메뉴 건너뛰기




Volumn 55, Issue 11, 2012, Pages 3021-3028

Elevated NEFA levels impair glucose effectiveness by increasing net hepatic glycogenolysis

Author keywords

Diabetes mellitus; Glucose production; Glycogen; Hyperglycaemia; NEFA; Non esterified fatty acids

Indexed keywords

CARBON 13; FATTY ACID; GLUCOSE; GLYCOGEN; GROWTH HORMONE; INSULIN; SOMATOSTATIN;

EID: 84867574113     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2662-6     Document Type: Article
Times cited : (22)

References (45)
  • 1
    • 0021691098 scopus 로고
    • Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulindependent diabetic subjects
    • Bogardus C, Lillioja S, Howard BV, Reaven G, Mott D (1984) Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulindependent diabetic subjects. J Clin Invest 74:1238-1246
    • (1984) J Clin Invest , vol.74 , pp. 1238-1246
    • Bogardus, C.1    Lillioja, S.2    Howard, B.V.3    Reaven, G.4    Mott, D.5
  • 2
    • 0024026298 scopus 로고
    • Lilly lecture 1987. The triumvirate: Beta-cell, muscle, liver. A collusion responsible for NIDDM
    • DeFronzo RA (1988) Lilly lecture 1987. The triumvirate: Beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37:667-687
    • (1988) Diabetes , vol.37 , pp. 667-687
    • DeFronzo, R.A.1
  • 3
    • 0032934847 scopus 로고    scopus 로고
    • Endogenous glucose production and glucose effectiveness in type 2 diabetic subjects derived from stable-labeled minimal model approach
    • Nagasaka S, Tokuyama K, Kusaka I et al (1999) Endogenous glucose production and glucose effectiveness in type 2 diabetic subjects derived from stable-labeled minimal model approach. Diabetes 48:1054-1060
    • (1999) Diabetes , vol.48 , pp. 1054-1060
    • Nagasaka, S.1    Tokuyama, K.2    Kusaka, I.3
  • 4
    • 0036307329 scopus 로고    scopus 로고
    • Glycemic control determines hepatic and peripheral glucose effectiveness in type 2 diabetic subjects
    • Hawkins M, Gabriely I, Wozniak R, Reddy K, Rossetti L, Shamoon H (2002) Glycemic control determines hepatic and peripheral glucose effectiveness in type 2 diabetic subjects. Diabetes 51:2179-2189
    • (2002) Diabetes , vol.51 , pp. 2179-2189
    • Hawkins, M.1    Gabriely, I.2    Wozniak, R.3    Reddy, K.4    Rossetti, L.5    Shamoon, H.6
  • 5
    • 0032529147 scopus 로고    scopus 로고
    • Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus
    • MevorachM, Giacca A, Aharon Y, Hawkins M, Shamoon H, Rossetti L (1998) Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus. J Clin Invest 102:744-753
    • (1998) J Clin Invest , vol.102 , pp. 744-753
    • Mevorach, M.1    Giacca, A.2    Aharon, Y.3    Hawkins, M.4    Shamoon, H.5    Rossetti, L.6
  • 6
    • 0031719659 scopus 로고    scopus 로고
    • Normal glucose-induced suppression of glucose production but impaired stimulation of glucose disposal in type 2 diabetes: Evidence for a concentration-dependent defect in uptake
    • Nielsen MF, Basu R, Wise S, Caumo A, Cobelli C, Rizza RA (1998) Normal glucose-induced suppression of glucose production but impaired stimulation of glucose disposal in type 2 diabetes: Evidence for a concentration-dependent defect in uptake. Diabetes 47:1735-1747
    • (1998) Diabetes , vol.47 , pp. 1735-1747
    • Nielsen, M.F.1    Basu, R.2    Wise, S.3    Caumo, A.4    Cobelli, C.5    Rizza, R.A.6
  • 8
    • 0013923479 scopus 로고
    • Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver
    • Williamson JR, Kreisberg RA, Felts PW (1966) Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. Proc Natl Acad Sci U S A 56:247-254
    • (1966) Proc Natl Acad Sci U S A , vol.56 , pp. 247-254
    • Williamson, J.R.1    Kreisberg, R.A.2    Felts, P.W.3
  • 10
    • 33748300622 scopus 로고    scopus 로고
    • Time-dependent effects of free fatty acids on glucose effectiveness in type 2 diabetes
    • Kishore P, Tonelli J, Koppaka S et al (2006) Time-dependent effects of free fatty acids on glucose effectiveness in type 2 diabetes. Diabetes 55:1761-1768
