Antipsychotic-like activity of Noni (Morinda citrifolia Linn.) in mice

BMC Complementary and Alternative Medicine

Volumn 12, Issue , 2012, Pages

  Pandy, Vijayapandi ^a   Narasingam, Megala ^a   Mohamed, Zahurin ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Apomorphine; Cage climbing; Dopamine; Methamphetamine; Noni fruits; Stereotypy

Indexed keywords

APOMORPHINE; HALOPERIDOL; METHAMPHETAMINE; MORINDA CITRIFOLIA EXTRACT;

ANIMAL EXPERIMENT; ARTICLE; CLIMBING; CONTROLLED STUDY; DRUG SAFETY; LOCOMOTION; MALE; MORINDA CITRIFOLIA; MOUSE; NONHUMAN; STEREOTYPY;

ANIMALS; ANTIPSYCHOTIC AGENTS; BEHAVIOR, ANIMAL; FRUIT; HUMANS; INDONESIA; MALE; MICE; MORINDA; PLANT EXTRACTS; PSYCHOTIC DISORDERS;

EID: 84867584245     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-12-186     Document Type: Article

References (56)

1. Ehmann T, Yager J, Hanson L. Early psychosis: a review of the treatment literature. Child Ment Health Policy Res Program 2004, 7:1-52.
2. Mathivanan N, Surendiran G, Srinivasan K, Sagadevan E, Malarvizhi K. Review on the current scenario of Noni research: taxonomy, distribution, chemistry, medicinal and therapeutic values of Morinda citrifolia. Int J Noni Res 2005, 1(1):1-16.
3. Wang MY, West BJ, Jensen CJ, Nowicki D, Su C, Palu A, Anderson G. Morinda citrifolia (Noni): a literature review and recent advances in Noni research. Acta Pharmacol Sin 2002, 23(12):1127-1141.
4. Smita N, Rajani S. Morinda Citrifolia: a review. J Pharm Res 2010, 3(8):1872-1874.
5. Younos C, Rolland A, Fleurentin J, Lanhers MC, Misslin R, Mortier F. Analgesic and behavioural effects of Morinda citrifolia. Planta Med 1990, 56:430-434. 10.1055/s-2006-961004, 1981810.
6. Basar S, Uhlenhut K, Hogger P, Schone F, Westendorf J. Analgesic and anti-inflammatory activity of Morinda citrifolia L. (Noni) fruit. Phytother Res 2010, 24:38-42. 10.1002/ptr.2863, 19548275.
7. Su BN, Pawlus AD, Jung HA, Keller WJ, McLaughlin JL, Kinghorn AD. Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity. J Natural Products 2005, 68:592-595.
8. Chanda S, Dave R, Kaneria M. In vitro antioxidant property of some Indian medicinal plants. Res J Med Plant 2011, 5:169-179.
9. Palu AK, Kim AH, West BJ, Deng S, Jensen J, White L. The effects of Morinda citrifolia L (noni) on the immune system: its molecular mechanisms of action. J Ethnopharmacol 2008, 115:502-506. 10.1016/j.jep.2007.10.023, 18063495.
10. Hirazumi A, Furusawa E. An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumor activity. Phytother Res 1999, 13:380-387. 10.1002/(SICI)1099-1573(199908/09)13:5<380::AID-PTR463>3.0.CO;2-M, 10441776.
11. Wang MY, Anderson G, Nowicki D, Jensen J. Hepatic protection by noni fruit juice against CCl (4)-induced chronic liver damage in female SD rats. Plant Foods Hum Nutr 2008, 63:141-145. 10.1007/s11130-008-0083-y, 18654853.
12. Runnie I, Salleh MN, Mohamed S, Head RJ, Abeywardena MY. Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed. J Ethnopharmacol 2004, 92:311-316. 10.1016/j.jep.2004.03.019, 15138017.
13. Gilani AH, Mandukhail SR, Iqbal J, Yasinzai M, Aziz N, Khan A, Rehman N. Antispasmodic and vasodilator activities of Morinda citrifolia root extract are mediated through blockade of voltage dependent calcium channels. BMC Compl Altern Med 2010, 10:2.
14. Salleh MN, Runnie I, Roach PD, Mohamed S, Abeywardena MY. Inhibition of low-density lipoprotein oxidation and up-regulation of low-density lipoprotein receptor in HepG2 cells by tropical plant extracts. J Agric Food Chem 2002, 50:3693-3697. 10.1021/jf011593f, 12059144.
15. Banerjee S, Johnson AD, Csiszar K, Wansley DL, McGeady P. An extract of Morinda citrifolia interferes with the serum-induced formation of filamentous structures in Candida albicans and inhibits germination of Aspergillus nidulans. Am J Chin Med 2006, 34:503-509. 10.1142/S0192415X0600403X, 16710899.
16. Chearskul S, Kooptiwut S, Chatchawalvanit S, Onreabroi S, Churintrapun M, Saralamp P, Soonthornchareonnon N. Morinda citrifolia has very weak estrogenic activity in vivo. Thai J Physiol Sci 2004, 17:22-29.
