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Volumn 89, Issue 5, 2012, Pages 373-384

Targeting the vascular endothelial growth factor in hematologic malignancies

Author keywords

Acute leukemias; Chronic leukemias; Hodgkin's lymphoma; Multiple myeloma; Non Hodgkin lymphoma; Vascular endothelial growth factor; Vascular endothelial growth factor receptor

Indexed keywords

6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; ARTESUNATE; BEVACIZUMAB; CEDIRANIB; DEHYDRODIDEMNIN B; PAZOPANIB; SEMAXANIB; SORAFENIB; SU 11657; SUNITINIB; UNCLASSIFIED DRUG; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VATALANIB;

EID: 84867454972     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/ejh.12009     Document Type: Review
Times cited : (19)

References (124)
  • 1
    • 0037280306 scopus 로고    scopus 로고
    • The role of VEGF in normal and neoplastic hematopoiesis
    • Gerber HP, Ferrara N. The role of VEGF in normal and neoplastic hematopoiesis. J Mol Med (Berl) 2003;81:20-31.
    • (2003) J Mol Med (Berl) , vol.81 , pp. 20-31
    • Gerber, H.P.1    Ferrara, N.2
  • 2
    • 84455193267 scopus 로고    scopus 로고
    • Endothelio-hematopoietic relationship: getting closer to the beginnings
    • Gordon-Keylock S, Medvinsky A. Endothelio-hematopoietic relationship: getting closer to the beginnings. BMC Biol 2011;9:88.
    • (2011) BMC Biol , vol.9 , pp. 88
    • Gordon-Keylock, S.1    Medvinsky, A.2
  • 3
    • 0345707040 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and its receptor KDR/flk-1 play important roles in hematopoiesis
    • Hong DL, Zhang YZ, Piacibello W, Aglietta M. Vascular endothelial growth factor and its receptor KDR/flk-1 play important roles in hematopoiesis. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2001;9:268-72.
    • (2001) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.9 , pp. 268-272
    • Hong, D.L.1    Zhang, Y.Z.2    Piacibello, W.3    Aglietta, M.4
  • 4
    • 24044441296 scopus 로고    scopus 로고
    • Evidence for the hemangioblast
    • Park C, Ma YD, Choi K. Evidence for the hemangioblast. Exp Hematol 2005;33:965-70.
    • (2005) Exp Hematol , vol.33 , pp. 965-970
    • Park, C.1    Ma, Y.D.2    Choi, K.3
  • 6
    • 0033861874 scopus 로고    scopus 로고
    • Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration
    • Dias S, Hattori K, Zhu Z, et al. Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration. J Clin Invest 2000;106:511-21.
    • (2000) J Clin Invest , vol.106 , pp. 511-521
    • Dias, S.1    Hattori, K.2    Zhu, Z.3
  • 7
    • 0036530301 scopus 로고    scopus 로고
    • VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition
    • Dias S, Shmelkov SV, Lam G, Rafii S. VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition. Blood 2002;99:2532-40.
    • (2002) Blood , vol.99 , pp. 2532-2540
    • Dias, S.1    Shmelkov, S.V.2    Lam, G.3    Rafii, S.4
  • 8
    • 33947642080 scopus 로고    scopus 로고
    • Autocrine VEGF loops, signaling pathways, and acute leukemia regulation
    • Fragoso R, Elias AP, Dias S. Autocrine VEGF loops, signaling pathways, and acute leukemia regulation. Leuk Lymphoma 2007;48:481-8.
    • (2007) Leuk Lymphoma , vol.48 , pp. 481-488
    • Fragoso, R.1    Elias, A.P.2    Dias, S.3
  • 9
    • 3242703539 scopus 로고    scopus 로고
    • VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia
    • Lee YK, Bone ND, Strege AK, Shanafelt TD, Jelinek DF, Kay NE. VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia. Blood 2004;104:788-94.
    • (2004) Blood , vol.104 , pp. 788-794
    • Lee, Y.K.1    Bone, N.D.2    Strege, A.K.3    Shanafelt, T.D.4    Jelinek, D.F.5    Kay, N.E.6
  • 10
    • 17144383220 scopus 로고    scopus 로고
    • VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance
    • Lee YK, Shanafelt TD, Bone ND, Strege AK, Jelinek DF, Kay NE. VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance. Leukemia 2005;19:513-23.
    • (2005) Leukemia , vol.19 , pp. 513-523
    • Lee, Y.K.1    Shanafelt, T.D.2    Bone, N.D.3    Strege, A.K.4    Jelinek, D.F.5    Kay, N.E.6
  • 11
    • 2342486598 scopus 로고    scopus 로고
    • Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways
    • Santos SC, Dias S. Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways. Blood 2004;103:3883-9.
    • (2004) Blood , vol.103 , pp. 3883-3889
    • Santos, S.C.1    Dias, S.2
  • 12
    • 0034655957 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma
    • Dankbar B, Padro T, Leo R, Feldmann B, Kropff M, Mesters RM, Serve H, Berdel WE, Kienast J. Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma. Blood 2000;95:2630-6.
    • (2000) Blood , vol.95 , pp. 2630-2636
    • Dankbar, B.1    Padro, T.2    Leo, R.3    Feldmann, B.4    Kropff, M.5    Mesters, R.M.6    Serve, H.7    Berdel, W.E.8    Kienast, J.9
  • 13
    • 0030933923 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia
    • Fiedler W, Graeven U, Ergun S, Verago S, Kilic N, Stockschlader M, Hossfeld DK. Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia. Blood 1997;89:1870-5.
    • (1997) Blood , vol.89 , pp. 1870-1875
    • Fiedler, W.1    Graeven, U.2    Ergun, S.3    Verago, S.4    Kilic, N.5    Stockschlader, M.6    Hossfeld, D.K.7
  • 14
    • 79960735663 scopus 로고    scopus 로고
    • Bone marrow stromal cell-derived vascular endothelial growth factor (VEGF) rather than chronic lymphocytic leukemia (CLL) cell-derived VEGF is essential for the apoptotic resistance of cultured CLL cells
    • Gehrke I, Gandhirajan RK, Poll-Wolbeck SJ, Hallek M, Kreuzer KA. Bone marrow stromal cell-derived vascular endothelial growth factor (VEGF) rather than chronic lymphocytic leukemia (CLL) cell-derived VEGF is essential for the apoptotic resistance of cultured CLL cells. Mol Med 2011;17:619-27.
