Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA polymerases

Journal of Biological Chemistry

Volumn 287, Issue 42, 2012, Pages 35516-35526

  Zhao, Linlin ^a   Pence, Matthew G ^a   Christov, Plamen P ^a   Wawrzak, Zdzislaw ^b   Choi, Jeong Yun ^c   Rizzo, Carmelo J ^a   Egli, Martin ^a   Guengerich, F Peter ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BASE PAIRING; BASE PAIRS; DNA ADDUCTS; DNA POLYMERASE; ENDOGENOUS PROCESS; GLYCOSIDIC BOND; HUMAN CARCINOGEN; HUMAN DNA POLYMERASE; LIPID PEROXIDATION; LOWER FREQUENCIES; PRIMER EXTENSION; RELATIVE EFFICIENCY; STEADY-STATE KINETICS; VINYL CHLORIDES; VINYL MONOMERS;

CHLORINE COMPOUNDS; HYDROGEN BONDS; OLIGONUCLEOTIDES;

DNA;

DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE ETA; DNA DIRECTED DNA POLYMERASE KAPPA; GUANINE DERIVATIVE; GUANOSINE DERIVATIVE; HYDROGEN; N2,3 ETHENOGUANINE; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; BASE MISPAIRING; CATALYSIS; CRYSTAL STRUCTURE; DNA ADDUCT; ENZYME KINETICS; ENZYME STRUCTURE; GENETIC CODE; HYDROGEN BOND; MUTAGENICITY; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROTEIN FAMILY; STEADY STATE; STRUCTURAL HOMOLOGY;

CELL-FREE SYSTEM; DNA ADDUCTS; DNA POLYMERASE BETA; DNA-DIRECTED DNA POLYMERASE; GUANINE; HUMANS; NUCLEAR PROTEINS; NUCLEOTIDYLTRANSFERASES;

EID: 84867415130     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.403253     Document Type: Article

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