Nuclear translocation of beta-catenin in colorectal cancer

British Journal of Cancer

Volumn 82, Issue 10, 2000, Pages 1689-1693

  Kobayashi, M ^a   Honma, T ^a   Matsuda, Y ^a   Suzuki, Y ^a   Narisawa, R ^a   Ajioka, Y ^a   Asakura, H ^a  

^a NIIGATA UNIVERSITY   (Japan)

Author keywords

Beta catenin; Colorectal cancer; Familial adenomatous polyposis (FAP); Immunohistochemistry

Indexed keywords

BETA CATENIN;

ARTICLE; CANCER INVASION; CELL NUCLEUS; COLON ADENOMA; COLON CARCINOGENESIS; COLON MUCOSA; COLON POLYPOSIS; COLORECTAL CANCER; CYTOPLASM; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT;

ADENOMA; BETA CATENIN; CELL MEMBRANE; CELL NUCLEUS; COLORECTAL NEOPLASMS; CYTOPLASM; CYTOSKELETAL PROTEINS; HUMANS; NEOPLASM PROTEINS; TRANS-ACTIVATORS;

EID: 0034095898     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Barth AI, Näthke IS and Nelson WJ (1997) Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways. Curr Opin Cell Biol 9: 683-690
2. Behrens J, von Kries J, Kuhl M, Bruhn L, Wedlich D, Grosschedl R and Birchmeier W (1996) Functional interaction of β-catenin with the transcription factor LEF-1. Nature 382: 638-642
3. Günther K, Brabletz T, Kraus C, Dworak O, Reymond MA, Jung A, Hohenberger W, Kirchner T, Köckerling F and Ballhausen WG (1998) Predictive value of nuclear beta-catenin expression for the occurrence of distant metastases in rectal cancer. Dis Colon Rectum 41: 1256-1261
4. Inomata M, Ochiai A, Akimoto S, Kitano S and Hirohashi S (1996) Alteration of β-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients. Cancer Res 56: 2213-2217
5. Iwao K, Nakamori S, Kameyama M, Imaoka S, Kinoshita M, Fukui T, Ishiguro S, Nakamura Y and Miyoshi Y (1998) Activation of the β-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations. Cancer Res 58: 1021-1026
6. Jen J, Powell SM, Papadopoulos N, Smith KJ, Hamilton SR, Vogelstein B and Kinzler KW (1994) Molecular determinants of dysplasia in colorectal lesions. Cancer Res 54: 5523-5526
7. Kitaeva MN, Grogan L, Williams JP, Dimond E, Nakahara K, Hausner P, DeNobile JW, Soballe PW and Kirsch IR (1997) Mutations in β-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors. Cancer Res 57: 4478-4481
8. Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B and Clevers H (1997) Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/-colon carcinoma. Science 275: 1784-1787
9. Miyoshi Y. Nagase H, Ando H, Horii A, Ichii S, Nakatsuru S, Aoki T, Miki Y, Mori T and Nakamura Y (1992) Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1: 229-233
10. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B and Kinzler KW (1997) Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275: 1787-1790
11. Müller O, Nimmrich I, Finke U, Friedl W and Hoffmann I (1998) A β-catenin mutation in a sporadic colorectal tumor of the RER phenotype and absence of β-catenin germline mutations in FAP patients. Genes Chromosomes Cancer 22: 37-41
12. Munemitsu S, Albert I, Souza B, Rubinfeld B and Polakis P (1995) Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci USA 92: 3046-3050
13. Näthke IS, Adams CL, Polakis P, Sellin JH and Nelson WJ (1996) The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J Cell Biol 134: 165-179
14. Novak A, Hsu SC, Leung-Hagesteijn C, Radeva G, Papkoff J, Montesano R, Roskelley C, Grosschedl R and Dedhar S (1998) Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways. Proc Natl Acad Sci USA 95: 4374-4379
15. Samowitz WS, Powers MD. Spirio LN, Nollet F, van Roy F and Slattery ML (1999) β-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas. Cancer Res 59: 1442-1444
16. Schlemper RJ, Itabashi M, Kato Y, Lewin KJ, Ridell RH, Shimoda T, Sipponen P, Stolte M and Watanabe H (1998) Differences in the diagnostic criteria used by Japanese and Western pathologists to diagnose colorectal carcinoma. Cancer 82: 60-69
17. Valizadeh A, Karayiannakis AJ, El-Hariry I, Kmiot W and Pignatelli M (1997) Expression of E-cadherin-associated molecules (α. β. and γ-catenin and p120) in colorectal polyps. Am J Pathol 150: 1977-1984
18. Vogelstein B, Fearon ER, Hamilton SR, Kerm SE, Preisinger AC. Leppert M. Nakamura Y, White R, Smitts Amm and Bos JL (1988) Genetic alterations during colorectal-tumour development. N Engl J Med 319: 525-532