    • (2011) Mol Med , vol.17 , pp. 619-627
    • Gehrke, I.1    Gandhirajan, R.K.2    Poll-Wolbeck, S.J.3    Hallek, M.4    Kreuzer, K.A.5
  • 15
    • 77349110254 scopus 로고    scopus 로고
    • Meeuwsen-de Boer TG, Kamps WA, de Bont ES. VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms
    • Roorda BD, Ter EA, Scherpen FJ. Meeuwsen-de Boer TG, Kamps WA, de Bont ES. VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms. Eur J Cancer 2010;46:974-82.
    • (2010) Eur J Cancer , vol.46 , pp. 974-982
    • Roorda, B.D.1    Ter, E.A.2    Scherpen, F.J.3
  • 16
    • 17144387901 scopus 로고    scopus 로고
    • PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways
    • Grandage VL, Gale RE, Linch DC, Khwaja A. PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways. Leukemia 2005;19:586-94.
    • (2005) Leukemia , vol.19 , pp. 586-594
    • Grandage, V.L.1    Gale, R.E.2    Linch, D.C.3    Khwaja, A.4
  • 17
    • 0031900740 scopus 로고    scopus 로고
    • Signal transduction through MAP kinase cascades
    • Lewis TS, Shapiro PS, Ahn NG. Signal transduction through MAP kinase cascades. Adv Cancer Res 1998;74:49-139.
    • (1998) Adv Cancer Res , vol.74 , pp. 49-139
    • Lewis, T.S.1    Shapiro, P.S.2    Ahn, N.G.3
  • 18
    • 0031923038 scopus 로고    scopus 로고
    • The JAK-STAT pathway: signal transduction involved in proliferation, differentiation and transformation
    • Weber-Nordt RM, Mertelsmann R, Finke J. The JAK-STAT pathway: signal transduction involved in proliferation, differentiation and transformation. Leuk Lymphoma 1998;28:459-67.
    • (1998) Leuk Lymphoma , vol.28 , pp. 459-467
    • Weber-Nordt, R.M.1    Mertelsmann, R.2    Finke, J.3
  • 19
    • 34247177839 scopus 로고    scopus 로고
    • Angiogenesis and antiangiogenic therapy in hematologic malignancies
    • Dong X, Han ZC, Yang R. Angiogenesis and antiangiogenic therapy in hematologic malignancies. Crit Rev Oncol Hematol 2007;62:105-18.
    • (2007) Crit Rev Oncol Hematol , vol.62 , pp. 105-118
    • Dong, X.1    Han, Z.C.2    Yang, R.3
  • 20
    • 77953520737 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-related pathways in hemato-lymphoid malignancies
    • Medinger M, Fischer N, Tzankov A. Vascular endothelial growth factor-related pathways in hemato-lymphoid malignancies. J Oncol 2010;2010:729725.
    • (2010) J Oncol , vol.2010 , pp. 729725
    • Medinger, M.1    Fischer, N.2    Tzankov, A.3
  • 21
    • 0035880256 scopus 로고    scopus 로고
    • Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration
    • Podar K, Tai YT, Davies FE, et al. Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration. Blood 2001;98:428-35.
    • (2001) Blood , vol.98 , pp. 428-435
    • Podar, K.1    Tai, Y.T.2    Davies, F.E.3
  • 22
    • 0037085765 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy
    • Dias S, Choy M, Alitalo K, Rafii S. Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy. Blood 2002;99:2179-84.
    • (2002) Blood , vol.99 , pp. 2179-2184
    • Dias, S.1    Choy, M.2    Alitalo, K.3    Rafii, S.4
  • 23
    • 13544255403 scopus 로고    scopus 로고
    • The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications
    • Podar K, Anderson KC. The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications. Blood 2005;105:1383-95.
    • (2005) Blood , vol.105 , pp. 1383-1395
    • Podar, K.1    Anderson, K.C.2
  • 24
    • 0028785350 scopus 로고
    • Possible participation of autocrine and paracrine vascular endothelial growth factors in hypoxia-induced proliferation of endothelial cells and pericytes
    • Nomura M, Yamagishi S, Harada S, Hayashi Y, Yamashima T, Yamashita J, Yamamoto H. Possible participation of autocrine and paracrine vascular endothelial growth factors in hypoxia-induced proliferation of endothelial cells and pericytes. J Biol Chem 1995;270:28316-24.
    • (1995) J Biol Chem , vol.270 , pp. 28316-28324
    • Nomura, M.1    Yamagishi, S.2    Harada, S.3    Hayashi, Y.4    Yamashima, T.5    Yamashita, J.6    Yamamoto, H.7
  • 25
    • 0033521040 scopus 로고    scopus 로고
    • Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis
    • Yonekura H, Sakurai S, Liu X, et al. Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis. J Biol Chem 1999;274:35172-8.
    • (1999) J Biol Chem , vol.274 , pp. 35172-35178
    • Yonekura, H.1    Sakurai, S.2    Liu, X.3
  • 27
    • 57649104690 scopus 로고    scopus 로고
    • Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators
    • Hatfield K, Oyan AM, Ersvaer E, Kalland KH, Lassalle P, Gjertsen BT, Bruserud O. Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators. Br J Haematol 2009;144:53-68.
    • (2009) Br J Haematol , vol.144 , pp. 53-68
    • Hatfield, K.1    Oyan, A.M.2    Ersvaer, E.3    Kalland, K.H.4    Lassalle, P.5    Gjertsen, B.T.6    Bruserud, O.7
  • 28
  • 29
    • 33845882259 scopus 로고    scopus 로고
    • The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma
    • Podar K, Tonon G, Sattler M, et al. The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma. Proc Natl Acad Sci U S A 2006;103:19478-83.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 19478-19483
    • Podar, K.1    Tonon, G.2    Sattler, M.3
  • 30
    • 60149100926 scopus 로고    scopus 로고
    • The role of VEGF and a functional link between VEGF and p27Kip1 in acute myeloid leukemia
    • Wegiel B, Ekberg J, Talasila KM, Jalili S, Persson JL. The role of VEGF and a functional link between VEGF and p27Kip1 in acute myeloid leukemia. Leukemia 2009;23:251-61.
