A Comparison of the Potency of a Novel Bispyridinium Oxime K203 and currently available Oximes (Obidoxime, HI-6) to Counteract the Acute Neurotoxicity of Sarin in Rats

Basic and Clinical Pharmacology and Toxicology

Volumn 111, Issue 5, 2012, Pages 333-338

  Kassa, Jiri ^a   Misik, Jan ^a   Karasova, Jana Zdarova ^b  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 (4 CARBAMOYLPYRIDINIUM) 4 (4 HYDROXYIMINOMETHYLPYRIDINIUM)BUT 2 ENE DIBROMIDE; ATROPINE; K 203; OBIDOXIME; OXIME DERIVATIVE; PYRIDINIUM DERIVATIVE; SARIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; MALE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME;

ANIMALS; ANTIDOTES; ATROPINE; AUTONOMIC NERVOUS SYSTEM; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; CZECH REPUBLIC; DRUG THERAPY, COMBINATION; LETHAL DOSE 50; MALE; MUSCARINIC ANTAGONISTS; NEURONS; NEUROTOXICITY SYNDROMES; OBIDOXIME CHLORIDE; OXIMES; PSYCHOMOTOR PERFORMANCE; PYRIDINIUM COMPOUNDS; RATS; RATS, WISTAR; SARIN;

RATTUS;

EID: 84867645595     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2012.00897.x     Document Type: Article

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