An inhibitor of Na + /H + exchanger (NHE), ethyl-isopropyl amiloride (EIPA), diminishes proliferation of MKN28 human gastric cancer cells by decreasing the cytosolic Cl - concentration via DIDS-sensitive pathways

Cellular Physiology and Biochemistry

Volumn 30, Issue 5, 2012, Pages 1241-1253

  Hosogi, Shigekuni ^a   Miyazaki, Hiroaki ^a   Nakajima, Ken Ichi ^a   Ashihara, Eishi ^a   Niisato, Naomi ^a,b   Kusuzaki, Katsuyuki ^a,b   Marunaka, Yoshinori ^a,b  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b Takatsuki city   (Japan)

Author keywords

Anion exchanger; Cell cycle; MAPK; P21; Rb

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 5 (N ETHYL N ISOPROPYL)AMILORIDE; CHLORIDE ION; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21; SODIUM PROTON EXCHANGE PROTEIN;

ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; STOMACH CANCER;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; AMILORIDE; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CHLORIDE CHANNELS; CHLORIDES; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PHOSPHOPROTEINS; SODIUM-HYDROGEN ANTIPORTER; STOMACH NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84867481528     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000343315     Document Type: Article

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