    • (2009) Leukemia , vol.23 , pp. 251-261
    • Wegiel, B.1    Ekberg, J.2    Talasila, K.M.3    Jalili, S.4    Persson, J.L.5
  • 33
    • 12444260791 scopus 로고    scopus 로고
    • Coculture of native human acute myelogenous leukemia blasts with fibroblasts and osteoblasts results in an increase of vascular endothelial growth factor levels
    • Glenjen NI, Hatfield K, Bruserud O. Coculture of native human acute myelogenous leukemia blasts with fibroblasts and osteoblasts results in an increase of vascular endothelial growth factor levels. Eur J Haematol 2005;74:24-34.
    • (2005) Eur J Haematol , vol.74 , pp. 24-34
    • Glenjen, N.I.1    Hatfield, K.2    Bruserud, O.3
  • 34
    • 81555220915 scopus 로고    scopus 로고
    • Angiogenesis in acute myeloid leukemia and opportunities for novel therapies
    • Trujillo A, McGee C, Cogle CR. Angiogenesis in acute myeloid leukemia and opportunities for novel therapies. J Oncol 2012;2012:128608.
    • (2012) J Oncol , vol.2012 , pp. 128608
    • Trujillo, A.1    McGee, C.2    Cogle, C.R.3
  • 35
    • 70249130158 scopus 로고    scopus 로고
    • Growth inhibition of AML cells with specific chromosome abnormalities by monoclonal antibodies to receptors for vascular endothelial growth factor
    • Imai N, Miwa H, Shikami M, et al. Growth inhibition of AML cells with specific chromosome abnormalities by monoclonal antibodies to receptors for vascular endothelial growth factor. Leuk Res 2009;33:1650-7.
    • (2009) Leuk Res , vol.33 , pp. 1650-1657
    • Imai, N.1    Miwa, H.2    Shikami, M.3
  • 36
    • 0036053859 scopus 로고    scopus 로고
    • Overexpression of vascular endothelial growth factor (VEGF) and its cellular receptor KDR (VEGFR-2) in the bone marrow of patients with acute myeloid leukemia
    • Padro T, Bieker R, Ruiz S, et al. Overexpression of vascular endothelial growth factor (VEGF) and its cellular receptor KDR (VEGFR-2) in the bone marrow of patients with acute myeloid leukemia. Leukemia 2002;16:1302-10.
    • (2002) Leukemia , vol.16 , pp. 1302-1310
    • Padro, T.1    Bieker, R.2    Ruiz, S.3
  • 40
    • 2942625727 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 and receptor-2 initiate a phosphatidylinositide 3-kinase-dependent clonogenic response in acute myeloid leukemia cells
    • List AF, Glinsmann-Gibson B, Stadheim C, Meuillet EJ, Bellamy W, Powis G. Vascular endothelial growth factor receptor-1 and receptor-2 initiate a phosphatidylinositide 3-kinase-dependent clonogenic response in acute myeloid leukemia cells. Exp Hematol 2004;32:526-35.
    • (2004) Exp Hematol , vol.32 , pp. 526-535
    • List, A.F.1    Glinsmann-Gibson, B.2    Stadheim, C.3    Meuillet, E.J.4    Bellamy, W.5    Powis, G.6
  • 42
    • 33750568635 scopus 로고    scopus 로고
    • t(8;21) acute myeloid leukaemia cells are dependent on vascular endothelial growth factor (VEGF)/VEGF receptor type2 pathway and phosphorylation of Akt
    • Imai N, Shikami M, Miwa H, et al. t(8;21) acute myeloid leukaemia cells are dependent on vascular endothelial growth factor (VEGF)/VEGF receptor type2 pathway and phosphorylation of Akt. Br J Haematol 2006;135:673-82.
    • (2006) Br J Haematol , vol.135 , pp. 673-682
    • Imai, N.1    Shikami, M.2    Miwa, H.3
  • 43
    • 0035282940 scopus 로고    scopus 로고
    • The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts
    • Smolich BD, Yuen HA, West KA, Giles FJ, Albitar M, Cherrington JM. The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. Blood 2001;97:1413-21.
    • (2001) Blood , vol.97 , pp. 1413-1421
    • Smolich, B.D.1    Yuen, H.A.2    West, K.A.3    Giles, F.J.4    Albitar, M.5    Cherrington, J.M.6
  • 44
    • 3242892278 scopus 로고    scopus 로고
    • Inhibition of both the autocrine and the paracrine growth of human leukemia with a fully human antibody directed against vascular endothelial growth factor receptor 2
    • Zhang H, Li Y, Li H, Bassi R, Jimenez X, Witte L, Bohlen P, Hicklin D, Zhu Z. Inhibition of both the autocrine and the paracrine growth of human leukemia with a fully human antibody directed against vascular endothelial growth factor receptor 2. Leuk Lymphoma 2004;45:1887-97.
    • (2004) Leuk Lymphoma , vol.45 , pp. 1887-1897
    • Zhang, H.1    Li, Y.2    Li, H.3    Bassi, R.4    Jimenez, X.5    Witte, L.6    Bohlen, P.7    Hicklin, D.8    Zhu, Z.9
  • 45
    • 27144487474 scopus 로고    scopus 로고
    • VEGF inhibition and cytotoxic effect of aplidin in leukemia cell lines and cells from acute myeloid leukemia
    • Biscardi M, Caporale R, Balestri F, Gavazzi S, Jimeno J, Grossi A. VEGF inhibition and cytotoxic effect of aplidin in leukemia cell lines and cells from acute myeloid leukemia. Ann Oncol 2005;16:1667-74.
    • (2005) Ann Oncol , vol.16 , pp. 1667-1674
    • Biscardi, M.1    Caporale, R.2    Balestri, F.3    Gavazzi, S.4    Jimeno, J.5    Grossi, A.6
  • 46
    • 2542547507 scopus 로고    scopus 로고
    • Targeting vascular endothelial growth factor for relapsed and refractory adult acute myelogenous leukemias: therapy with sequential 1-beta-d-arabinofuranosylcytosine, mitoxantrone, and bevacizumab
    • Karp JE, Gojo I, Pili R, et al. Targeting vascular endothelial growth factor for relapsed and refractory adult acute myelogenous leukemias: therapy with sequential 1-beta-d-arabinofuranosylcytosine, mitoxantrone, and bevacizumab. Clin Cancer Res 2004;10:3577-85.
    • (2004) Clin Cancer Res , vol.10 , pp. 3577-3585
    • Karp, J.E.1    Gojo, I.2    Pili, R.3
  • 48
    • 0043245991 scopus 로고    scopus 로고
    • SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes
    • Giles FJ, Stopeck AT, Silverman LR, et al. SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes. Blood 2003;102:795-801.
