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Volumn 2, Issue 1, 2011, Pages 9-17

Management of hyponatraemia in older people: Old threats and new opportunities

Author keywords

arginine vasopressin; elderly; hyponatraemia; syndrome of inappropriate antidiuretic hormone; tolvaptan; vasopressin receptor antagonist

Indexed keywords


EID: 84993660884     PISSN: 20420986     EISSN: 20420994     Source Type: Journal    
DOI: 10.1177/2042098610394233     Document Type: Review
Times cited : (33)

References (59)
  • 1
    • 0035916832 scopus 로고    scopus 로고
    • Hyponatraemic emergency – a serious effect of thiazide treatment in the elderly
    • Aaseth J.O. Tangen M.K. Beitnes J.O. (2001) Hyponatraemic emergency – a serious effect of thiazide treatment in the elderly. Tidsskr Nor Laegeforen 121: 921–923.
    • (2001) Tidsskr Nor Laegeforen , vol.121 , pp. 921-923
    • Aaseth, J.O.1    Tangen, M.K.2    Beitnes, J.O.3
  • 3
    • 0017225309 scopus 로고
    • Neurological manifestations of morbidity of hyponatremia: Correlation with brain water and electrolytes
    • Arieff A.I. Llach F. Massry S.G. (1976) Neurological manifestations of morbidity of hyponatremia: Correlation with brain water and electrolytes. Medicine 55: 121–129.
    • (1976) Medicine , vol.55 , pp. 121-129
    • Arieff, A.I.1    Llach, F.2    Massry, S.G.3
  • 4
    • 84993755337 scopus 로고    scopus 로고
    • The outcome of hyponatraemia in a general hospital population
    • Baron D. Hutchinson T.A. (2005) The outcome of hyponatraemia in a general hospital population. Q J Med 98: 620–621.
    • (2005) Q J Med , vol.98 , pp. 620-621
    • Baron, D.1    Hutchinson, T.A.2
  • 5
    • 12244280829 scopus 로고    scopus 로고
    • Randomized, controlled trial on the effect of 20% mannitol solution and a 7.5% saline/6% dextran solution on increased intracranial pressure after brain injury
    • Battison C. Andrews P.J. Graham C. Petty T. (2005) Randomized, controlled trial on the effect of 20% mannitol solution and a 7.5% saline/6% dextran solution on increased intracranial pressure after brain injury. Crit Care Med 33: 196–200.
    • (2005) Crit Care Med , vol.33 , pp. 196-200
    • Battison, C.1    Andrews, P.J.2    Graham, C.3    Petty, T.4
  • 6
    • 0018191624 scopus 로고
    • Water disturbances in patients treated with oral lithium carbonate
    • Baylis P.H. Heath D.A. (1978) Water disturbances in patients treated with oral lithium carbonate. Ann Intern Med 88: 607–609.
    • (1978) Ann Intern Med , vol.88 , pp. 607-609
    • Baylis, P.H.1    Heath, D.A.2
  • 8
    • 34248587209 scopus 로고    scopus 로고
    • Hyponatraemia: current treatment strategies and the role if vasopressin antagonists
    • Cawley M.J. (2007) Hyponatraemia: current treatment strategies and the role if vasopressin antagonists. Ann Pharmacol 41: 840–850.
    • (2007) Ann Pharmacol , vol.41 , pp. 840-850
    • Cawley, M.J.1
  • 9
    • 34548784452 scopus 로고    scopus 로고
    • Prognostic implications of hyponatraemia in elderly hospitalized patients
    • Chua M. Hoyle G.E. Soiza R.L. (2007) Prognostic implications of hyponatraemia in elderly hospitalized patients. Arch Gerontol Geriatr 45: 253–258.
    • (2007) Arch Gerontol Geriatr , vol.45 , pp. 253-258
    • Chua, M.1    Hoyle, G.E.2    Soiza, R.L.3
  • 10
    • 33748101587 scopus 로고    scopus 로고
    • Severe hyponatraemia in medical in-patients: Aetiology, assessment and outcome
    • Clayton J.A. Le Jeune I.R. Hall I.P. (2006) Severe hyponatraemia in medical in-patients: Aetiology, assessment and outcome. Q J Med 99: 505–511.
