 14616466 (Pubitemid 37475827)
90. YY Chiou NT Chiu ST Wang HL Cheng MJ Tang 2004 Factors associated with the outcomes of children with unilateral ureteropelvic junction obstruction J Urol 171 397 402 14665942 (Pubitemid 37549196)
91. Y Shi M Pedersen C Li JG Wen K Thomsen H Stodkilde-Jorgensen TM Jorgensen MA Knepper S Nielsen JC Djurhuus J Frokiaer 2004 Early release of neonatal ureteral obstruction preserves renal function Am J Physiol 286 F1087 F1099 1:CAS:528:DC%2BD2cXkvFCqsLc%3D (Pubitemid 38656364)
92. RL Chevalier BA Thornhill AY Chang 2000 Unilateral ureteral obstruction in neonatal rats leads to renal insufficiency in adulthood Kidney Int 58 1987 1995 1:STN:280:DC%2BD3M%2FivFSksg%3D%3D 11044219
93. W Fenghua S Junjie D Gaoyan M Jiacong 2009 Does intervention in utero preserve the obstructed kidneys of fetal lambs? A histological, cytological, and molecular study Pediatr Res 66 145 148 19390481
94. MD Hughson AB Farris R Douglas-Denton WE Hoy JF Bertram 2003 Glomerular number and size in autopsy kidneys: the relationship to birth weight Kidney Int 63 2113 2122 12753298 (Pubitemid 36605822)
95. WE Hoy M Rees E Kile JD Mathews Z Wang 1999 A new dimension to the Barker hypothesis: low birthweight and susceptibility to renal disease Kidney Int 56 1072 1077 1:STN:280:DyaK1MzpvVGgtQ%3D%3D 10469376 (Pubitemid 29411735)
96. VA Luyckx BM Brenner 2005 Low birth weight, nephron number, and kidney disease Kidney Int 68 S68 S77
97. JS Elder R Stansbrey BB Dahms AA Selzman 1995 Renal histological changes secondary to ureteropelvic junction obstruction J Urol 154 719 722 1:STN:280:DyaK2Mzjtlequg%3D%3D 7609162
98. JA Stock HF Krous J Heffernan M Packer GW Kaplan 1995 Correlation of renal biopsy and radionuclide renal scan differential function in patients with unilateral ureteropelvic junction obstruction J Urol 154 716 718 1:STN:280:DyaK2MzjtleqtQ%3D%3D 7609161
99. L Pascual J Oliva J Vega I Principi P Valles 1998 Renal histology in ureteropelvic junction obstruction: are histological changes a consequence of hyperfiltration? J Urol 160 976 979 1:STN:280:DyaK1czotlOguw%3D%3D 9719257 (Pubitemid 29477727)
100. PL Zhang CA Peters S Rosen 2000 Ureteropelvic junction obstruction: morphological and clinical studies Pediatr Nephrol 14 820 826 1:STN:280:DC%2BD3M%2FktlyksQ%3D%3D 10955936 (Pubitemid 30462176)
101. KS Roth WH Carter Jr JCM Chan 2001 Obstructive nephropathy in children: long-term progression after relief of posterior urethral valve Pediatrics 107 1004 1010 1:STN:280:DC%2BD3M3ptVChsw%3D%3D 11331678
102. JM Biard MP Johnson MC Carr RD Wilson HL Hedrick C Pavlock NS Adzick 2005 Long-term outcomes in children treated by prenatal vesicoamniotic shunting for lower urinary tract obstruction Obstet Gynecol 106 503 508 16135579 (Pubitemid 41208781)
103. D Edouga B Hugueny B Gasser L Bussières K Laborde 2001 Recovery after relief of fetal urinary obstruction: morphological, functional and molecular aspects Am J Physiol 281 F26 F37 1:CAS:528:DC%2BD3MXltVyntbc%3D (Pubitemid 32911868)
104. WE Hoy MD Hughson JF Bertram R Douglas-Denton K Amann 2005 Nephron number, hypertension, renal disease, and renal failure J Am Soc Nephrol 16 2557 2564 16049069 (Pubitemid 41725078)
105. CA Peters 1995 Urinary tract obstruction in children J Urol 154 1874 1883 1:STN:280:DyaK28%2FgvVCnsA%3D%3D 7563375
106. Biomarkers Definitions Working Group 2001 Biomarkers and surrogate endpoints: preferred definitions and conceptual framework Clin Pharmacol Ther 69 89 95
