(-)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68

Free Radical Biology and Medicine

Volumn 50, Issue 10, 2011, Pages 1324-1335

  Tanaka, Tomoko ^a   Ishii, Takeshi ^b   Mizuno, Daisuke ^a   Mori, Taiki ^b   Yamaji, Ryoichi ^a   Nakamura, Yoshimasa ^c   Kumazawa, Shigenori ^b   Nakayama, Tsutomu ^b   Akagawa, Mitsugu ^a  

^a Osaka Prefecture University   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

( ) Epigallocatechin 3 gallate; Cancer; Free radicals; Green tea; p68; Polyphenol; Proteomics; Quinone

Indexed keywords

BETA CATENIN; CELL PROTEIN; CYCLOHEXIMIDE; CYSTEINE; DEAD BOX PROTEIN; EPIGALLOCATECHIN GALLATE; PROTEIN P68;

APOPTOSIS; ARTICLE; AUTOOXIDATION; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CELL CULTURE; CELL PROLIFERATION; COVALENT BOND; DISEASE COURSE; HUMAN; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEOMICS; RADIOIMMUNOPRECIPITATION; SIGNAL TRANSDUCTION; STOMACH CANCER; TUMOR CELL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CATECHIN; CELL PROLIFERATION; DEAD-BOX RNA HELICASES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR CONFORMATION; STEREOISOMERISM; STOMACH NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 79955466143     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.01.024     Document Type: Article

References (63)

