Attentional bias to negative information and 5-HTTLPR genotype interactively predict students' emotional reactivity to first university semester

Emotion

Volumn 12, Issue 3, 2012, Pages 460-469

  Osinsky, Roman ^a   Lösch, Alea ^b   Hennig, Juergen ^c   Alexander, Nina ^d   MacLeod, Colin ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

5 HTTLPR; Anxiety; Attentional bias; Dysphoria; Emotional vulnerability

Indexed keywords

5 HTTLPR PROTEIN; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG; SLC6A4 PROTEIN, HUMAN;

ADOLESCENT; ANXIETY; ARTICLE; CHEEK; DYSPHORIA; EMOTIONALITY; ENVIRONMENTAL STRESS; FEMALE; GEL ELECTROPHORESIS; GENETIC MARKER; GENOTYPING TECHNIQUE; HUMAN; MALE; POLYMERASE CHAIN REACTION; QUESTIONNAIRE; UNIVERSITY STUDENT; ALLELE; ATTENTION; EMOTION; GENETICS; GENOTYPE; HOMOZYGOTE; LIFE EVENT; MENTAL STRESS; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; STUDENT;

ADOLESCENT; ALLELES; ANXIETY; ATTENTION; EMOTIONS; FEMALE; GENOTYPE; HOMOZYGOTE; HUMANS; LIFE CHANGE EVENTS; MALE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS, PSYCHOLOGICAL; STUDENTS;

EID: 84867394550     PISSN: 15283542     EISSN: 19311516     Source Type: Journal    
DOI: 10.1037/a0026674     Document Type: Article

References (75)

