Transcriptional networks controlling adipocyte differentiation

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 76, Issue , 2011, Pages 247-255

  Siersbaek R ^a   Mandrup, S ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; CYCLIC AMP; DEOXYRIBONUCLEASE I; GLUCOCORTICOID RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; RETINOID X RECEPTOR; SOMATOMEDIN RECEPTOR; STAT5A PROTEIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; TRANSCRIPTION FACTOR;

ADIPOCYTE; ADIPOGENESIS; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN STRUCTURE; DNA PACKAGING; GENE LOCUS; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; MOLECULAR INTERACTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; GENOME; TRANSCRIPTION REGULATION;

ADIPOCYTES; ADIPOGENESIS; ANIMALS; CELL DIFFERENTIATION; GENE REGULATORY NETWORKS; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MODELS, BIOLOGICAL;

EID: 84867421989     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2011.76.010512     Document Type: Article

References (85)

1. Aagaard MM, Siersbæk R, Mandrup S. 2011. Molecular basis for gene-specific transactivation by nuclear receptors. Biochim Biophys Acta 1812: 824-835.
2. Biddie SC, John S, Sabo PJ, Thurman RE, Johnson TA, Schiltz RL, Miranda TB, Sung MH, Trump S, Lightman SL, et al. 2011. Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding. Mol Cell 43: 145-155.
3. Birsoy K, Chen Z, Friedman J. 2008. Transcriptional regulation of adipogenesis by KLF4. Cell Metab 7: 339-347.
4. Boney CM, Smith RM, Gruppuso PA. 1998. Modulation of insulin-like growth factor I mitogenic signaling in 3T3-L1 preadipocyte differentiation. Endocrinology 139: 1638-1644.
5. Boyle AP, Davis S, Shulha HP, Meltzer P, Margulies EH, Weng Z, Furey TS, Crawford GE. 2008. High-resolution mapping and characterization of open chromatin across the genome. Cell 132: 311-322.
6. Cao Z, Umek RM, McKnight SL. 1991. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev 5: 1538-1552.
7. Caprio M, Feve B, Claes A, Viengchareun S, Lombes M, Zennaro MC. 2007. Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis. FASEB J 21: 2185-2194.
8. Caprio M, Antelmi A, Chetrite G, Muscat A, Mammi C, Marzolla V, Fabbri A, Zennaro MC, Feve B. 2011. Antiadipogenic effects of the mineralocorticoid receptor antagonist drospirenone: Potential implications for the treatment of metabolic syndrome. Endocrinology 152: 113-125.
9. Chen Z, Torrens JI, Anand A, Spiegelman BM, Friedman JM. 2005. Krox20 stimulates adipogenesis via C/EBPbdependent and -independent mechanisms. Cell Metab 1: 93-106.
10. Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, Wong E, Orlov YL, Zhang W, Jiang J, et al. 2008. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133: 1106-1117.
11. Crawford GE, Davis S, Scacheri PC, Renaud G, Halawi MJ, Erdos MR, Green R, Meltzer PS, Wolfsberg TG, Collins FS. 2006a. DNase-chip: A high-resolution method to identify DNase I hypersensitive sites using tiled microarrays. Nat Meth 3: 503-509.
12. Crawford GE, Holt IE, Whittle J, Webb BD, Tai D, Davis S, Margulies EH, Chen Y, Bernat JA, Ginsburg D, et al. 2006b. Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS). Genome Res 16: 123-131.
13. Cui TX, Lin G, LaPensee CR, Calinescu AA, Rathore M, Streeter C, Piwien-Pilipuk G, Lanning N, Jin H, Carter-Su C, et al. 2011. C/EBPb mediates growth hormone-regulated expression of multiple target genes. Mol Endocrinol 25: 681-693.
14. Dorschner MO, Hawrylycz M, Humbert R, Wallace JC, Shafer A, Kawamoto J, Mack J, Hall R, Goldy J, Sabo PJ, et al. 2004. High-throughput localization of functional elements by quantitative chromatin profiling. Nat Meth 1: 219-225.