1. N. Khan, and H. Mukhtar Tea polyphenols for health promotion Life Sci. 81 2007 519 533 (Pubitemid 47212236)
2. N.T. Zaveri Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications Life Sci. 78 2006 2073 2080
3. E.C. Stuart, M.J. Scandlyn, and R.J. Rosengren Role of epigallocatechin gallate (EGCG) in the treatment of breast and prostate cancer Life Sci. 79 2006 2329 2336 (Pubitemid 44772933)
4. C.S. Yang, X. Wang, G. Lu, and S.C. Picinich Cancer prevention by tea: animal studies, molecular mechanisms and human relevance Nat. Rev. Cancer 9 2009 429 439
5. A.M. Park, and Z. Dong Signal transduction pathways: targets for green and black tea polyphenols J. Biochem. Mol. Biol. 36 2003 66 77 (Pubitemid 36836258)
6. N. Khan, F. Afaq, and M. Saleem Ahmad, N; Mukhtar, H. Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate Cancer Res. 66 2006 2500 2505
7. L. Chen, and H.Y. Zhang Cancer preventive mechanisms of the green tea polyphenol (-)-epigallocatechin-3-gallate Molecules 12 2007 946 957
8. S. Jagtap, K. Meganathan, V. Wagh, J. Winkler, J. Hescheler, and A. Sachinidis Chemoprotective mechanism of the natural compounds, epigallocatechin-3-O-gallate, quercetin and curcumin against cancer and cardiovascular diseases Curr. Med. Chem. 16 2009 1451 1462
9. S.K. Patra, F. Rizzi, A. Silva, D.O. Rugina, and S. Bettuzzi Molecular targets of (-)-epigallocatechin-3-gallate (EGCG): specificity and interaction with membrane lipid rafts J. Physiol. Pharmacol. 59 2008 217 235
10. N. Khan, and H. Mukhtar Multitargeted therapy of cancer by green tea polyphenols Cancer Lett. 269 2008 269 280
11. H. Tachibana, K. Koga, Y. Fujimura, and K. Yamada A receptor for green tea polyphenol EGCG Nat. Struct. Mol. Biol. 11 2004 380 381 (Pubitemid 38436804)
12. D. Umeda, S. Yano, K. Yamada, and H. Tachibana Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor J. Biol. Chem. 283 2008 3050 3058
13. S. Ermakova, B.Y. Choi, H.S. Choi, B.S. Kang, A.M. Bode, and Z. Dong The intermediate filament protein vimentin is a new target for epigallocatechin gallate J. Biol. Chem. 280 2005 16882 16890 (Pubitemid 41389147)
14. M. Li, Z. He, S. Ermakova, D. Zheng, F. Tang, Y.Y. Cho, F. Zhu, W.Y. Ma, Y. Sham, E.A. Rogozin, A.M. Bode, Y. Cao, and Z. Dong Direct inhibition of insulin-like growth factor-I receptor kinase activity by (-)-epigallocatechin-3- gallate regulates cell transformation Cancer Epidemiol. Biomarkers Prev. 16 2007 598 605 (Pubitemid 46548666)
15. Z. He, F. Tang, S. Ermakova, M. Li, Q. Zhao, Y.Y. Cho, W.Y. Ma, H.S. Choi, A.M. Bode, C.S. Yang, and Z. Dong Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation Mol. Carcinog. 47 2008 172 183 (Pubitemid 351409338)
16. S.P. Ermakova, B.S. Kang, B.Y. Choi, H.S. Choi, T.F. Schuster, W.Y. Ma, A.M. Bode, and Z. Dong (-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78 Cancer Res. 66 2006 9260 9269 (Pubitemid 44521148)
17. J.H. Shim, Z.Y. Su, J.I. Chae, D.J. Kim, F. Zhu, W.Y. Ma, A.M. Bode, C.S. Yang, and Z. Dong Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1 Cancer Prev. Res. 3 2010 670 679
18. J.H. Shim, H.S. Choi, A. Pugliese, S.Y. Lee, J.I. Chae, B.Y. Choi, A.M. Bode, and Z. Dong (-)-Epigallocatechin gallate regulates CD3-mediated T cell receptor signaling in leukemia through the inhibition of ZAP-70 kinase J. Biol. Chem. 283 2008 28370 28379
19. T. Ishii, T. Mori, T. Tanaka, D. Mizuno, R. Yamaji, S. Kumazawa, T. Nakayama, and M. Akagawa Covalent modification of proteins by green tea polyphenol (-)-epigallocatechin-3-gallate through autoxidation Free Radic. Biol. Med. 45 2008 1384 1394
20. S. Sang, I. Yang, B. Buckley, C.T. Ho, and C.S. Yang Autoxidative quinone formation in vitro and metabolite formation in vivo from tea polyphenol (-)-epigallocatechin-3-gallate: studied by real-time mass spectrometry combined with tandem mass ion mapping Free Radic. Biol. Med. 43 2007 362 371 (Pubitemid 46977623)
21. Y. Mizooku, M. Yoshikawa, T. Tsuneyoshi, and R. Arakawa Analysis of oxidized epigallocatechin gallate by liquid chromatography/mass spectrometry Rapid Commun. Mass Spectrom. 17 2003 1915 1918 (Pubitemid 36975480)
