Protective effect of fruits of Morinda citrifolia L. on scopolamine induced memory impairment in mice: A behavioral, biochemical and cerebral blood flow study

Journal of Ethnopharmacology

Volumn 139, Issue 1, 2012, Pages 34-41

  Pachauri, Shakti Deep ^a   Tota, Santoshkumar ^a   Khandelwal, Kiran ^a   Verma, P R P ^b   Nath, Chandishwar ^a   Hanif, Kashif ^a   Shukla, Rakesh ^a   Saxena, J K ^a   Dwivedi, Anil Kumar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b BIRLA INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Acetylcholinesterase; Cerebral blood flow; Memory; Noni fruit; Scopolamine

Indexed keywords

ACETIC ACID ETHYL ESTER; ACETYLCHOLINESTERASE; ALCOHOL; BUTANOL; CHLOROFORM; DONEPEZIL; GLUTATHIONE; MALONALDEHYDE; MORINDA CITRIFOLIA EXTRACT; NEUROPROTECTIVE AGENT; SCOPOLAMINE;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; CONTROLLED STUDY; ENZYME ACTIVITY; FRUIT; IN VITRO STUDY; INHIBITION KINETICS; LASER DOPPLER FLOWMETRY; LOCOMOTION; MALE; MEDICINAL PLANT; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PASSIVE AVOIDANCE; PROTEIN BLOOD LEVEL;

ACETYLCHOLINESTERASE; ANIMALS; ANTIOXIDANTS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; BRAIN; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; FRUIT; GLUTATHIONE; MALE; MALONDIALDEHYDE; MEMORY DISORDERS; MICE; MORINDA; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; QUERCETIN; RUTIN; SCOPOLAMINE HYDROBROMIDE; SCOPOLETIN;

MORINDA CITRIFOLIA; MUS;

EID: 83555161656     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.09.057     Document Type: Article

References (47)