17. Palu A, Su C, Zhou BN, West B, Jensen J. Wound healing effects of noni (Morinda citrifolia L.) leaves: a mechanism involving its PDGF/A2A receptor ligand binding and promotion of wound closure. Phytother Res 2010, 24(10):1437-1441. 10.1002/ptr.3150, 20878690.
18. Hamid M, Bohari SPM, Bastami MS, Ali AM, Mustapha NM, Shari K. Evaluation of the insulinotrophic activity of Malaysian traditional plants extract. J Biol Sci 2008, 8:201-204.
19. Shirwaikar A, Kamariya Y, Patel B, Nanda S, Parmar V, Khan S. Methanol extract of the fruits of Morinda citrifolia Linn. restores bone loss in ovariectomized rats. Int J Pharmacol 2011, 7:446-454.
20. Deng S, West BJ, Palu AK, Zhou BN, Jensen CJ. Noni as an anxiolytic and sedative: a mechanism involving its gamma-aminobutyric acidergic effects. Phytomed 2007, 14:517-522.
21. Muralidharan P, Kumar VR, Balamurugan G. Protective effect of Morinda citrifolia fruits on beta-amyloid (25-35) induced cognitive dysfunction in mice: an experimental and biochemical study. Phytother Res 2010, 24:252-258.
22. Muralidharan P, Srikanth J. Anti-Epileptic activity of Morinda citrifolia Linn fruit extract. E- J Chem 2010, 7(2):612-616.
23. Muto J, Hosung L, Uwaya K, Isami F, Ohno M, Mikami T. Morinda citrifolia fruit reduces stress-induced impairment of cognitive function accompanied by vasculature improvement in mice. Physiol Behav 2010, 101(2):211-217. 10.1016/j.physbeh.2010.04.014, 20416332.
24. Margarita BU, Sanchez N, Perez-Saad H, Gloria L, Isidoro S. Perfil neurofarmacológico del zumo de Morinda citrifolia. Bol Latinoam Caribe Plant Med Aromat 2011, 10(2):159-166.
25. Nima S, Kasiwong S, Ridtitid W, Thaenmanee N, Mahattanadul S. Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models. J Ethnopharmacol 2012, 142:354-361. 10.1016/j.jep.2012.04.044, 22580040.
26. Ekpalakorn W, Supjaroen S, Keawkomol P, Chompuwiset K, Limangkoon P, Boonchui W. A clinical study of Morinda citrifolia Linn. In the treatment of nausea and vomiting. Office of the Primary Health Care, Ministry of Public Health. Research Reports on Medicinal Plants, Medicinal Plants and Primary Health Care Project 1987, 40-41. Bangkok: Veteran Administration Printing.
27. Chuthaputti A, Pattaloong PN, Permpipat U, Techadamrongsin Y. Study on antiemetic activity of Morinda citrifolia fruits. Thai J Pharm Sci 1996, 20:195-202.
28. Howard-Jones NA. A CIOMS ethical code for animal experimentation. WHO Chron 1985, 39:51-56.
29. Costall B, Naylor RJ, Nohria V. Climbing behaviour induced by apomorphine in mice: a potential model for the detection of neuroleptic activity. Eur J Pharmacol 1978, 50:39-50. 10.1016/0014-2999(78)90251-0, 28233.
30. Protais P, Costentin J, Schwartz JC. Climbing behaviour induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum. Psychopharmacol 1976, 50:1-6.
31. Seeman P. Brain dopamine receptor. Pharmacol Rev 1980, 32:229-313.
32. Stoff JC, Kebabian JW. Two dopamine receptor: biochemistry physiology and pharmacology. Life Sci 1984, 35:2281-2296. 10.1016/0024-3205(84)90519-8, 6390056.
33. Kelly PH, Seviour PW, Iversen SD. Amphetamine and apomorphine response in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Res 1975, 94(3):507-522. 10.1016/0006-8993(75)90233-4, 1171714.
34. Lipska BK, Weinberger DR. To model a psychiatric disorder in animals: schizophrenia as a reality test. Neuropsychopharmacol 2000, 23:223-239.
35. Gardner DM, Baldessarini RJ, Waraich P. Modern antipsychotic drugs: a critical overview. Can Med Assoc J 2005, 172:1703-1711.
36. Rothman RB, Baumann MH, Der-sch CM, Romero DV, Rice KC, Carroll FI, Partilla JS. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Synapse 2001, 39:32-41. 10.1002/1098-2396(20010101)39:1<32::AID-SYN5>3.0.CO;2-3, 11071707.
37. Iversen SD. Neural substrates mediating amphetamine response. Cocaine and other stimulants 1977, 31-45. New York: Plenum, Ellinwood EH, Kilbey MM.
