메뉴 건너뛰기




Volumn , Issue , 2012, Pages

Protection by glia-conditioned medium in a cell model of Huntington disease

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROPROPIONIC ACID; BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; HEAT SHOCK PROTEIN 70; HUNTINGTIN; NEUROTOXIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; CHAPERONE; FREE RADICAL; LACTATE DEHYDROGENASE; NEUROTROPHIC FACTOR; FIBROBLAST GROWTH FACTOR; HYDROGEN PEROXIDE;

EID: 84867459086     PISSN: None     EISSN: 21573999     Source Type: Journal    
DOI: 10.1371/4fbca54a2028b     Document Type: Article
Times cited : (23)

References (56)
  • 1
    • 0024411737 scopus 로고
    • Clinical-pathologic correlation in Huntington's disease: A neuropsychological and computed tomography study
    • Bamford KA, Caine ED, Kido DK et al. (1989) Clinical-pathologic correlation in Huntington's disease: a neuropsychological and computed tomography study. Neurology 39:796-801
    • (1989) Neurology , vol.39 , pp. 796-801
    • Bamford, K.A.1    Caine, E.D.2    Kido, D.K.3
  • 4
    • 1242338856 scopus 로고    scopus 로고
    • Huntingtin-protein interactions and the pathogenesis of Huntington's disease
    • Li SH, Li XJ (2004) Huntingtin-protein interactions and the pathogenesis of Huntington's disease. Trends Genet 20:146-154
    • (2004) Trends Genet , vol.20 , pp. 146-154
    • Li, S.H.1    Li, X.J.2
  • 5
    • 77955643169 scopus 로고    scopus 로고
    • Molecular mechanisms and potential therapeutical targets in Huntington's disease
    • Zuccato C, Valenza M, Cattaneo E (2010) Molecular mechanisms and potential therapeutical targets in Huntington's disease. Physiol Rev 90:905-981
    • (2010) Physiol Rev , vol.90 , pp. 905-981
    • Zuccato, C.1    Valenza, M.2    Cattaneo, E.3
  • 6
    • 67649411510 scopus 로고    scopus 로고
    • Effects of partial suppression of parkin on huntingtin mutant R6/1 mice
    • Rubio I, Rodriguez-Navarro JA, Tomas-Zapico C et al. (2009) Effects of partial suppression of parkin on huntingtin mutant R6/1 mice. Brain Res 1281:91-100
    • (2009) Brain Res , vol.1281 , pp. 91-100
    • Rubio, I.1    Rodriguez-Navarro, J.A.2    Tomas-Zapico, C.3
  • 7
    • 77951925392 scopus 로고    scopus 로고
    • Differential vulnerability of neurons in Huntington's disease: The role of cell type-specific features
    • Han I, You Y, Kordower JH et al. (2010) Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features. J Neurochem113:1073-1091
    • (2010) J Neurochem , vol.113 , pp. 1073-1091
    • Han, I.1    You, Y.2    Kordower, J.H.3
  • 8
    • 74849091009 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington's disease
    • Ribeiro FM, Paquet M, Ferreira LT et al. (2010) Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington's disease. J Neurosci 30:316-324
    • (2010) J Neurosci , vol.30 , pp. 316-324
    • Ribeiro, F.M.1    Paquet, M.2    Ferreira, L.T.3
  • 9
    • 79951552862 scopus 로고    scopus 로고
    • Huntington's disease and Group I metabotropic glutamate receptors
    • Ribeiro FM, Pires RG, Ferguson SS (2011) Huntington's disease and Group I metabotropic glutamate receptors. Mol Neurobiol 43:1-11
    • (2011) Mol Neurobiol , vol.43 , pp. 1-11
    • Ribeiro, F.M.1    Pires, R.G.2    Ferguson, S.S.3
  • 10
    • 77952420149 scopus 로고    scopus 로고
    • Oxidative stress and plasma aminopeptidase activity in Huntington's disease
