Phosphorylation of C3a Receptor at Multiple Sites Mediates Desensitization, β-Arrestin-2 Recruitment and Inhibition of NF-κB Activity in Mast Cells

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Gupta, Kshitij ^a   Subramanian, Hariharan ^a   Klos, Andreas ^b   Ali, Hydar ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BETA ARRESTIN 2; CALCIUM ION; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C3A RECEPTOR; COMPLEMENT RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SERINE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM MOBILIZATION; CELL STRAIN HEK293; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MAST CELL DEGRANULATION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RECEPTOR DOWN REGULATION; SITE DIRECTED MUTAGENESIS; WILD TYPE;

AMINO ACID SEQUENCE; ARRESTINS; COMPLEMENT C3A; HEK293 CELLS; HUMANS; MAST CELLS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NF-KAPPA B; PHOSPHORYLATION; RECEPTORS, COMPLEMENT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84867544941     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046369     Document Type: Article

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