    • (2003) Blood , vol.102 , pp. 795-801
    • Giles, F.J.1    Stopeck, A.T.2    Silverman, L.R.3
  • 49
    • 33744482540 scopus 로고    scopus 로고
    • Phase 1 study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome
    • Roboz GJ, Giles FJ, List AF, et al. Phase 1 study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome. Leukemia 2006;20:952-7.
    • (2006) Leukemia , vol.20 , pp. 952-957
    • Roboz, G.J.1    Giles, F.J.2    List, A.F.3
  • 50
    • 36549068842 scopus 로고    scopus 로고
    • Bouma-Ter Steege JC, Hahlen K, Kamps WA, de Bont ES. Addition of PTK787/ZK 222584 can lower the dosage of amsacrine to achieve equal amounts of acute myeloid leukemia cell death
    • Weidenaar AC, de Jonge HJ, Fidler V, Ter EA, Meeuwsen-de BT, Douwes J. Bouma-Ter Steege JC, Hahlen K, Kamps WA, de Bont ES. Addition of PTK787/ZK 222584 can lower the dosage of amsacrine to achieve equal amounts of acute myeloid leukemia cell death. Anticancer Drugs 2008;19:45-54.
    • (2008) Anticancer Drugs , vol.19 , pp. 45-54
    • Weidenaar, A.C.1    de Jonge, H.J.2    Fidler, V.3    Ter, E.A.4    Meeuwsen-de, B.T.5    Douwes, J.6
  • 51
    • 0035412371 scopus 로고    scopus 로고
    • Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia
    • Mesters RM, Padro T, Bieker R, et al. Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia. Blood 2001;98:241-3.
    • (2001) Blood , vol.98 , pp. 241-243
    • Mesters, R.M.1    Padro, T.2    Bieker, R.3
  • 52
    • 0141993064 scopus 로고    scopus 로고
    • A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia
    • Fiedler W, Mesters R, Tinnefeld H, et al. A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia. Blood 2003;102:2763-7.
    • (2003) Blood , vol.102 , pp. 2763-2767
    • Fiedler, W.1    Mesters, R.2    Tinnefeld, H.3
  • 53
    • 19944431093 scopus 로고    scopus 로고
    • A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease
    • Fiedler W, Serve H, Dohner H, et al. A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Blood 2005;105:986-93.
    • (2005) Blood , vol.105 , pp. 986-993
    • Fiedler, W.1    Serve, H.2    Dohner, H.3
  • 54
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge SR, Kendrew J, Hennequin LF, et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 2005;65:4389-400.
    • (2005) Cancer Res , vol.65 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3
  • 55
    • 74849101514 scopus 로고    scopus 로고
    • An open-label, Phase I study of cediranib (RECENTIN) in patients with acute myeloid leukemia
    • Fiedler W, Mesters R, Heuser M, et al. An open-label, Phase I study of cediranib (RECENTIN) in patients with acute myeloid leukemia. Leuk Res 2010;34:196-202.
    • (2010) Leuk Res , vol.34 , pp. 196-202
    • Fiedler, W.1    Mesters, R.2    Heuser, M.3
  • 56
    • 0031059348 scopus 로고    scopus 로고
    • Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia
    • Perez-Atayde AR, Sallan SE, Tedrow U, Connors S, Allred E, Folkman J. Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. Am J Pathol 1997;150:815-21.
    • (1997) Am J Pathol , vol.150 , pp. 815-821
    • Perez-Atayde, A.R.1    Sallan, S.E.2    Tedrow, U.3    Connors, S.4    Allred, E.5    Folkman, J.6
  • 57
    • 0035186128 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in newly diagnosed and recurrent childhood acute lymphoblastic leukemia as measured by real-time quantitative polymerase chain reaction
    • Koomagi R, Zintl F, Sauerbrey A, Volm M. Vascular endothelial growth factor in newly diagnosed and recurrent childhood acute lymphoblastic leukemia as measured by real-time quantitative polymerase chain reaction. Clin Cancer Res 2001;7:3381-4.
    • (2001) Clin Cancer Res , vol.7 , pp. 3381-3384
    • Koomagi, R.1    Zintl, F.2    Sauerbrey, A.3    Volm, M.4
  • 58
    • 34547551162 scopus 로고    scopus 로고
    • Angiogenesis factor pattern differs in acute lymphoblastic leukemia and chronic lymphocytic leukemia
    • Aref S, Salama O, Shamaa S, El-Refaie M, Mourkos H. Angiogenesis factor pattern differs in acute lymphoblastic leukemia and chronic lymphocytic leukemia. Hematology 2007;12:319-24.
    • (2007) Hematology , vol.12 , pp. 319-324
    • Aref, S.1    Salama, O.2    Shamaa, S.3    El-Refaie, M.4    Mourkos, H.5
  • 59
    • 32644457459 scopus 로고    scopus 로고
    • VEGFR-1 (FLT-1) activation modulates acute lymphoblastic leukemia localization and survival within the bone marrow, determining the onset of extramedullary disease
    • Fragoso R, Pereira T, Wu Y, Zhu Z, Cabecadas J, Dias S. VEGFR-1 (FLT-1) activation modulates acute lymphoblastic leukemia localization and survival within the bone marrow, determining the onset of extramedullary disease. Blood 2006;107:1608-16.
    • (2006) Blood , vol.107 , pp. 1608-1616
    • Fragoso, R.1    Pereira, T.2    Wu, Y.3    Zhu, Z.4    Cabecadas, J.5    Dias, S.6
  • 60
    • 0034499732 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and the regulation of angiogenesis
    • Ferrara N. Vascular endothelial growth factor and the regulation of angiogenesis. Recent Prog Horm Res 2000;55:15-35.
    • (2000) Recent Prog Horm Res , vol.55 , pp. 15-35
    • Ferrara, N.1
  • 61
    • 0037299464 scopus 로고    scopus 로고
    • Vascularity, angiogenesis and angiogenic factors in leukemias and myelodysplastic syndromes
    • Aguayo A, Giles F, Albitar M. Vascularity, angiogenesis and angiogenic factors in leukemias and myelodysplastic syndromes. Leuk Lymphoma 2003;44:213-22.
    • (2003) Leuk Lymphoma , vol.44 , pp. 213-222
    • Aguayo, A.1    Giles, F.2    Albitar, M.3
  • 62
    • 58549119944 scopus 로고    scopus 로고
    • Secretion of MMP-2 and MMP-9 induced by VEGF autocrine loop correlates with clinical features in childhood acute lymphoblastic leukemia
    • Poyer F, Coquerel B, Pegahi R, Cazin L, Norris V, Vannier JP, Lamacz M. Secretion of MMP-2 and MMP-9 induced by VEGF autocrine loop correlates with clinical features in childhood acute lymphoblastic leukemia. Leuk Res 2009;33:407-17.
