Self-resistance to an antitumor antibiotic: A DNA glycosylase triggers the base-excision repair system in yatakemycin biosynthesis

Angewandte Chemie - International Edition

Volumn 51, Issue 42, 2012, Pages 10532-10536

  Xu, Hui ^a   Huang, Wei ^a   He, Qing Li ^a   Zhao, Zhi Xiong ^a   Zhang, Feng ^a   Wang, Renxiao ^a   Kang, Jingwu ^b   Tang, Gong Li ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

antibiotics; base excision repair; DNA damage; yatakemycin; YtkR2

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; DNA GLYCOSYLTRANSFERASE; INDOLE DERIVATIVE; PYRROLE DERIVATIVE; YATAKEMYCIN;

AMINO ACID SEQUENCE; ARTICLE; BACILLUS CEREUS; CHEMICAL STRUCTURE; DNA DAMAGE; DNA REPAIR; DRUG RESISTANCE; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; STREPTOMYCES;

AMINO ACID SEQUENCE; ANTIBIOTICS, ANTINEOPLASTIC; BACILLUS CEREUS; BASE SEQUENCE; CLONING, MOLECULAR; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; DRUG RESISTANCE, NEOPLASM; INDOLES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PYRROLES; STREPTOMYCES;

EID: 84867495693     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201204109     Document Type: Article

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