    • Duran R, Barrero FJ, Morales B et al. (2010) Oxidative stress and plasma aminopeptidase activity in Huntington's disease. J Neural Transm 117:325-332
    • (2010) J Neural Transm , vol.117 , pp. 325-332
    • Duran, R.1    Barrero, F.J.2    Morales, B.3
  • 11
    • 0031036917 scopus 로고    scopus 로고
    • An essential role for free radicals and derived species in signal transduction
    • Lander HM (1997) An essential role for free radicals and derived species in signal transduction. Faseb J 11:118-124
    • (1997) Faseb J , vol.11 , pp. 118-124
    • Lander, H.M.1
  • 12
    • 38549164060 scopus 로고    scopus 로고
    • Glial dysfunction in parkin null mice: Effects of aging
    • Solano RM, Casarejos MJ, Menendez-Cuervo J et al. (2008) Glial dysfunction in parkin null mice: effects of aging. J Neurosci 28:598-611
    • (2008) J Neurosci , vol.28 , pp. 598-611
    • Solano, R.M.1    Casarejos, M.J.2    Menendez-Cuervo, J.3
  • 13
    • 0035161933 scopus 로고    scopus 로고
    • Oxidative stress induces apoptosis in C6 glioma cells: Involvement of mitogen-activated protein kinases and nuclear factor kappa B
    • Marangolo M, McGee MM, Tipton KF et al. (2001) Oxidative stress induces apoptosis in C6 glioma cells: involvement of mitogen-activated protein kinases and nuclear factor kappa B. Neurotox Res 3:397-409
    • (2001) Neurotox Res , vol.3 , pp. 397-409
    • Marangolo, M.1    McGee, M.M.2    Tipton, K.F.3
  • 14
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787-795
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 15
    • 77953302472 scopus 로고    scopus 로고
    • Nature and cause of mitochondrial dysfunction in Huntington's disease: Focusing on huntingtin and the striatum
    • Oliveira JM (2010) Nature and cause of mitochondrial dysfunction in Huntington's disease: focusing on huntingtin and the striatum. J Neurochem 114:1-12
    • (2010) J Neurochem , vol.114 , pp. 1-12
    • Oliveira, J.M.1
  • 16
    • 78651422988 scopus 로고    scopus 로고
    • Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: A multimodal imaging study
    • Politis M, Pavese N, Tai YF et al. (2011) Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging study. Hum Brain Mapp 32:258-270
    • (2011) Hum Brain Mapp , vol.32 , pp. 258-270
    • Politis, M.1    Pavese, N.2    Tai, Y.F.3
  • 17
    • 57449104707 scopus 로고    scopus 로고
    • Glial cells as players in parkinsonism: The good, the bad, and the mysterious glia
    • Mena MA, Garcia de Yebenes J (2008) Glial cells as players in parkinsonism: the good, the bad, and the mysterious glia. Neuroscientist 14:544-560
    • (2008) Neuroscientist , vol.14 , pp. 544-560
    • Mena, M.A.1    Garcia de Yebenes, J.2
  • 18
    • 79952163901 scopus 로고    scopus 로고
    • Neuronal degeneration in striatal transplants and Huntington's disease: Potential mechanisms and clinical implications
    • Cicchetti F, Soulet D, Freeman TB (2011) Neuronal degeneration in striatal transplants and Huntington's disease: potential mechanisms and clinical implications. Brain 134:641-652
    • (2011) Brain , vol.134 , pp. 641-652
    • Cicchetti, F.1    Soulet, D.2    Freeman, T.B.3
  • 19
    • 76049118058 scopus 로고    scopus 로고
    • Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms
    • Bradford J, Shin JY, Roberts M et al. (2009) Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc Natl Acad Sci U S A 106:22480-22485
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 22480-22485
    • Bradford, J.1    Shin, J.Y.2    Roberts, M.3
