Prevalence of hyponatremia on geriatric wards compared to other settings over four decades: A systematic review

Ageing Research Reviews

Volumn 12, Issue 1, 2013, Pages 165-173

  Mannesse, Cyndie K ^a   Vondeling, Ariël M ^b   van Marum, Rob J ^b   van Solinge, Wouter W ^c   Egberts, Toine C G ^c,d   Jansen, Paul A F ^c  

^a Vlietland Hospital   (Netherlands)

^b JEROEN BOSCH HOSPITAL   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Geriatric patients; Hyponatremia; Meta analysis; Pooled analysis; Prevalence

Indexed keywords

SODIUM;

AGE; DEVELOPING COUNTRY; GENDER; HUMAN; HYPONATREMIA; INTENSIVE CARE UNIT; MENTAL HOSPITAL; NURSING HOME; OUTPATIENT DEPARTMENT; POLYPHARMACY; PREVALENCE; REVIEW; SODIUM BLOOD LEVEL; SYSTEMATIC REVIEW; WARD;

EID: 84867473223     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2012.04.006     Document Type: Review

References (102)

1. Adragoé H.J., Madias N.E. Hyponatremia. New England Journal of Medicine 2000, 342:1581-1589.
2. Aitchison K.J., Tsapakis E.M., Huezo-Diaz P., Kerwin R.W., Forsling M.L., Wolff K. Ecstasy (MDMA)-induced hyponatremia is associated with genetic variants in CYP2D6 and COMT. Journal of Psychopharmacology 2012, 26:408-4018.
3. Alvarez A., Coto E. Long-term stability of clinical laboratory data - sodium as benchmark. Clinical Chemistry 2011, 57:1616-1617.
4. Anderson R.J., Chung H.M., Kluge R., Schrier R.W. Hyponatremia: A prospective analysis of its epidemiology and the pathogenetic role of vasopressin. Annals of Internal Medicine 1985, 102:164-168.
5. Anpalahan M. Chronic idiopathic hyponatremia in older people due to SIADH possibly related to ageing. Journal of the American Geriatrics Society 2001, 49:788-792.
6. Arieff A.I., Llach F., Massary S.G. Neurological manifestations and morbidity of hyponatremia: correlation with brain water and electrolytes. Medicine (Baltimore) 1976, 55:121-129.
7. Baglin A., Prinseau J., Aegerter P., Piette A.M., Mornet P., Goupil M., Lesur G., Gayno J.P., Bournerias F., Remy J.M., Andrieu J., Valcke J.C., Durand H., Wolmark Y. Diuretics, ACE inhibitors and electrolyte anomalies in aged persons. Multicentric study during hospitalization of 631 patients aged 70 years and over. Revue de Medecine Interne 1991, 12:S293.
8. Barsoney J., Xu Q., Sandberg T., Verbalis J.G. Chronic mild hyponatremia causes bone loss. Endocrine Reviews 2011, 32:2-105.
9. Bennani S.L., Abouqal R., Zeggwagh A.A., Madani N., Abidi K., Zekraoui A., Kerkeb O. Incidence, causes and prognostic factors of hyponatremia in intensive care. Revue de Medecine Interne 2003, 24:224-229.
10. Beukhof C.M., Hoorn E.J., Lindemans J., Zietse R. Novel risk factors for hospital-acquired hyponatraemia: A matched case-control study. Clinical Endocrinology 2007, 66:367-372.
11. Bissram M., Scott F.D., Liu L., Rosner M.H. Risk factors for symptomatic hyponatraemia: The role of pre-existing asymptomatic hyponatraemia. Internal Medicine Journal 2007, 37:149-155.
12. Bouman W.P., Pinner G., Johnson H. Incidence of selective serotonin reuptake inhibitor (SSRI) induced hyponatraemia due to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion in the elderly. International Journal of Geriatric Psychiatry 1998, 13:12-15.
13. Bun S., Serby M.J., Friedmann P. Psychotropic medication use, hyponatremia, and falls in an inpatient population. Journal of Clinical Psychopharmacology 2011, 31:395-397.
14. Byatt C.M., Millard P.H., Levin G.E. Diuretics and electrolyte disturbances in 1000 consecutive geriatric admissions. Journal of the Royal Society of Medicine 1990, 83:704-708.
15. Callahan M.A., Do H.T., Caplan D.W., Yoon-Flannery K. Economic impact of hyponatremia in hospitalized patients: a retrospective cohort study. Postgraduate Medicine 2009, 121:186-191.
