-
1
-
-
0036937699
-
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
-
Augustinack JC, Schneider A, Mandelkow EM, Hyman BT, (2002) Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta Neuropathol 103: 26-35.
-
(2002)
Acta Neuropathol
, vol.103
, pp. 26-35
-
-
Augustinack, J.C.1
Schneider, A.2
Mandelkow, E.M.3
Hyman, B.T.4
-
2
-
-
0030966679
-
Tissue kallikrein-like immunoreactive material decorates neuritic plaques of Alzheimer patients
-
Bernstein HG, (1997) Tissue kallikrein-like immunoreactive material decorates neuritic plaques of Alzheimer patients. Clin Neuropathol 16: 69-71.
-
(1997)
Clin Neuropathol
, vol.16
, pp. 69-71
-
-
Bernstein, H.G.1
-
3
-
-
77955927938
-
Tau protein and tau aggregation inhibitors
-
Bulic B, Pickhardt M, Mandelkow EM, Mandelkow E, (2010) Tau protein and tau aggregation inhibitors. Neuropharmacology 59: 276-289.
-
(2010)
Neuropharmacology
, vol.59
, pp. 276-289
-
-
Bulic, B.1
Pickhardt, M.2
Mandelkow, E.M.3
Mandelkow, E.4
-
4
-
-
0028947294
-
Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system
-
Cataldo AM, Barnett JL, Berman SA, Li J, Quarless S, Bursztajn S, et al, (1995) Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system. Neuron 14: 671-680.
-
(1995)
Neuron
, vol.14
, pp. 671-680
-
-
Cataldo, A.M.1
Barnett, J.L.2
Berman, S.A.3
Li, J.4
Quarless, S.5
Bursztajn, S.6
-
5
-
-
77951540816
-
Caspase activation precedes and leads to tangles
-
de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT, (2010) Caspase activation precedes and leads to tangles. Nature 464: 1201-1204.
-
(2010)
Nature
, vol.464
, pp. 1201-1204
-
-
De Calignon, A.1
Fox, L.M.2
Pitstick, R.3
Carlson, G.A.4
Bacskai, B.J.5
Spires-Jones, T.L.6
Hyman, B.T.7
-
6
-
-
35748954923
-
The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy
-
Eckermann K, Mocanu MM, Khlistunova I, Biernat J, Nissen A, Hofmann A, et al, (2007) The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. J Biol Chem 282: 31755-31765.
-
(2007)
J Biol Chem
, vol.282
, pp. 31755-31765
-
-
Eckermann, K.1
Mocanu, M.M.2
Khlistunova, I.3
Biernat, J.4
Nissen, A.5
Hofmann, A.6
-
7
-
-
44849122277
-
Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes
-
Fein JA, Sokolow S, Miller CA, Vinters HV, Yang F, Cole GM, Gylys KH, (2008) Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes. Am J Pathol 172: 1683-1692.
-
(2008)
Am J Pathol
, vol.172
, pp. 1683-1692
-
-
Fein, J.A.1
Sokolow, S.2
Miller, C.A.3
Vinters, H.V.4
Yang, F.5
Cole, G.M.6
Gylys, K.H.7
-
8
-
-
0041689948
-
Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease
-
Gamblin TC, Chen F, Zambrano A, Abraha A, Lagalwar S, Guillozet AL, et al, (2003) Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci U S A 100: 10032-10037.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 10032-10037
-
-
Gamblin, T.C.1
Chen, F.2
Zambrano, A.3
Abraha, A.4
Lagalwar, S.5
Guillozet, A.L.6
-
9
-
-
78449296170
-
Cleavage of Tau by calpain in Alzheimer's disease: The quest for the toxic 17 kD fragment
-
Garg S, Timm T, Mandelkow EM, Mandelkow E, Wang Y, (2011) Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment. Neurobiol Aging 32: 1-14.
-
(2011)
Neurobiol Aging
, vol.32
, pp. 1-14
-
-
Garg, S.1
Timm, T.2
Mandelkow, E.M.3
Mandelkow, E.4
Wang, Y.5
-
10
-
-
0035943436
-
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
-
Gotz J, Chen F, van Dorpe J, Nitsch RM, (2001) Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science 293: 1491-1495.
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
Van Dorpe, J.3
Nitsch, R.M.4
-
11
-
-
7244223228
-
Synaptic changes in Alzheimer's disease: Increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence
-
Gylys KH, Fein JA, Yang F, Wiley DJ, Miller CA, Cole GM, (2004) Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. Am J Pathol 165: 1809-1817.
-
(2004)
Am J Pathol
, vol.165
, pp. 1809-1817
-
-
Gylys, K.H.1
Fein, J.A.2
Yang, F.3
Wiley, D.J.4
Miller, C.A.5
Cole, G.M.6
-
12
-
-
33751221596
-
Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex
-
Gylys KH, Fein JA, Yang F, Miller CA, Cole GM, (2007) Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex. Neurobiol Aging 28: 8-17.