  • 20
    • 77955376527 scopus 로고    scopus 로고
    • Increased energy metabolism rescues glia-induced pathology in a Drosophila model of Huntington's disease
    • Besson MT, Dupont P, Fridell YW, Lievens JC (2010) Increased energy metabolism rescues glia-induced pathology in a Drosophila model of Huntington's disease. Hum Mol Genet 19:3372-3382
    • (2010) Hum Mol Genet , vol.19 , pp. 3372-3382
    • Besson, M.T.1    Dupont, P.2    Fridell, Y.W.3    Lievens, J.C.4
  • 21
    • 47349104402 scopus 로고    scopus 로고
    • Glial reactions in Parkinson's disease
    • McGeer PL, McGeer EG (2008) Glial reactions in Parkinson's disease. Mov Disord 23:474-483
    • (2008) Mov Disord , vol.23 , pp. 474-483
    • McGeer, P.L.1    McGeer, E.G.2
  • 22
    • 0030880246 scopus 로고    scopus 로고
    • Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms
    • Mena MA, Casarejos MJ, Carazo A et al. (1997) Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms. J Neural Transm 104:317-328
    • (1997) J Neural Transm , vol.104 , pp. 317-328
    • Mena, M.A.1    Casarejos, M.J.2    Carazo, A.3
  • 23
    • 0041837545 scopus 로고    scopus 로고
    • Glia-conditioned medium induces de novo synthesis of tyrosine hydroxylase and increases dopamine cell survival by differential signaling pathways
    • de Bernardo S, Canals S, Casarejos MJ et al. (2003) Glia-conditioned medium induces de novo synthesis of tyrosine hydroxylase and increases dopamine cell survival by differential signaling pathways. J Neurosci Res 73:818-830
    • (2003) J Neurosci Res , vol.73 , pp. 818-830
    • de Bernardo, S.1    Canals, S.2    Casarejos, M.J.3
  • 25
    • 0034703869 scopus 로고    scopus 로고
    • Dominant phenotypes produced by the HD mutationin STHdh(Q111) striatal cells
    • Trettel F, Rigamonti D, Hilditch-Maguire P et al. (2000) Dominant phenotypes produced by the HD mutationin STHdh(Q111) striatal cells. Hum Mol Genet 9:2799-2809
    • (2000) Hum Mol Genet , vol.9 , pp. 2799-2809
    • Trettel, F.1    Rigamonti, D.2    Hilditch-Maguire, P.3
  • 26
    • 26444441008 scopus 로고    scopus 로고
    • HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism
    • Seong IS, Ivanova E, Lee JM et al. (2005) HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism. Hum Mol Genet 14:2871-2880
    • (2005) Hum Mol Genet , vol.14 , pp. 2871-2880
    • Seong, I.S.1    Ivanova, E.2    Lee, J.M.3
  • 27
    • 0037335074 scopus 로고    scopus 로고
    • Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice
    • Gines S, Seong IS, Fossale E et al. (2003) Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice. Hum Mol Genet 12:497-508
    • (2003) Hum Mol Genet , vol.12 , pp. 497-508
    • Gines, S.1    Seong, I.S.2    Fossale, E.3
  • 28
    • 1842533573 scopus 로고    scopus 로고
    • Striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to mitochondrial complex II inhibitor-induced cell death through a non-apoptotic pathway
    • Ruan Q, Lesort M, MacDonald ME, Johnson GV (2004) Striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to mitochondrial complex II inhibitor-induced cell death through a non-apoptotic pathway. Hum Mol Genet 13:669-681
    • (2004) Hum Mol Genet , vol.13 , pp. 669-681
    • Ruan, Q.1    Lesort, M.2    Macdonald, M.E.3    Johnson, G.V.4
  • 29
    • 33645450264 scopus 로고    scopus 로고
    • Cystamine and cysteamine prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells
    • Mao Z, Choo YS, Lesort M (2006) Cystamine and cysteamine prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells. Eur J Neurosci 23:1701-1710
    • (2006) Eur J Neurosci , vol.23 , pp. 1701-1710
    • Mao, Z.1    Choo, Y.S.2    Lesort, M.3
  • 30
    • 24744444740 scopus 로고    scopus 로고
    • Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin
    • Milakovic T, Johnson GV (2005) Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin. J Biol Chem 280:30773-30782
    • (2005) J Biol Chem , vol.280 , pp. 30773-30782
    • Milakovic, T.1    Johnson, G.V.2
  • 31
    • 0027462802 scopus 로고
    • Levodopa toxicity in foetal rat midbrain neurones in culture: Modulation by ascorbic acid
    • Mena MA, Pardo B, Paino CL, De Yebenes JG (1993) Levodopa toxicity in foetal rat midbrain neurones in culture: modulation by ascorbic acid. Neuroreport 4:438-440
    • (1993) Neuroreport , vol.4 , pp. 438-440
    • Mena, M.A.1    Pardo, B.2    Paino, C.L.3    de Yebenes, J.G.4
  • 32
    • 0038260916 scopus 로고    scopus 로고
    • Neuronal-enriched cultures from embryonic rat ventral mesencephalon for pharmacological studies of dopamine neurons
    • Pardo B, Paino CL, Casarejos MJ, Mena MA (1997) Neuronal-enriched cultures from embryonic rat ventral mesencephalon for pharmacological studies of dopamine neurons. Brain Res Brain Res Protoc 1:127-132
    • (1997) Brain Res Brain Res Protoc , vol.1 , pp. 127-132
    • Pardo, B.1    Paino, C.L.2    Casarejos, M.J.3    Mena, M.A.4
  • 33
    • 23844529467 scopus 로고    scopus 로고
    • Differential effects of l-DOPA on monoamine metabolism, cell survival and glutathione production in midbrain neuronal-enriched cultures from parkin knockout and wildtype mice
    • Casarejos MJ, Solano RM, Menendez J et al. (2005) Differential effects of l-DOPA on monoamine metabolism, cell survival and glutathione production in midbrain neuronal-enriched cultures from parkin knockout and wildtype mice. J Neurochem 94:1005-1014
    • (2005) J Neurochem , vol.94 , pp. 1005-1014
    • Casarejos, M.J.1    Solano, R.M.2    Menendez, J.3
  • 34
    • 0014481378 scopus 로고
    • Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
    • Tietze F (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27:502-522
    • (1969) Anal Biochem , vol.27 , pp. 502-522
    • Tietze, F.1
  • 35
    • 0035977206 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase: A guardian angel protecting the genome and suppressing tumorigenesis
    • Tong WM, Cortes U, Wang ZQ (2001) Poly(ADP-ribose) polymerase: a guardian angel protecting the genome and suppressing tumorigenesis. Biochim Biophys Acta 1552:27-37
    • (2001) Biochim Biophys Acta , vol.1552 , pp. 27-37
    • Tong, W.M.1    Cortes, U.2    Wang, Z.Q.3
  • 36
    • 0027285510 scopus 로고
    • GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin LF, Doherty DH, Lile JD et al. (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260:1130-1132
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.F.1    Doherty, D.H.2    Lile, J.D.3
  • 37
    • 0028109526 scopus 로고
    • Glial cell line-derived neurotrophic factor reverses toxininduced injury to midbrain dopaminergic neurons in vivo
    • Hoffer BJ, Hoffman A, Bowenkamp K et al. (1994) Glial cell line-derived neurotrophic factor reverses toxininduced injury to midbrain dopaminergic neurons in vivo. Neurosci Lett 182:107-111
    • (1994) Neurosci Lett , vol.182 , pp. 107-111
    • Hoffer, B.J.1    Hoffman, A.2    Bowenkamp, K.3