16. Chawla J.A., Sterns R.H., Nigwwekar S.U., Cappuccio J.D. Mortality and the serum sodium: do patients die with or from hyponatremia?. Clinical Journal of the American Society of Nephrology 2011, 6:960-965.
17. Chen L.-K., Lin M.-H., Hwang S.J., Chen T.-W. Hyponatremia among the institutionalized elderly in 2 long-term care facilities in Taipei. Journal of Chinese Medical Association 2006, 69:115-119.
18. Chua M., Hoyle G.E., Soiza R.L. Prognostic implications of hyponatremia in elderly hospitalized patients. Archives of Gerontology and Geriatrics 2007, 45:253-258.
19. Clayton J.A., Le Jeune I.R., Hall I.P. Severe hyponatraemia in medical in-patients: Aetiology, assessment and outcome. QJM 2006, 99:505-511.
20. Critchlow S. Hyponatremia in elderly and adult psychiatric inpatients. Irish Journal of Psychological Medicine 1998, 15:6-9.
21. Crook M.A., Velauthar U., Moran L., Griffiths W. Review of investigation and management of severe hyponatraemia in a hospital population. Annals of Clinical Biochemistry 1999, 36:158-162.
22. Crowe M. Hyponatraemia due to syndrome of inappropriate antidiuretic hormone secretion in the elderly. Irish Medical Journal 1980, 73:482-483.
23. Crowe M.J., Forsling M.L., Rolls B.J., Phillips P.A., Ledingham J.C.G., Smith R.F. Altered water excretion in healthy elderly men. Age and Ageing 1987, 16:285-293.
24. Deeks J.J., Higgins J.P.T., Altman D.G. Analysing and presenting results. Cochrane handbook for systematic reviews and interventions, 4.2.5 [updated May 2005] 2005, 127. John Wiley & Sons Ltd, Chichester. J.P.T. Higgins, S. Green (Eds.).
25. Devane S., Turley C., O'Mullane J., Walsh C.H. Hyponatraemia in a general hospital. Irish Medical Journal 1983, 76:17-18.
26. DeVita M.V., Gardenswartz M.H., Konecky A., Zabetakis P.M. Incidence and etiology of hyponatremia in an intensive care unit. Clinical Nephrology 1990, 34:163-166.
27. Duursma S., Castleden M., Cherubini A., Cruz Jentoft A., Pitkala K., Rainfray M., Sieber C., Sinclair A. European Union Geriatric Medicine Society. Position statement on geriatric medicine and the provision of health care services to older people. Journal of Nutrition, Health and Aging 2004, 8:190-195.
28. Dvir D., Beigel R., Hoffmann C., Tsarfati G., Farfel Z., Pauzner R. Hyponatremic brain edema: correlation with serial computed tomography scans. The Israel Medical Association Journal 2009, 11:442-443.
29. Elisaf M.S., Milionis H.J., Siamopoulos K.C. Electrolyte abnormalities in elderly patients admitted to a general medical ward. Geriatric Nephrology and Urology 1997, 7:73-79.
30. Ellison D.H., Berl T. Clinical practice. The syndrome of inappropriate antidiuresis. New England Journal of Medicine 2007, 356:2064-2072.
31. Erasmus R.T., Matsha T.E. The frequency, aetiology and outcome of severe hyponatraemia in adult hospitalised patients. Central African Journal of Medicine 1998, 44:154-158.
32. Esposito P., Piotti G., Bianzina S., Malul T., Dal Canton A. The syndrome of inappropriate antidiuresis: pathophysiology, clinical management and new therapeutic options. Nephron Clinical Practice 2011, 119:c62-c73.
33. Farooqui M.A., Ahmed S. Severe hyponatremia in hospitalised adults at Sultan Qaboos University Hospital. The Journal of the Pakistan Medical Association 2003, 53:180-182.
34. Flear C.T.G., Gill G.V., Burn J. Hyponatraemia: mechanisms and management. Lancet 1981, 2:26-31.
35. Fortgens P., OPillay T.S. Pseudohyponatremia revised. A modern-day pitfall. Archives of Pathology and Laboratory Medicine 2011, 135:516-519.
36. Frenkel W.N., van den Blom B.J., van Munster B.C., Korevaar J.C., de Rooij S.E. The association between serum sodium levels at time of admission and mortality and morbidity in acutely admitted elderly patients: a prospective cohort study. Journal of the American Geriatrics Society 2010, 58:2227-2228.
37. Galperin I., Friedmann R., Feldman H., Sonnenblick M. Urinary retention: a cause of hyponatremia?. Gerontology 2007, 53:121-124.
