A powerful selection assay for mixture libraries of DNA alkylating agents

Journal of the American Chemical Society

Volumn 126, Issue 30, 2004, Pages 9194-9195

  Ham, Young Wan ^a   Boger, Dale L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,9,9A TETRAHYDROCYCLOPROPA[C]BENZ[E]INDOL 4 ONE; 2 INDOLECARBOXYLIC ACID; ALKYLATING AGENT; CYTOTOXIC AGENT; DOUBLE STRANDED DNA; DUOCARMYCIN A; DUOCARMYCIN DERIVATIVE; DUOCARMYCIN SA; INDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMBINATORIAL CHEMISTRY; DNA ALKYLATION; DRUG DETERMINATION; DRUG IDENTIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

ALKYLATING AGENTS; ALKYLATION; BINDING, COMPETITIVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; DNA; INDOLES; PYRROLES; PYRROLIDINONES;

EID: 3342951752     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0477930     Document Type: Article

References (19)

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15. 2Me was compared to the Ad-CBI-TMI calibration curve al at three different concentrations with percent error ≤10%. Details are described in Supporting Information.
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19. The identity of compounds with the same molecular weight but with different structures was determined by HPLC correlation of retention times with the products obtained by treating the individual candidate compounds with hpDNA.