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Volumn 9, Issue 4, 2011, Pages 225-230

A comparison of the reactivating and therapeutic efficacy of the newly developed bispyridinium oxime K203 with currently available oximes, in sarin poisoned rats and mice

Author keywords

Acetylcholinesterase; HI 6; K203; Mice; Obidoxime; Rats; Sarin; Trimedoxime

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 (4 CARBAMOYLPYRIDINIUM) 4 (4 HYDROXYIMINOMETHYLPYRIDINIUM) BUT 2 ENE DIBROMIDE; ACETYLCHOLINESTERASE; K 203; OBIDOXIME; OXIME DERIVATIVE; PYRIDINIUM DERIVATIVE; SARIN; TRIMEDOXIME; UNCLASSIFIED DRUG;

EID: 80053165223     PISSN: 1214021X     EISSN: 12140287     Source Type: Journal    
DOI: 10.2478/v10136-011-0011-6     Document Type: Article
Times cited : (11)

References (32)
  • 1
    • 10044275708 scopus 로고    scopus 로고
    • Organophosphate/nerve agent poisoning: Mechanism of action, diagnosis, prophylaxis, and treatment
    • Bajgar J. Organophosphate/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment. Adv Clin Chem. 38: 151-216, 2004.
    • (2004) Adv Clin Chem , vol.38 , pp. 151-216
    • Bajgar, J.1
  • 2
    • 0023615814 scopus 로고
    • Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice
    • Clement JG, Shiloff JD, Gennings Ch. Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice. Arch Toxicol. 61: 70-75, 1987.
    • (1987) Arch Toxicol , vol.61 , pp. 70-75
    • Clement, J.G.1    Shiloff, J.D.2    Gennings, C.3
  • 3
    • 0026609482 scopus 로고
    • Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice
    • Clement JG, Hansen AS, Boulet CA. Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice. Arch Toxicol. 66:216-219, 1992.
    • (1992) Arch Toxicol , vol.66 , pp. 216-219
    • Clement, J.G.1    Hansen, A.S.2    Boulet, C.A.3
  • 4
    • 0028132872 scopus 로고
    • Review of oximes available for treatment of nerve agent poisoning
    • Dawson RM. Review of oximes available for treatment of nerve agent poisoning. J Appl Toxicol. 14: 317-331, 1994.
    • (1994) J Appl Toxicol , vol.14 , pp. 317-331
    • Dawson, R.M.1
  • 5
    • 30144445702 scopus 로고    scopus 로고
    • Structural changes of phenylalanine 338 and histidine 447 revealed by the crystal structures of tabun-inhibited murine acetylcholinesterase
    • Ekström F, Akfur C, Tunemalm AK, Lundberg S. Structural changes of phenylalanine 338 and histidine 447 revealed by the crystal structures of tabun-inhibited murine acetylcholinesterase. Biochemistry. 45: 74-81, 2006.
    • (2006) Biochemistry , vol.45 , pp. 74-81
    • Ekström, F.1    Akfur, C.2    Tunemalm, A.K.3    Lundberg, S.4
  • 7
    • 67949099098 scopus 로고    scopus 로고
    • Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds
    • Jokanović M, Prostran M. Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds. Curr Med Chem. 16: 2177-2188, 2009.
    • (2009) Curr Med Chem , vol.16 , pp. 2177-2188
    • Jokanović, M.1    Prostran, M.2
  • 8
    • 35948955541 scopus 로고    scopus 로고
    • HPLC analysis of HI-6 dichloride and dimethanesulfonate - antidotes against nerve agents and organophosphorus pesticides
    • Jun D, Kuca K, Stodulka P, Koleckar V, Dolezal B, Simon P, Veverka M. HPLC analysis of HI-6 dichloride and dimethanesulfonate - antidotes against nerve agents and organophosphorus pesticides. Anal Lett. 40: 2783-2787, 2007.
    • (2007) Anal Lett , vol.40 , pp. 2783-2787
    • Jun, D.1    Kuca, K.2    Stodulka, P.3    Koleckar, V.4    Dolezal, B.5    Simon, P.6    Veverka, M.7
  • 9
    • 0036447187 scopus 로고    scopus 로고
    • Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents
    • Kassa J. Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J Toxicol Clin Toxicol. 40: 803-816, 2002.
    • (2002) J Toxicol Clin Toxicol , vol.40 , pp. 803-816