    • (2006) Diabetes , vol.55 , pp. 1761-1768
    • Kishore, P.1    Tonelli, J.2    Koppaka, S.3
  • 11
    • 0242300566 scopus 로고    scopus 로고
    • Contribution of elevated free fatty acid levels to the lack of glucose effectiveness in type 2 diabetes
    • Hawkins M, Tonelli J, Kishore P et al (2003) Contribution of elevated free fatty acid levels to the lack of glucose effectiveness in type 2 diabetes. Diabetes 52:2748-2758
    • (2003) Diabetes , vol.52 , pp. 2748-2758
    • Hawkins, M.1    Tonelli, J.2    Kishore, P.3
  • 12
    • 77952991165 scopus 로고    scopus 로고
    • Adipocyte-derived factors potentiate nutrient-induced production of plasminogen activator inhibitor-1 by macrophages
    • Kishore P, Li W, Tonelli J, et al (2010) Adipocyte-derived factors potentiate nutrient-induced production of plasminogen activator inhibitor-1 by macrophages. Sci Transl Med 2: 20ra15
    • (2010) Sci Transl Med , vol.2
    • Kishore, P.1    Li, W.2    Tonelli, J.3
  • 13
    • 0023245416 scopus 로고
    • Estimation of endogenous glucose production during hyperinsulinemic- euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates
    • Finegood DT, Bergman RN, Vranic M (1987) Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates. Diabetes 36:914-924
    • (1987) Diabetes , vol.36 , pp. 914-924
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 14
    • 0036299136 scopus 로고    scopus 로고
    • Acute elevation of NEFA causes hyperinsulinemia without effect on insulin secretion rate in healthy human subjects
    • Balent B, Goswami G, Goodloe G et al (2002) Acute elevation of NEFA causes hyperinsulinemia without effect on insulin secretion rate in healthy human subjects. Ann N Y Acad Sci 967:535-543
    • (2002) Ann N Y Acad Sci , vol.967 , pp. 535-543
    • Balent, B.1    Goswami, G.2    Goodloe, G.3
  • 16
    • 0030666933 scopus 로고    scopus 로고
    • Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele
    • Rossetti L, Chen W, Hu M, Hawkins M, Barzilai N, Efrat S (1997) Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele. Am J Physiol 273:E743-E750
    • (1997) Am J Physiol , vol.273
    • Rossetti, L.1    Chen, W.2    Hu, M.3    Hawkins, M.4    Barzilai, N.5    Efrat, S.6
  • 18
    • 79251576452 scopus 로고    scopus 로고
    • Transaldolase exchange and its effects on measurements of gluconeogenesis in humans
    • Basu R, Barosa C, Basu A et al (2011) Transaldolase exchange and its effects on measurements of gluconeogenesis in humans. Am J Physiol Endocrinol Metab 300:E296-E303
    • (2011) Am J Physiol Endocrinol Metab , vol.300
    • Basu, R.1    Barosa, C.2    Basu, A.3
  • 20
    • 84055184949 scopus 로고    scopus 로고
    • Activation of KATP channels suppresses glucose production in humans
    • Kishore P, Boucai L, Zhang K et al (2011) Activation of KATP channels suppresses glucose production in humans. J Clin Invest 121:4916-4920
    • (2011) J Clin Invest , vol.121 , pp. 4916-4920
    • Kishore, P.1    Boucai, L.2    Zhang, K.3
  • 21
    • 0023627826 scopus 로고
    • Glucagon and insulin metabolism in a portal-hypertensive rat model
    • Sikuler E, Polio J, Groszmann RJ, Hendler R (1987) Glucagon and insulin metabolism in a portal-hypertensive rat model. Am J Physiol 253:G110-G115
    • (1987) Am J Physiol , vol.253
    • Sikuler, E.1    Polio, J.2    Groszmann, R.J.3    Hendler, R.4
  • 22
    • 0025079179 scopus 로고
    • Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. Demonstration of hepatic autoregulation without a change in plasma glucose concentration
    • Jenssen T, Nurjhan N, Consoli A, Gerich JE (1990) Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. Demonstration of hepatic autoregulation without a change in plasma glucose concentration. J Clin Invest 86:489-497
    • (1990) J Clin Invest , vol.86 , pp. 489-497
    • Jenssen, T.1    Nurjhan, N.2    Consoli, A.3    Gerich, J.E.4
  • 23
    • 0032520870 scopus 로고    scopus 로고
    • Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans
    • Petersen KF, Laurent D, Rothman DL, Cline GW, Shulman GI (1998) Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. J Clin Invest 101:1203-1209
    • (1998) J Clin Invest , vol.101 , pp. 1203-1209
    • Petersen, K.F.1    Laurent, D.2    Rothman, D.L.3    Cline, G.W.4    Shulman, G.I.5
  • 24
    • 0027199061 scopus 로고
    • Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes
    • Rossetti L, Giaccari A, Barzilai N, Howard K, Sebel G, Hu M (1993) Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes. J Clin Invest 92:1126-1134
    • (1993) J Clin Invest , vol.92 , pp. 1126-1134
    • Rossetti, L.1    Giaccari, A.2    Barzilai, N.3    Howard, K.4    Sebel, G.5    Hu, M.6
  • 26
    • 0038660083 scopus 로고    scopus 로고
    • Glucose 6-phosphate regulates hepatic glycogenolysis through inactivation of phosphorylase
    • Aiston S, Andersen B, Agius L (2003) Glucose 6-phosphate regulates hepatic glycogenolysis through inactivation of phosphorylase. Diabetes 52:1333-1339
    • (2003) Diabetes , vol.52 , pp. 1333-1339
    • Aiston, S.1    Andersen, B.2    Agius, L.3
  • 27
    • 0024244339 scopus 로고
    • Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM
    • Reaven GM, Hollenbeck C, Jeng CY, Wu MS, Chen YD (1988) Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes 37:1020-1024
    • (1988) Diabetes , vol.37 , pp. 1020-1024
    • Reaven, G.M.1    Hollenbeck, C.2    Jeng, C.Y.3    Wu, M.S.4    Chen, Y.D.5
  • 28
    • 1542325351 scopus 로고    scopus 로고
    • New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system
    • van de Werve G, Lange A, Newgard C, Mechin MC, Li Y, Berteloot A (2000) New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. Eur J Biochem 267:1533-1549
    • (2000) Eur J Biochem , vol.267 , pp. 1533-1549
    • Van De Werve, G.1    Lange, A.2    Newgard, C.3    Mechin, M.C.4    Li, Y.5    Berteloot, A.6
  • 29
    • 0037303077 scopus 로고    scopus 로고
    • Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites
    • Lam TK, van de Werve G, Giacca A (2003) Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites. Am J Physiol Endocrinol Metab 284:E281-E290
    • (2003) Am J Physiol Endocrinol Metab , vol.284
    • Lam, T.K.1    Van De Werve, G.2    Giacca, A.3
  • 30
    • 0030689043 scopus 로고    scopus 로고
    • Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
    • Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW (1997) Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46:1768-1774
    • (1997) Diabetes , vol.46 , pp. 1768-1774
    • Oakes, N.D.1    Cooney, G.J.2    Camilleri, S.3    Chisholm, D.J.4    Kraegen, E.W.5
  • 31
    • 0034072554 scopus 로고    scopus 로고
    • Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans
    • Roden M, Stingl H, Chandramouli V et al (2000) Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans. Diabetes 49:701-707
    • (2000) Diabetes , vol.49 , pp. 701-707
    • Roden, M.1    Stingl, H.2    Chandramouli, V.3
  • 32
    • 0035121962 scopus 로고    scopus 로고
    • Lipid-dependent control of hepatic glycogen stores in healthy humans
    • Stingl H, Krššák M, Krebs M et al (2001) Lipid-dependent control of hepatic glycogen stores in healthy humans. Diabetologia 44:48-54
    • (2001) Diabetologia , vol.44 , pp. 48-54
    • Stingl, H.1    Krššák, M.2    Krebs, M.3
  • 33
    • 0035082482 scopus 로고    scopus 로고
    • Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes
    • Boden G, Chen X, Capulong E, Mozzoli M (2001) Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes. Diabetes 50:810-816
    • (2001) Diabetes , vol.50 , pp. 810-816
    • Boden, G.1    Chen, X.2    Capulong, E.3    Mozzoli, M.4
  • 34
    • 0037223317 scopus 로고    scopus 로고
    • Elevated free fatty acids impair glucose metabolism in women
    • Shah P, Vella A, Basu A et al (2003) Elevated free fatty acids impair glucose metabolism in women. Diabetes 52:38-42
