Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models

Journal of Ethnopharmacology

Volumn 142, Issue 2, 2012, Pages 354-361

  Nima, Sawpheeyah ^a   Kasiwong, Srirat ^a   Ridtitid, Wibool ^b   Thaenmanee, Niwan ^a   Mahattanadul, Sirima ^a  

^a PRINCE OF SONGKLA UNIVERSITY   (Thailand)

^b WALAILAK UNIVERSITY   (Thailand)

Author keywords

5 HT 4 receptor agonist; Aqueous noni fruit extract; Bioavailability; Gastric emptying; Gastrokinetic; Morinda citrifolia (L.)

Indexed keywords

MORINDA CITRIFOLIA EXTRACT; RANITIDINE; SCOPOLETIN; SEROTONIN 4 RECEPTOR;

ADULT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; CASE REPORT; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; FEMALE; FRUIT; HUMAN; HUMAN EXPERIMENT; MALE; MORINDA CITRIFOLIA; NONHUMAN; RANDOMIZED CONTROLLED TRIAL; RAT; STOMACH FUNDUS; STOMACH MOTILITY;

ADOLESCENT; ADULT; ANIMALS; AREA UNDER CURVE; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FRUIT; GASTROINTESTINAL AGENTS; GASTROINTESTINAL MOTILITY; HUMANS; INTESTINAL ABSORPTION; MALE; MIDDLE AGED; MORINDA; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PLANT EXTRACTS; RANITIDINE; RATS, WISTAR; RECEPTORS, SEROTONIN; SCOPOLETIN; SEROTONIN RECEPTOR AGONISTS; STOMACH; YOUNG ADULT;

MORINDA CITRIFOLIA; RATTUS;

EID: 84862898267     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.04.044     Document Type: Article

References (19)

1. L. Brunton, K. Parker, D. Blumenthal, and I. Buxton Goodman & Gilmans Manual of Pharmacology and Therapeutics 2008 The McGraw-Hill Companies New York pp. 633-636
2. A. Chuthaputti, P.N. Pattaloong, U. Permpipat, and Y. Techadamrongsin Study on antiemetic activity of Morinda citrifolia fruits Thai Journal of Pharmaceutical Sciences 20 1996 195 202
3. Z. Dragica, and S. Trajce High-performance liquid chromatographic determination of famotidine in human plasma using solid-phase column extraction Journal of the Serbian Chemical Society 68 2003 883 892
4. Z. Dragica, and S. Trajce Development of an HPLC method for the determination of ranitidine and cimetidine in human plasma following SPE Journal of Pharmaceutical and Biomedical Analysis 33 2003 165 173
5. Ekpalakorn, W., Supjaroen, S., Keawkomol, P., Chompuwiset, K., Limangkoon, P., Boonchui, W., 1987. A clinical study of Morinda citrifolia Linn. in the treatment of nausea and vomiting. In: Office of the Primary Health Care, Ministry of Public Health. Research Reports on Medicinal Plants, Medicinal Plants and Primary Health Care Project. Veteran Administration Printing, Bangkok, pp. 40-41 (in Thai).
6. S. Engdal, and O.G. Nilsen Inhibition of P-glycoprotein in Caco-2 cells: effects of herbal remedies frequently used by cancer patients Xenobiotica 38 2008 559 573
7. N.R. Farnsworth, and N. Bunyapraphatsara Thai medicinal plant: Recommended for primary health care system 1992 Prachachon Co., Ltd Thailand pp. 173-175
8. H.T. Lee, E.K. Seo, S.J. Chung, and C.K. Shim Prokinetic activity of an aqueous extract from dried immature fruit of Poncirus trifoliate (L.) Raf Journal of Ethnopharmacology. 102 2005 131 136
9. K.A. Lentz, J.W. Polli, S.A. Wring, J.E. Humphreys, and J.E. Polli Influence of passive permeability on apparent P-glycoprotein kinetics Pharmaceutical Research 17 2000 1456 1460
10. O. Levand, and H.O. Larson Some chemical constituents of Morinda citrifolia Planta Medica 36 1979 186 187
11. S. Mahattanadul, W. Rittitid, S. Nima, N. Phdoongsombut, P. Ratanasuwon, and S. Kasiwong Effects of Morinda citrifolia aqueous fruit extract and its biomarker scopoletin on reflux esophagitis and gastric ulcer in rats Journal of Ethnopharmacology 134 2011 243 250
12. A.J. McLean, H. Skews, A. Bobik, and F.J. Dudley Interaction between oral propranolol and hydralazine Clinical Pharmacology and Therapeutics 27 1980 726 732
13. E.J. Oliveira, M.A. Romero, M.S. Silva, B.A. Silva, and I.A. Medeiros Intracellular calcium mobilization as a target for the spasmolytic action of scopoletin Planta Medica 67 2001 605 608
14. S. Panda, and A. Kar Evaluation of the antithyroid, antioxidative and antihyperglycemic activity of scopoletin from Aegle marmelos leaves in hyperthyroid rats Phytotherapy Research 20 2006 1103 1105
15. H.F. Pu, W.J. Huang, W.M. Tseng, S.W. Wang, Y.W. Liu, M.L. Doong, and P.S. Wang Effects of juice from Morinda citrifolia (Noni) on gastric emptying in male rats Chinese Journal of Physiology 47 2004 169 174
16. The Staff of the Department of Pharmacology, University of Edinburgh Pharmacological experiment on isolated preparation 1970 Churchill Livingstone England pp. 88-91
17. K.E. Thummel, and G.R. Wilkinson In vitro and in vivo drug interactions involving human CYP3A Annual Review of Pharmacology and Toxicology 38 1998 389 430
18. B.J. West, C.J. Jensen, J. Westendorf, and L.D. White A safety review of noni fruit juice Journal of Food Science 71 2006 R100 R106
19. D.B. William, and R.R. Schade Gastroesophageal reflux disease J.T. Dipiro, R.L. Talbert, G.C. Yee, G.R. Matzke, B.G. Wells, L.M. Posey, Pharmacotherapy: A Pathophysiologic Approach 2008 The McGraw-Hill companies Inc. New York 555 567