1. Aiken, L. S., & West, S. G. (1991). Multiple regression: Testing and interpreting interactions. Newbury Park, CA: Sage.
2. Alexander, N., Küpper, Y., Schmitz, A., Osinsky, R., Kozyra, E., & Hennig, J. (2009). Gene-environment interactions predict cortisol responses after acute stress: Implications for the etiology of depression. Psychoneuroendocrinology, 34, 1294-1303. doi:10.1016/j.psyneuen .2009.03.017
3. Amir, N., Weber, G., Beard, C., Bomyea, J., & Taylor, C. T. (2008). The effect of a single-session attention modification program on response to a public-speaking challenge in socially anxious individuals. Journal of Abnormal Psychology, 117, 860-868. doi:10.1037/a0013445
4. Bar-Haim, Y., Lamy, D., Pergamin, L., Bakermans-Kranenburg, M., & van IJzendoorn, M. (2007). Threat-related attentional bias in anxious and nonanxious individuals: A meta-analytic study. Psychological Bulletin, 133, 1. doi:10.1037/0033-2909.133.1.1
5. Baron, R. M., & Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51, 1173-1182. doi:10.1037/0022-3514.51.6.1173
6. Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Manual for the Beck Depression Inventory-II. San Antonio, TX: Psychological Corporation.
7. Beck, A. T. (2008). The evolution of the cognitive model of depression and its neurobiological correlates. American Journal of Psychiatry, 165, 969-977. doi:10.1176/appi.ajp.2008.08050721
8. Beevers, C., Gibb, B., McGeary, J., & Miller, I. (2007). Serotonin transporter genetic variation and biased attention for emotional word stimuli among psychiatric inpatients. Journal of Abnormal Psychology, 116, 208-212. doi:10.1037/0021-843X.116.1.208
9. Beevers, C., Pacheco, J., Clasen, P., McGeary, J., & Schnyer, D. (2010). Prefrontal morphology, 5 HTTLPR polymorphism and biased attention for emotional stimuli. Genes, Brain and Behavior, 9, 224-233. doi: 10.1111/j.1601-183X.2009.00550.x
10. Beevers, C., Wells, T., Ellis, A., & McGeary, J. (2009). Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli. Journal of Abnormal Psychology, 118, 670-681. doi:10.1037/a0016198
11. Beevers, C. G., & Carver, C. S. (2003). Attentional bias and mood pesistence as prospective predictors of dysphoria. Cognitive Therapy and Research, 27, 619-637. doi:10.1023/A:1026347610928
12. Beevers, C. G., Ellis, A. J., Wells, T. T., & McGeary, J. E. (2010). Serotonin transporter gene promoter region polymorphism and selective processing of emotional images. Biological Psychology, 83, 260-265. doi:10.1016/j.biopsycho.2009.08.007
13. Canli, T., & Lesch, K. (2007). Long story short: The serotonin transporter in emotion regulation and social cognition. Nature Neuroscience, 10, 1103-1109. doi:10.1038/nn1964
14. Canli, T., Omura, K., Haas, B. W., Fallgatter, A., Constable, R. T., & Lesch, K. P. (2005). Beyond affect: A role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proceedings of the National Academy of Sciences, USA, 102, 12224-12229. doi:10.1073/pnas.0503880102
15. Caspi, A., Hariri, A., Holmes, A., Uher, R., & Moffitt, T. (2010). Genetic sensitivity to the environment: The case of the serotonin transporter gene and its implications for studying complex diseases and traits. American Journal of Psychiatry, 167, 509. doi:10.1176/appi.ajp.2010.09101452
16. Caspi, A., Sugden, K., Moffitt, T., Taylor, A., Craig, I., Harrington, H.,Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386. doi:10.1126/ science.1083968
17. Cavanagh, S. R., Urry, H. L., & Shin, L. M. (2011). Mood-induced shifts in attentional bias to emotional information predict illand well-being. Emotion, 11, 241-248. doi:10.1037/a0022572
18. Cisler, J. M., Bacon, A. K., & Williams. N. L. (2009). Phenomenological characteristics of attentional biases towards threat: A critical review. Cognitive Therapy and Research, 33, 221-234. doi:10.1007/s10608007-9161-y
19. Cisler, J. M., & Koster, E. (2010). Mechanisms of attentional biases towards threat in anxiety disorders: An integrative review. Clinical Psychology Review, 30, 203-216. doi:10.1016/j.cpr.2009.11.003
20. Clarke, P., MacLeod, C., & Shirazee, N. (2008). Prepared for the worst: Readiness to acquire threat bias and susceptibility to elevate trait anxiety. Emotion, 8, 47-57. doi:10.1037/1528-3542.8.1.47
