Increase of INS-1 cell apoptosis under glucose fluctuation and the involvement of FOXO-SIRT pathway

Diabetes Research and Clinical Practice

Volumn 98, Issue 1, 2012, Pages 132-139

  Kim, Mikyung ^a   Chung, Hyesuk ^a   Yoon, Changsin ^a   Lee, Eunju ^a   Kim, Taenyun ^a   Kim, Taekyoon ^a   Kwon, Minjeong ^a   Lee, Soonhee ^a   Rhee, Byoungdoo ^a   Park, Jeonghyun ^a  

^a Inje University   (South Korea)

Author keywords

Apoptosis; FOXO; Glucose variability; INS cell; SIRT

Indexed keywords

CASPASE 3; EPIDERMAL GROWTH FACTOR; GLUCOSE; NICOTINAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN BCL 2; SIRTUIN; TRANSCRIPTION FACTOR FOXO; TRICHOSTATIN A; WORTMANNIN;

ACETYLATION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DEACETYLATION; FOXO SIRT SIGNALING PATHWAY; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; INTERMITTENT HIGH GLUCOSE; METABOLIC PARAMETERS; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUSTAINED HIGH GLUCOSE;

ACETYLATION; ANIMALS; APOPTOSIS; CELL SURVIVAL; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; PHOSPHORYLATION; RATS; SIRTUIN 1; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84867395442     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2012.04.013     Document Type: Article

References (35)

