Probing the structural basis of Zn2+ regulation of the epithelial Na+ channel

Journal of Biological Chemistry

Volumn 287, Issue 42, 2012, Pages 35589-35598

  Chen, Jingxin ^a   Winarski, Katie L ^a   Myerburg, Mike M ^a   Pitt, Bruce R ^b   Sheng, Shaohu ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID-SENSING ION CHANNELS; BIPHASIC EFFECTS; CLOSE PROXIMITY; DOSE RESPONSE; DUAL EFFECT; EXTRACELLULAR; INHIBITORY EFFECT; INHIBITORY SITES; SELF-INHIBITION; STRUCTURAL BASIS; STRUCTURAL HOMOLOGY; SUBDOMAIN;

CHEMICAL ACTIVATION;

ZINC;

ASPARTIC ACID; EPITHELIAL SODIUM CHANNEL; HISTIDINE; MEMBRANE PROTEIN; PROTEIN GAMMAH193A; PROTEIN GAMMAH200A; PROTEIN GAMMAH202A; PROTEIN GAMMAH239A; PROTEIN GAMMAH88A; UNCLASSIFIED DRUG; ZINC ION;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; MEMBRANE DAMAGE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY;

AMINO ACID SUBSTITUTION; ANIMALS; CATIONS, DIVALENT; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL SODIUM CHANNELS; MICE; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; SODIUM CHANNEL BLOCKERS; STRUCTURAL HOMOLOGY, PROTEIN; XENOPUS LAEVIS; ZINC;

EID: 84867433124     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.394734     Document Type: Article

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