38. Gankam Kengne F., Andres C., Sattar L., Melot C., Decaux G. Mild hyponatremia and risk of fracture in the ambulataory elderly. Quarterly Journal of Medicine 2008, 101:583-588.
39. Hawkins R.C. Age and gender as risk factors for hyponatremia and hypernatremia. Clinica Chimica Acta 2003, 337:169-172.
40. Hochman I., Cabili S., Peer G. Hyponatremia in internal medicine ward patients: Causes, treatment and prognosis. Israel Journal of Medical Sciences 1989, 25:73-76.
41. Hoorn E.J., Lindemans J., Zietse R. Development of severe hyponatraemia in hospitalized patients: Treatment-related risk factors and inadequate management. Nephrology, Dialysis, Transplantation 2006, 21:70-76.
42. Hoorn E.J., Rivadeneira F., van Meurs J.B.J., Ziere G., Stricker B.H.C., Hofman A., Pols H.A.P., Zietse R., Uitterlinden A.G., Zillikens M.C. Mild Hyponatremia as a risk factor for fractures: The Rotterdam Study. Journal of Bone and Mineral Research 2011, 10.1002/jbmr.380.
43. Hoorn E.J., Zietse R. Hyponatremia and mortality: how innocent is the bystander. Clinical Journal of the American Society of Nephrology 2011, 6:951-953.
44. Hoyle G., Chua M., Soiza R. Prevalence of hyponatremia in elderly patients. Journal of the American Geriatrics Society 2006, 54:1473-1474.
45. Jamieson M.J. Hyponatraemia. British Medical Journal 1985, 290:1723-1728.
46. Juergenson I., Zappini F., Fiaschi A., Tonin P., Bonetti B. Teaching neuroimages: neuroradiologic findings in pontine and extrapontine myelinolysis. Neurology 2012, 78:e1.
47. Kang S.H., Kim H.W., Lee S.Y., Sun I.O., Hwang H.S., Choi S.R., Chung B.H., Park H.S., Park C.W., Yang C.W., Kim Y.S., Choi B.S. Is the sodium level per se related to mortality in hospitalized patients with severe hyponatremia?. Clinical Nephrology 2012, 77:182-187.
48. Kende M., Ray U., Hanhupa B. Review of cases of hyponatraemia in the Port Moresby General Hospital between August 1993 and June 1995. Papua New Guinea Medical Journal 1999, 42:84-89.
49. Kennedy P.G.E., Mitchell D.M., Hoffbrand B.I. Severe hyponatraemia in hospital inpatients. British Medical Journal 1978, 2:1251-1253.
50. Kim D.K., Joo K.W. Hyponatremia in patients with neurologic disorders. Electrolytes & Blood Pressure 2009, 7:51-57.
51. Kim K.-H., Lee S., Lee S., Ra Yun N., Joong Kim N., Yu K.-S., Jang I.-J., Beom Park W., Oh M.-D. Voriconazole-associated severe hyponatremia. Medical Mycology 2012, 50:103-105.
52. Kinsella S., Moran S., Sullivan M.O., Molloy M.G., Eustace J.A. Hyponatremia independent of osteoporosis is associated with fracture occurrence. Clinical Journal of the American Society of Nephrology 2010, 5.
53. Kirby D., Ames D. Hyponatraemia and selective serotonin re-uptake inhibitors in elderly patients. International Journal of Geriatric Psychiatry 2001, 16:484-493.
54. Kleinfeld M., Casimir M., Borra S. Hyponatremia as observed in a chronic disease facility. Journal of the American Geriatrics Society 1979, 27:156-161.
55. Lee C.T., Guo H.R., Chen J.B. Hyponatremia in the emergency department. American Journal of Emergency Medicine 2000, 18:264-268.
56. Letmaier M., Painold A., Holl A.K., Vergin H., Engel R., Konstantinidis A., Kasper S., Grohmann R. Hyponatremia during psychopharmacological treatment: results of a drug surveillance programme. International Journal of Neuropsychopharmacology 2011, 1-10. 10.1017/S1461145711001192.
57. Leung A.A., Wright A., Pazo V., Karson A., Bates D.W. Risk of thiazide-induced hyponatremia in patients with hypertension. American Journal of Medicine 2011, 124:1064-1072.
58. Liamis G., Milionis H., Elisaf M. Review of drug-induced hyponatremia. American Journal of Kidney Diseases 2008, 52:144-153.
59. Lim J.K., Yap K.B. Hyponatraemia in hospitalised elderly patients. Medical Journal of Malaya 2001, 56:232-235.
60. Lota A.S., Dubrey S.W. Profound hyponatremia following a tramadol overdose. Quarterly Journal of Medicine 2012, 105:397-398.