1. The Diabetes Control Complications Trial Research Group The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993, 329(14):977-986.
2. UK Prospective Diabetes Study (UKPDS) Group Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998, 352(9131):837-853.
3. Stettler C., Allemann S., Juni P., Cull C.A., Holman R.R., Egger M., et al. Glycemic control and macrovascular disease in types 1 and 2 diabetes mellitus: meta-analysis of randomized trials. Am Heart J 2006, 152(1):27-38.
4. Cavalot F., Petrelli A., Traversa M., Bonomo K., Fiora E., Conti M., et al. Postprandial blood glucose is a stronger predictor of cardiovascular events than fasting blood glucose in type 2 diabetes mellitus, particularly in women: lessons from the San Luigi Gonzaga Diabetes Study. J Clin Endocrinol Metab 2006, 91(3):813-819.
5. Shiraiwa T., Kaneto H., Miyatsuka T., Kato K., Yamamoto K., Kawashima A., et al. Postprandial hyperglycemia is a better predictor of the progression of diabetic retinopathy than HbA1c in Japanese type 2 diabetic patients. Diabetes Care 2005, 28(11):2806-2807.
6. Ceriello A. Postprandial hyperglycemia and diabetes complications: is it time to treat?. Diabetes 2005, 54(1):1-7.
7. Quagliaro L., Piconi L., Assaloni R., Martinelli L., Motz E., Ceriello A. Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes 2003, 52(11):2795-2804.
8. Quagliaro L., Piconi L., Assaloni R., Da Ros R., Maier A., Zuodar G., et al. Intermittent high glucose enhances ICAM-1 VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production. Atherosclerosis 2005, 183(2):259-267.
9. Azuma K., Kawamori R., Toyofuku Y., Kitahara Y., Sato F., Shimizu T., et al. Repetitive fluctuations in blood glucose enhance monocyte adhesion to the endothelium of rat thoracic aorta. Arterioscler Thromb Vasc Biol 2006, 26(10):2275-2280.
10. Otsuka A., Azuma K., Iesaki T., Sato F., Hirose T., Shimizu T., et al. Temporary hyperglycaemia provokes monocyte adhesion to endothelial cells in rat thoracic aorta. Diabetologia 2005, 48(12):2667-2674.
11. Murata G.H., Duckworth W.C., Shah J.H., Wendel C.S., Hoffman R.M. Sources of glucose variability in insulin-treated type 2 diabetes: the Diabetes Outcomes in Veterans Study (DOVES). Clin Endocrinol (Oxf) 2004, 60(4):451-456.
12. Hou Z.Q., Li H.L., Gao L., Pan L., Zhao J.J., Li G.W. Involvement of chronic stresses in rat islet and INS-1 cell glucotoxicity induced by intermittent high glucose. Mol Cell Endocrinol 2008, 291(1-2):71-78.
13. Kohnert K.D., Augstein P., Zander E., Heinke P., Peterson K., Freyse E.J., et al. Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents. Diabetes Care 2009, 32(6):1058-1062.
14. Ceriello A., Esposito K., Piconi L., Ihnat M.A., Thorpe J.E., Testa R., et al. Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes 2008, 57(5):1349-1354.
15. Hodgkinson A.D., Bartlett T., Oates P.J., Millward B.A., Demaine A.G. The response of antioxidant genes to hyperglycemia is abnormal in patients with type 1 diabetes and diabetic nephropathy. Diabetes 2003, 52(3):846-851.
16. Greer E.L., Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 2005, 24(50):7410-7425.
17. Kitamura Y.I.K., Kruse J.P., Raum J.C., Stein R., Gu W., Accili D. FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab 2005, 2(September (3)):153-163.
18. Kitamura T., Nakae J., Kitamura Y., Kido Y., Biggs W.H., Wright C.V., et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 2002, 110(12):1839-1847.
19. Nakae J., Biggs W.H., Kitamura T., Cavenee W.K., Wright C.V., Arden K.C., et al. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet 2002, 32(2):245-253.
20. Brunet A.S., Sturgill L.B., Chua J.F., Greer K.F., Lin P.L., Tran Y.H., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004, 303(5666):2011-2015.
21. Daitoku H.H.M., Matsuzaki H., Aratani S., Ohshima T., Miyagishi M., Nakajima T., et al. Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A 2004, 101(27):10042-10047.
22. van der Horst A., de Vries-Smits L.M., Frye R.A., Medema R.H., Burgering B.M. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem 2004, 279(July (28)):28873-28879.
23. DECODE study group, the European Diabetes Epidemiology Group Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-h diagnostic criteria. Arch Intern Med 2001, 161(3):397-405.
24. Nakagami T., Qiao Q., Tuomilehto J., Balkau B., Tajima N., Hu G., et al. Screen-detected diabetes, hypertension and hypercholesterolemia as predictors of cardiovascular mortality in five populations of Asian origin: the DECODA study. Eur J Cardiovasc Prev Rehabil 2006, 13(4):555-561.
25. Meigs J.B., Nathan D.M., D'Agostino R.B., Wilson P.W. Fasting and postchallenge glycemia and cardiovascular disease risk: the Framingham Offspring Study. Diabetes Care 2002, 25(10):1845-1850.
26. Glauser D.A., Schlegel W. The emerging role of FOXO transcription factors in pancreatic beta cells. J Endocrinol 2007, 193(2):195-207.
27. Trumper K., Trumper A., Trusheim H., Arnold R., Goke B., Horsch D. Integrative mitogenic role of protein kinase B/Akt in beta-cells. Ann N Y Acad Sci 2000, 921:242-250.
28. Wrede C.E., Dickson L.M., Lingohr M.K., Briaud I., Rhodes C.J. Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem 2002, 277(51):49676-49684.
29. Buteau J., Spatz M.L., Accili D. Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. Diabetes 2006, 55(5):1190-1196.
30. Burgering B.M., Medema R.H. Decisions on life and death: FOXO forkhead transcription factors are in command when PKB/Akt is off duty. J Leukoc Biol 2003, 73(6):689-701.
31. Accili D., Arden K.C. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 2004, 117(4):421-426.
32. Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., et al. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 1999, 96(6):857-868.
33. Brunet A., Sweeney L.B., Sturgill J.F., Chua K.F., Greer P.L., Lin Y., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004, 303(5666):2011-2015.
34. Motta M.C., Divecha N., Lemieux M., Kamel C., Chen D., Gu W., et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 2004, 116(4):551-563.
35. van der Horst A., Tertoolen L.G., de Vries-Smits L.M., Frye R.A., Medema R.H., Burgering B.M. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem 2004, 279(28):28873-28879.