Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase

Drug Metabolism and Disposition

Volumn 32, Issue 5, 2004, Pages 497-504

  Nagai, Mime ^a   Conney, Allan H ^b   Zhu, Bao Ting ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL ESTROGEN; CATECHOL METHYLTRANSFERASE; FISETIN; QUERCETIN;

ARTICLE; COMPARATIVE STUDY; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG INHIBITION; DRUG POTENCY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; IC 50; LIVER CYTOSOL; LIVER MICROSOME METABOLISM; METHYLATION; PRIORITY JOURNAL; TEA;

CATALYSIS; CATECHIN; CATECHOL O-METHYLTRANSFERASE; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ESTROGENS, CATECHOL; FLAVONOIDS; HUMANS; LIVER; METHYLATION; PLANT EXTRACTS; TEA;

CAMELLIA SINENSIS;

EID: 2042441765     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.32.5.497     Document Type: Article

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