Nuclear depletion of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1) is an indicator of energy disruption in neurons

Free Radical Biology and Medicine

Volumn 53, Issue 9, 2012, Pages 1782-1790

  Singh, Shilpee ^a   Englander, Ella W ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Ape1; ATP; Base excision repair; DNA damage; Ischemia; Mitochondrial respiration; Neuron

Indexed keywords

ADENOSINE TRIPHOSPHATE; APURINIC APYRIMIDINIC ENDONUCLEASE 1; DNA GLYCOSYLTRANSFERASE; HISTONE H2AX; HYDROGEN PEROXIDE; OLIGOMYCIN; REDOX EFFECTOR FACTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CELL; BRAIN ISCHEMIA; BRAIN REGION; CELL COMPARTMENTALIZATION; CELL SURVIVAL; CELL TYPE; CEREBROVASCULAR ACCIDENT; CHROMATIN; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EMBRYO; ENERGY BALANCE; ENZYME MECHANISM; EXCISION REPAIR; IN VIVO STUDY; MITOCHONDRIAL RESPIRATION; MITOSIS; MOUSE; NERVE CELL NECROSIS; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL NUCLEUS; CELLS, CULTURED; DNA DAMAGE; DNA LIGASES; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DNA-BINDING PROTEINS; ENERGY METABOLISM; HYDROGEN PEROXIDE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; NEURONS; OLIGOMYCINS; OXIDANTS; OXYGEN CONSUMPTION; PROTEIN TRANSPORT;

EID: 84867402556     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.07.025     Document Type: Article

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