61. Madiba T.E., Haffejee A.A., Mokoena T.R. Hyponatraemia - a prospective analysis of surgical patients. South African Journal of Surgery 1998, 36:78-81.
62. Mann J. The silent epidemic of thiazide-induced hyponatremia. Journal of Clinical Hypertension 2008, 10:477-484.
63. Mannesse C.K., van Puijenbroek E.P., Jansen P.A.F., Van Marum R.J., Souverein P.C., Egberts T.C.G. Hyponatremia as an adverse drug reaction of antipsychotics. A case-control study in VigiBase. Drug Safety 2010, 33:569-578.
64. Masiba T.E., Haffejee A.A., Mokoena T.R. Hyponatraemia - a prospective analysis of surgical patients. SAJS 1998, 36:78-81.
65. Meulendijks D., Mannesse C.K., Jansen P.A.F., van Marum R.J., Egberts A.C.G. Antipsychotic-induced hyponatremia: a systematic review of the published evidence. Drug Safety 2010, 33:101-114.
66. Miller M. Hyponatremia and arginine vasopressin dysregulation: Mechanisms, clinical consequences, and management. Journal of the American Geriatrics Society 2006, 54:345-353.
67. Miller M., Hecker M.S., Friedlander D.A., Carter J.M. Apparent idiopathic hyponatremia in an ambulatory geriatric population. Journal of the American Geriatrics Society 1996, 44:404-408.
68. Miller M., Morley J.E., Rubenstein L.Z. Hyponatremia in a nursing home population. Journal of the American Geriatrics Society 1995, 43:1410-1413.
69. Miller R.A. Hyponatremia: a common occurrence. Journal of the American Osteopathic Association 1978, 77:717-723.
70. Misra S.C., Mansharamani G.G. Hyponatremia in elderly hospital in-patients. British Journal of Clinical Practice 1989, 43:295-296.
71. Movig K.L.L., Leufkens H.G.M., Lenderink A.W., Egberts A.C.G. Validity of hospital discharge International Classification of Diseases (ICD) codes for identifying patients with hyponatremia. Journal of Clinical Epidemiology 2003, 56:530-535.
72. Naharci I.M., Bozoglu E., Karadurmus N., Karaman M., Kurt O., Doruk H. Rivastigmine associated hyponatremia in an older patient with Alzheimer's disease. JAGS 2011, 59:1351-1352.
73. Natkunam A., Shek C.C., Swaminathan R. Hyponatremia in a hospital population. Journal of Medicine 1991, 22:83-96.
74. Niland J.C., Stiller T., Neat J., Londrc A., Johnson D., Pannoni S. Improving patient safety via automated laboratory-based adverse event grading. Journal of the American Medical Informatics Association 2012, 19:111-115.
75. O'Connor K.A., Cotter P.E., Kingston M., Twomey C., O'Mahony D. The pattern of plasma sodium abnormalities in an acute elderly care ward: a cross-sectional study. Irish Journal of Medical Science 2006, 175:28-31.
76. Ohsawa H., Kishimoto T., Hirai M., Shimayoshi N., Matsumura K., Oribe H., Hirao F., Ikawa G., Nakai T., Miyake M., Kurata S. An epidemiological study on hyponatremia in psychiatric patients in mental hospitals in Nara Prefecture. Japanese Journal of Psychiatry and Neurology 1992, 46:883-889.
77. Passare G., Viitanen M., Torring O., Winblad B., Fastbom J. Sodium and potassium disturbances in the elderly: Prevalence and association with drug use. Clinical Drug Investigation 2004, 24:535-544.
78. Pottier P., Agard C., Trewick D., Planchon B., Barrier J. Prevalence and description of hyponatremia in internal medicine departments of the France west area. A " one day" multicentric descriptive study. Revue de Medecine Interne 2007, 28:206-212.
79. Pyle R., Scott M.J.W., Bartholomew J., McGrath S., Moffett B. Accidental polydipsia and hyponatremia from diphenhydramine urinary retention. American Journal of Medicine 2011, 124:e5-e6.
80. Rahil A.I., Khan F.Y., Al Badri M.M. Clinical profile of hyponatraemia in adult patients admitted to Hamad general hospital, Qatar: Experience with 53 cases. JCDR 2009, 3:1419-1425.
81. Renneboog B., Musch W., Vandemergel X., Manto M.U., Decaux G. Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. American Journal of Medicine 2006, 119(71):e71-e78.