22. M. Akagawa, T. Shigemitsu, and K. Suyama Production of hydrogen peroxide by polyphenols and polyphenol-rich beverages under quasi-physiological conditions Biosci. Biotechnol. Biochem. 67 2003 2632 2640 (Pubitemid 39251617)
23. N. Wakabayashi, A.T. Dinkova-Kostova, W.D. Holtzclaw, M.I. Kang, A. Kobayashi, M. Yamamoto, T.W. Kensler, and P. Talalay Formation of disulfide bond in p53 correlates with inhibition of DNA binding and tetramerization Proc. Natl. Acad. Sci. USA 101 2004 2040 2045
24. B. Liu, and Y. Chen St Clair, D. K. ROS and p53: a versatile partnership Free Radic. Biol. Med. 44 2008 1529 1535
25. H.K. Na, and Y.J. Surh Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection Mol. Carcinog. 45 2006 368 380
26. N.C. Wortham, E. Ahamed, S.M. Nicol, R.S. Thomas, M. Periyasamy, J. Jiang, A.M. Ochocka, S. Shousha, L. Huson, S.E. Bray, R.C. Coombes, S. Ali, and F.V. Fuller-Pace The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer Oncogene 28 2009 4053 4064
27. E.L. Clark, A. Coulson, C. Dalgliesh, P. Rajan, S.M. Nicol, S. Fleming, R. Heer, L. Gaughan, H.Y. Leung, D.J. Elliott, F.V. Fuller-Pace, and C.N. Robson The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer Cancer Res. 68 2008 7938 7946
28. S. Shin, K.L. Rossow, J.P. Grande, and R. Janknecht Involvement of RNA helicases p68 and p72 in colon cancer Cancer Res. 67 2007 7572 7578 (Pubitemid 47281348)
29. G.J. Bates, S.M. Nicol, B.J. Wilson, A.M. Jacobs, J.C. Bourdon, J. Wardrop, D.J. Gregory, D.P. Lane, N.D. Perkins, and F.V. Fuller-Pace The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor EMBO J. 24 2005 543 553 (Pubitemid 40343256)
30. M.A. Paz, R. Fluchiger, A. Boak, H.M. Kagan, and P.M. Gallop Specific detection of quinoproteins by redox-cycling staining J. Biol. Chem. 266 1991 689 692 (Pubitemid 21907168)
31. E. Schreiber, P. Matthias, M.M. Müler, and W. Schaffner Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells Nucleic Acids Res. 17 1989 6419 (Pubitemid 19198635)
32. M.J. LaVoie, B.L. Ostaszewski, A. Weihofen, M.G. Schlossmacher, and D.J. Selkoe Dopamine covalently modifies and functionally inactivates parkin Nat. Med. 11 2005 1214 1221 (Pubitemid 43093669)
33. M. Akagawa, T. Handoyo, T. Ishii, S. Kumazawa, N. Morita, and K. Suyama Proteomic analysis of wheat flour allergens J. Agric. Food. Chem. 55 2007 6863 6870 (Pubitemid 47338919)
34. R. Flückiger, T. Woodtli, and P.M. Gallop The interaction of aminogroups with pyrroloquinoline quinone as detected by the reduction of nitroblue tetrazolium Biochem. Biophys. Res. Commun. 153 1988 353 358
35. M. Akagawa, and K. Suyama Amine oxidase-like activity of polyphenols: mechanism and properties Eur. J. Biochem. 268 2001 1953 1963 (Pubitemid 32852936)
36. T. Fukuda, K. Yamagata, S. Fujiyama, T. Matsumoto, I. Koshida, K. Yoshimura, M. Mihara, M. Naitou, H. Endoh, T. Nakamura, C. Akimoto, Y. Yamamoto, T. Katagiri, C. Foulds, S. Takezawa, H. Kitagawa, K. Takeyama, B.W. O'Malley, and S. Kato DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs Nat. Cell Biol. 9 2007 604 611 (Pubitemid 46696543)
37. F.V. Fuller-Pace, and S. Ali The DEAD box RNA helicases p68 (Ddx5) and p72 (Ddx17): novel transcriptional co-regulators Biochem. Soc. Trans. 36 2008 609 612
38. F.V. Fuller-Pace DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation Nucleic Acids Res. 34 2006 4206 4215 (Pubitemid 44542200)
39. L. Yang, C. Lin, S. Zhao, H. Wang, and Z.R. Liu Phosphorylation of p68 RNA helicase plays a role in platelet-derived growth factor-induced cell proliferation by up-regulating cyclin D1 and c-Myc expression J. Biol. Chem. 282 2007 16811 16819 (Pubitemid 47093229)
40. L. Yang, C. Lin, and Z.R. Liu p68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin Cell 127 2006 139 155 (Pubitemid 44466634)
41. R. Karim, G. Tse, T. Putti, R. Scolyer, and S. Lee The significance of the Wnt pathway in the pathology of human cancers Pathology 36 2004 120 128 (Pubitemid 38507872)
42. M. Mochizuki, S. Yamazaki, K. Kano, and T. Ikeda Kinetic analysis and mechanistic aspects of autoxidation of catechins Biochim. Biophys. Acta 1569 2002 35 44 (Pubitemid 34165555)
43. I. Naasani, F. Oh-hashi, T. Oh-hara, W.Y. Feng, J. Johnston, K. Chan, and T. Tsuruo Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo Cancer Res. 63 2003 824 830 (Pubitemid 36231983)