21. Covault, J., Tennen, H., Armeli, S., Conner, T., Herman, A., Cillessen, A., & Kanzler, H. R. (2007). Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use. Biological Psychiatry, 61, 609-616. doi: 10.1016/j.biopsych.2006.05.018
22. Dandeneau, S. D., Baldwin, M. W., Baccus, J. R., Sakellaropoulo, M., & Pruessner, J. C. (2007). Cutting stress off at the pass: Reducing vigilance and responsiveness to social threat by manipulating attention. Journal of Personality and Social Psychology, 93, 651-666. doi:10.1037/00223514.93.4.651
23. De Raedt, R., & Koster, E. H. W. (2010). Understanding vulnerability for depression from a cognitive neuroscience perspective: A reappraisal of attentional factors and a new conceptual framework. Cognitive, Affective, & Behavioral Neuroscience, 10, 50-70. doi:10.3758/CABN.10.1.50
24. Eley, T. C., Hudson, J. L., Creswell, C., Tropeano, M., Lester, K. J., Cooper, P.,Collier, D. A. (2011). Therapygenetics: The 5HTTLPR and response to psychological therapy. Molecular Psychiatry. doi: 10.1038/mp.2011.132
25. Ellenbogen, M. A., Carson, R. J., & Pishva, R. (2010). Automatic emotional information processing and the cortisol response to acute psychosocial stress. Cognitive, Affective, & Behavioral Neuroscience, 10, 71-82. doi:10.3758/CABN.10.1.71
26. Firk, C., & Markus, C. (2007). Review: Serotonin by stress interaction: A susceptibility factor for the development of depression? Journal of Psychopharmacology, 21, 538. doi:10.1177/0269881106075588
27. Fox, E., Cahill, S., & Zougkou, K. (2010). Preconscious processing biases predict emotional reactivity to stress. Biological Psychiatry, 67, 371-377. doi:10.1016/j.biopsych.2009.11.018
28. Fox, E., Ridgewell, A., & Ashwin, C. (2009). Looking on the bright side: Biased attention and the human serotonin transporter gene. Proceedings of the Royal Society B: Biological Sciences, 276, 1747-1751. doi: 10.1098/rspb.2008.1788
29. Fox, E., Russo, R., Bowles, R., & Dutton, K. (2001). Do threatening stimuli draw or hold visual attention in subclinical anxiety? Journal of Experimental Psychology General, 130, 681-700. doi:10.1037/00963445.130.4.681
30. Fox, E., Zougkou, K., Ridgewell, A., & Garner, K. (2011). The serotonin transporter gene alters sensitivity to attention bias modification: Evidence for a plasticity gene. Biological Psychiatry, 70, 1049-1054. doi:10.1016/j.biopsych.2011.07.004
31. Gotlib, I. H., Joormann, J., Minor, K., & Hallmayer, J. (2008). HPA axis reactivity: A mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biological Psychiatry, 63, 847-851. doi:10.1016/j.biopsych.2007.10.008
32. Gotlib, I. H., & Joormann, J. (2010). Cognition aand depression: Current status and future directions. Annual Review of Clinical Psychology, 6, 285-312. doi:10.1146/annurev.clinpsy.121208.131305
33. Gunthert, K., Conner, T., Armeli, S., Tennen, H., Covault, J., & Kranzler, H. (2007). Serotonin transporter gene polymorphism (5-HTTLPR) and anxiety reactivity in daily life: A daily process approach to geneenvironment interaction. Psychosomatic Medicine, 69, 762-768. doi: 10.1097/PSY.0b013e318157ad42
34. Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996). Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry, 66, 2621-2624. doi: 10.1046/j.1471-4159.1996.66062621.x
35. Heinz, A., Jones, D., Mazzanti, C., Goldman, D., Ragan, P., Hommer, D.,Weinberger, D. R. (2000). A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biological Psychiatry, 47, 643-649. doi:10.1016/S00063223(99)00171-7
36. Jacobson, N. S., & Truax, P. (1991). Clinical significance: A statistical approach to defining meaningful change in psychotherapy research. Journal of Consulting and Clinical Psychology, 59, 12-19. doi:10.1037/0022-006X.59.1.12
37. Jans, L. A., Riedel, W. J., Markus, C. R., & Blokland, A. (2007). Serotonergic vulnerability and depression: Assumptions, experimental evidence and implications. Molecular Psychiatry, 12, 522-543. doi: 10.1038/sj.mp.4001920
38. Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2010). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression metaanalysis revisited: Evidence of genetic moderation. Archives of General Psychiatry, 68, 444-454. doi:10.1001/archgenpsychiatry.2010.189
39. Kaufman, J., Yang, B., Douglas-Palumberi, H., Crouse-Artus, M., Lipschitz, D., Krystal, J., & Gelernter, J. (2007). Genetic and environmental predictors of early alcohol use. Biological Psychiatry, 61, 1228-1234. doi:10.1016/j.biopsych.2006.06.039
