Synthetic Lethal Interactions between EGFR and PARP Inhibition in Human Triple Negative Breast Cancer Cells

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Nowsheen, Somaira ^a   Cooper, Tiffiny ^a   Stanley, Jennifer A ^a   Yang, Eddy S ^a,b  

^a UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; DOUBLE STRANDED DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; LAPATINIB; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; VELIPARIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MONOTHERAPY; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RECOMBINATION REPAIR; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; TRIPLE NEGATIVE BREAST CANCER;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BENZIMIDAZOLES; BRCA1 PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; DNA BREAKS, DOUBLE-STRANDED; DRUG SYNERGISM; FEMALE; HUMANS; MICE; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN BINDING; PROTEIN TRANSPORT; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; RECOMBINATIONAL DNA REPAIR; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84867409347     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046614     Document Type: Article

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