15. Fan W, Imamura T, Sonoda N, Sears DD, Patsouris D, Kim JJ, Olefsky JM. 2009. FOXO1 transrepresses peroxisome proliferator-activated receptor g transactivation, coordinating an insulin-induced feed-forward response in adipocytes. J Biol Chem 284: 12188-12197.
16. Farmer SR. 2006. Transcriptional control of adipocyte formation. Cell Metab 4: 263-273.
17. Floyd ZE, Stephens JM. 2003. STAT5A promotes adipogenesis in nonprecursor cells and associates with the glucocorticoid receptor during adipocyte differentiation. Diabetes 52: 308-314.
18. Fontde Mora J, Porras A, Ahn N, Santos E. 1997. Mitogenactivated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation. Mol Cell Biol 17: 6068-6075.
19. Gerin I, Bommer GT, Lidell ME, Cederberg A, Enerback S, MacDougald OA. 2009. On the role of FOX transcription factors in adipocyte differentiation and insulin-stimulated glucose uptake. J Biol Chem 284: 10755-10763.
20. Green H, Kehinde O. 1975. An established preadipose cell line and its differentiation in culture II. Factors affecting the adipose conversion. Cell 5: 19-27.
21. Grøntved L, Madsen MS, Boergesen M, Roeder RG, Mandrup S. 2010. MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor g and is required for full transcriptional activity and adipogenesis. Mol Cell Biol 30: 2155-2169.
22. Hamm JK, Park BH, Farmer SR. 2001. A role for C/EBPb in regulating peroxisome proliferator-activated receptor g activity during adipogenesis in 3T3-L1 preadipocytes. J Biol Chem 276: 18464-18471.
23. Hamza MS, Pott S, Vega VB, Thomsen JS, Kandhadayar GS, Ng PW, Chiu KP, Pettersson S, Wei CL, Ruan Y, Liu ET. 2009. De-novo identification of PPARg/RXR binding sites and direct targets during adipogenesis. PLoS One 4: e4907.
24. Hansen JB, Petersen RK, Jorgensen C, Kristiansen K. 2002. Deregulated MAPK activity prevents adipocyte differentiation of fibroblasts lacking the retinoblastoma protein. J Biol Chem 277: 26335-26339.
25. He A, Kong SW, Ma Q, Pu WT. 2011. Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart. Proc Natl Acad Sci 108: 5632-5637.
26. Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. 2010. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 38: 576-589.
27. Hesselberth JR, Chen X, Zhang Z, Sabo PJ, Sandstrom R, Reynolds AP, Thurman RE, Neph S, Kuehn MS, Noble WS, et al. 2009. Global mapping of protein-DNA interactions in vivo by digital genomic footprinting. Nat Meth 6: 283-289.
28. Hurtado A, Holmes KA, Ross-Innes CS, Schmidt D, Carroll JS. 2011. FOXA1 is a key determinant of estrogen receptor function and endocrine response. Nat Genet 43: 27-33.
29. Hwang CS, Loftus TM, Mandrup S, Lane MD. 1997. Adipocyte differentiation and leptin expression. Annu Rev Cell Dev Biol 13: 231-259.
30. Janderova L, McNeil M, Murrell AN, Mynatt RL, Smith SR. 2003. Human mesenchymal stem cells as an in vitro model for human adipogenesis. Obes Res 11: 65-74.
31. John S, Sabo PJ, Johnson TA, Sung MH, Biddie SC, Lightman SL, Voss TC, Davis SR, Meltzer PS, Stamatoyannopoulo J, Hager GL. 2008. Interaction of the glucocorticoid receptor with the chromatin landscape. Mol Cell 29: 611-624.
32. John S, Sabo PJ, Thurman RE, Sung MH, Biddie SC, Johnson TA, Hager GL, Stamatoyannopoulo J. 2011. Chromatin accessibility pre-determines glucocorticoid receptor binding patterns. Nat Genet 43: 264-268.