1. R. Agrawal, E. Tyagi, R. Shukla, and C. Nath Effect of insulin and melatonin on acetylcholinesterase activity in the brain of amnesic mice Behavioural Brain Research 189 2008 381 386
2. H. Awasthi, S. Tota, K. Hanif, C. Nath, and R. Shukla Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow Life Sciences 86 2010 87 94
3. S. Basar, K. Uhlenhut, P. Hogger, F. Schone, and J. Westendorf Analgesic and antiinflammatory activity of Morinda citrifolia L. (Noni) fruit Phytotherapy Research 24 2010 38 42
4. P. Bhutada, Y. Mundhada, K. Bansod, C. Bhutada, S. Tawari, P. Dixit, and D. Mundhada Ameliorative effect of quercetin on memory dysfunction in streptozotocin-induced diabetic rats Neurobiology of Learning and Memory 94 2010 293 302
5. Y.K. Chung, H.J. Heo, E.K. Kim, H.K. Kim, T.L. Huh, Y. Lim, S.K. Kim, and D.H. Shin Inhibitory effect of ursolic acid purified from Origanum majorana L. on the acetylcholinesterase Molecular Cells 11 2001 137 143 (Pubitemid 33663351)
6. M.I. Colado, E. O'Shea, R. Granados, A. Misra, T.K. Murray, and A.R. Green A study of the neurotoxic effect of MDMA ('ecstasy') on 5-HT neurones in the brains of mothers and neonates following administration of the drug during pregnancy British Journal of Pharmacology 121 1997 827 833 (Pubitemid 27260791)
7. S. Deng, B.J. West, A.K. Palu, B.N. Zhou, and C.J. Jensen Noni as an anxiolytic and sedative: a mechanism involving its gamma-aminobutyric acidergic effects Phytomedicine 14 2007 517 522 (Pubitemid 47071884)
8. G.L. Ellman Tissue sulfhydryl groups Archives of Biochemistry and Biophysics 82 1959 70 77
9. G.L. Ellman, K.D. Courtney, V. Andres Jr.; and R.M. Feather-Stone A new and rapid colorimetric determination of acetylcholinesterase activity Biochemical Pharmacology 7 1961 88 95
10. D.A. El-Sherbiny, A.E. Khalifa, A.S. Attia, and D. Eldenshary Eel Hypericum perforatum extract demonstrates antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine Pharmacology, Biochemistry, and Behaviour 76 2003 525 533 (Pubitemid 37487909)
11. A.H. Gilani, S.U. Mandukhail, J. Iqbal, M. Yasinzai, N. Aziz, A. Khan, and N.U. Rehman Antispasmodic and vasodilator activities of Morinda citrifolia root extract are mediated through blockade of voltage dependent calcium channels BMC Complementary and Alternative Medicine 10 2010 2
12. S. Harada, W. Hamabe, K. Kamiya, T. Satake, J. Yamamoto, and S. Tokuyama Preventive effect of Morinda citrifolia fruit juice on neuronal damage induced by focal ischemia Biological and Pharmaceutical Bulletin 32 2009 405 409
13. M.F. Hernandez, P.L.V. Fale, M.E.M. Araujo, and M.L.M. Serralheiro Acetylcholinesterase inhibition and antioxidant activity of the water extracts of several Hypericum species Food Chemistry 120 2010 1076 1082
14. A. Hirazumi, and E. Furusawa An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumor activity Phytotherapy Research 13 1999 380 387 (Pubitemid 29401386)
15. W.G. Honer, I. Prohovnik, G. Smith, and L.R. Lucas Scopolamine reduces frontal cortex perfusion Journal of Cerebral Blood Flow and Metabolism 8 1988 635 641
16. E.J. Jeong, K.Y. Lee, S.H. Kim, S.H. Sung, and Y.C. Kim Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice European Journal of Pharmacology 588 2008 78 84
17. R.W. Jones, K.A. Wesnes, and J. Kirby Effects of NMDA modulation in scopolamine dementia Annals of the New York Acadamy of Sciences 640 1991 241 244
18. S.S. Kang, J.Y. Lee, Y.K. Choi, S.S. Song, J.S. Kim, S.J. Jeon, Y.N. Han, K.H. Son, and B.H. Han Neuroprotective effects of naturally occurring biflavonoids Bioorganic and Medicinal Chemistry Letters 15 2005 3588 3591
19. K.R. Kirtikar, and B.D. Basu Morinda citrifolia L.M. Basu, Indian Medicinal Plants 1981 International Book Distributors Bombay
20. J.H. Lee, K.T. Lee, J.H. Yang, N.I. Baek, and D.K. Kim Acetylcholinesterase inhibitors from the twigs of Vaccinium oldhami Miquel Archieves of Pharmacal Research 27 2004 53 56 (Pubitemid 43154541)
21. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent Journal of Biological Chemistry 193 1951 265 275
22. W. McClatchey From Polynesian healers to health food stores: changing perspectives of Morinda citrifolia (Rubiaceae) Integrative Cancer Therapies 1 2002 110 120 discussion 120 (Pubitemid 36834917)
23. P. Muralidharan, V.R. Kumar, and G. Balamurugan Protective effect of Morinda citrifolia fruits on beta-amyloid (25-35) induced cognitive dysfunction in mice: an experimental and biochemical study Phytotherapy Research 24 2010 252 258
24. M. Ogawa, Y. Magata, Y. Ouchi, H. Fukuyama, H. Yamauchi, J. Kimura, Y. Yonekura, and J. Konishi Scopolamine abolishes cerebral blood flow response to somatosensory stimulation in anesthetized cats: PET study Brain Research 650 1994 249 252 (Pubitemid 24207069)
25. I. Orhan, F. Tosun, and B. Sener Coumarin, anthroquinone and stilbene derivatives with anticholinesterase activity Z Naturforsch C. 63 2008 366 370
