Vitamin D receptor activation enhances benzo[a]pyrene metabolism via CYP1A1 expression in macrophages

Drug Metabolism and Disposition

Volumn 40, Issue 11, 2012, Pages 2059-2066

  Matsunawa, Manabu ^a,c   Akagi, Daisuke ^a,b   Uno, Shigeyuki ^a   Endo Umeda, Kaori ^a   Yamada, Sachiko ^a   Ikeda, Kazumasa ^b   Makishima, Makoto ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NIHON UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA NAPHTHOFLAVONE; AROMATIC HYDROCARBON; BENZO[A]PYRENE; CALCITRIOL; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; MESSENGER RNA; VITAMIN D RECEPTOR;

ARTICLE; BREAST CANCER; CANCER CELL; CELL LINE; CELL STRAIN THP 1; CELL STRAIN U937; CHROMATIN IMMUNOPRECIPITATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA ADDUCT; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYDROXYLATION; KIDNEY CELL; KIDNEY EPITHELIUM; MACROPHAGE; MOLECULAR INTERACTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN MOTIF; RECEPTOR BINDING; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; XENOBIOTIC METABOLISM;

BENZO(A)PYRENE; CALCITRIOL; CELL LINE; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; HEK293 CELLS; HUMANS; MACROPHAGES; MCF-7 CELLS; METABOLIC DETOXICATION, DRUG; PROMOTER REGIONS, GENETIC; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, CALCITRIOL; RETINOID X RECEPTORS; TRANSCRIPTION, GENETIC; U937 CELLS;

EID: 84867665350     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.046839     Document Type: Article

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