    • (2009) Leuk Res , vol.33 , pp. 407-417
    • Poyer, F.1    Coquerel, B.2    Pegahi, R.3    Cazin, L.4    Norris, V.5    Vannier, J.P.6    Lamacz, M.7
  • 63
    • 15044359505 scopus 로고    scopus 로고
    • VEGF-induced phosphorylation of Bcl-2 influences B lineage leukemic cell response to apoptotic stimuli
    • Wang L, Chen L, Benincosa J, Fortney J, Gibson LF. VEGF-induced phosphorylation of Bcl-2 influences B lineage leukemic cell response to apoptotic stimuli. Leukemia 2005;19:344-53.
    • (2005) Leukemia , vol.19 , pp. 344-353
    • Wang, L.1    Chen, L.2    Benincosa, J.3    Fortney, J.4    Gibson, L.F.5
  • 65
    • 0034665786 scopus 로고    scopus 로고
    • Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes
    • Aguayo A, Kantarjian H, Manshouri T, et al. Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes. Blood 2000;96:2240-5.
    • (2000) Blood , vol.96 , pp. 2240-2245
    • Aguayo, A.1    Kantarjian, H.2    Manshouri, T.3
  • 66
    • 0037085781 scopus 로고    scopus 로고
    • Prognostic significance of cellular vascular endothelial growth factor expression in chronic phase chronic myeloid leukemia
    • Verstovsek S, Kantarjian H, Manshouri T, Cortes J, Giles FJ, Rogers A, Albitar M. Prognostic significance of cellular vascular endothelial growth factor expression in chronic phase chronic myeloid leukemia. Blood 2002;99:2265-7.
    • (2002) Blood , vol.99 , pp. 2265-2267
    • Verstovsek, S.1    Kantarjian, H.2    Manshouri, T.3    Cortes, J.4    Giles, F.J.5    Rogers, A.6    Albitar, M.7
  • 67
    • 0037111665 scopus 로고    scopus 로고
    • BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin
    • Mayerhofer M, Valent P, Sperr WR, Griffin JD, Sillaber C. BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin. Blood 2002;100:3767-75.
    • (2002) Blood , vol.100 , pp. 3767-3775
    • Mayerhofer, M.1    Valent, P.2    Sperr, W.R.3    Griffin, J.D.4    Sillaber, C.5
  • 68
    • 32144440087 scopus 로고    scopus 로고
    • Elevated plasma levels of vascular endothelial growth factor is associated with marked splenomegaly in chronic myeloid leukemia
    • Liu P, Li J, Han ZC, Lu H, Wang Y, Xu B, Peng Z. Elevated plasma levels of vascular endothelial growth factor is associated with marked splenomegaly in chronic myeloid leukemia. Leuk Lymphoma 2005;46:1761-4.
    • (2005) Leuk Lymphoma , vol.46 , pp. 1761-1764
    • Liu, P.1    Li, J.2    Han, Z.C.3    Lu, H.4    Wang, Y.5    Xu, B.6    Peng, Z.7
  • 69
    • 70449560976 scopus 로고    scopus 로고
    • Prognostic significance of cellular vascular endothelial growth factor (VEGF) expression in the course of chronic myeloid leukaemia
    • Vidovic A, Jankovic G, Tomin D, Perunicic-Jovanovic M, Djunic I, Djurasinovic V, Colovic M. Prognostic significance of cellular vascular endothelial growth factor (VEGF) expression in the course of chronic myeloid leukaemia. Srp Arh Celok Lek 2009;137:379-83.
    • (2009) Srp Arh Celok Lek , vol.137 , pp. 379-383
    • Vidovic, A.1    Jankovic, G.2    Tomin, D.3    Perunicic-Jovanovic, M.4    Djunic, I.5    Djurasinovic, V.6    Colovic, M.7
  • 70
    • 3142583182 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571) decreases the vascular endothelial growth factor plasma concentration in patients with chronic myeloid leukemia
    • Legros L, Bourcier C, Jacquel A, Mahon FX, Cassuto JP, Auberger P, Pages G. Imatinib mesylate (STI571) decreases the vascular endothelial growth factor plasma concentration in patients with chronic myeloid leukemia. Blood 2004;104:495-501.
    • (2004) Blood , vol.104 , pp. 495-501
    • Legros, L.1    Bourcier, C.2    Jacquel, A.3    Mahon, F.X.4    Cassuto, J.P.5    Auberger, P.6    Pages, G.7
  • 72
  • 73
    • 84982295131 scopus 로고    scopus 로고
    • [Effect of siRNA targeting VEGF on cell apoptosis and the expression of survivin in K562 cells.]
    • Li FF, Zheng GH, Xu YH, Luo Q. [Effect of siRNA targeting VEGF on cell apoptosis and the expression of survivin in K562 cells.] Zhonghua Xue Ye Xue Za Zhi 2009;30:825-8.
    • (2009) Zhonghua Xue Ye Xue Za Zhi , vol.30 , pp. 825-828
    • Li, F.F.1    Zheng, G.H.2    Xu, Y.H.3    Luo, Q.4
  • 74
    • 58849165398 scopus 로고    scopus 로고
    • [Vascular endothelial growth factor antisense oligodeoxynucleotide enhance drug-sensitivity of myeloid leukemia cells to homoharringtonine]
    • Fei J, Zhang H. [Vascular endothelial growth factor antisense oligodeoxynucleotide enhance drug-sensitivity of myeloid leukemia cells to homoharringtonine]. Zhonghua Xue Ye Xue Za Zhi 2005;26:27-30.
    • (2005) Zhonghua Xue Ye Xue Za Zhi , vol.26 , pp. 27-30
    • Fei, J.1    Zhang, H.2
  • 75
    • 34447628307 scopus 로고    scopus 로고
    • Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemia K562 cells
    • Zhou HJ, Wang WQ, Wu GD, Lee J, Li A. Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemia K562 cells. Vascul Pharmacol 2007;47:131-8.