-
(2007)
Neurobiol Aging
, vol.28
, pp. 8-17
-
-
Gylys, K.H.1
Fein, J.A.2
Yang, F.3
Miller, C.A.4
Cole, G.M.5
-
13
-
-
0031025396
-
The tau protein in human cerebrospinal fluid in Alzheimer's disease consists of proteolytically derived fragments
-
Johnson GV, Seubert P, Cox TM, Motter R, Brown JP, Galasko D, (1997) The tau protein in human cerebrospinal fluid in Alzheimer's disease consists of proteolytically derived fragments. J Neurochem 68: 430-433.
-
(1997)
J Neurochem
, vol.68
, pp. 430-433
-
-
Johnson, G.V.1
Seubert, P.2
Cox, T.M.3
Motter, R.4
Brown, J.P.5
Galasko, D.6
-
14
-
-
78649360496
-
Anti-tau oligomers passive vaccination for the treatment of Alzheimer disease
-
Kayed R, (2010) Anti-tau oligomers passive vaccination for the treatment of Alzheimer disease. Hum Vaccin 6: 931-935.
-
(2010)
Hum Vaccin
, vol.6
, pp. 931-935
-
-
Kayed, R.1
-
15
-
-
0029817689
-
Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments
-
Kimura T, Ono T, Takamatsu J, Yamamoto H, Ikegami K, Kondo A, et al, (1996) Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments. Dementia 7: 177-181.
-
(1996)
Dementia
, vol.7
, pp. 177-181
-
-
Kimura, T.1
Ono, T.2
Takamatsu, J.3
Yamamoto, H.4
Ikegami, K.5
Kondo, A.6
-
16
-
-
78649503285
-
Preparation and characterization of neurotoxic tau oligomers
-
Lasagna-Reeves CA, Castillo-Carranza DL, Guerrero-Muoz MJ, Jackson GR, Kayed R, (2010) Preparation and characterization of neurotoxic tau oligomers. Biochemistry 49: 10039-10041.
-
(2010)
Biochemistry
, vol.49
, pp. 10039-10041
-
-
Lasagna-Reeves, C.A.1
Castillo-Carranza, D.L.2
Guerrero-Muoz, M.J.3
Jackson, G.R.4
Kayed, R.5
-
17
-
-
33244456786
-
Increased levels of granular tau oligomers: An early sign of brain aging and Alzheimer's disease
-
Maeda S, Sahara N, Saito Y, Murayama S, Ikai A, Takashima A, (2006) Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease. Neurosci Res 54: 197-201.
-
(2006)
Neurosci Res
, vol.54
, pp. 197-201
-
-
Maeda, S.1
Sahara, N.2
Saito, Y.3
Murayama, S.4
Ikai, A.5
Takashima, A.6
-
18
-
-
33947691643
-
Granular tau oligomers as intermediates of tau filaments
-
Maeda S, Sahara N, Saito Y, Murayama M, Yoshiike Y, Kim H, et al, (2007) Granular tau oligomers as intermediates of tau filaments. Biochemistry 46: 3856-3861.
-
(2007)
Biochemistry
, vol.46
, pp. 3856-3861
-
-
Maeda, S.1
Sahara, N.2
Saito, Y.3
Murayama, M.4
Yoshiike, Y.5
Kim, H.6
-
19
-
-
0028670166
-
Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum
-
Mak K, Yang F, Vinters HV, Frautschy SA, Cole GM, (1994) Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum. Brain Res 667: 138-142.
-
(1994)
Brain Res
, vol.667
, pp. 138-142
-
-
Mak, K.1
Yang, F.2
Vinters, H.V.3
Frautschy, S.A.4
Cole, G.M.5
-
20
-
-
1542614533
-
Regional analysis of differently phosphorylated tau proteins in brains from patients with Alzheimer's disease
-
Nakano H, Kobayashi K, Sugimori K, Shimazaki M, Miyazu K, Hayashi M, Furuta H, (2004) Regional analysis of differently phosphorylated tau proteins in brains from patients with Alzheimer's disease. Dement Geriatr Cogn Disord 17: 122-131.
-
(2004)
Dement Geriatr Cogn Disord
, vol.17
, pp. 122-131
-
-
Nakano, H.1
Kobayashi, K.2
Sugimori, K.3
Shimazaki, M.4
Miyazu, K.5
Hayashi, M.6
Furuta, H.7
-
21
-
-
0034507918
-
A "protease activation cascade" in the pathogenesis of Alzheimer's disease
-
Nixon RA, (2000) A "protease activation cascade" in the pathogenesis of Alzheimer's disease. Ann N Y Acad Sci 924: 117-131.
-
(2000)
Ann N y Acad Sci
, vol.924
, pp. 117-131
-
-
Nixon, R.A.1
-
22
-
-
11444267601
-
Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases
-
Nixon RA, (2005) Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases. Neurobiol Aging 26: 373-382.
-
(2005)
Neurobiol Aging
, vol.26
, pp. 373-382
-
-
Nixon, R.A.1
-
23
-
-
33846015514
-
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
-
Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs DH, LaFerla FM, (2006) Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem 281: 39413-39423.