33. Juvet LK, Andresen SM, Schuster GU, Dalen KT, Tobin KA, Hollung K, Haugen F, Jacinto S, Ulven SM, Bamberg K, et al. 2003. On the role of liver X receptors in lipid accumulation in adipocytes. Mol Endocrinol 17: 172-182.
34. Keene MA, Corces V, Lowenhaupt K, Elgin SC. 1981. DNase I hypersensitive sites in Drosophila chromatin occur at the 50 ends of regions of transcription. Proc Natl Acad Sci 78: 143-146.
35. Kim JB, Spiegelman BM. 1996. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev 10: 1096-1107.
36. Lay SL, Lefrere I, Trautwein C, Dugail I, Krief S. 2002. Insulin and sterol-regulatory element-binding protein-1c (SREBP-1C) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein b as an SREBP-1C target. J Biol Chem 277: 35625-35634.
37. Lefterova MI, Lazar MA. 2009. New developments in adipogenesis. Trends Endocrinol Metab 20: 107-114.
38. Lefterova MI, Zhang Y, Steger DJ, Schupp M, Schug J, Cristancho A, Feng D, Zhuo D, Stoeckert CJ Jr, Liu XS, Lazar MA. 2008. PPARg and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev 22: 2941-2952.
39. Lefterova MI, Steger DJ, Zhuo D, Qatanani M, Mullican SE, Tuteja G, Manduchi E, Grant GR, Lazar MA. 2010. Cellspecific determinants of peroxisome proliferator-activated receptor g function in adipocytes and macrophages. Mol Cell Biol 30: 2078-2089.
40. Li XY, Thomas S, Sabo PJ, Eisen MB, Stamatoyannopoulo J, Biggin MD. 2011. The role of chromatin accessibility in directing the widespread, overlapping patterns of Drosophila transcription factor binding. Genome Biol 12: R34.
41. Lo KA, Bauchmann MK, Baumann AP, Donahue CJ, Thiede MA, Hayes LS, des Etages SA, Fraenkel E. 2011. Genomewide profiling of H3K56 acetylation and transcription factor binding sites in human adipocytes. PLoS One 6: e19778.
42. MacDougald OA, Mandrup S. 2002. Adipogenesis: Forces that tip the scales. Trends Endocrinol Metab 13: 5-11.
43. McArthur M, Gerum S, Stamatoyannopoulo G. 2001. Quantification of DNaseI-sensitivity by real-time PCR: Quantitative analysis of DNaseI-hypersensitivity of the mouse b-globin LCR. J Mol Biol 313: 27-34.
44. Mikkelsen TS, Xu Z, Zhang X, Wang L, Gimble JM, Lander ES, Rosen ED. 2010. Comparative epigenomic analysis of murine and human adipogenesis. Cell 143: 156-169.
45. Mori T, Sakaue H, Iguchi H, Gomi H, Okada Y, Takashima Y, Nakamura K, Nakamura T, Yamauchi T, Kubota N, et al. 2005. Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J Biol Chem 280: 12867-12875.
46. Nielsen R, Pedersen TA, Hagenbeek D, Moulos P, Siersbæk R, Megens E, Denissov S, Borgesen M, Francoijs KJ, Mandrup S, Stunnenberg HG. 2008. Genome-wide profiling of PPARg:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis. Genes Dev 22: 2953-2967.
47. Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, Nishimura G, Maemura K, Yamauchi T, Kubota N, et al. 2005. Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab 1: 27-39.
48. Pantoja C, Huff JT, Yamamoto KR. 2008. Glucocorticoid signaling defines a novel commitment state during adipogenesis in vitro. Mol Biol Cell 19: 4032-4041.
49. Petersen RK, Madsen L, Pedersen LM, Hallenborg P, Hagland H, Viste K, Doskeland SO, Kristiansen K. 2008. Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac-and cAMPdependent protein kinase-dependent processes. Mol Cell Biol 28: 3804-3816.