    • (2007) Vascul Pharmacol , vol.47 , pp. 131-138
    • Zhou, H.J.1    Wang, W.Q.2    Wu, G.D.3    Lee, J.4    Li, A.5
  • 76
    • 0034329298 scopus 로고    scopus 로고
    • In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells
    • Chen H, Treweeke AT, West DC, Till KJ, Cawley JC, Zuzel M, Toh CH. In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells. Blood 2000;96:3181-7.
    • (2000) Blood , vol.96 , pp. 3181-3187
    • Chen, H.1    Treweeke, A.T.2    West, D.C.3    Till, K.J.4    Cawley, J.C.5    Zuzel, M.6    Toh, C.H.7
  • 78
    • 0032705222 scopus 로고    scopus 로고
    • Increased serum levels of vascular endothelial growth factor predict risk of progression in early B-cell chronic lymphocytic leukaemia
    • Molica S, Vitelli G, Levato D, Gandolfo GM, Liso V. Increased serum levels of vascular endothelial growth factor predict risk of progression in early B-cell chronic lymphocytic leukaemia. Br J Haematol 1999;107:605-10.
    • (1999) Br J Haematol , vol.107 , pp. 605-610
    • Molica, S.1    Vitelli, G.2    Levato, D.3    Gandolfo, G.M.4    Liso, V.5
  • 81
    • 23744478390 scopus 로고    scopus 로고
    • VEGF-induced survival of chronic lymphocytic leukemia is independent of Bcl-2 phosphorylation
    • Wang L, Coad JE, Fortney JM, Gibson LF. VEGF-induced survival of chronic lymphocytic leukemia is independent of Bcl-2 phosphorylation. Leukemia 2005;19:1486-7.
    • (2005) Leukemia , vol.19 , pp. 1486-1487
    • Wang, L.1    Coad, J.E.2    Fortney, J.M.3    Gibson, L.F.4
  • 82
    • 79955809893 scopus 로고    scopus 로고
    • Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1
    • Huber S, Oelsner M, Decker T, et al. Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1. Leukemia 2011;25:838-47.
    • (2011) Leukemia , vol.25 , pp. 838-847
    • Huber, S.1    Oelsner, M.2    Decker, T.3
  • 83
    • 0031436969 scopus 로고    scopus 로고
    • B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues
    • Frank DA, Mahajan S, Ritz J. B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. J Clin Invest 1997;100:3140-8.
    • (1997) J Clin Invest , vol.100 , pp. 3140-3148
    • Frank, D.A.1    Mahajan, S.2    Ritz, J.3
  • 84
    • 85047695527 scopus 로고    scopus 로고
    • Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
    • Niu G, Wright KL, Huang M, et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 2002;21:2000-8.
    • (2002) Oncogene , vol.21 , pp. 2000-2008
    • Niu, G.1    Wright, K.L.2    Huang, M.3
  • 85
    • 78650070633 scopus 로고    scopus 로고
    • Phase II trials of single-agent anti-VEGF therapy for patients with chronic lymphocytic leukemia
    • Shanafelt T, Zent C, Byrd J, et al. Phase II trials of single-agent anti-VEGF therapy for patients with chronic lymphocytic leukemia. Leuk Lymphoma 2010;51:2222-9.
    • (2010) Leuk Lymphoma , vol.51 , pp. 2222-2229
    • Shanafelt, T.1    Zent, C.2    Byrd, J.3
  • 87
    • 0035195019 scopus 로고    scopus 로고
    • Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications
    • Gupta D, Treon SP, Shima Y, et al. Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications. Leukemia 2001;15:1950-61.
    • (2001) Leukemia , vol.15 , pp. 1950-1961
    • Gupta, D.1    Treon, S.P.2    Shima, Y.3
  • 88
    • 0033083962 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies
    • Bellamy WT, Richter L, Frutiger Y, Grogan TM. Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies. Cancer Res 1999;59:728-33.
    • (1999) Cancer Res , vol.59 , pp. 728-733
    • Bellamy, W.T.1    Richter, L.2    Frutiger, Y.3    Grogan, T.M.4
  • 89
    • 0036731996 scopus 로고    scopus 로고
    • The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment
    • Lin B, Podar K, Gupta D, et al. The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment. Cancer Res 2002;62:5019-26.
    • (2002) Cancer Res , vol.62 , pp. 5019-5026
    • Lin, B.1    Podar, K.2    Gupta, D.3
  • 90
    • 0032708238 scopus 로고    scopus 로고
    • Thalidomide-a revival story
    • Raje N, Anderson K. Thalidomide-a revival story. N Engl J Med 1999;341:1606-9.
    • (1999) N Engl J Med , vol.341 , pp. 1606-1609
    • Raje, N.1    Anderson, K.2
  • 91
    • 77649193345 scopus 로고    scopus 로고
    • Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs
    • Ramakrishnan V, Timm M, Haug JL, Kimlinger TK, Wellik LE, Witzig TE, Rajkumar SV, Adjei AA, Kumar S. Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs. Oncogene 2010;29:1190-202.
    • (2010) Oncogene , vol.29 , pp. 1190-1202
    • Ramakrishnan, V.1    Timm, M.2    Haug, J.L.3    Kimlinger, T.K.4    Wellik, L.E.5    Witzig, T.E.6    Rajkumar, S.V.7    Adjei, A.A.8    Kumar, S.9
  • 92
    • 11144354204 scopus 로고    scopus 로고
    • GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment
    • Podar K, Catley LP, Tai YT, et al. GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment. Blood 2004;103:3474-9.
    • (2004) Blood , vol.103 , pp. 3474-3479
    • Podar, K.1    Catley, L.P.2    Tai, Y.T.3
  • 93
    • 66549095182 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibition is not an effective therapeutic strategy for relapsed or refractory multiple myeloma: a phase 2 study of pazopanib (GW786034)
    • Prince HM, Honemann D, Spencer A, et al. Vascular endothelial growth factor inhibition is not an effective therapeutic strategy for relapsed or refractory multiple myeloma: a phase 2 study of pazopanib (GW786034). Blood 2009;113:4819-20.
    • (2009) Blood , vol.113 , pp. 4819-4820
    • Prince, H.M.1    Honemann, D.2    Spencer, A.3
  • 94
    • 33747644424 scopus 로고    scopus 로고
    • A phase II study of ZD6474 (Zactima, a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma-NCIC CTG IND.145
    • Kovacs MJ, Reece DE, Marcellus D, Meyer RM, Mathews S, Dong RP, Eisenhauer E. A phase II study of ZD6474 (Zactima, a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma-NCIC CTG IND.145. Invest New Drugs 2006;24:529-35.
