Structure-function studies of the C3a-receptor: C-terminal serine and threonine residues which influence receptor internalization and signaling

European Journal of Immunology

Volumn 33, Issue 4, 2003, Pages 920-927

  Settmacher, Britta ^a   Rheinheimer, Claudia ^a   Hamacher, Henning ^a   Ames, Robert S ^c   Wise, Alan ^b   Jenkinson, Lesley ^b   Bock, Daniel ^a   Schaefer, Myriam ^a   Köhl, Jörg ^a   Klos, Andreas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b GLAXOSMITHKLINE   (United Kingdom)

^c GLAXOSMITHKLINE   (United States)

Author keywords

Complement; Iflammation; Internalization; Receptor; Regulation

Indexed keywords

CALCIUM ION; COMPLEMENT COMPONENT C3 RECEPTOR; COMPLEMENT COMPONENT C3A; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); PROTEIN SUBUNIT; SERINE; SULFUR 35; THREONINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CLONE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INFLAMMATION; INTERNALIZATION; ISOTOPE LABELING; LIGAND BINDING; MUTANT; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CELL LINE; ENDOCYTOSIS; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; KINETICS; MEMBRANE PROTEINS; MUTATION; RATS; RECEPTORS, COMPLEMENT; SERINE; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; THREONINE;

EID: 0038068127     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200323293     Document Type: Article

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