26. A.K. Palu, A.H. Kim, B.J. West, S. Deng, J. Jensen, and L. White The effects of Morinda citrifolia L (noni) on the immune system: its molecular mechanisms of action Journal of Ethnopharmacology 115 2008 502 506 (Pubitemid 350299089)
27. A.D. Pawlus, and D.A. Kinghorn Review of the ethnobotany, chemistry, biological activity and safety of the botanical dietary supplement Morinda citrifolia (noni) Journal of Pharmacy and Pharmacology 59 2007 1587 1609 (Pubitemid 350221804)
28. F. Pu, K. Mishima, K. Irie, K. Motohashi, Y. Tanaka, K. Orito, T. Egawa, Y. Kitamura, N. Egashira, K. Iwasaki, and M. Fujiwara Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats Journal of Pharmacological Sciences 104 2007 329 334 (Pubitemid 47378420)
29. M. Rastogi Compendium of Indian Medicinal Plants 1990 Publication and Information Directorate, CSIR New Delhi
30. S.K. Richetti, M. Blank, K.M. Capiotti, A.L. Piato, M.R. Bogo, M.R. Vianna, and C.D. Bonan Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish Behavioural Brain Research 217 2010 10 15
31. J.M. Rollinger, A. Hornick, T. Langer, H. Stuppner, and H. Prast Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural products Journal of Medicinal Chemistry 47 2004 6248 6254 (Pubitemid 39587249)
32. I. Runnie, M.N. Salleh, S. Mohamed, R.J. Head, and M.Y. Abeywardena Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed Journal of Ethnopharmacology 92 2004 311 316 (Pubitemid 38610115)
33. T. Sakurai, T. Kato, K. Mori, E. Takano, S. Watabe, and T. Nabeshima Nefiracetam elevates extracellular acetylcholine level in the frontal cortex of rats with cerebral cholinergic dysfunctions: an in vivo microdialysis study Neuroscience Letters 246 1998 69 72 (Pubitemid 28207078)
34. V. Samoylenko, J. Zhao, D.C. Dunbar, I.A. Khan, J.W. Rushing, and I. Muhammad New constituents from noni (Morinda citrifolia) fruit juice Journal of Agricultural Food and Chemistry 54 2006 6398 6402 (Pubitemid 44367608)
35. G. Saxena, S.P. Singh, R. Pal, S. Singh, R. Pratap, and C. Nath Gugulipid, an extract of Commiphora whighitii with lipid-lowering properties, has protective effects against streptozotocin-induced memory deficits in mice Pharmacology, Biochemistry, and Behavior 86 2007 797 805 (Pubitemid 46829332)
36. D. Sharma, M. Puri, A.K. Tiwary, N. Singh, and A.S. Jaggi Antiamnesic effect of stevioside in scopolamine-treated rats Indian Journal of Pharmacology 42 2010 164 167
37. B.N. Su, A.D. Pawlus, H.A. Jung, W.J. Keller, J.L. McLaughlin, and A.D. Kinghorn Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity Journal of Natural Products 68 2005 592 595 (Pubitemid 40586327)
38. S. Tota, H. Awasthi, P.K. Kamat, C. Nath, and K. Hanif Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice Behavioural Brain Research 209 2010 73 79
39. S. Tota, P.K. Kamat, H. Awasthi, N. Singh, R. Raghubir, C. Nath, and K. Hanif Candesartan improves memory decline in mice: involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin Behavioural Brain Research 199 2009 235 240
40. S. Tota, P.K. Kamat, R. Shukla, and C. Nath Improvement of brain energy metabolism and cholinergic functions contributes to the beneficial effects of silibinin against streptozotocin induced memory impairment Behavioural Brain Research 221 2011 207 215
41. H. Tsukada, T. Kakiuchi, I. Ando, and Y. Ouchi Functional activation of cerebral blood flow abolished by scopolamine is reversed by cognitive enhancers associated with cholinesterase inhibition: a positron emission tomography study in unanesthetized monkeys Journal of Pharmacology and Experimental Therapeutics 281 1997 1408 1414 (Pubitemid 27258401)
42. C. Wang, and R.L. Smith Lowry determination of protein in the presence of Triton X-100 Analytical Biochemistry 63 1975 414 417
43. M.Y. Wang, G. Anderson, D. Nowicki, and J. Jensen Hepatic protection by noni fruit juice against CCl(4)-induced chronic liver damage in female SD rats Plant Foods for Human Nutrition 63 2008 141 145
44. M.Y. Wang, B.J. West, C.J. Jensen, D. Nowicki, C. Su, A.K. Palu, and G. Anderson Morinda citrifolia (Noni): a literature review and recent advances in Noni research Acta Pharmacologica Sinica 23 2002 1127 1141 (Pubitemid 35470338)
45. R. Wang, H. Yan, and X.C. Tang Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine Acta Pharmacologica Sinica 27 2006 1 26 (Pubitemid 43051942)
46. D. Wyper, E. Teasdale, J. Patterson, D. Montaldi, D. Brown, R. Hunter, D. Graham, and J. McCulloch Abnormalities in rCBF and computed tomography in patients with Alzheimer′s disease and in controls British Journal of Radiology 66 1993 23 27 (Pubitemid 23049577)
47. C. Younos, A. Rolland, J. Fleurentin, M.C. Lanhers, R. Misslin, and F. Mortier Analgesic and behavioural effects of Morinda citrifolia Planta Medica 56 1990 430 434 (Pubitemid 20347577)