    • (2006) Invest New Drugs , vol.24 , pp. 529-535
    • Kovacs, M.J.1    Reece, D.E.2    Marcellus, D.3    Meyer, R.M.4    Mathews, S.5    Dong, R.P.6    Eisenhauer, E.7
  • 95
    • 1642453748 scopus 로고    scopus 로고
    • Phase II study of SU5416, a small molecule vascular endothelial growth factor tyrosine kinase receptor inhibitor, in patients with refractory multiple myeloma
    • Zangari M, Anaissie E, Stopeck A, et al. Phase II study of SU5416, a small molecule vascular endothelial growth factor tyrosine kinase receptor inhibitor, in patients with refractory multiple myeloma. Clin Cancer Res 2004;10:88-95.
    • (2004) Clin Cancer Res , vol.10 , pp. 88-95
    • Zangari, M.1    Anaissie, E.2    Stopeck, A.3
  • 96
    • 38649131327 scopus 로고    scopus 로고
    • The importance of angiogenesis markers in the outcome of patients with diffuse large B cell lymphoma: a retrospective study of 97 patients
    • Ganjoo KN, Moore AM, Orazi A, Sen JA, Johnson CS, An CS. The importance of angiogenesis markers in the outcome of patients with diffuse large B cell lymphoma: a retrospective study of 97 patients. J Cancer Res Clin Oncol 2008;134:381-7.
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 381-387
    • Ganjoo, K.N.1    Moore, A.M.2    Orazi, A.3    Sen, J.A.4    Johnson, C.S.5    An, C.S.6
  • 97
    • 67650892411 scopus 로고    scopus 로고
    • The prognostic significance of VEGF-C and VEGF-A in non-Hodgkin lymphomas
    • Paydas S, Seydaoglu G, Ergin M, Erdogan S, Yavuz S. The prognostic significance of VEGF-C and VEGF-A in non-Hodgkin lymphomas. Leuk Lymphoma 2009;50:366-73.
    • (2009) Leuk Lymphoma , vol.50 , pp. 366-373
    • Paydas, S.1    Seydaoglu, G.2    Ergin, M.3    Erdogan, S.4    Yavuz, S.5
  • 98
    • 70350747488 scopus 로고    scopus 로고
    • Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas
    • Jorgensen JM, Sorensen FB, Bendix K, Nielsen JL, Funder A, Karkkainen MJ, Tainola T, Sorensen AB, Pedersen FS, D'Amore F. Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas. Leuk Lymphoma 2009;50:1647-60.
    • (2009) Leuk Lymphoma , vol.50 , pp. 1647-1660
    • Jorgensen, J.M.1    Sorensen, F.B.2    Bendix, K.3    Nielsen, J.L.4    Funder, A.5    Karkkainen, M.J.6    Tainola, T.7    Sorensen, A.B.8    Pedersen, F.S.9    D'Amore, F.10
  • 99
    • 0036765823 scopus 로고    scopus 로고
    • Immunohistochemical detection of C-kit (CD117) and vascular endothelial growth factor (VEGF) overexpression in mantle cell lymphoma
    • Potti A, Ganti AK, Kargas S, Koch M. Immunohistochemical detection of C-kit (CD117) and vascular endothelial growth factor (VEGF) overexpression in mantle cell lymphoma. Anticancer Res 2002;22:2899-901.
    • (2002) Anticancer Res , vol.22 , pp. 2899-2901
    • Potti, A.1    Ganti, A.K.2    Kargas, S.3    Koch, M.4
  • 100
    • 37549055122 scopus 로고    scopus 로고
    • Prognostic significance of VEGF, VEGF receptors, and microvessel density in diffuse large B cell lymphoma treated with anthracycline-based chemotherapy
    • Gratzinger D, Zhao S, Tibshirani RJ, et al. Prognostic significance of VEGF, VEGF receptors, and microvessel density in diffuse large B cell lymphoma treated with anthracycline-based chemotherapy. Lab Invest 2008;88:38-47.
    • (2008) Lab Invest , vol.88 , pp. 38-47
    • Gratzinger, D.1    Zhao, S.2    Tibshirani, R.J.3
  • 103
    • 67651166709 scopus 로고    scopus 로고
    • Effects of the anti-VEGF monoclonal antibody bevacizumab in a preclinical model and in patients with refractory and multiple relapsed Hodgkin lymphoma
    • Reiners KS, Gossmann A, von Strandmann EP, Boll B, Engert A, Borchmann P. Effects of the anti-VEGF monoclonal antibody bevacizumab in a preclinical model and in patients with refractory and multiple relapsed Hodgkin lymphoma. J Immunother 2009;32:508-12.
    • (2009) J Immunother , vol.32 , pp. 508-512
    • Reiners, K.S.1    Gossmann, A.2    von Strandmann, E.P.3    Boll, B.4    Engert, A.5    Borchmann, P.6
  • 104
    • 34447300966 scopus 로고    scopus 로고
    • Elevated vascular endothelial growth factor pretreatment levels are correlated with the tumor burden in Hodgkin lymphoma and continue to be elevated in prolonged complete remission
    • Rueda A, Olmos D, Villareal V, Torres E, Pajares BI, Alba E. Elevated vascular endothelial growth factor pretreatment levels are correlated with the tumor burden in Hodgkin lymphoma and continue to be elevated in prolonged complete remission. Clin Lymphoma Myeloma 2007;7:400-5.
    • (2007) Clin Lymphoma Myeloma , vol.7 , pp. 400-405
    • Rueda, A.1    Olmos, D.2    Villareal, V.3    Torres, E.4    Pajares, B.I.5    Alba, E.6
  • 107
    • 0141995781 scopus 로고    scopus 로고
    • Re: Doussis-Anagnostopoulou Vascular endothelial growth factor (VEGF) is expressed by neoplastic Hodgkin-Reed-Sternberg cells in Hodgkin's disease. J Pathol 2002; 197: 677-683
    • Agarwal B, Naresh KN. Re: Doussis-Anagnostopoulou et al. Vascular endothelial growth factor (VEGF) is expressed by neoplastic Hodgkin-Reed-Sternberg cells in Hodgkin's disease. J Pathol 2002; 197: 677-683. J Pathol 2003;201:334-5.
    • (2003) J Pathol , vol.201 , pp. 334-335
    • Agarwal, B.1    Naresh, K.N.2
  • 108
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9:669-76.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 109
    • 30644476010 scopus 로고    scopus 로고
    • Micro-vessel density and the expression of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PdEGF) in classical Hodgkin lymphoma (HL)
    • Mainou-Fowler T, Angus B, Miller S, Proctor SJ, Taylor PR, Wood KM. Micro-vessel density and the expression of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PdEGF) in classical Hodgkin lymphoma (HL). Leuk Lymphoma 2006;47:223-30.