82. Rosenblatt D.E., Opdycke R.A.C., Kustrzyk B.M., Hickey K.A. Incidence of hyponatremia in elderly patients on hospital admission. Journal of Geriatric Drug Therapy 1996, 11:71-84.
83. Rosholm J.U., Nybo H., Ranberg K.A., Himmelstrup B., Skjelbo E., Christensen K., Gram L.F. Hyponatraemia in very old nonhospitalised people: Association with drug use. Drugs and Aging 2002, 19:685-693.
84. Rubin B., Hollandsworth D.L. Hyponatremia in the clinical hospital setting. Journal of the American Osteopathic Association 1979, 78:583-587.
85. Rustad P., Felding P., Franzson L., Kairisto L., Lahti V., Martensson A.A. The Nordic Reference Interval Project 2000: recommended reference intervals for 25 common biochemical properties. Scandinavian Journal of Clinical and Laboratory Investigation 2004, 64:271-283.
86. Schwab M., Roder F., Morike K., Thon K.P., Klotz U. Drug-induced hyponatraemia in elderly patients. British Journal of Clinical Pharmacology 1999, 48:105-106.
87. Siegler E.L., Tamres D., Berlin J.A., Allen-Taylor L., Strom B.L. Risk factors for the development of hyponatremia in psychiatric inpatients. Archives of Internal Medicine 1995, 155:953-957.
88. Siragy H.M. Hyponatremia, fluid-electrolyte disorders, and the syndrome of inappropriate antidiuretic hormone secretion: diagnosis and treatment options. Endodontic Practice 2006, 12:446-447.
89. Soiza R.L., Talbot H.S.C. Management of hyponatremia in older people: old threats and new opportunities. Therapeutic Advances in Drug Safety 2011, 2:9-17.
90. Sorensen I.J., Matzen L.E. Serum electrolytes and drug therapy of patients admitted to a geriatric department. Ugeskrift for Laeger 1993, 155:3921-3924.
91. Sunderam S.G., Mankikar G.D. Hyponatraemia in the elderly. Age and Ageing 1983, 12:77-80.
92. Terzian C., Frye E.B., Piotrowski Z.H. Admission hyponatremia in the elderly: factors influencing prognosis. Journal of General Internal Medicine 1994, 9:89-91.
93. Tierney W.M., Martin D.K., Greenlee M.C. The prognosis of hyponatremia at hospital admission. Journal of General Internal Medicine 1986, 1:380-385.
94. Tolias C.M. Severe hyponatraemia in elderly patients: cause for concern. Annals of the Royal College of Surgeons of England 1995, 77:346-348.
95. van Esch S., van Milligen de Wit M., van Laarhoven K., Rensma P.L. Episodic electrolyte disorders and renal failure due to a rare disease: the McKattrick-Wheelock syndrome. Clinical Kidney Journal 2012, 5:166-167.
96. Verbalis J.G.J.B., Sugimura Y., Tian Y., Adams D.J., Carter E.A., et al. Hyponatremia-induced osteoporosis. Journal of Bone and Mineral Research 2010, 25:554-572.
97. Vurgese T.A., Radhakrishan S.B., Wahap Mapkar O.A. Frequency and etiology of hyponatremia in adult hospitalized patients in medical wards of a general hospital in Kuwait. Kuwait Medical Journal 2006, 38(3):211-213.
98. Waikar S.S., Mount D.B., Curhan G.C. Mortality after hospitalization with mild, moderate, and severe hyponatremia. American Journal of Medicine 2009, 122:857-865.
99. Wald R., Jaber B.L., Lyn Price L., Upadhyay A., Madias N.E. Impact of hospital-associated hyponatremia on selected outcomes. Archives of Internal Medicine 2010, 170:294-302.
100. Wilkinson T.J., Begg E.J. Incidence and risk factors for hyponatraemia following treatment with fluoxetine or paroxetine in elderly people. British Journal of Clinical Pharmacology 1999, 47:211-217.
101. Yam F.K., Eraly S.A. Syndrome of inappropriate antidiuretic hormone associated with moxifloxacin. American Journal of Health-System Pharmacy 2012, 69:217-220.
102. Zilberberg M.D., Exuzides A., Spalding J., Foerman A., Jones A.G., Colby C., Shorr A.F. Epidemiology, clinical and economic outcomes of admission hyponatremia among hosptitalized patients. Current Medical Research and Opinion 2008, 24:1601-1606.