    • Kassa, J.1
  • 10
    • 0033037801 scopus 로고    scopus 로고
    • A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods
    • Kassa J, Cabal J. A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods. Toxicology. 132: 111-118, 1999a.
    • (1999) Toxicology , vol.132 , pp. 111-118
    • Kassa, J.1    Cabal, J.2
  • 11
    • 0032929883 scopus 로고    scopus 로고
    • A comparison of the efficacy of acetylcholinesterase reactivators against cyclohexyl methylphosphonofluoridate (GF agent) by in vitro and in vivo methods
    • Kassa J, Cabal J. A comparison of the efficacy of acetylcholinesterase reactivators against cyclohexyl methylphosphonofluoridate (GF agent) by in vitro and in vivo methods. Pharmacol Toxicol. 84: 41-45, 1999b.
    • (1999) Pharmacol Toxicol , vol.84 , pp. 41-45
    • Kassa, J.1    Cabal, J.2
  • 12
    • 33847239864 scopus 로고    scopus 로고
    • The development of new structural analogues of oximes for the antidotal treatment of poisoning by nerve agents and the comparison of their reactivating and therapeutic efficacy with currently available oximes
    • Kassa J, Kuča K, Bartošová L, Kunešová G. The development of new structural analogues of oximes for the antidotal treatment of poisoning by nerve agents and the comparison of their reactivating and therapeutic efficacy with currently available oximes. Cur Org Chem. 11: 267-283, 2007.
    • (2007) Cur Org Chem , vol.11 , pp. 267-283
    • Kassa, J.1    Kuča, K.2    Bartošová, L.3    Kunešová, G.4
  • 13
    • 37149011244 scopus 로고    scopus 로고
    • An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice
    • Kassa J, Karasová J, Musílek K, Kuča K. An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology. 243: 311-316, 2008.
    • (2008) Toxicology , vol.243 , pp. 311-316
    • Kassa, J.1    Karasová, J.2    Musílek, K.3    Kuča, K.4
  • 14
    • 0026101738 scopus 로고
    • Protective effects of mixture of oximes in poisoning by nerve chemical warfare agents
    • Kovacević V, Maksimović M, Deljać V, Binenfeld Z. Protective effects of mixture of oximes in poisoning by nerve chemical warfare agents. Acta Pharm Jugosl. 41: 75-78, 1991.
    • (1991) Acta Pharm Jugosl , vol.41 , pp. 75-78
    • Kovacević, V.1    Maksimović, M.2    Deljać, V.3    Binenfeld, Z.4
  • 16
    • 6344241309 scopus 로고    scopus 로고
    • A comparison of the efficacy of a bispyridinium oxime - 1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods
    • Kuča K, Cabal J, Kassa J. A comparison of the efficacy of a bispyridinium oxime - 1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods. Pharmazie. 59: 795-798, 2004.
    • (2004) Pharmazie , vol.59 , pp. 795-798
    • Kuča, K.1    Cabal, J.2    Kassa, J.3
  • 17
    • 33646056667 scopus 로고    scopus 로고
    • Structural requirements of acetylcholinesterase reactivators
    • Kuca K, Jun D, Musilek K. Structural requirements of acetylcholinesterase reactivators. Mini Rev Med Chem. 6: 269-277, 2006.
    • (2006) Mini Rev Med Chem , vol.6 , pp. 269-277
    • Kuca, K.1    Jun, D.2    Musilek, K.3
  • 18
    • 35648933466 scopus 로고    scopus 로고
    • Structure-activity relationship of acetylcholinesterase reactivators - antidotes against nerve agents
    • Kuca K, Racakova V, Jun D, Bajgar J. Structure-activity relationship of acetylcholinesterase reactivators - antidotes against nerve agents. Lett Org Chem. 4: 212-217, 2007.
    • (2007) Lett Org Chem , vol.4 , pp. 212-217
    • Kuca, K.1    Racakova, V.2    Jun, D.3    Bajgar, J.4
  • 20
    • 0003107857 scopus 로고    scopus 로고
    • Organophosphorus compounds
    • In Spencer PS, Schaumburg HH (eds.), Oxford University Press, New York