    • (2006) Q J Med , vol.99 , pp. 505-511
    • Clayton, J.A.1    Le Jeune, I.R.2    Hall, I.P.3
  • 11
    • 0036230497 scopus 로고    scopus 로고
    • Irreversible nephrotoxicity from demeclocycline in the treatment of hyponatraemia
    • Curtis N.J. van Heyningen C. Turner J.J. (2002) Irreversible nephrotoxicity from demeclocycline in the treatment of hyponatraemia. Age Ageing 31: 151–153.
    • (2002) Age Ageing , vol.31 , pp. 151-153
    • Curtis, N.J.1    van Heyningen, C.2    Turner, J.J.3
  • 12
    • 0035348291 scopus 로고    scopus 로고
    • Long term treatment of patients with inappropriate antidiuretic hormone secretion by the vasopressin receptor antagonist, urea or furosemide
    • Decaux G. (2001) Long term treatment of patients with inappropriate antidiuretic hormone secretion by the vasopressin receptor antagonist, urea or furosemide. Am J Med 110: 582–584.
    • (2001) Am J Med , vol.110 , pp. 582-584
    • Decaux, G.1
  • 13
    • 46249105557 scopus 로고    scopus 로고
    • Mild hyponatremia and risk of fracture in the ambulatory elderly
    • Gankam Kegne F. Andres C. Sattar L. Melot C. Decaux G. (2008) Mild hyponatremia and risk of fracture in the ambulatory elderly. Q J Med 101: 583–588.
    • (2008) Q J Med , vol.101 , pp. 583-588
    • Gankam Kegne, F.1    Andres, C.2    Sattar, L.3    Melot, C.4    Decaux, G.5
  • 14
    • 33744963977 scopus 로고    scopus 로고
    • Efficacy and safety of oral conivaptan: A V1a /V2 vasopressin receptor antagonist assessed in randomized, placebo-controlled trial in patients with euvolemic or hypovolemic hyponatremia
    • Ghali J.K. Koren M.J. Taylor J.R. Brooks-Asplund E. Fan K. Long N.A. (2006) Efficacy and safety of oral conivaptan: A V1a /V2 vasopressin receptor antagonist assessed in randomized, placebo-controlled trial in patients with euvolemic or hypovolemic hyponatremia. J Clin Endocrinol Metabol 91: 2145–2152.
    • (2006) J Clin Endocrinol Metabol , vol.91 , pp. 2145-2152
    • Ghali, J.K.1    Koren, M.J.2    Taylor, J.R.3    Brooks-Asplund, E.4    Fan, K.5    Long, N.A.6
  • 15
    • 33645089230 scopus 로고    scopus 로고
    • Vasopressin V2 receptor blockade with tolvaptan versus fluid restriction in the treatment of hyponatremia
    • Gheorghiade M. Gottlieb S.S. Udelson J.E. Konstam M.A. Czerwiec F. Ouyang J. (2006) Vasopressin V2 receptor blockade with tolvaptan versus fluid restriction in the treatment of hyponatremia. Am J Med 97: 1064–1067.
    • (2006) Am J Med , vol.97 , pp. 1064-1067
    • Gheorghiade, M.1    Gottlieb, S.S.2    Udelson, J.E.3    Konstam, M.A.4    Czerwiec, F.5    Ouyang, J.6
  • 16
    • 33746103739 scopus 로고    scopus 로고
    • Characteristics and mortality of severe hyponatraemia – a hospital based study
    • Gill G. Huda B. Boyd A. Skagen K. Wile D. Watson I. (2006) Characteristics and mortality of severe hyponatraemia – a hospital based study. Clin Endocrinol 65: 246–249.
    • (2006) Clin Endocrinol , vol.65 , pp. 246-249
    • Gill, G.1    Huda, B.2    Boyd, A.3    Skagen, K.4    Wile, D.5    Watson, I.6
  • 17
    • 45849115436 scopus 로고    scopus 로고
    • Treatment of hyponatraemia
    • Gross P. (2008) Treatment of hyponatraemia. Intern Med 47: 885–891.
