Is the sodium level per se related to mortality in hospitalized patients with severe hyponatremia?

Clinical Nephrology

Volumn 77, Issue 3, 2012, Pages 182-187

  Kang, Seok Hui ^a   Kim, Hyung Wook ^a   Lee, So Young ^a   Sun, In O ^a   Hwang, Hyeon Seok ^a   Choi, Sun Ryoung ^a   Chung, Byung Ha ^a   Park, Hun Suk ^a   Park, Cheol Whee ^a   Yang, Chul Woo ^a   Kim, Yong Soo ^a   Choi, Bum Soon ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Charlson risk index; Clinical outcome; Hyponatremia

Indexed keywords

GLUCOCORTICOID; SODIUM; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; CAUSE OF DEATH; COMORBIDITY; CONGESTIVE HEART FAILURE; CONSERVATIVE TREATMENT; DISEASE ASSOCIATION; DISEASE SEVERITY; DYSPNEA; EXTRACELLULAR FLUID; FEMALE; FOLLOW UP; HEMATEMESIS; HOSPITAL ADMISSION; HOSPITAL PATIENT; HUMAN; HYPONATREMIA; HYPOTHYROIDISM; INAPPROPRIATE VASOPRESSIN SECRETION; KIDNEY FAILURE; LABORATORY TEST; LIVER CIRRHOSIS; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MORTALITY; NAUSEA AND VOMITING; OVERALL SURVIVAL; PHYSICAL EXAMINATION; PLASMA OSMOLARITY; PNEUMONIA; POLYDIPSIA; RETROSPECTIVE STUDY; RISK ASSESSMENT; SEIZURE; SODIUM BLOOD LEVEL; URINE OSMOLALITY; WATER DEPRIVATION; WEAKNESS; BLOOD; CHI SQUARE DISTRIBUTION; HOSPITALIZATION; KAPLAN MEIER METHOD; MIDDLE AGED; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; STATISTICAL MODEL; STATISTICS; SURVIVAL RATE; TIME; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CHI-SQUARE DISTRIBUTION; COMORBIDITY; FEMALE; HOSPITAL MORTALITY; HOSPITALIZATION; HUMANS; HYPONATREMIA; INPATIENTS; KAPLAN-MEIER ESTIMATE; LINEAR MODELS; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SODIUM; SURVIVAL RATE; TIME FACTORS; TREATMENT OUTCOME;

EID: 84859479725     PISSN: 03010430     EISSN: None     Source Type: Journal    
DOI: 10.5414/CN107177     Document Type: Article

References (24)

1. Flear CT, Gill GV, Burn J. Hyponatraemia: mechanisms and management. Lancet. 1981; 2: 26-31. doi:10.1016/S0140-6736(81)90261-0
2. Smith DM, McKenna K, Thompson CJ. Hyponatraemia. Clin Endocrinol (Oxf). 2000; 52: 667-678. doi:10.1046/j.1365-2265.2000.01027.x
3. Gill G, Huda B, Boyd A, Skagen K, Wile D, Watson I, van Heyningen C. Characteristics and mortality of severe hyponatraemia--a hospital-based study. Clin Endocrinol (Oxf). 2006; 65: 246-249. doi:10.1111/j.1365-2265.2006.02583.x PubMed
4. Shapiro DS, Sonnenblick M, Galperin I, Melkonyan L, Munter G. Severe hyponatraemia in elderly hospitalized patients: prevalence, aetiology and outcome. Intern Med J. 2010; 40: 574-580. doi:10.1111/ j.1445-5994.2010.02217.x PubMed
5. Asadollahi K, Beeching N, Gill G. Hyponatraemia as a risk factor for hospital mortality. QJM. 2006; 99: 877-880. doi:10.1093/qjmed/hcl120 PubMed
6. Erasmus RT, Matsha TE. The frequency, aetiology and outcome of severe hyponatraemia in adult hospitalised patients. Cent Afr J Med. 1998; 44: 154-158. PubMed
7. Crook MA, Velauthar U, Moran L, Griffiths W. Review of investigation and management of severe hyponatraemia in a hospital population. Ann Clin Biochem. 1999; 36: 158-162. PubMed
8. th edn. Boston, USA: Saunders; 2008. p. 459-504.
9. th edn. New work: McGraw-Hill Book Co; 2008. p. 274-285.
10. th edn. New York: McGraw-Hill Book Co; 2001. p. 696-745.
11. D'Hoore W, Sicotte C, Tilquin C. Risk adjustment in outcome assessment: the Charlson comorbidity index. Methods Inf Med. 1993; 32: 382-387. PubMed
12. Charlson M, Szatrowski TP, Peterson J, Gold J. Validation of a combined comorbidity index. J Clin Epidemiol. 1994; 47: 1245-1251. doi:10.1016/0895-4356(94)90129-5 PubMed
13. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987; 40: 373-383. doi:10.1016/0021-9681(87)90171-8 PubMed
14. Gill G, Leese G. Hyponatraemia: biochemical and clinical perspectives. Postgrad Med J. 1998; 74: 516-523. doi:10.1136/pgmj.74.875.516 PubMed
15. Hawkins RC. Age and gender as risk factors for hyponatremia and hypernatremia. Clin Chim Acta. 2003; 337: 169-172. doi:10.1016/j.cccn. 20 03. 08.001 PubMed
16. Saeed BO, Beaumont D, Handley GH, Weaver JU. Severe hyponatraemia: investigation and management in a district general hospital. J Clin Pathol. 2002; 55: 893-896. doi:10.1136/jcp.55. 12. 893 PubMed
17. Waikar SS, Mount DB, Curhan GC. Mortality after hospitalization with mild, moderate, and severe hyponatremia. Am J Med. 2009; 122: 857-865. doi:10.1016/j.amjmed.2009.01.027 PubMed
18. Nzerue CM, Baffoe-Bonnie H, You W, Falana B, Dai S. Predictors of outcome in hospitalized patients with severe hyponatremia. J Natl Med Assoc. 2003; 95: 335-343. PubMed
19. Clayton JA, Le Jeune IR, Hall IP. Severe hyponatraemia in medical in-patients: aetiology, assessment and outcome. QJM. 2006; 99: 505-511. doi: 10.1093/qjmed/hcl071 PubMed
20. Funk GC, Lindner G, Druml W, Metnitz B, Schwarz C, Bauer P, Metnitz PG. Incidence and prognosis of dysnatremias present on ICU admission. Intensive Care Med. 2010; 36: 304-311. doi: 10. 1007/s00134-009-1692-0 PubMed
21. th edn. Philadelphia, USA:Saunders, 2010, 100-117.
22. Sterns RH, Hix JK, Silver S. Treatment of hyponatremia. Curr Opin Nephrol Hypertens. 2010; 19: 493-498. doi:10.1097/MNH.0b013e32833bfa64 PubMed
23. Ayus JC, Arieff AI. Abnormalities of water metabolism in the elderly. Semin Nephrol. 1996; 16: 277-288. PubMed
24. Levey AS, Greene T, Kusek JW, Beck GJ. A simplified equation to predict glomerular filtration rate from serum creatinine. J Am Soc Nephrol. 2000; 11: A0828.