    • Lotti M. Organophosphorus compounds. In Spencer PS, Schaumburg HH (eds.): Experimental and Clinical Neurotoxicology, Oxford University Press, New York 2000, pp. 898-925.
    • (2000) Experimental and Clinical Neurotoxicology , pp. 898-925
    • Lotti, M.1
  • 21
    • 34247096612 scopus 로고    scopus 로고
    • Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning
    • Lundy PM, Raveh L, Amitai G. Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning. Toxicol Rev. 25: 231-243, 2006.
    • (2006) Toxicol Rev , vol.25 , pp. 231-243
    • Lundy, P.M.1    Raveh, L.2    Amitai, G.3
  • 22
    • 0024547881 scopus 로고
    • Protective and reactivating effects of HI-6-toxogonin mixture in rats and guinea-pigs poisoned by nerve agents
    • Maksimović M, Kovačević V. Protective and reactivating effects of HI-6-toxogonin mixture in rats and guinea-pigs poisoned by nerve agents. Acta Pharm Jugosl. 39: 27-33, 1989.
    • (1989) Acta Pharm Jugosl , vol.39 , pp. 27-33
    • Maksimović, M.1    Kovačević, V.2
  • 23
    • 0027281533 scopus 로고
    • Organophosphate poisoning
    • Marrs TC. Organophosphate poisoning. Pharmacol Ther. 58: 51-66, 1993.
    • (1993) Pharmacol Ther , vol.58 , pp. 51-66
    • Marrs, T.C.1
  • 24
    • 34247152147 scopus 로고    scopus 로고
    • The role of oximes in the treatment of nerve agent poisoning in civilian casualties
    • Marrs TC, Rice P, Vale JA. The role of oximes in the treatment of nerve agent poisoning in civilian casualties. Toxicol Rev. 25: 297-323, 2006.
    • (2006) Toxicol Rev , vol.25 , pp. 297-323
    • Marrs, T.C.1    Rice, P.2    Vale, J.A.3
  • 25
    • 33845870911 scopus 로고    scopus 로고
    • Synthesis of bispyridinium compounds bearing propane linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase
    • Musílek K, Kuča K, Jun D, Doležal M. Synthesis of bispyridinium compounds bearing propane linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase. Lett Org Chem. 3: 831-835, 2006.
    • (2006) Lett Org Chem , vol.3 , pp. 831-835
    • Musílek, K.1    Kuča, K.2    Jun, D.3    Doležal, M.4
  • 26
    • 39349101032 scopus 로고    scopus 로고
    • Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase
    • Musílek K, Holas O, Kuča K, Jun D, Dohnal V, Oplet-aletalová V, Doležal M. Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase. J Enzyme Inhib Med Chem. 23: 70-76, 2008.
    • (2008) J Enzyme Inhib Med Chem , vol.23 , pp. 70-76
    • Musílek, K.1    Holas, O.2    Kuča, K.3    Jun, D.4    Dohnal, V.5    Oplet-Aletalová, V.6    Doležal, M.7
  • 27
    • 77952683199 scopus 로고    scopus 로고
    • The effect of trimedoxime on acetylcholinesterase and on the cholinergic system of the rat bladder
    • Soukup O, Holas O, Binder J, Killy K, Tobin G, Jun D, Fusek J, Kuča K. The effect of trimedoxime on acetylcholinesterase and on the cholinergic system of the rat bladder. J Appl Biomed. 8: 87-92, 2010.
    • (2010) J Appl Biomed , vol.8 , pp. 87-92
    • Soukup, O.1    Holas, O.2    Binder, J.3    Killy, K.4    Tobin, G.5    Jun, D.6    Fusek, J.7    Kuča, K.8
  • 30
    • 0000249736 scopus 로고    scopus 로고
    • Anticholinesterase agents
    • In Hardman JG, Limbird LE (eds.), McGraw Hill, New York
    • Taylor P. Anticholinesterase agents. In Hardman JG, Limbird LE (eds.): The Pharmacological Basis of Therapeutics, McGraw Hill, New York 2001, pp. 175-191.
    • (2001) The Pharmacological Basis of Therapeutics , pp. 175-191
    • Taylor, P.1
  • 32
    • 36148961940 scopus 로고    scopus 로고
    • Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro
    • Worek F, Aurbek N, Thiermann H. Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro. J Appl Toxicol. 27: 582-588, 2007.
    • (2007) J Appl Toxicol , vol.27 , pp. 582-588
    • Worek, F.1    Aurbek, N.2    Thiermann, H.3


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