    • (2008) Intern Med , vol.47 , pp. 885-891
    • Gross, P.1
  • 18
    • 0031991258 scopus 로고    scopus 로고
    • The treatment of severe hyponatraemia
    • Gross P. Reimann D. Neidel J. (1998) The treatment of severe hyponatraemia. Kidney Int 64: S6–S11.
    • (1998) Kidney Int , vol.64 , pp. S6-S11
    • Gross, P.1    Reimann, D.2    Neidel, J.3
  • 19
    • 77953646715 scopus 로고    scopus 로고
    • The syndrome of inappropriate antidiuretic hormone: Prevalence, causes and consequences
    • Hannon M.J. Thompson C.J. (2010) The syndrome of inappropriate antidiuretic hormone: Prevalence, causes and consequences. Eur J Endocrin 162: S5–S12.
    • (2010) Eur J Endocrin , vol.162 , pp. S5-S12
    • Hannon, M.J.1    Thompson, C.J.2
  • 20
    • 0015903285 scopus 로고
    • Rapid correction of hyponatraemia in the syndrome of inappropriate antidiuretic hormone. An alternative treatment to hypertonic saline
    • Hantman D. Rossier B. Zohlman R. Schrier R. (1973) Rapid correction of hyponatraemia in the syndrome of inappropriate antidiuretic hormone. An alternative treatment to hypertonic saline. Ann Intern Med 78: 780–785.
    • (1973) Ann Intern Med , vol.78 , pp. 780-785
    • Hantman, D.1    Rossier, B.2    Zohlman, R.3    Schrier, R.4
  • 22
    • 33644902352 scopus 로고    scopus 로고
    • Sodium supplementation is not required to maintain serum sodium concentrations during an Ironman triathlon
    • Hew-Butler T.D. Sharwood K. Collins M. Speedy D. Noakes T. (2006) Sodium supplementation is not required to maintain serum sodium concentrations during an Ironman triathlon. Br J Sports Med 40: 255–259.
    • (2006) Br J Sports Med , vol.40 , pp. 255-259
    • Hew-Butler, T.D.1    Sharwood, K.2    Collins, M.3    Speedy, D.4    Noakes, T.5
  • 23
    • 33645762295 scopus 로고    scopus 로고
    • Acute and concomitant deterioration of hyponatraemia and renal dysfunction associated with heart and liver failure
    • Hoorn E.J. Lindemans J. Zieste R. (2006) Acute and concomitant deterioration of hyponatraemia and renal dysfunction associated with heart and liver failure. Clin Nephrol 65: 248–255.
    • (2006) Clin Nephrol , vol.65 , pp. 248-255
    • Hoorn, E.J.1    Lindemans, J.2    Zieste, R.3
  • 24
    • 33748429702 scopus 로고    scopus 로고
    • Prevalence of hyponatremia in elderly patients
    • Hoyle G.E. Chua M. Soiza R.L. (2006) Prevalence of hyponatremia in elderly patients. J Am Geriatr Soc 54: 1473–1473.
    • (2006) J Am Geriatr Soc , vol.54 , pp. 1473
    • Hoyle, G.E.1    Chua, M.2    Soiza, R.L.3
  • 25
    • 84993751119 scopus 로고    scopus 로고
    • Volaemic assessment of the elderly hyponatraemic patient: Reliability of clinical assessment and validation of bioelectrical impedance analysis
    • 7 September (Epub ahead of print)
    • Hoyle G.E. Chua M. Soiza R.L. (2010) Volaemic assessment of the elderly hyponatraemic patient: Reliability of clinical assessment and validation of bioelectrical impedance analysis. Q J Med 7 September (Epub ahead of print).
    • (2010) Q J Med
    • Hoyle, G.E.1    Chua, M.2    Soiza, R.L.3
  • 27
    • 33947713810 scopus 로고    scopus 로고
    • Effect of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial
    • Konstam M.A. Gheorghiade M. Burnett J.C. Jr Grinfeld L. Maggioni A.P. Swedberg K. (2007) Effect of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial. JAMA 297: 1319–1331.