    • (2006) Leuk Lymphoma , vol.47 , pp. 223-230
    • Mainou-Fowler, T.1    Angus, B.2    Miller, S.3    Proctor, S.J.4    Taylor, P.R.5    Wood, K.M.6
  • 112
    • 0242550768 scopus 로고    scopus 로고
    • Prognostic significance of microvessel density and vascular endothelial growth factor (VEGF) expression in non-Hodgkin's lymphoma
    • Hazar B, Paydas S, Zorludemir S, Sahin B, Tuncer I. Prognostic significance of microvessel density and vascular endothelial growth factor (VEGF) expression in non-Hodgkin's lymphoma. Leuk Lymphoma 2003;44:2089-93.
    • (2003) Leuk Lymphoma , vol.44 , pp. 2089-2093
    • Hazar, B.1    Paydas, S.2    Zorludemir, S.3    Sahin, B.4    Tuncer, I.5
  • 113
    • 0035845561 scopus 로고    scopus 로고
    • Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias
    • Dias S, Hattori K, Heissig B, et al. Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias. Proc Natl Acad Sci U S A 2001;98:10857-62.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10857-10862
    • Dias, S.1    Hattori, K.2    Heissig, B.3
  • 114
    • 0038204144 scopus 로고    scopus 로고
    • SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • O'Farrell AM, Abrams TJ, Yuen HA, et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 2003;101:3597-605.
    • (2003) Blood , vol.101 , pp. 3597-3605
    • O'Farrell, A.M.1    Abrams, T.J.2    Yuen, H.A.3
  • 116
    • 6944253220 scopus 로고    scopus 로고
    • VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis
    • Le GS, Podar K, Amiot M, et al. VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis. Blood 2004;104:2886-92.
    • (2004) Blood , vol.104 , pp. 2886-2892
    • Le, G.S.1    Podar, K.2    Amiot, M.3
  • 117
    • 8844219644 scopus 로고    scopus 로고
    • PI3-K/AKT/FKHR and MAPK signaling cascades are redundantly stimulated by a variety of cytokines and contribute independently to proliferation and survival of multiple myeloma cells
    • Lentzsch S, Chatterjee M, Gries M, Bommert K, Gollasch H, Dorken B, Bargou RC. PI3-K/AKT/FKHR and MAPK signaling cascades are redundantly stimulated by a variety of cytokines and contribute independently to proliferation and survival of multiple myeloma cells. Leukemia 2004;18:1883-90.
    • (2004) Leukemia , vol.18 , pp. 1883-1890
    • Lentzsch, S.1    Chatterjee, M.2    Gries, M.3    Bommert, K.4    Gollasch, H.5    Dorken, B.6    Bargou, R.C.7
  • 118
    • 77949325941 scopus 로고    scopus 로고
    • VEGF/VEGFR2 interaction down-regulates matrix metalloproteinase-9 via STAT1 activation and inhibits B chronic lymphocytic leukemia cell migration
    • Ugarte-Berzal E, Redondo-Munoz J, Eroles P, Del Cerro MH, Garcia-Marco JA, Terol MJ, Garcia-Pardo A. VEGF/VEGFR2 interaction down-regulates matrix metalloproteinase-9 via STAT1 activation and inhibits B chronic lymphocytic leukemia cell migration. Blood 2010;115:846-9.
    • (2010) Blood , vol.115 , pp. 846-849
    • Ugarte-Berzal, E.1    Redondo-Munoz, J.2    Eroles, P.3    Del Cerro, M.H.4    Garcia-Marco, J.A.5    Terol, M.J.6    Garcia-Pardo, A.7
  • 119
    • 70349171778 scopus 로고    scopus 로고
    • Strong correlation between VEGF and MCL-1 mRNA expression levels in B-cell chronic lymphocytic leukemia
    • Veronese L, Tournilhac O, Verrelle P, et al. Strong correlation between VEGF and MCL-1 mRNA expression levels in B-cell chronic lymphocytic leukemia. Leuk Res 2009;33:1623-6.
    • (2009) Leuk Res , vol.33 , pp. 1623-1626
    • Veronese, L.1    Tournilhac, O.2    Verrelle, P.3
  • 120
    • 0034923443 scopus 로고    scopus 로고
    • Clinical importance of serum vascular endothelial and basic fibroblast growth factors in children with acute lymphoblastic leukemia
    • Yetgin S, Yenicesu I, Cetin M, Tuncer M. Clinical importance of serum vascular endothelial and basic fibroblast growth factors in children with acute lymphoblastic leukemia. Leuk Lymphoma 2001;42:83-8.
    • (2001) Leuk Lymphoma , vol.42 , pp. 83-88
    • Yetgin, S.1    Yenicesu, I.2    Cetin, M.3    Tuncer, M.4
  • 122
    • 16444379474 scopus 로고    scopus 로고
    • Circulating vascular endothelial growth factor (VEGF) and its soluble receptors in patients with chronic lymphocytic leukemia
    • Gora-Tybor J, Blonski JZ, Robak T. Circulating vascular endothelial growth factor (VEGF) and its soluble receptors in patients with chronic lymphocytic leukemia. Eur Cytokine Netw 2005;16:41-6.
    • (2005) Eur Cytokine Netw , vol.16 , pp. 41-46
    • Gora-Tybor, J.1    Blonski, J.Z.2    Robak, T.3
  • 123
    • 0035207927 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor and its receptors in multiple myeloma and other hematopoietic malignancies
    • Bellamy WT. Expression of vascular endothelial growth factor and its receptors in multiple myeloma and other hematopoietic malignancies. Semin Oncol 2001;28:551-9.
    • (2001) Semin Oncol , vol.28 , pp. 551-559
    • Bellamy, W.T.1
  • 124
    • 0030764802 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in lymphomas and Castleman's disease
    • Foss HD, Araujo I, Demel G, Klotzbach H, Hummel M, Stein H. Expression of vascular endothelial growth factor in lymphomas and Castleman's disease. J Pathol 1997;183:44-50.
    • (1997) J Pathol , vol.183 , pp. 44-50
    • Foss, H.D.1    Araujo, I.2    Demel, G.3    Klotzbach, H.4    Hummel, M.5    Stein, H.6


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