Nuclear Retention Prevents Premature Cytoplasmic Appearance of mRNA

Molecular Cell

Volumn 48, Issue 1, 2012, Pages 145-152

  Kallehauge, Thomas Beuchert ^a,b   Robert, Marie Cécile ^b   Bertrand, Edouard ^b   Jensen, Torben Heick ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; HEAT SHOCK PROTEIN 104; MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; NONHUMAN; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RNA ANALYSIS; RNA TRANSLATION; RNA TRANSPORT;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENOSINE TRIPHOSPHATASES; CELL NUCLEUS; CYTOPLASM; EXOSOME MULTIENZYME RIBONUCLEASE COMPLEX; GENES, FUNGAL; HEAT-SHOCK PROTEINS; MUTATION; RNA, FUNGAL; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84867400842     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.07.022     Document Type: Article

References (43)

1. Assenholt J., Mouaikel J., Andersen K.R., Brodersen D.E., Libri D., Jensen T.H. Exonucleolysis is required for nuclear mRNA quality control in yeast THO mutants. RNA 2008, 14:2305-2313.
2. Blake W.J., Balazsi G., Kohanski M.A., Isaacs F.J., Murphy K.F., Kuang Y., Cantor C.R., Walt D.R., Collins J.J. Phenotypic consequences of promoter-mediated transcriptional noise. Mol. Cell 2006, 24:853-865.
3. Chubb J.R., Trcek T., Shenoy S.M., Singer R.H. Transcriptional pulsing of a developmental gene. Curr. Biol. 2006, 16:1018-1025.
4. Dias A.P., Dufu K., Lei H., Reed R. A role for TREX components in the release of spliced mRNA from nuclear speckle domains. Nat. Commun. 2010, 1:97.
5. Dower K., Kuperwasser N., Merrikh H., Rosbash M. A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcript. RNA 2004, 10:1888-1899.
6. Dunn E.F., Hammell C.M., Hodge C.A., Cole C.N. Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export. Genes Dev. 2005, 19:90-103.
7. Femino A.M., Fay F.S., Fogarty K., Singer R.H. Visualization of single RNA transcripts in situ. Science 1998, 280:585-590.
8. Fox A.H., Lamond A.I. Paraspeckles. Cold Spring Harb. Perspect. Biol. 2010, 2:a000687.
9. Gonzalez-Aguilera C., Tous C., Gomez-Gonzalez B., Huertas P., Luna R., Aguilera A. The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability. Mol. Biol. Cell 2008, 19:4310-4318.
10. Gwizdek C., Iglesias N., Rodriguez M.S., Ossareh-Nazari B., Hobeika M., Divita G., Stutz F., Dargemont C. Ubiquitin-associated domain of Mex67 synchronizes recruitment of the mRNA export machinery with transcription. Proc. Natl. Acad. Sci. USA 2006, 103:16376-16381.
11. Hilleren P., Parker R. Defects in the mRNA export factors Rat7p, Gle1p, Mex67p, and Rat8p cause hyperadenylation during 3'-end formation of nascent transcripts. RNA 2001, 7:753-764.
12. Hilleren P., McCarthy T., Rosbash M., Parker R., Jensen T.H. Quality control of mRNA 3'-end processing is linked to the nuclear exosome. Nature 2001, 413:538-542.
13. Jensen T.H., Boulay J., Rosbash M., Libri D. The DECD box putative ATPase Sub2p is an early mRNA export factor. Curr. Biol. 2001, 11:1711-1715.
14. Jensen T.H., Patricio K., McCarthy T., Rosbash M. A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription. Mol. Cell 2001, 7:887-898.
15. Jensen T.H., Boulay J., Olesen J.R., Colin J., Weyler M., Libri D. Modulation of transcription affects mRNP quality. Mol. Cell 2004, 16:235-244.
16. Jimeno S., Rondon A.G., Luna R., Aguilera A. The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability. EMBO J. 2002, 21:3526-3535.
17. Jimeno S., Tous C., Garcia-Rubio M.L., Ranes M., Gonzalez-Aguilera C., Marin A., Aguilera A. New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation. Mol. Cell. Biol. 2011, 31:674-685.
18. Johnson S.A., Kim H., Erickson B., Bentley D.L. The export factor Yra1 modulates mRNA 3' end processing. Nat. Struct. Mol. Biol. 2011, 18:1164-1171.
19. Juge F., Zaessinger S., Temme C., Wahle E., Simonelig M. Control of poly(A) polymerase level is essential to cytoplasmic polyadenylation and early development in Drosophila. EMBO J. 2002, 21:6603-6613.