107. S Decramer S Wittke H Mischak P Zurbig M Walden F Bouissou JL Bascands JP Schanstra 2006 Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis Nat Med 12 398 400 1:CAS:528:DC%2BD28XjtFKjtLc%3D 16550189
108. P Zurbig S Decramer M Dakna J Jantos DM Good JJ Coon F Bandin H Mischak JL Bascands JP Schanstra 2009 The human urinary proteome reveals high similarity between kidney aging and chronic kidney disease Proteomics 9 2108 2117 19296547
109. RS Lee FM Monigatti M Lutchman T Patterson B Budnik JAJ Steen MR Freeman H Steen 2008 Temporal variations of the postnatal rat urinary proteome as a reflection of systemic maturation Proteomics 8 1097 1112 1:CAS:528: DC%2BD1cXktVeks7s%3D 18324733 (Pubitemid 351441447)
110. PD Furness III M Maizels SW Han RA Cohn EY Cheng 1999 Elevated bladder urine concentration of transforming growth factor-β1 correlates with upper urinary tract obstruction in children J Urol 162 1033 1036 10458426 (Pubitemid 29434666)
111. SP Yang AS Woolf HT Yuan RJ Scott RA Risdon MJ O'Hare PJD Winyard 2000 Potential biological role of transforming growth factor-β1 in human congenital kidney malformations Am J Pathol 157 1633 1647 1:CAS:528: DC%2BD3cXosFyhs7s%3D 11073823
112. G Grandaliano L Gesualdo F Bartoli E Ranieri R Monno A Leggio G Paradies E Caldarulo B Infante FP Schena 2000 MCP-1 and EGF renal expression and urine excretion in human congenital obstructive nephropathy Kidney Int 58 182 192 1:CAS:528:DC%2BD3cXltVyjtLk%3D 10886563 (Pubitemid 30429863)
113. KS Eardley D Zehnder M Quinkler J Lepenies RL Bates CO Savage AJ Howie D Adu P Cockwell 2006 The relationship between albuminuria, MCP-1/CCL2, and interstitial macrophages in chronic kidney disease Kidney Int 69 1189 1197 1:CAS:528:DC%2BD28XivFOmsbc%3D 16609683
114. G Guron P Friberg 2000 An intact renin-angiotensin system is a prerequisite for normal renal development J Hypertens 18 123 137 1:CAS:528:DC%2BD3cXhsFahsL0%3D 10694179 (Pubitemid 30114057)
115. S Kagami WA Border DE Miller NA Noble 1994 Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-Beta expression in rat glomerular mesangial cells J Clin Invest 93 2431 2437 1:CAS:528:DyaK2cXlsV2ktLw%3D 8200978 (Pubitemid 24177156)
116. G Ardissino S Vigano S Testa V Dacco F Paglialonga A Leoni M Belingheri L Avolio A Ciofani A Claris-Appiani D Cusi A Edefonti A Ammenti M Cecconi C Fede L Ghio A La Manna S Maringhini T Papalia I Pela L Pisanello IM Ratsch 2007 No clear evidence of ACEi efficacy on the progression of chronic kidney disease in children with hypodysplastic nephropathy-report from the ItalKid project database Nephrol Dial Transplant 22 2525 2530 17526542 (Pubitemid 47365516)
117. RL Chevalier S Goyal BA Thornhill 1999 EGF improves recovery following relief of unilateral ureteral obstruction in the neonatal rat J Urol 162 1532 1536 1:STN:280:DyaK1MvhvF2quw%3D%3D 10492250 (Pubitemid 29428631)
118. RL Chevalier S Goyal A Kim AY Chang D Landau D LeRoith 2000 Renal tubulointerstitial injury from ureteral obstruction in the neonatal rat is attenuated by IGF-1 Kidney Int 57 882 890 1:CAS:528:DC%2BD3cXktFGgtr0%3D 10720941 (Pubitemid 30434778)
119. AB Fogo 2003 The potential for regression of renal scarring Curr Opin Nephrol Hypertens 12 223 225 12698058
120. AA Eddy 2005 Can renal fibrosis be reversed? Pediatr Nephrol 20 1369 1375 15947978
121. KH Yoo BA Thornhill MS Forbes CM Coleman ES Marcinko L Liaw RL Chevalier 2006 Osteopontin regulates renal apoptosis and interstitial fibrosis in neonatal chronic unilateral ureteral obstruction Kidney Int 70 1735 1741 1:CAS:528:DC%2BD28XhtFKitrvP 17003824 (Pubitemid 44684804)