  • 38
    • 0028111551 scopus 로고
    • Mesencephalic type 1 astrocytes rescue dopaminergic neurons from death induced by serum deprivation
    • Takeshima T, Johnston JM, Commissiong JW (1994) Mesencephalic type 1 astrocytes rescue dopaminergic neurons from death induced by serum deprivation. J Neurosci 14:4769-4779
    • (1994) J Neurosci , vol.14 , pp. 4769-4779
    • Takeshima, T.1    Johnston, J.M.2    Commissiong, J.W.3
  • 39
    • 0028936198 scopus 로고
    • Astroglial neurotrophic and neurite-promoting factors
    • Muller HW, Junghans U, Kappler J (1995) Astroglial neurotrophic and neurite-promoting factors. Pharmacol Ther 65:1-18
    • (1995) Pharmacol Ther , vol.65 , pp. 1-18
    • Muller, H.W.1    Junghans, U.2    Kappler, J.3
  • 40
    • 0026076380 scopus 로고
    • Conditioned media derived from glial cell lines promote survival and differentiation of dopaminergic neurons in vitro: Role of mesencephalic glia
    • Engele J, Schubert D, Bohn MC (1991) Conditioned media derived from glial cell lines promote survival and differentiation of dopaminergic neurons in vitro: role of mesencephalic glia. J Neurosci Res 30:359-371
    • (1991) J Neurosci Res , vol.30 , pp. 359-371
    • Engele, J.1    Schubert, D.2    Bohn, M.C.3
  • 41
    • 0035985232 scopus 로고    scopus 로고
    • The role of astroglia on the survival of dopamine neurons
    • Mena MA, de Bernardo S, Casarejos MJ et al. (2002) The role of astroglia on the survival of dopamine neurons. Mol Neurobiol 25:245-263
    • (2002) Mol Neurobiol , vol.25 , pp. 245-263
    • Mena, M.A.1    de Bernardo, S.2    Casarejos, M.J.3
  • 42
    • 0032432604 scopus 로고    scopus 로고
    • An immortalized, type-1 astrocyte of mesencephalic origin source of a dopaminergic neurotrophic factor
    • Panchision DM, Martin-DeLeon PA, Takeshima T et al. (1998) An immortalized, type-1 astrocyte of mesencephalic origin source of a dopaminergic neurotrophic factor. J Mol Neurosci 11:209-221
    • (1998) J Mol Neurosci , vol.11 , pp. 209-221
    • Panchision, D.M.1    Martin-Deleon, P.A.2    Takeshima, T.3
  • 43
    • 0034527579 scopus 로고    scopus 로고
    • Survival and differentiation of dopaminergic mesencephalic neurons are promoted by dopamine-mediated induction of FGF-2 in striatal astroglial cells
    • Reuss B, Unsicker K (2000) Survival and differentiation of dopaminergic mesencephalic neurons are promoted by dopamine-mediated induction of FGF-2 in striatal astroglial cells. Mol Cell Neurosci 16:781-792
    • (2000) Mol Cell Neurosci , vol.16 , pp. 781-792
    • Reuss, B.1    Unsicker, K.2
  • 44
    • 79955930293 scopus 로고    scopus 로고
    • Mitochondrial dysfunction, metabolic deficits, and increased oxidative stress in Huntington's disease
    • Chen CM (2011) Mitochondrial dysfunction, metabolic deficits, and increased oxidative stress in Huntington's disease. Chang Gung Med J 34:135-152
    • (2011) Chang Gung Med J , vol.34 , pp. 135-152
    • Chen, C.M.1
  • 45
    • 0030919567 scopus 로고    scopus 로고
    • Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia
    • Browne SE, Bowling AC, MacGarvey U et al. (1997) Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia. Ann Neurol 41:646-653
    • (1997) Ann Neurol , vol.41 , pp. 646-653
    • Browne, S.E.1    Bowling, A.C.2    Macgarvey, U.3
  • 46
    • 0033520166 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex
    • Polidori MC, Mecocci P, Browne SE et al. (1999) Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex. Neurosci Lett 272:53-56