-
(2006)
J Biol Chem
, vol.281
, pp. 39413-39423
-
-
Oddo, S.1
Vasilevko, V.2
Caccamo, A.3
Kitazawa, M.4
Cribbs, D.H.5
Laferla, F.M.6
-
24
-
-
20044370830
-
The generation of a 17 kDa neurotoxic fragment: An alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration
-
Park SY, Ferreira A, (2005) The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration. J Neurosci 25: 5365-5375.
-
(2005)
J Neurosci
, vol.25
, pp. 5365-5375
-
-
Park, S.Y.1
Ferreira, A.2
-
25
-
-
79959571777
-
Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease
-
Patterson KR, Remmers C, Fu Y, Brooker S, Kanaan NM, Vana L, et al, (2011) Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease. J Biol Chem 286: 23063-23076.
-
(2011)
J Biol Chem
, vol.286
, pp. 23063-23076
-
-
Patterson, K.R.1
Remmers, C.2
Fu, Y.3
Brooker, S.4
Kanaan, N.M.5
Vana, L.6
-
26
-
-
0042738868
-
Hydrogen magnetic resonance spectroscopy in Alzheimer's disease
-
Rapoport SI, (2002) Hydrogen magnetic resonance spectroscopy in Alzheimer's disease. Lancet Neurol 1: 82.
-
(2002)
Lancet Neurol
, vol.1
, pp. 82
-
-
Rapoport, S.I.1
-
27
-
-
3242749074
-
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology
-
Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, et al, (2004) Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest 114: 121-130.
-
(2004)
J Clin Invest
, vol.114
, pp. 121-130
-
-
Rissman, R.A.1
Poon, W.W.2
Blurton-Jones, M.3
Oddo, S.4
Torp, R.5
Vitek, M.P.6
-
28
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model
-
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, et al, (2007) Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science 316: 750-754.
-
(2007)
Science
, vol.316
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
-
29
-
-
34249990083
-
Assembly of two distinct dimers and higher-order oligomers from full-length tau
-
Sahara N, Maeda S, Murayama M, Suzuki T, Dohmae N, Yen SH, Takashima A, (2007) Assembly of two distinct dimers and higher-order oligomers from full-length tau. Eur J Neurosci 25: 3020-3029.
-
(2007)
Eur J Neurosci
, vol.25
, pp. 3020-3029
-
-
Sahara, N.1
Maeda, S.2
Murayama, M.3
Suzuki, T.4
Dohmae, N.5
Yen, S.H.6
Takashima, A.7
-
30
-
-
0026061995
-
A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification
-
Schmid I, Uittenbogaart CH, Giorgi JV, (1991) A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification. Cytometry 12: 279-285.
-
(1991)
Cytometry
, vol.12
, pp. 279-285
-
-
Schmid, I.1
Uittenbogaart, C.H.2
Giorgi, J.V.3
-
31
-
-
84857032432
-
AD synapses contain abundant Abeta monomer and multiple soluble oligomers, including a 56-kDa assembly
-
(in press).
-
Sokolow S, Henkins KM, Bilousova T, Miller CA, Vinters HV, Poon W, et al, (2011) AD synapses contain abundant Abeta monomer and multiple soluble oligomers, including a 56-kDa assembly. Neurobiol Aging (in press).
-
(2011)
Neurobiol Aging
-
-
Sokolow, S.1
Henkins, K.M.2
Bilousova, T.3
Miller, C.A.4
Vinters, H.V.5
Poon, W.6
-
32
-
-
77952878634
-
Co-occurrence of Alzheimer's disease β-amyloid and tau pathologies at synapses
-
Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK, (2010) Co-occurrence of Alzheimer's disease β-amyloid and tau pathologies at synapses. Neurobiol Aging 31: 1145-1152.
-
(2010)
Neurobiol Aging
, vol.31
, pp. 1145-1152
-
-
Takahashi, R.H.1
Capetillo-Zarate, E.2
Lin, M.T.3
Milner, T.A.4
Gouras, G.K.5
-
33
-
-
34547203592
-
Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model
-
Wang YP, Biernat J, Pickhardt M, Mandelkow E, Mandelkow EM, (2007) Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model. Proc Natl Acad Sci U S A 104: 10252-10257.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 10252-10257
-
-
Wang, Y.P.1
Biernat, J.2
Pickhardt, M.3
Mandelkow, E.4
Mandelkow, E.M.5
-
34
-
-
33744818219
-
Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains
-
Zhou XW, Li X, Bjorkdahl C, Sjogren MJ, Alafuzoff I, Soininen H, et al, (2006) Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains. Neurobiol Dis 22: 657-668.
-
(2006)
Neurobiol Dis
, vol.22
, pp. 657-668
-
-
Zhou, X.W.1
Li, X.2
Bjorkdahl, C.3
Sjogren, M.J.4
Alafuzoff, I.5
Soininen, H.6
|