    • (2007) JAMA , vol.297 , pp. 1319-1331
    • Konstam, M.A.1    Gheorghiade, M.2    Burnett, J.C.3    Grinfeld, L.4    Maggioni, A.P.5    Swedberg, K.6
  • 28
    • 0032543910 scopus 로고    scopus 로고
    • Sodium
    • Kumar S. Berl T. (1998) Sodium. Lancet 352: 220–228.
    • (1998) Lancet , vol.352 , pp. 220-228
    • Kumar, S.1    Berl, T.2
  • 30
    • 33645053034 scopus 로고    scopus 로고
    • Hyponatremia and arginine vasopressin dysregulation: Mechanisms, clinical consequences, and management
    • Miller M. (2006) Hyponatremia and arginine vasopressin dysregulation: Mechanisms, clinical consequences, and management. J Am Geriatr Soc 54: 345–353.
    • (2006) J Am Geriatr Soc , vol.54 , pp. 345-353
    • Miller, M.1
  • 32
    • 77954144776 scopus 로고    scopus 로고
    • 100 cc 3% sodium chloride bolus: A novel treatment for hyponatraemic encephalopathy
    • Moritz L. Ayus J.C. (2010) 100 cc 3% sodium chloride bolus: A novel treatment for hyponatraemic encephalopathy. Metabol Brain Dis 25: 91–96.
    • (2010) Metabol Brain Dis , vol.25 , pp. 91-96
    • Moritz, L.1    Ayus, J.C.2
  • 33
    • 42149146711 scopus 로고    scopus 로고
    • Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: Mechanisms of aquaporin-2 dwon-regulation and cellular proliferation
    • Nielsen J. Hoffert D.J. Knepper M.A. Agre P. Nielsen S. Fenton R.A. (2008) Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: Mechanisms of aquaporin-2 dwon-regulation and cellular proliferation. Proc Nat Acad Sci U S A 105: 3634–3639.
    • (2008) Proc Nat Acad Sci U S A , vol.105 , pp. 3634-3639
    • Nielsen, J.1    Hoffert, D.J.2    Knepper, M.A.3    Agre, P.4    Nielsen, S.5    Fenton, R.A.6
  • 34
    • 0041319050 scopus 로고    scopus 로고
    • Predictors of outcome in hospitalized patients with severe hyponatraemia
    • Nzerue C.M. Baffoe-Bonnie H. You W. Falana B. Dai S. (2003) Predictors of outcome in hospitalized patients with severe hyponatraemia. J Natl Med Assoc 95: 335–343.
    • (2003) J Natl Med Assoc , vol.95 , pp. 335-343
    • Nzerue, C.M.1    Baffoe-Bonnie, H.2    You, W.3    Falana, B.4    Dai, S.5
  • 35
    • 30944460468 scopus 로고    scopus 로고
    • Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits
    • Renneboog B. Musch W. Vandemergel X. Manto M.U. DeCaux G. (2006) Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med 119: 71–78.
    • (2006) Am J Med , vol.119 , pp. 71-78
    • Renneboog, B.1    Musch, W.2    Vandemergel, X.3    Manto, M.U.4    DeCaux, G.5
  • 36
    • 0026546057 scopus 로고
    • Orthostatic hypotension in older adults. The Cardiovascular Health Study. CHS Collaborative Research Group
    • Rutan G.H. Hermanson B. Bild D.E. Kittner S.J. LaBaw F. Tell G.S. (1992) Orthostatic hypotension in older adults. The Cardiovascular Health Study. CHS Collaborative Research Group. Hypertension 19: 508–519.