50. Petrovic N, Walden TB, Shabalina IG, Timmons JA, Cannon B, Nedergaard J. 2010. Chronic peroxisome proliferator-activated receptor g (PPARg) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J Biol Chem 285: 7153-7164.
51. Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ. 2000. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRa and LXRb. Genes Dev 14: 2819-2830.
52. Reusch JEB, Colton LA, Klemm DJ. 2000. CREB activation induces adipogenesis in 3T3-L1 Cells. Mol Cell Biol 20: 1008-1020.
53. Rosen ED, MacDougald OA. 2006. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 7: 885-896.
54. Rosen ED, Spiegelman BM. 2000. Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 16: 145-171.
55. Ross SE, Erickson RL, Gerin I, DeRose PM, Bajnok L, Longo KA, Misek DE, Kuick R, Hanash SM, Atkins KB, et al. 2002. Microarray analyses during adipogenesis: understanding the effects of WNT signaling on adipogenesis and the roles of liver X receptor a in adipocyte metabolism. Mol Cell Biol 22: 5989.
56. Sabo PJ, Kuehn MS, Thurman R, Johnson BE, Johnson EM, Cao H, Yu M, Rosenzweig E, Goldy J, Haydock A, et al. 2006. Genome-scale mapping of DNase I sensitivity in vivo using tiling DNA microarrays. Nat Meth 3: 511-518.
57. Sakaue H, OgawaW, Matsumoto M, Kuroda S, Takata M, Sugimoto T, Spiegelman BM, Kasuga M. 1998. Posttranscriptional control of adipocyte differentiation through activation of phosphoinositide 3-kinase. J Biol Chem 273: 28945-28952.
58. Sale EM, Atkinson PG, Sale GJ. 1995. Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p90 S6 kinase and for insulin or serum stimulation of DNA synthesis. EMBO J 14: 674-684.
59. Salma N, Xiao H, Mueller E, Imbalzano AN. 2004. Temporal recruitment of transcription factors and SWI/SNF chromatinremodeling enzymes during adipogenic induction of the peroxisome proliferator-activated receptor g nuclear hormone receptor. Mol Cell Biol 24: 4651-4663.
60. Salma N, Xiao H, Imbalzano AN. 2006. Temporal recruitment of CCAAT/enhancer-binding proteins to early and late adipogenic promoters in vivo. J Mol Endocrinol 36: 139-151.
61. Schmidt W, Poll JG, Loffler G. 1990. Adipose conversion of 3T3-L1 cells in a serum-free culture system depends on epidermal growth factor, insulin-like growth factor I, corticosterone, and cyclic AMP. J Biol Chem 265: 15489-15495.
62. Schmidt S, Jorgensen M, Chen Y, Nielsen R, Sandelin A, Mandrup S. 2011. Cross species comparison of C/EBPa and PPARg profiles in mouse and human adipocytes reveals interdependent retention of binding sites. BMC Genomics 12: 152.
63. Siersbæk R, Nielsen R, Mandrup S. 2010. PPARg in adipocyte differentiation and metabolism-Novel insights from genome-wide studies. FEBS Lett 584: 3242-3249.
64. Siersbæk R, Nielsen R, John S, Sung MH, Baek S, Loft A, Hager GL, Mandrup S. 2011. Extensive chromatin remodelling and establishment of transcription factor "hotspots" during early adipogenesis. EMBO J 30: 1459-1472.
65. Smith PJ, Wise LS, Berkowitz R, Wan C, Rubin CS. 1988. Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes. J Biol Chem 263: 9402-9408.
66. Soccio RE, Tuteja G, Everett LJ, Li Z, Lazar MA, Kaestner KH. 2011. Species-specific strategies underlying conserved functions of metabolic transcription factors. Mol Endocrinol 25: 694-706.
67. Steger DJ, Grant GR, Schupp M, Tomaru T, Lefterova MI, Schug J, Manduchi E, Stoeckert CJ Jr, Lazar MA. 2010. Propagation of adipogenic signals through an epigenomic transition state. Genes Dev 24: 1035-1044.
