Analgesic and antiinflammatory activity of Morinda citrifolia L. (Noni) fruit

Phytotherapy Research

Volumn 24, Issue 1, 2010, Pages 38-42

  Basar, Simla ^a   Uhlenhut, Klaus ^b   Högger, Petra ^b   Schöne, Florian ^a   Westendorf, Johannes ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Analgesic; Antiinflammatory; Metalloproteinase; MMP 9; Morinda citrifolia; Noni

Indexed keywords

ALCOHOL; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; DRINKING WATER; GELATINASE B; HYDROCORTISONE; LIPOPOLYSACCHARIDE; MORINDA CITRIFOLIA EXTRACT; NALOXONE; TRAMADOL;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; FREEZING; HOT PLATE TEST; HUMAN; HUMAN CELL; JOINT DESTRUCTION; MALE; MONOCYTE; MORINDA CITRIFOLIA; MOUSE; NOCICEPTION; NONHUMAN; PAIN;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; DIPYRONE; FRUIT; HUMANS; MALE; MATRIX METALLOPROTEINASE 9; MICE; MONOCYTES; MORINDA; PLANT EXTRACTS; TRAMADOL;

MORINDA CITRIFOLIA; MUS;

EID: 74249083705     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2863     Document Type: Article

References (26)

1. Akihisa T, Matsumoto K, Tokuda H et al. 2007. Anti-inflammatory and potential cancer chemopreventive constituents of the fruits of Morinda citrifolia (Noni). J Nat Prod 70: 754-757.
2. Bamigbade TA, Langford RM. 1998. Tramadol hydrochloride: an overview of current use. Hosp Med 59: 373-376.
3. Brien S, Lewith GT, McGregor G. 2006. Devil's claw ( Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety. J Altern Complement Med 12: 981-993.
4. Commission E. 2003. Commission decision of 5 June 2003 authorising the placing on the market of 'noni juice' (juice of the fruit of Morinda citrifolia L.) as a novel food ingredient under regulation (EC) No 258/97 of the European parliament and of the council. In Official Journal of the European Union, 2003, 001.
5. Dixon AR, McMillan H, Atkin NL. 1999. Ferment this: The transformation of Noni, a traditional Polynesian medicine (Morinda Citrifolia, Rubiaceae). Econ Bot 53: 51-68.
6. Grimm T, Chovanova Z, Muchova J et al. 2006. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). J Inflamm (Lond) 3: 1.
7. Grzanna R, Lindmark L, Frondoza CG. 2005. Ginger - an herbal medicinal product with broad anti-inflammatory actions. J Med Food 8: 125-132.
8. Hardin SR. 2007. Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis. Complement Ther Clin Pract 13: 25-28.
9. Hulejova H, Baresova V, Klezl Z et al. 2007. Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone. Cytokine 38: 151-156.
10. Leval X, Julemont F, Delarge J et al. 2002. New trends in dual 5-LOX/COX inhibition. Curr Med Chem 9: 941-962.
11. Li RW, Myers SP, Leach DN et al. 2003. A cross-cultural study: anti-inflammatory activity of Australian and Chinese plants. J Ethnopharmacol 85: 25-32.
12. Mazario J, Herrero JF. 1999. Antinociceptive effects of metamizol (dipyrone) in rat single motor units. Neurosci Lett 274: 179-182.
13. McClatchey W. 2002. From Polynesian healers to health food stores: changing perspectives of Morinda citrifolia (Rubiaceae). Integr Cancer Ther 1: 110-120; discussion 120.
14. McKoy ML, Thomas EA, Simon OR. 2002. Preliminary investigation of the anti-inflammatory properties of an aqueous extract from Morinda citrifolia (noni). Proc West Pharmacol Soc 45: 76-78.
15. Nagase H, Kashiwagi M. 2003. Aggrecanases and cartilage matrix degradation. Arthritis Res Ther 5: 94-103.
16. Palu A, Su C, Zhou B et al. 2004. Morinda citrifolia L., a dual inhibitor of COX-2 and 5-LOX enzymes. In Proceedings of the 5th International Conference and Exhibition on Neutraceuticals and Functional Foods. San Francisco, CA, USA, 2004. 470.
17. Pande M, Naiker N, Mills G et al. 2005. The Kura files: qualitatively social survey. Pacific Health Surv Resp 12: 85-93.
18. Pirmohamed M, James S, Meakin S et al. 2004. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. Br Med J 329: 15 -19.
19. Punjanon T, Nandhasri P. 2005. Analgesic effects of the alcoholic extract from fruits of Morinda citrifolia. Acta Hort (ISHS): 103-106.
20. Schlondorff D. 1993. Renal complications of nonsteroidal anti-inflammatory drugs. Kidney Int 44: 643-653.
21. Su C, Jensen JC, Wang M et al. 2001. A new selective COX-2 inhibitor: Morinda citrifolia (Noni). In Proceedings of the 7th Annual Conference on Eicosanoids and Other Bioactive Lipids. Nashville, TN, USA, 127.
22. Vane JR, Botting RM. 1998. Mechanism of action of nonsteroidal anti-inflammatory drugs. Am J Med 104: 2S-8S; discussion 21S-22S.
23. Vazquez E, Hernandez N, Escobar W et al. 2005. Antinociception induced by intravenous dipyrone (metamizol) upon dorsal horn neurons: involvement of endogenous opioids at the periaqueductal gray matter, the nucleus raphe magnus, and the spinal cord in rats. Brain Res 1048: 211-217.
24. West BJ, Jensen CJ, Westendorf J et al. 2006. A safety review of noni fruit juice. J Food Sci 71: R100-R106.
25. Westendorf J, Effenberger K, Iznaguen H et al. 2007. Toxicological and analytical investigations of noni ( Morinda citrifolia) fruit juice. J Agric Food Chem 55: 529-537.
26. Woolfe G, MacDonald A. 1944. The evaluation of analgesic action of pethidine hydrochloride (demerol). J. Pharmacol. Exp. Ther 80: 300-307.