40. Kilpatrick, D., Koenen, K., Ruggiero, K., Acierno, R., Galea, S., Resnick, H.,Gelernter, J. (2007). The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults. American Journal of Psychiatry, 164, 1693. doi:10.1176/appi.ajp.2007.06122007
41. Koster, E. H. W., Crombez, G., Verschuere, B., & De Houwer, J. (2004). Selective attention to threat in the dot probe paradigm: Differentiating vigilance and difficulty to disengage. Behavior Research and Therapy, 42, 1183-1192. doi:10.1016/j.brat.2003.08.001
42. Kucera, H., & Francis, W. N. (1967). Computational analysis of present day American English. Providence, MA: Boston University Press.
43. Lee, A. C., Watson, D., & Mineka, S. (1994). Temperament, personality, and the mood and anxiety disorders. Journal of Abnormal Psychology, 103, 103-116. doi:10.1037/0021-843X.103.1.103
44. Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, E. D., Petri, S.,Murphy, D. L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 152-1531. doi:10.1126/science.274.5292.1527
45. Lim, J. E., Papp, A., Pinsonneault, J., Sadée, W., & Saffen, D. (2006). Allelic expression of serotonin transporter (SERT) mRNA in human pons: Lack of correlation with the polymorphism SERTLPR. Molecular Psychiatry, 11, 649-662. doi:10.1038/sj.mp.4001797
46. Lonsdorf, T. B., Rück, C., Bergström, J., Andersson, G., Öhman, A., Schalling, M., & Lindefors, N. (2009). The symptomatic profile of panic disorder is shaped by the 5-HTTLPR polymorphism. Progress in NeuroPsychopharmacology & Biological Psychiatry, 33, 1479-1483. doi: 10.1016/j.pnpbp.2009.08.004
47. Lowry, C. A., Hale, M. W., Evans, A. K., Heerkens, J., Staub, D. R., Gasser, P. J., & Shekhar, A. (2008). Serotonergic systems, anxiety, and affective disorder: Focus on the dorsomedial part of the dorsal raphe nucleus. Annals of the New York Academy of Sciences, 1148, 86-94. doi:10.1196/annals.1410.004
48. MacLeod, C., & Hagan, R. (1992). Individual differences in the selective processing of threatening information, and emotional responses to a stressful life event. Behavioral Research and Therapy, 30, 151-161. doi:10.1016/0005-7967(92)90138-7
49. MacLeod, C., Mathews, A., & Tata, P. (1986). Attentional bias in emotional disorders. Journal of Abnormal Psychology, 95, 15-20. doi: 10.1037/0021-843X.95.1.15
50. MacLeod, C., Rutherford, E., Campbell, L., Ebsworthy, G., & Holker, L. (2002). Selective attention and emotional vulnerability: Assessing the causal basis of their association through the experimental manipulation of attentional bias. Journal of Abnormal Psychology, 111, 107-123. doi:10.1037/0021-843X.111.1.107
51. Mathews, A., & MacLeod, C. (2005). Cognitive vulnerability to emotional disorders. Clinical Psychology, 1, 167. doi:10.1146/annurev.clinpsy .1.102803.143916
52. Mogg, K., & Bradley, B. P. (2005). Attentional bias in generalized anxiety disorder versus depressive disorder. Cognitive Therapy and Research, 29, 29-45. doi:10.1007/s10608-005-1646-y
53. Munafò, M. R., Brown, S. M., & Hariri, A. R. (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis. Biological Psychiatry, 63, 852-857. doi:10.1016/j.biopsych.2007.08.016
54. Munafò, M. R., Clark, T., & Flint, J. (2005). Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis. Molecular Psychiatry, 10, 415-419. doi:10.1038/sj.mp.4001627
55. Munafò, M. R., Durrant, C., Lewis, G., & Flint, J. (2009). Gene x environment interactions at the serotonin tranporter locus. Biological Psychiatry, 65, 211-219. doi:10.1016/j.biopsych.2008.06.009
56. Murthy, N. V., Selvaraj, S., Cowen, P. J., Bhagwagar, Z., Riedel, W. J., Peers, P.,Grasby, P. M. (2010). Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain. Neuroimage, 52, 50-54. doi:10.1016/j.neuroimage.2010.04.032
57. Osinsky, R., Alexander, N., Schmitz, A., Küpper, Y., Müller, E., Beer, L., Köppe, L., & Hennig, J. (2010). Genetic influences on implicit measures of personality. Journal of Individual Differences, 31, 115-123. doi: 10.1027/1614-0001/a000007
58. Osinsky, R., Reuter, M., Küpper, Y., Schmitz, A., Kozyra, E., Alexander, N., & Hennig, J. (2008). Variation in the serotonin transporter gene modulates selective attention to threat. Emotion, 8, 584-588. doi: 10.1037/a0012826