68. Stitzel ML, Sethupathy P, Pearson DS, Chines PS, Song L, Erdos MR, Welch R, Parker SC, Boyle AP, Scott LJ, et al. 2010. Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab 12: 443-455.
69. Student AK, Hsu RY, Lane MD. 1980. Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes. J Biol Chem 255: 4745-4750.
70. Tanaka T, Yoshida N, Kishimoto T, Akira S. 1997. Defective adipocyte differentiation in mice lacking the C/EBPb and/ or C/EBPd gene. EMBO J 16: 7432-7443.
71. Tang QQ, Lane MD. 1999. Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation. Genes Dev 13: 2231-2241.
72. Tang QQ, Otto TC, Lane MD. 2003a. CCAAT/enhancerbinding protein b is required for mitotic clonal expansion during adipogenesis. Proc Natl Acad Sci 100: 850-855.
73. Tang QQ, Otto TC, Lane MD. 2003b. Mitotic clonal expansion: A synchronous process required for adipogenesis. Proc Natl Acad Sci 100: 44-49.
74. Tang QQ, Gronborg M, Huang H, Kim JW, Otto TC, Pandey A, Lane MD. 2005. Sequential phosphorylation of CCAAT enhancer-binding protein b by MAPK and glycogen synthase kinase 3b is required for adipogenesis. Proc Natl Acad Sci 102: 9766-9771.
75. Thomas S, Li XY, Sabo PJ, Sandstrom RB, Thurman RE, Canfield TD, Giste E, FisherW, Hammonds A, Celniker SE, et al. 2011. Dynamic reprogramming of chromatin accessibility during Drosophila embryo development. Genome Biol 12: R43.
76. Tontonoz P, Spiegelman BM. 2008. Fat and beyond: The diverse biology of PPARg. Annu Rev Biochem 77: 289-312.
77. Valet P, Tavernier G, Castan-Laurell I, Saulnier-Blache JS, Langin D. 2002. Understanding adipose tissue development from transgenic animal models. J Lipid Res 43: 835-860.
78. Wabitsch M, Brenner RE, Melzner I, Braun M, Moller P, Heinze E, Debatin KM, Hauner H. 2001. Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation. Int J Obes Relat Metab Disord 25: 8-15.
79. Wakabayashi Ki, Okamura M, Tsutsumi S, Nishikawa NS, Tanaka T, Sakakibara I, Kitakami Ji, Ihara S, Hashimoto Y, Hamakubo T, et al. 2009. The peroxisome proliferatoractivated receptor g/retinoid X receptor a heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. Mol Cell Biol 29: 3544-3555.
80. Wu C. 1980. The 5' ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I. Nature 286: 854-860.
81. Wu C, Wong YC, Elgin SC. 1979. The chromatin structure of specific genes: II. Disruption of chromatin structure during gene activity. Cell 16: 807-814.
82. Wu Z, Rosen ED, Brun R, Hauser S, Adelmant G, Troy AE, McKeon C, Darlington GJ, Spiegelman BM. 1999. Crossregulation of C/EBP a and PPAR g controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell 3: 151-158.
83. Yarwood SJ, Sale EM, Sale GJ, Houslay MD, Kilgour E, Anderson NG. 1999. Growth hormone-dependent differentiation of 3T3-F442A preadipocytes requires Janus kinase/signal transducer and activator of transcription but not mitogen-activated protein kinase or p70 S6 kinase signaling. J Biol Chem 274: 8662-8668.
84. Yeh WC, Cao Z, Classon M, McKnight SL. 1995. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev 9: 168-181.
85. Yu CY, Mayba O, Lee JV, Tran J, Harris C, Speed TP, Wang JC. 2010. Genome-wide analysis of glucocorticoid receptor binding regions in adipocytes reveal gene network involved in triglyceride homeostasis. PLoS One 5: e15188.