Expression of cyclin D1 is associated with β-catenin expression and correlates with good prognosis in colorectal adenocarcinoma

Translational Oncology

Volumn 5, Issue 5, 2012, Pages 370-378

  Jang, Kyu Yun ^a,b   Kim, Yo Na ^a   Bae, Jun Sang ^a   Chung, Myoung Ja ^a,b   Moon, Woo Sung ^a,b   Kang, Myoung Jae ^a   Lee, Dong Geun ^a   Park, Ho Sung ^a,b  

^a Chonbuk National University Medical School   (South Korea)

^b Chonbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CARCINOEMBRYONIC ANTIGEN; CYCLIN D1;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER LOCALIZATION; CANCER PATIENT; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER STAGING; COLORECTAL CARCINOMA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; OVERALL SURVIVAL; PREDICTION; PREOPERATIVE EVALUATION; PREVALENCE; RECURRENCE FREE SURVIVAL; STATISTICAL SIGNIFICANCE; TISSUE MICROARRAY; TUMOR DIFFERENTIATION; UNIVARIATE ANALYSIS;

EID: 84867544060     PISSN: None     EISSN: 19365233     Source Type: Journal    
DOI: 10.1593/tlo.12220     Document Type: Article

References (37)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, and Parkin DM (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127, 2893-2917.
2. Cunningham D, Atkin W, Lenz HJ, Lynch HT, Minsky B, Nordlinger B, and Starling N (2010). Colorectal cancer. Lancet 375, 1030-1047.
3. Kinzler KW and Vogelstein B (1996). Lessons from hereditary colorectal cancer. Cell 87, 159-170.
4. Munemitsu S, Albert I, Souza B, Rubinfeld B, and Polakis P (1995). Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumorsuppressor protein. Proc Natl Acad Sci USA 92, 3046-3050.
5. Aberle H, Schwartz H, and Kemler R (1996). Cadherin-catenin complex: protein interactions and their implications for cadherin function. J Cell Biochem 61, 514-523.
6. Molenaar M, van de Wetering M, Oosterwegel M, Peterson-Maduro J, Godsave S, Korinek V, Roose J, Destree O, and Clevers H (1996). XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos. Cell 86, 391-399.
7. Behrens J, von Kries JP, Kuhl M, Bruhn L, Wedlich D, Grosschedl R, and Birchmeier W (1996). Functional interaction of β-catenin with the transcription factor LEF-1. Nature 382, 638-642.
8. Tetsu O and McCormick F (1999). β-Catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398, 422-426.
9. Brabletz T, Jung A, Dag S, Hlubek F, and Kirchner T (1999). β-Catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol 155, 1033-1038.
10. Delektorskaia VV, Perevoshchikov AG, Golovkov DA, and Kushlinskii NE (2005). Immunohistochemical study of E-cadherin, beta-catenin and CD-44v6 expression in the cells of primary colon cancer and its metastases. Ark Patol 67, 34-38.
11. Hugh TJ, Dillon SA, Taylor BA, Pignatelli M, Poston GJ, and Kinsella AR (1999). Cadherin-catenin expression in primary colorectal cancer: a survival analysis. Br J Cancer 80, 1046-1051.
12. Dilek FH, Topak N, Tokyol C, Akbulut G, and Dilek ON (2010). β-Catenin and its relation to VEGF and cyclin D1 expression in pT3 rectosigmoid cancers. Turk J Gastroenterol 21, 365-371.
13. Alao JP (2007). The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention. Mol Cancer 6, 24.
14. Tashiro E, Tsuchiya A, and Imoto M (2007). Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression. Cancer Sci 98, 629-635.
15. Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R, and Ben-Ze'ev A (1999). The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway. Proc Natl Acad Sci USA 96, 5522-5527.
16. Maeda K, Chung YS, Kang SM, Ogawa M, Onoda N, Nakata B, Nishiguchi Y, Ikehara T, Okuno M, and Sowa M (1997). Overexpression of cyclin D1 and p53 associated with disease recurrence in colorectal adenocarcinoma. Int J Cancer 74, 310-315.
17. Bahnassy AA, Zekri AR, El-Houssini S, El-Shehaby AM, Mahmoud MR, Abdallah S, and El-Serafi M (2004). Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients. BMC Gastroenterol 4, 22.
18. Holland TA, Elder J, McCloud JM, Hall C, Deakin M, Fryer AA, Elder JB, and Hoban PR (2001). Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21WAF1/CIP1 expression and correlates with patient survival. Int J Cancer 95, 302-306.