    • (1992) Hypertension , vol.19 , pp. 508-519
    • Rutan, G.H.1    Hermanson, B.2    Bild, D.E.3    Kittner, S.J.4    LaBaw, F.5    Tell, G.S.6
  • 37
    • 0031001022 scopus 로고    scopus 로고
    • Acute aquaresis by the non-peptide arginine vasopressin (AVP) antagonist OPC-31260 improves hyponatremia in patients with syndrome of inappropriate antidiuretic hormone (SIADH)
    • Saito T. Ishikawa S. Abe K. Kamoi K. Yamada K. Shimizu K. (1997) Acute aquaresis by the non-peptide arginine vasopressin (AVP) antagonist OPC-31260 improves hyponatremia in patients with syndrome of inappropriate antidiuretic hormone (SIADH). J Clin Endocrinol Metabol 82: 1054–1057.
    • (1997) J Clin Endocrinol Metabol , vol.82 , pp. 1054-1057
    • Saito, T.1    Ishikawa, S.2    Abe, K.3    Kamoi, K.4    Yamada, K.5    Shimizu, K.6
  • 39
    • 77955788600 scopus 로고    scopus 로고
    • Severe hyponatraemia in elderly hospitalised patients: prevalence, aetiology and outcome
    • Shapiro D.S. Sonnenblick M. Galperin I. Melkonyan L. Munter G. (2010) Severe hyponatraemia in elderly hospitalised patients: prevalence, aetiology and outcome. Intern Med J 40: 574–580.
    • (2010) Intern Med J , vol.40 , pp. 574-580
    • Shapiro, D.S.1    Sonnenblick, M.2    Galperin, I.3    Melkonyan, L.4    Munter, G.5
  • 40
    • 77953640001 scopus 로고    scopus 로고
    • The syndrome of inappropriate antidiuretic hormone: Current and future management options
    • Sherlock M. Thompson C.J. (2010) The syndrome of inappropriate antidiuretic hormone: Current and future management options. Eur J Endocrinol 162: S13–S18.
    • (2010) Eur J Endocrinol , vol.162 , pp. S13-S18
    • Sherlock, M.1    Thompson, C.J.2
  • 41
    • 34547951340 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic interaction between tolvaptan, a non-peptide AVP antagonist, and furosemide or hydrocholorothiazide
    • Shoaf S.E. Bramer S.L. Bricmont P. Zimmer C.A. (2007) Pharmacokinetic and pharmacodynamic interaction between tolvaptan, a non-peptide AVP antagonist, and furosemide or hydrocholorothiazide. J Cardiovasc Pharmacol 50: 213–222.
    • (2007) J Cardiovasc Pharmacol , vol.50 , pp. 213-222
    • Shoaf, S.E.1    Bramer, S.L.2    Bricmont, P.3    Zimmer, C.A.4
  • 43
    • 36849045208 scopus 로고    scopus 로고
    • Osmotic demyelination syndrome following rapid correction of hyponatraemia
    • Snell D.M. Bartley C. (2008) Osmotic demyelination syndrome following rapid correction of hyponatraemia. Anaesthesia 63: 92–95.
    • (2008) Anaesthesia , vol.63 , pp. 92-95
    • Snell, D.M.1    Bartley, C.2
  • 44
    • 84993794014 scopus 로고    scopus 로고
    • The syndrome of appropriate antidiuretic hormone: Difficulties with diagnosing SIADH in older people
    • (in press)
    • Soiza R.L. Hoyle G.E. (2010) The syndrome of appropriate antidiuretic hormone: Difficulties with diagnosing SIADH in older people. Intern Med J (in press).
    • (2010) Intern Med J
    • Soiza, R.L.1    Hoyle, G.E.2
  • 45
    • 67649238689 scopus 로고    scopus 로고
    • Electrolyte and salt disturbances in older people: Causes, management and implications
    • Soiza R.L. Hoyle G.E. Chua M.P.W. (2008) Electrolyte and salt disturbances in older people: Causes, management and implications. Rev Clin Gerontol 18: 143–158.
    • (2008) Rev Clin Gerontol , vol.18 , pp. 143-158
    • Soiza, R.L.1    Hoyle, G.E.2    Chua, M.P.W.3
  • 46
    • 33847293959 scopus 로고    scopus 로고
    • Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone with salvaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist
    • Soupart A. Gross P. Legros J.J. Alfodi S. Annane D. Heshmati H.M. (2006) Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone with salvaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist. Clin J Am Soc Nephrol 1: 1154–1160.