20. Kaiser T.E., Intine R.V., Dundr M. De novo formation of a subnuclear body. Science 2008, 322:1713-1717.
21. Libri D., Dower K., Boulay J., Thomsen R., Rosbash M., Jensen T.H. Interactions between mRNA export commitment, 3'-end quality control, and nuclear degradation. Mol. Cell. Biol. 2002, 22:8254-8266.
22. Mao Y.S., Zhang B., Spector D.L. Biogenesis and function of nuclear bodies. Trends Genet. 2011, 27:295-306.
23. Prasanth K.V., Prasanth S.G., Xuan Z., Hearn S., Freier S.M., Bennett C.F., Zhang M.Q., Spector D.L. Regulating gene expression through RNA nuclear retention. Cell 2005, 123:249-263.
24. Qu X., Lykke-Andersen S., Nasser T., Saguez C., Bertrand E., Jensen T.H., Moore C. Assembly of an export-competent mRNP is needed for efficient release of the 3'-end processing complex after polyadenylation. Mol. Cell. Biol. 2009, 29:5327-5338.
25. Rougemaille M., Gudipati R.K., Olesen J.R., Thomsen R., Seraphin B., Libri D., Jensen T.H. Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants. EMBO J. 2007, 26:2317-2326.
26. Rougemaille M., Dieppois G., Kisseleva-Romanova E., Gudipati R.K., Lemoine S., Blugeon C., Boulay J., Jensen T.H., Stutz F., Devaux F., et al. THO/Sub2p functions to coordinate 3'-end processing with gene-nuclear pore association. Cell 2008, 135:308-321.
27. Saguez C., Schmid M., Olesen J.R., Ghazy M.A., Qu X., Poulsen M.B., Nasser T., Moore C., Jensen T.H. Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation. Mol. Cell 2008, 31:91-103.
28. Segref A., Sharma K., Doye V., Hellwig A., Huber J., Luhrmann R., Hurt E. Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. EMBO J. 1997, 16:3256-3271.
29. Shevtsov S.P., Dundr M. Nucleation of nuclear bodies by RNA. Nat. Cell Biol. 2011, 13:167-173.
30. Spector D.L., Lamond A.I. Nuclear speckles. Cold Spring Harb. Perspect. Biol. 2011, 3:a000646.
31. Strasser K., Hurt E. Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export. EMBO J. 2000, 19:410-420.
32. Strasser K., Hurt E. Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p. Nature 2001, 413:648-652.
33. Strasser K., Masuda S., Mason P., Pfannstiel J., Oppizzi M., Rodriguez-Navarro S., Rondon A.G., Aguilera A., Struhl K., Reed R., et al. TREX is a conserved complex coupling transcription with messenger RNA export. Nature 2002, 417:304-308.
34. Stutz F., Kantor J., Zhang D., McCarthy T., Neville M., Rosbash M. The yeast nucleoporin rip1p contributes to multiple export pathways with no essential role for its FG-repeat region. Genes Dev. 1997, 11:2857-2868.
35. Stutz F., Bachi A., Doerks T., Braun I.C., Seraphin B., Wilm M., Bork P., Izaurralde E. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. RNA 2000, 6:638-650.
36. Thomsen R., Libri D., Boulay J., Rosbash M., Jensen T.H. Localization of nuclear retained mRNAs in Saccharomyces cerevisiae. RNA 2003, 9:1049-1057.
37. Thomsen R., Saguez C., Nasser T., Jensen T.H. General, rapid, and transcription-dependent fragmentation of nucleolar antigens in S. cerevisiae mRNA export mutants. RNA 2008, 14:706-716.
38. Tutucci E., Stutz F. Keeping mRNPs in check during assembly and nuclear export. Nat. Rev. Mol. Cell Biol. 2011, 12:377-384.
39. Vainberg I.E., Dower K., Rosbash M. Nuclear export of heat shock and non-heat-shock mRNA occurs via similar pathways. Mol. Cell. Biol. 2000, 20:3996-4005.
40. Vodala S., Abruzzi K.C., Rosbash M. The nuclear exosome and adenylation regulate posttranscriptional tethering of yeast GAL genes to the nuclear periphery. Mol. Cell 2008, 31:104-113.
41. Zenklusen D., Vinciguerra P., Strahm Y., Stutz F. The yeast hnRNP-Like proteins Yra1p and Yra2p participate in mRNA export through interaction with Mex67p. Mol. Cell. Biol. 2001, 21:4219-4232.
42. Zenklusen D., Vinciguerra P., Wyss J.C., Stutz F. Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Mol. Cell. Biol. 2002, 22:8241-8253.
43. Zenklusen D., Larson D.R., Singer R.H. Single-RNA counting reveals alternative modes of gene expression in yeast. Nat. Struct. Mol. Biol. 2008, 15:1263-1271.