Mechanisms for epigallocatechin gallate induced inhibition of drug metabolizing enzymes in rat liver microsomes

Toxicology Letters

Volumn 214, Issue 3, 2012, Pages 328-338

  Weng, Zuquan ^a   Greenhaw, James ^a   Salminen, William F ^a   Shi, Qiang ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Covalent binding; Cytochrome P450; Epigallocatechin gallate; Glutathione; Microsome; Rat

Indexed keywords

ACTIN; AGAROSE; ANTIBODY; BINDING PROTEIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; DRUG METABOLIZING ENZYME; EPIGALLOCATECHIN GALLATE; GLUTATHIONE; GLUTATHIONE TRANSFERASE T1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; COVALENT BOND; DRUG PROTEIN BINDING; ENZYME INHIBITION; LIVER MICROSOME; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; CATECHIN; CYTOCHROME P-450 ENZYME SYSTEM; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ANTAGONISM; ENZYME INHIBITORS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; MALE; MICROSOMES, LIVER; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84867603970     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.09.011     Document Type: Article

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