44. T. Walle, T.S. Vincent, and U.K. Walle Evidence of covalent binding of the dietary flavonoid quercetin to DNA and protein in human intestinal and hepatic cells Biochem. Pharmacol. 65 2003 1603 1610 (Pubitemid 36577273)
45. H. van der Woude, G.M. Alink, B.E. van Rossum, K. Walle, H. van Steeg, T. Walle, and I.M. Rietjens Formation of transient covalent protein and DNA adducts by quercetin in cells with and without oxidative enzyme activity Chem. Res. Toxicol. 18 2005 1907 1916 (Pubitemid 43023049)
46. H.M. Awad, M.G. Boersma, S. Boeren, P.J. Van Bladeren, J. Vervoort, and I.M. Rietjens Quenching of quercetin quinone/quinone methides by different thiolate scavengers: stability and reversibility of conjugate formation Chem. Res. Toxicol. 16 2003 822 831 (Pubitemid 36898996)
47. G. Galati, M.Y. Moridani, T.S. Chan, and P.J. O'Brien Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation Free Radic Biol. Med. 30 2001 370 382 (Pubitemid 32155536)
48. T. Ishii, M. Ishikawa, N. Miyoshi, M. Yasunaga, M. Akagawa, K. Uchida, and Y. Nakamura Catechol type polyphenol is a potential modifier of protein sulfhydryls: development and application of a new probe for understanding the dietary polyphenol actions Chem. Res. Toxicol. 22 2009 1689 1698
49. M. Akagawa, Y. Ishii, T. Ishii, T. Shibata, M. Yotsu-Yamashita, K. Suyama, and K. Uchida Metal-catalyzed oxidation of protein-bound dopamine Biochemistry 45 2006 15120 15128 (Pubitemid 44937025)
50. J. Ying, N. Clavreul, M. Sethuraman, T. Adachi, and R.A. Cohen Thiol oxidation in signaling and response to stress: detection and quantification of physiological and pathophysiological thiol modifications Free Radic. Biol. Med. 43 2007 1099 1108 (Pubitemid 47374443)
51. L.J. Macpherson, A.E. Dubin, M.J. Evans, F. Marr, P.G. Schultz, B.F. Cravatt, and A. Patapoutian Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines Nature 445 2007 541 545 (Pubitemid 46197634)
52. K. Doyle, and F.A. Fitzpatrick Redox signaling, alkylation (carbonylation) of conserved cysteines inactivates class I histone deacetylases 1, 2, and 3 and antagonizes their transcriptional repressor function J. Biol. Chem. 285 2010 17417 17424
53. C. Merkwirth, and T. Langer Prohibitin function within mitochondria: essential roles for cell proliferation and cristae morphogenesis Biochim. Biophys. Acta 1793 2009 27 32
54. S.M. Mooney, J.P. Grande, J.L. Salisbury, and R. Janknecht Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential Biochemistry 49 2010 1 10
55. A.A. Cohen, N. Geva-Zatorsky, E. Eden, M. Frenkel-Morgenstern, I. Issaeva, A. Sigal, R. Milo, C. Cohen-Saidon, Y. Liron, Z. Kam, L. Cohen, T. Danon, N. Perzov, and U. Alon Dynamic proteomics of individual cancer cells in response to a drug Science 322 2008 1511 1616
56. J. Kim, X. Zhang, K.M. Rieger-Christ, I.C. Summerhayes, D.E. Wazer, K.E. Paulson, and A.S. Yee Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells: requirement of the transcriptional repressor HBP1 J. Biol. Chem. 281 2006 10865 10875 (Pubitemid 43855509)
57. R.L. Thangapazham, N. Passi, and R.K. Maheshwari Green tea polyphenol and epigallocatechin gallate induce apoptosis and inhibit invasion in human breast cancer cells Cancer Biol. Ther. 6 2007 1938 1943 (Pubitemid 351590407)
58. min/+ mice by (-)-epigallocatechin-3- gallate, the major catechin in green tea Cancer Res. 65 2005 10623 10631 (Pubitemid 41743758)
59. R.J. Deshaies, and C.A. Joazeiro RING domain E3 ubiquitin ligases Annu. Rev. Biochem. 78 2009 399 434
60. F. Hong, K.R. Sekhar, M.L. Freeman, and D.C. Liebler Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation J. Biol. Chem. 280 2005 31768 31775 (Pubitemid 41291926)
61. K.R. Sekhar, G. Rachakonda, and M.L. Freeman Cysteine-based regulation of the CUL3 adaptor protein Keap1 Toxicol. Appl. Pharmacol. 244 2010 21 26
62. M. Causevic, R.G. Hislop, N.M. Kernohan, F.A. Carey, R.A. Kay, R.J. Steele, and F.V. Fuller-Pace Overexpression and poly-ubiquitylation of the DEAD-box RNA helicase p68 in colorectal tumours Oncogene 20 2001 7734 7743 (Pubitemid 33121946)
63. H. Wang, X. Gao, Y. Huang, J. Yang, and Z.R. Liu p68 RNA helicase is a nucleocytoplasmic shuttling protein Cell Res. 19 2009 1388 1400