38. Costall B, Marsden CD, Naylor RJ, Pycock CJ. Stereotyped behaviour patterns and hyperactivity induced by amphetamine and apomorphine after discrete 6-hydroxydopamine lesions of extrapyramidal and mesolimbic nuclei. Brain Res 1977, 123:89-111. 10.1016/0006-8993(77)90645-X, 300267.
39. Kelley AE, Lang CG, Gauthier AM. Induction of oral stereotypy following amphetamine microinjection into a discrete sub region of the striatum. Psychopharmacol 1988, 95:556-559.
40. Delfs JM, Kelley AE. The role of D1 and D2 dopamine receptors in oral stereotypy induced by dopaminergic stimulation of the ventrolateral striatum. Neurosci 1990, 39:59-67.
41. Budygin EA. Dopamine uptake inhibition is positively correlated with cocaine-induced stereotyped behavior. Neurosci Lett 2007, 429:55-58. 10.1016/j.neulet.2007.09.064, 2220010, 17980487.
42. Segal DS, Kuczenski R. An escalating dose " binge" model of amphetamine psychosis: behavioral and neurochemical characteristics. J Neurosci 1997, 17:2551-2566.
43. Woods-Kettelberger A, Kongsamut S, Smith CP, Winslow JT, Corbett R. Animal models with potential applications for screening compounds for the treatment of obsessive-compulsive disorder. Expert Opin Invest Drugs 1997, 6:1369-1381.
44. Moy SS, Nadler JJ, Poe MD, Nonneman RJ, Young NB, Koller BH, Crawley JN, Duncan GE, Bodfish JM. Development of a mouse test for repetitive, restricted behaviors: relevance to autism. Behav Brain Res 2008, 188:178-194. 10.1016/j.bbr.2007.10.029, 2349090, 18068825.
45. Okuyama S, Kawashima N, Chaki S, Yoshikawa R, Funakoshi T, Ogawa SI, Suzuki Y, Ikeda Y, Kumagai T, Nakazato A, Nagamine M, Tomisawa K. A selective dopamine D4 receptor antagonist, NRA0160: a preclinical neuropharmacological profile. Life Sci 1999, 65:2109-2125. 10.1016/S0024-3205(99)00476-2, 10579464.
46. Kitanaka J, Kitanaka N, Tatsuta T, Morita Y, Takemura M. Blockade of brain histamine metabolism alters methamphetamine-induced expression pattern of stereotypy in mice via histamine H1 receptors. Neurosci 2007, 147:765-777.
47. Kumar M, Shek A, Akbar Z. A review on analgesic: from natural sources. Int J Pharm Biol Arch 2010, 1:95-100.
48. West BJ, Jensen CJ, Westendorf J, White LD. A safety review of noni fruit juice. J Food Sci 2006, 71:R100-R106.
49. Product Safety Labs Guinea pig antigenicity study. Tahitian Noni puree, Tahitian Noni juice, and Tahitian Noni concentrate 2000, East Brunswick, NJ: Eurofins Scientific, Product Safety Labs.
50. Sunisa P, Arunporn I. Morinda Citrifolia Linn. for Prevention of Postoperative Nausea and Vomiting. J Med Assoc Thai 2010, 93(Suppl. 7):S204-S209.
51. Andrews PLR, Davis CJ, Bingham S, Davidson HIM, Hawthorn J, Maskell L. The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity. Can J Physiol Pharmacol 1990, 68:325-345. 10.1139/y90-047, 2178756.
52. Harding RK, Hugenholtz H, Kucharczyk J, Lemoine J. Central mechanisms for Apomorphine-induced emesis in the dog. Eur J Pharmacol 1987, 144:61-65. 10.1016/0014-2999(87)90009-4, 3436361.
53. Takashi Y, Naoyuki Y, Makoto O. The broad-spectrum anti-emetic activity of AS-8112, a novel dopamine D2, D3 and 5-HT3 receptors antagonist. Br J Pharmacol 2001, 133(2):253-260. 10.1038/sj.bjp.0704078, 1572785, 11350861.
54. Deutsch SI, Long K, Richard BR, Tizabi Y, Weizman R, Eller J, Mastropaolo J. Animal Models of Psychosis. Contemporary Clinical Neuroscience: Transgenic and Knockout Models of Neuropsychiatric Disorders 2006, 193-220. Totowa, NJ: Humana Press Inc, Fisch GS, Flint J.
55. Vijayapandi P, Nagappa AN. Biphasic effects of losartan potassium on immobility in mice. Yakugaku Zasshi 2005, 125(8):653-657. 10.1248/yakushi.125.653, 16079616.
56. Pachauri SD, Santoshkumar T, Kiran K, Verma PRP, Chandishwar N, Kashif H, Rakesh S, Saxenad JK, Anil Kumar D. Protective effect of fruits of Morinda citrifolia L. on scopolamine induced memory impairment in mice: a behavioral, biochemical and cerebral blood flow study. J Ethnopharmacol 2012, 139:34-41. 10.1016/j.jep.2011.09.057, 22107832.