Analysis of key cell-cycle checkpoint proteins in colorectal tumours

Journal of Pathology

Volumn 196, Issue 4, 2002, Pages 386-393

  McKay, Judith A ^a   Douglas, Joy J ^a   Ross, Val G ^a   Curran, Stephanie ^a   Loane, Joseph F ^a   Ahmed, Fareeda Y ^a   Cassidy, Jim ^a   McLeod, Howard L ^a   Murray, Graeme I ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Cell cycle; Checkpoints; Colorectal cancer; Immunohistochemistry; Prognosis

Indexed keywords

CYCLIN D1; CYCLINE; PROTEIN P16; PROTEIN P21; PROTEIN P27; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ADENOCARCINOMA; ADULT; AGE; AGED; ARTICLE; CANCER LOCALIZATION; CANCER SURVIVAL; CELL CYCLE; CELL PROLIFERATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; CORRELATION FUNCTION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CELL CYCLE PROTEINS; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PROGNOSIS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 0036202598     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1053     Document Type: Article

References (55)

1. Estimates of the worldwide incidence of eighteen major cancers in 1985
2. Tumour markers of prognosis in colorectal cancer
3. Genetic pathways in colorectal and other cancers
4. Cancer cell cycles
5. Role of the retinoblastoma protein in the pathogenesis of human cancer
6. Cell cycle control in mammalian cells: Role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs)
7. Tumour-suppressor p53: Implications for tumour development and prognosis
8. p21-negative regulator of the cell cycle
9. Assessing cell proliferation: A methodological review
10. Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer
11. Cell cycle control as a basis for cancer drug development
12. Expression of cell-cycle control proteins in primary colorectal tumours does not always predict expression in lymph node metastases
13. Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis
14. Retinoblastoma (pRb) protein immunoexpression in colorectal cancer
15. Prognostic impact of p21/waf1/cip1 in colorectal cancer
16. Correlation of p16 hypermethylation with p16 protein loss in sporadic gastric carcinomas
17. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
18. p53 and PCNA expression in advanced colorectal cancer: Response to chemotherapy and long-term prognosis
19. Cyclin D1 protein expression and gene polymorphism in colorectal cancer
20. Butyrate stimulates cyclin D and p21 and inhibits cyclin-dependent kinase 2 expression in HT-29 colonic epithelial cells
21. p53 - Integrating the complexity
22. Colorectal cancer: Evidence for distinct genetic categories based on proximal or distal tumour location
23. Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer
24. p53 in colorectal cancer: Clinicopathological correlation and prognostic significance
25. Cytoplasmic accumulation of p53 protein: An independent prognostic indicator in colorectal adenocarcinoma
26. p53 alterations are associated with improved prognosis in distal colonic carcinomas
27. Multiple genetic alterations in distal and proximal colorectal cancer
28. The relationship of DNA aneuploidy to molecular genetic alterations in colorectal carcinoma
29. WAF1/CIP1 expression in colorectal carcinoma correlates with advanced disease stage and p53 mutations
30. p21 expression in colorectal carcinomas: A study on 103 cases with analysis of p53 gene mutation/expression and clinico-pathological correlations
31. Prognostic significance of p53 overexpression in gastric and colorectal carcinoma
32. KIP1 in multistage colorectal carcinogenesis
33. Expression of cell cycle markers in colorectal carcinoma: Superiority of cyclin A as an indicator of poor prognosis
34. Cyclin D1 overexpression and prognosis in colorectal adenocarcinoma
35. Expression of cyclin D1 and retinoblastoma protein in colorectal cancer
36. Cyclin D1 and prognosis in human breast cancer
37. Cyclin D1 expression in non-small-cell lung cancers: Its association with altered p53 expression, cell proliferation and clinical outcome
38. G1 checkpoint protein and p53 abnormalities occur in most invasive transitional cell carcinomas of the urinary bladder
39. Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the S-phase and inhibits growth
40. Apoptosis induced by ectopic expression of cyclin D1 but not cyclin E
41. Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma
42. p21/WAF1 expression in human colorectal carcinoma: Association with p53, transcription factor AP-2 and prognosis
43. kip1: A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancer
44. Prognostic significance of p27(Kip1) expression in colorectal cancer: A clinico-pathological characterization
45. Down-regulation of p27 is a significant predictor of poor overall survival and may facilitate metastasis in colorectal carcinomas
46. Paradoxical correlations of cyclin-dependent kinase inhibitors p21 waf1/cip1 and p27 kip1 in metastatic colorectal carcinoma
47. Kip1, a cyclin-cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest
48. Loss of nuclear p16 protein expression correlates with increased tumour cell proliferation (Ki-67) and poor prognosis in patients with vertical growth phase melanoma
49. p16 protein expression is associated with a poor prognosis in squamous cell carcinoma of the lung
50. The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer
51. Prognostic significance of proliferating cell nuclear antigen expression in colorectal cancer
52. Serum carcinoembryonic antigen levels and proliferating cell nuclear antigen labeling index for patients with colorectal carcinoma
53. Cyclin/proliferation cell nuclear antigen immunohistochemistry does not improve the prognostic power of Dukes' or Jass' classification for colorectal cancer
54. Proliferating cell nuclear antigen (PCNA) in relation to ras, c-erbB-s, p53, clinico-pathological variables and prognosis in colorectal adenocarcinoma
55. Cancer prognostics: Past, present and p27