    • (2003) Diabetes , vol.52 , pp. 38-42
    • Shah, P.1    Vella, A.2    Basu, A.3
  • 35
    • 79960773090 scopus 로고    scopus 로고
    • Preservation of beta-cell function: The key to diabetes prevention
    • DeFronzo RA, Abdul-Ghani MA (2011) Preservation of beta-cell function: The key to diabetes prevention. J Clin Endocrinol Metab 96:2354-2366
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 2354-2366
    • DeFronzo, R.A.1    Abdul-Ghani, M.A.2
  • 36
    • 9444262473 scopus 로고    scopus 로고
    • Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes
    • Krssak M, Brehm A, Bernroider E et al (2004) Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes. Diabetes 53:3048-3056
    • (2004) Diabetes , vol.53 , pp. 3048-3056
    • Krssak, M.1    Brehm, A.2    Bernroider, E.3
  • 37
    • 79959442449 scopus 로고    scopus 로고
    • Postprandial and fasting hepatic glucose fluxes in long-standing type 1 diabetes
    • Kacerovsky M, Jones J, Schmid AI et al (2011) Postprandial and fasting hepatic glucose fluxes in long-standing type 1 diabetes. Diabetes 60:1752-1758
    • (2011) Diabetes , vol.60 , pp. 1752-1758
    • Kacerovsky, M.1    Jones, J.2    Schmid, A.I.3
  • 38
    • 0028172989 scopus 로고
    • 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus
    • Cline GW, Rothman DL, Magnusson I, Katz LD, Shulman GI (1994) 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus. J Clin Invest 94:2369-2376
    • (1994) J Clin Invest , vol.94 , pp. 2369-2376
    • Cline, G.W.1    Rothman, D.L.2    Magnusson, I.3    Katz, L.D.4    Shulman, G.I.5
  • 39
    • 0028847792 scopus 로고
    • Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study
    • Hwang JH, Perseghin G, Rothman DL et al (1995) Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study. J Clin Invest 95:783-787
    • (1995) J Clin Invest , vol.95 , pp. 783-787
    • Hwang, J.H.1    Perseghin, G.2    Rothman, D.L.3
  • 40
    • 0025098765 scopus 로고
    • Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
    • Shulman GI, Rothman DL, Jue T, Stein P, DeFronzo RA, Shulman RG (1990) Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.NEngl JMed 322:223-228
    • (1990) NEngl JMed , vol.322 , pp. 223-228
    • Shulman, G.I.1    Rothman, D.L.2    Jue, T.3    Stein, P.4    DeFronzo, R.A.5    Shulman, R.G.6
  • 41
    • 49649099805 scopus 로고    scopus 로고
    • Glucokinase and molecular aspects of liver glycogen metabolism
    • Agius L (2008) Glucokinase and molecular aspects of liver glycogen metabolism. Biochem J 414:1-18
    • (2008) Biochem J , vol.414 , pp. 1-18
    • Agius, L.1
  • 42
    • 0029851722 scopus 로고    scopus 로고
    • Evidence for a role of glucose-induced translocation of glucokinase in the control of hepatic glycogen synthesis
    • Agius L, Peak M, Newgard CB, Gomez-Foix AM, Guinovart JJ (1996) Evidence for a role of glucose-induced translocation of glucokinase in the control of hepatic glycogen synthesis. J Biol Chem 271:30479-30486
    • (1996) J Biol Chem , vol.271 , pp. 30479-30486
    • Agius, L.1    Peak, M.2    Newgard, C.B.3    Gomez-Foix, A.M.4    Guinovart, J.J.5
  • 43
    • 0034034229 scopus 로고    scopus 로고
    • Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes
    • Clore JN, Stillman J, Sugerman H (2000) Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes. Diabetes 49:969-974
    • (2000) Diabetes , vol.49 , pp. 969-974
    • Clore, J.N.1    Stillman, J.2    Sugerman, H.3
  • 45
    • 0029796293 scopus 로고    scopus 로고
    • Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase
    • Seoane J, Gomez-Foix AM, O'Doherty RM, Gomez-Ara C, Newgard CB, Guinovart JJ (1996) Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase. J Biol Chem 271:23756-23760
    • (1996) J Biol Chem , vol.271 , pp. 23756-23760
    • Seoane, J.1    Gomez-Foix, A.M.2    O'Doherty, R.M.3    Gomez-Ara, C.4    Newgard, C.B.5    Guinovart, J.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.