    • (2006) Clin J Am Soc Nephrol , vol.1 , pp. 1154-1160
    • Soupart, A.1    Gross, P.2    Legros, J.J.3    Alfodi, S.4    Annane, D.5    Heshmati, H.M.6
  • 47
    • 0029790541 scopus 로고    scopus 로고
    • Therapeutic recommendations for management of severe hyponatremia: Current concept on pathogenesis and prevention of neurologic complications
    • Soupart A. Decaux G. (1996) Therapeutic recommendations for management of severe hyponatremia: Current concept on pathogenesis and prevention of neurologic complications. Clin Nephrol 46: 149–169.
    • (1996) Clin Nephrol , vol.46 , pp. 149-169
    • Soupart, A.1    Decaux, G.2
  • 48
    • 0028373265 scopus 로고
    • Neurologic sequelae after treatment of severe hyponatremia: A multicentre perspective
    • Sterns R.H. Cappucio J.D. Silver S.M. (1994) Neurologic sequelae after treatment of severe hyponatremia: A multicentre perspective. J Am Soc Nephrol 8: 1522–1530.
    • (1994) J Am Soc Nephrol , vol.8 , pp. 1522-1530
    • Sterns, R.H.1    Cappucio, J.D.2    Silver, S.M.3
  • 51
    • 77953647400 scopus 로고    scopus 로고
    • Hyponatraemia: New associations and new treatments
    • Thompson C.J. (2010) Hyponatraemia: New associations and new treatments. Eur J Endocrin 162: S1–S3.
    • (2010) Eur J Endocrin , vol.162 , pp. S1-S3
    • Thompson, C.J.1
  • 52
    • 33745684087 scopus 로고    scopus 로고
    • Incidence and prevalence of hyponatremia
    • Upadhyay A. Jaber B.L. Madias N.E. (2006) Incidence and prevalence of hyponatremia. Am J Med 119: S30–S35.
    • (2006) Am J Med , vol.119 , pp. S30-S35
    • Upadhyay, A.1    Jaber, B.L.2    Madias, N.E.3
  • 55
    • 68749103375 scopus 로고    scopus 로고
    • Mortality after hospitalization with mild, moderate and severe hyponatremia
    • Walkar S.S. Mount D.B. Curhan G.C. (2009) Mortality after hospitalization with mild, moderate and severe hyponatremia. Am J Med 122: 679–686.
    • (2009) Am J Med , vol.122 , pp. 679-686
    • Walkar, S.S.1    Mount, D.B.2    Curhan, G.C.3
  • 56
    • 0023685324 scopus 로고
    • A longitudinal assessment of renal function during treatment with lithium
    • Waller D.G. Edwards J.G. Papasthatis-Papayanni S. (1988) A longitudinal assessment of renal function during treatment with lithium. Q J Med 65: 553–558.
    • (1988) Q J Med , vol.65 , pp. 553-558
    • Waller, D.G.1    Edwards, J.G.2    Papasthatis-Papayanni, S.3
  • 58
    • 0037223321 scopus 로고    scopus 로고
    • A vasopressin receptor antagonist (VPA-985) improves serum sodium concentration in patients with hyponatremia: a multicenter, randomized, placebo-controlled trial
    • Wong F. Blei A.T. Blendis L.M. Thuluvath P.J. (2003) A vasopressin receptor antagonist (VPA-985) improves serum sodium concentration in patients with hyponatremia: a multicenter, randomized, placebo-controlled trial. Hepatology 37: 182–191.
    • (2003) Hepatology , vol.37 , pp. 182-191
    • Wong, F.1    Blei, A.T.2    Blendis, L.M.3    Thuluvath, P.J.4
  • 59
    • 84863695146 scopus 로고    scopus 로고
    • Current and future treatment options in SIADH
    • Zietse R. Lubbe N. Hoorn E. (2009) Current and future treatment options in SIADH. NDT Plus 2: iii12–iii19.
    • (2009) NDT Plus , vol.2 , pp. iii12-iii19
    • Zietse, R.1    Lubbe, N.2    Hoorn, E.3


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