    • (1999) Neurosci Lett , vol.272 , pp. 53-56
    • Polidori, M.C.1    Mecocci, P.2    Browne, S.E.3
  • 47
    • 34247230363 scopus 로고    scopus 로고
    • Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells
    • Li N, Liu B, Dluzen DE, Jin Y (2007) Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells. J Ethnopharmacol 111:458-463
    • (2007) J Ethnopharmacol , vol.111 , pp. 458-463
    • Li, N.1    Liu, B.2    Dluzen, D.E.3    Jin, Y.4
  • 48
    • 0028793257 scopus 로고
    • Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
    • Ankarcrona M, Dypbukt JM, Bonfoco E et al. (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15:961-973
    • (1995) Neuron , vol.15 , pp. 961-973
    • Ankarcrona, M.1    Dypbukt, J.M.2    Bonfoco, E.3
  • 49
    • 0023137252 scopus 로고
    • Ionic dependence of glutamate neurotoxicity
    • Choi DW (1987) Ionic dependence of glutamate neurotoxicity. J Neurosci 7:369-379
    • (1987) J Neurosci , vol.7 , pp. 369-379
    • Choi, D.W.1
  • 50
    • 0023865274 scopus 로고
    • Clinical and neuropathologic assessment of severity in Huntington's disease
    • Myers RH, Vonsattel JP, Stevens TJ et al. (1988) Clinical and neuropathologic assessment of severity in Huntington's disease. Neurology 38:341-347
    • (1988) Neurology , vol.38 , pp. 341-347
    • Myers, R.H.1    Vonsattel, J.P.2    Stevens, T.J.3
  • 51
    • 45149107487 scopus 로고    scopus 로고
    • Mechanisms of neurodegeneration in Huntington's disease
    • Gil JM, Rego AC (2008) Mechanisms of neurodegeneration in Huntington's disease. Eur J Neurosci 27:2803- 2820
    • (2008) Eur J Neurosci , vol.27 , pp. 2803-2820
    • Gil, J.M.1    Rego, A.C.2
  • 52
    • 0027433553 scopus 로고
    • Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid
    • Beal MF, Brouillet E, Jenkins BG et al. (1993) Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J Neurosci 13:4181-4192
    • (1993) J Neurosci , vol.13 , pp. 4181-4192
    • Beal, M.F.1    Brouillet, E.2    Jenkins, B.G.3
  • 53
    • 29144460321 scopus 로고    scopus 로고
    • Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
    • Shin, J.Y., Fang, Z.H., Yu, Z.X., Wang, C.E., Li, S.H. and Li, X.J (2005) Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. J Cell Biol. 171:1001-1012
    • (2005) J Cell Biol , vol.171 , pp. 1001-1012
    • Shin, J.Y.1    Fang, Z.H.2    Yu, Z.X.3    Wang, C.E.4    Li, S.H.5    Li, X.J.6
  • 55
    • 41549117229 scopus 로고    scopus 로고
    • Expandedpolyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes
    • Chou, S.Y., Weng, J.Y., Lai, H.L., Liao, F., Sun, S.H., Tu, P.H., Dickson, D.W. and Chern, Y (2008) Expandedpolyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes. J Neurosci. 28:3277-90
    • (2008) J Neurosci , vol.28 , pp. 3277-3290
    • Chou, S.Y.1    Weng, J.Y.2    Lai, H.L.3    Liao, F.4    Sun, S.H.5    Tu, P.H.6    Dickson, D.W.7    Chern, Y.8
  • 56
    • 77951238141 scopus 로고    scopus 로고
    • Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice
    • Bradford, J., Shin, J.Y., Roberts, M., Wang, C.E., Sheng, G., Li, S. and Li, X.J (2010) Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice. J Biol Chem. 285:10653-61.
    • (2010) J Biol Chem , vol.285 , pp. 10653-10661
    • Bradford, J.1    Shin, J.Y.2    Roberts, M.3    Wang, C.E.4    Sheng, G.5    Li, S.6    Li, X.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.