Transcriptional Regulation of Adipogenesis by KLF4

Cell Metabolism

Volumn 7, Issue 4, 2008, Pages 339-347

  Birsoy, Kivanç ^a   Chen, Zhu ^a,b   Friedman, Jeffrey ^a,c  

^a ROCKEFELLER UNIVERSITY   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

HUMDISEASE

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; CYCLIC AMP; GLUCOCORTICOID; INSULIN; ISOBUTYLMETHYLXANTHINE; KRUPPEL LIKE FACTOR 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR KROX20; UNCLASSIFIED DRUG;

ADIPOGENESIS; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL STRAIN 3T3; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REPORTER GENE; TRANSCRIPTION REGULATION;

1-METHYL-3-ISOBUTYLXANTHINE; 3T3-L1 CELLS; ADIPOGENESIS; ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL DIFFERENTIATION; DEXAMETHASONE; EARLY GROWTH RESPONSE PROTEIN 2; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INSULIN; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; PROTEIN BINDING; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

EID: 41449116010     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2008.02.001     Document Type: Article

References (30)

1. Boyer-Guittaut M., Birsoy K., Potel C., Elliot G., Jaffray E., Desterro J., Hay R., and Oelgeschläger T. SUMO-1 modification of human transcription factor (TF) IID complex subunits. J. Biol. Chem. 280 (2005) 9937-9945
2. Cao Z., Umek R.M., and McKnight S.L. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5 (1991) 1538-1552
3. Chen X., Johns D.C., Geiman D.E., Marban E., Dang D.T., Hamlin G., Sun R., and Yang V.W. Krüppel-like factor 4 (gut-enriched Krüppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle. J. Biol. Chem. 276 (2001) 30423-30428
4. Chen X., Whitney E.M., Gao S.Y., and Yang V.W. Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. J. Mol. Biol. 326 (2003) 665-677
5. Chen Z., Torrens J.I., Anand A., Spiegelman B.M., and Friedman J. Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metab. 1 (2005) 93-106
6. Dou Y., Milne T., Tackett A., Smith E., Fukuda A., Wysocka J., Allis C., Chait B., Hess J., and Roeder R. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell 121 (2005) 873-885
7. Farmer S.R. Transcriptional control of adipocyte formation. Cell Metab. 4 (2006) 263-273
8. Feinberg M.W., Cao Z., Wara A.K., Lebedeva M.A., Senbanerjee S., and Jain M.K. Krüppel-like factor 4 is a mediator of proinflammatory signaling in macrophages. J. Biol. Chem. 280 (2005) 38247-38258
9. Friedman J.M. Modern science versus the stigma of obesity. Nat. Med. 10 (2004) 563-569
10. Garrett-Sinha L.A., Eberspecher H., Seldin M.F., and de Crombrugghe B. A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J. Biol. Chem. 271 (1996) 31384-31390
11. Ghaleb A.M., Nandan M.O., Chanchevalap S., Dalton W.B., Hisamuddin I.M., and Yang V.W. Kruppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Cell Res. 15 (2005) 92-96
12. Green H., and Meuth M. An established pre-adipose cell line and its differentiation in culture. Cell 3 (1975) 127-133
13. Jones J.R., Barrick C., Kim K.A., Linder J., Blondeau B., Fujimoto Y., Shiota M., Kesterson R.A., Kahn B.B., and Magnuson M.A. Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc. Natl. Acad. Sci. USA 102 (2005) 6207-6212
14. Lane M.D., Tang Q.Q., and Jiang M.S. Role of the CCAAT enhancer binding proteins in adipocyte differentiation. Biochem. Biophys. Res. Commun. 266 (1999) 677-683
15. Li D., Yea S., Li S., Chen Z., Narla G., Banck M., Laborda J., Tan S., Friedman J.M., Friedman S.L., and Walsh M.J. Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1. J. Biol. Chem. 280 (2005) 26941-26952
16. Mori T., Sakaue H., Iguchi H., Gomi H., Okada Y., Takashima Y., Nakamura K., Nakamura T., Yamauchi T., Kubota N., et al. Role of Krüppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J. Biol. Chem. 280 (2005) 12867-12875
17. Morlon A., and Sassone-Corsi P. The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1. Proc. Natl. Acad. Sci. USA 100 (2003) 3977-3982
18. Oishi Y., Manabe I., Tobe K., Tsushima K., Shindo T., Fujiu K., Nishimura G., Maemura K., Yamauchi T., Kubota N., et al. Krüppel-like transcription factor KLF5 is key regulator of adipocyte differentiation. Cell Metab. 1 (2005) 27-39
19. Reusch J.E., Colton L.A., and Klemm D.J. CREB activation induces adipogenesis in 3T3-L1 cells. Mol. Cell. Biol. 20 (2000) 1008-1020
20. Rosen E.D., Hsu C.H., Wang X., Sakai S., Freeman M.W., Gonzalez F.J., and Spiegelman B.M. C/EBPα induces adipogenesis through PPARγ: a unified pathway. Genes Dev. 16 (2002) 22-26
21. Segre J.A., Bauer C., and Fuchs E. Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat. Genet. 22 (1999) 356-360
22. Shields J.M., Christy R.J., and Yang V.W. Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J. Biol. Chem. 271 (1996) 20009-20017
23. Soukas A., Socci N.D., Saatkamp B., Novelli S., and Friedman J.M. Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J. Biol. Chem. 276 (2001) 34167-34174
24. Stanger B.Z., Tanaka A.J., and Melton D.A. Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature 445 (2007) 886-891
25. Takahashi K., and Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126 (2006) 663-676
26. Tontonoz P., Hu E., and Spiegelman B.M. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 79 (1994) 1147-1156
27. Wu Z., Xie Y., Bucher N.L., and Farmer S.R. Conditional ectopic expression of C/EBPβ in NIH-3T3 cells induces PPARγ and stimulates adipogenesis. Genes Dev. 9 (1995) 2350-2363
28. Yeh W.C., Cao Z., Classon M., and McKnight S.L. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 9 (1995) 168-181
29. Yoon H.S., Chen X., and Yang V.W. Krüppel-like factor 4 mediates p53-dependent G1/S cell arrest in response to DNA damage. J. Biol. Chem. 278 (2003) 2101-2105
30. Zhang J.-W., Klemm D.J., Vinson C., and Lane M.D. Role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein β gene during adipogenesis. J. Biol. Chem. 279 (2004) 4471-4478