3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38α mitogen activated protein kinase and casein kinase 1δ

Journal of Medicinal Chemistry

Volumn 52, Issue 23, 2009, Pages 7618-7630

  Peifer, Christian ^a,c   Abadleh, Mohammed ^a   Bischof, Joachim ^a   Hauser, Dominik ^a,d   Schattel, Verena ^a   Hirner, Heidrun ^b   Knippschild, Uwe ^b   Laufer, Stefan ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d C a i r Biosciences GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 ( 4 FLUOROPHENYL) N [ 4 ( 3 ( 4 FLUOROPHENYL) 5 ISOPROPYLISOXAZOL 4 YL)PYRIDIN 2 YL]ACETAMIDE; 3 ( 2,4 DIMETHOXYPHENYL) N ( 4 [ 3 ( 4 FLUOROPHENYL) 5 ISOPROPYLISOXAZOL 4 YL]PYRIDIN 2 YL)ACRYLAMIDE; 3 ( 2,4 DIMETHOXYPHENYL) N ( 4 [ 5 ( 4 FLUOROPHENYL) 2 METHYLSULFANYL 3H IMIDAZOL 4 YL]PYRIDIN 2 YL)ACRYLAMIDE; 4 [ 3 ( 4 FLUOROPHENYL) 5 ISOPROPYLISOXAZOL 4 YL] N ( 1 PHENYLETHYL)PYRIDIN 2 AMINE; 4 [ 3 ( 4 FLUOROPHENYL) 5 ISOPROPYLISOXAZOL 4 YL] N (TETRAHYDRO 2H PYRAN 4 YL)PYRIDIN 2 AMINE; 4 [ 3 ( 4 FLUOROPHENYL) 5 ISOPROPYLISOXAZOL 4 YL]PYRIDIN 2 AMINE; 7 [ 3 ( 4 FLUOROPHENYL) 5 ISOPROPYLISOXAZOL 4 YL]TETRAZOLO[ 1,5-A]PYRIDINE; CASEIN KINASE IDELTA; IMIDAZOLE DERIVATIVE; ISOXAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 14; N [ 4 ( 3 ( 4 FLUOROPHENYL) 5 ISOPROPYLISOXAZOL 4 YL)PYRIDIN 2 YL] 2 PHENOXYPROPANAMIDE; N [ 4 ( 3 ( 4 FLUOROPHENYL) 5 ISOPROPYLISOXAZOL 4 YL)PYRIDIN 2 YL]ACETAMIDE; N SEC BUTYL 4 [ 3 ( 4 FLUOROPHENYL) 5 ISOPROPYLISOXAZOL 4 YL]PYRIDIN 2 AMINE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL TRAIT; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TROPHOBLAST; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CASEIN KINASE IDELTA; CELL LINE; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; ISOXAZOLES; MITOGEN-ACTIVATED PROTEIN KINASE 14; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN CONFORMATION; RATS; TROPHOBLASTS;

EID: 72249098737     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9005127     Document Type: Article

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