19. Ogino S, Nosho K, Irahara N, Kure S, Shima K, Baba Y, Toyoda S, Chen L, Giovannucci EL, Meyerhardt JA, et al. (2009). A cohort study of cyclin D1 expression and prognosis in 602 colon cancer cases. Clin Cancer Res 15, 4431-4438.
20. McKay JA, Douglas JJ, Ross VG, Curran S, Loane JF, Ahmed FY, Cassidy J, McLeod HL, and Murray GI (2002). Analysis of key cell-cycle checkpoint proteins in colorectal tumours. J Pathol 196, 386-393.
21. Knosel T, Emde A, Schluns K, Chen Y, Jurchott K, Krause M, Dietel M, and Petersen I (2005). Immunoprofiles of 11 biomarkers using tissue microarrays identify prognostic subgroups in colorectal cancer. Neoplasia 7, 741-747.
22. Hilska M, Collan YU, O Laine VJ, Kossi J, Hirsimaki P, Laato M, and Roberts PJ (2005). The significance of tumor markers for proliferation and apoptosis in predicting survival in colorectal cancer. Dis Colon Rectum 48, 2197-2208.
23. Rubinfeld B, Souza B, Albert I, Muller O, Chamberlain SH, Masiarz FR, Munemitsu S, and Polakis P (1993). Association of the APC gene product with β-catenin. Science 262, 1731-1734.
24. Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, and Polakis P (1996). Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly. Science 272, 1023-1026.
25. Hao X, Tomlinson I, Ilyas M, Palazzo JP, and Talbot IC (1997). Reciprocity between membranous and nuclear expression of β-catenin in colorectal tumours. Virchows Arch 431, 167-172.
26. Kobayashi M, Honma T, Matsuda Y, Suzuki Y, Narisawa R, Ajioka Y, and Asakura H (2000). Nuclear translocation of beta-catenin in colorectal cancer. Br J Cancer 82, 1689-1693.
27. Chung GG, Provost E, Kielhorn EP, Charette LA, Smith BL, and Rimm DL (2001). Tissue microarray analysis of β-catenin in colorectal cancer shows nuclear phospho-β-catenin is associated with a better prognosis. Clin Cancer Res 7, 4013-4020.
28. Horst D, Reu S, Kriegl L, Engel J, Kirchner T, and Jung A (2009). The intratumoral distribution of nuclear β-catenin is a prognostic marker in colon cancer. Cancer 115, 2063-2070.
29. Mao TL, Chu JS, Jeng YM, Lai PL, and Hsu HC (2001). Expression of mutant nuclear β-catenin correlates with non-invasive hepatocellular carcinoma, absence of portal vein spread, and good prognosis. J Pathol 193, 95-101.
30. Gamallo C, Palacios J, Moreno G, Calvo de Mora J, Suarez A, and Armas A (1999). β-Catenin expression pattern in stage I and II ovarian carcinomas: relationship with β-catenin gene mutations, clinicopathological features, and clinical outcome. Am J Pathol 155, 527-536.
31. Fu M, Wang C, Li Z, Sakamaki T, and Pestell RG (2004). Minireview: cyclin D1: normal and abnormal functions. Endocrinology 145, 5439-5447.
32. Popat S, Hubner R, and Houlston RS (2005). Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol 23, 609-618.
33. MyongNH(2008). Cyclin D1 overexpression, p16 loss, and pRb inactivation play a key role in pulmonary carcinogenesis and have a prognostic implication for the longterm survival in non-small cell lung carcinoma patients. Cancer Res Treat 40, 45-52.
34. Reis-Filho JS, Savage K, Lambros MB, James M, Steele D, Jones RL, and Dowsett M (2006). Cyclin D1 protein overexpression and CCND1 amplification in breast carcinomas: an immunohistochemical and chromogenic in situ hybridisation analysis. Mod Pathol 19, 999-1009.
35. Tut VM, Braithwaite KL, Angus B, Neal DE, Lunec J, and Mellon JK (2001). Cyclin D1 expression in transitional cell carcinoma of the bladder: correlation with p53, waf1, pRb and Ki67. Br J Cancer 84, 270-275.
36. Nosho K, Kawasaki T, Chan AT, Ohnishi M, Suemoto Y, Kirkner GJ, Fuchs CS, and Ogino S (2008). Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype. Histopathology 53, 588-598.
37. Kuroda Y, Sakai A, Tsuyama N, Katayama Y, Munemasa S, Asaoku H, Okikawa Y, Nakaju N, Mizuno M, Ogawa K, et al. (2008). Ectopic cyclin D1 overexpression increases chemosensitivity but not cell proliferation in multiple myeloma. Int J Oncol 33, 1201-1213.