Synthesis and screening of novel vitamin e derivatives for anticancer functions

European Journal of Medicinal Chemistry

Volumn 58, Issue , 2012, Pages 72-83

  Chen, Wenbin ^a   Park, Sook Kyung ^a   Yu, Weiping ^a   Xiong, Ailian ^b   Sanders, Bob G ^a   Kline, Kimberly ^b  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b The University of Texas at Austin   (United States)

Author keywords

TEA; Anticancer activity; Chemical synthesis; Vitamin E derivative

Indexed keywords

2 ( 2 METHYL 2 (( 3',7',11' TRIMETHYLDODECYLOXY)METHYL)CHROMAN 6 YLOXY)ACETIC ACID; 2 ( 7 FLUORO 2 METHYL 2 ( 4',8',12' TRIMETHYLTRIDECYL)CHROMAN 6 YLOXY)ACETIC ACID; 6 HYDROXY 7 FLUORO 2 METHYL 2 ( 4',8',12' TRIMETHYLTRIDECENYL) 2,3 DIHYDROBENZOFURAN; ACETIC ACID DERIVATIVE; ALPHA TOCOPHEROL; ALPHA TOCOPHEROL DERIVATIVE; ALPHA TOCOPHEROL ETHER ACETIC ACID; ANTINEOPLASTIC AGENT; CHROMAN DERIVATIVE; ETHER; ETHYL 2 ( 7 FLUORO 2 METHYL 2 ( 4',8',12' TRIMETHYLTRIDECYL)CHROMAN 6 YLOXY)ACETIC ACID; FLUORINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL DEATH; CELL STRAIN MCF 7; CHEMICAL BOND; CONTROLLED STUDY; CROSS LINKING; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; FLUORINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MCF-7 CELLS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; VITAMIN E;

EID: 84867590296     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.09.045     Document Type: Article

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