59. Parsey, R. V., Hastings, R. S., Oquendo, M. A., Hu, X., Goldman, D., Huang, Y. Y.,Mann, J. J. (2006). Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. American Journal of Psychiatry, 163, 48-51. doi:10.1176/appi.ajp.163.1.48
60. Pérez-Edgar, K., Bar-Haim, Y., McDermott, J., Gorodetsky, E., Hodgkinson, C., Goldman, D.,Fox, N. A. (2010). Variations in the serotonintransporter gene are associated with attention bias patterns to positive and negative emotion faces. Biological Psychology, 83, 269-271. doi: 10.1016/j.biopsycho.2009.08.009
61. Pezawas, L., Meyer-Lindenberg, A., Goldman, A. L., Verschinski, B. A., Chen, G., Kolachana, B. S.,Weinberger, D. R. (2008). Evidence of biological epistasis between BDNF and SLC6A4 and implications for depression. Molecular Psychiatry, 13, 709-716. doi:10.1038/mp.2008.32
62. Pilgrim, K., Marin, M. F., & Lupien, S. J. (2010). Attentional orienting toward social stress stimuli predicts increased cortisol responsivity to psychosocial stress irrespective of the early socioeconomic status. Psychoneuroendocrinology, 35, 588-595. doi:10.1016/j.psyneuen.2009.09.015
63. Praschak-Rieder, N., Kennedy, J., Wilson, A. A., Hussey, D., Booveriwala, A., Willeit, M.,Meyer, J. H. (2007). Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: A [(11)C] DASB positron emission tomography study. Biological Psychiatry, 62, 327-331. doi:10.1016/j.biopsych.2006.09.022
64. Rao, H., Gillihan, S. J., Wang, J., Korczykowski, M., Sankoorikal, G. M., Kaercher, K. A.,Farah, M. J. (2007). Genetic variation in serotonin transporter alters resting brain function in healthy individuals. Biological Psychiatry, 62, 600-606. doi:10.1016/j.biopsych.2006.11.028
65. Reimold, M., Smolka, M. N., Schuhmann, G., Zimmer, A., Wrase, J., Mann, K.,Heinz, A. (2007). Midbrain serotonin transporter binding potential measured with [11C]DASB is affected by serotonin transporter genotype. Journal of Neural Transmission, 114, 635-639. doi:10.1007/s00702-006-0609-0
66. Risch, N., Herrell, R., Lehner, T., Liang, K. Y., Eaves, L., Hoh, J.,Merikangas, K. R. (2009). Interaction between the serotonin transporter gene (5-HTTPLR), stressful life events, and risk of depression. A meta analysis. Journal of the American Medical Association, 301, 2462-2471. doi:10.1001/jama.2009.878
67. Schmidt, N. B., Richey, J. A., Buckner, J. D., & Timpano, K. R. (2009). Attention training for generalized social anxiety disorder. Journal of Abnormal Psychology, 118, 5-14. doi:10.1037/a0013643
68. See, J., MacLeod, C., & Bridle, R. (2009). The reduction of anxiety vulnerability through the modification of attentional bias: A real-world study using a home-based cognitive bias modification procedure. Journal of Abnormal Psychology, 118, 65-75. doi:10.1037/a0014377
69. Sen, S., Burmeister, M., & Ghosh, D. (2004). Meta-analysis of the association between a serotonin transporter promoter polymorphism (5HTTLPR) and anxiety-related personality traits. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 127, 85-89. doi: 10.1002/ajmg.b.20158
70. Spielberger, C. D., Gorsuch, R. L., Lushene, R., Vagg, P. R., & Jacobs, G. A. (1983). Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychology Press.
71. Stein, M., Campbell-Sills, L., & Gelernter, J. (2009). Genetic variation in 5HTTLPR is associated with emotional resilience. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150, 900-906. doi:10.1002/ajmg.b.30916
72. Sugden, K., Arseneault, L., Harrington, H., Moffitt, T. E., Williams, B., & Caspi, A. (2010). Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization. Journal of the American Academy of Child & Adolescent Psychiatry, 49, 830-840. doi:10.1016/j.jaac.2010.01.024
73. Thomason, M. E., Henry, M. L., Hamilton, J. P., Joormann, J., Pine, D. S., Ernst, M.,Gotlib, I. H. (2010). Neural and behavioral responses to threatening emotion faces in children as a function of the short allele of the serotonin transporter gene. Biological Psychology, 85, 38-44. doi: 10.1016/j.biopsycho.2010.04.009
74. Way, B., & Taylor, S. (2010). The serotonin transporter promoter polymorphism is associated with cortisol response to psychosocial stress. Biological Psychiatry, 67, 487-492. doi:10.1016/j.biopsych.2009.10.021
75. Williams, J. M., Mathews, A., & MacLeod, C. (1996). The emotional Stroop task and psychopathology. Psychological Bulletin, 120, 3-24. doi:10.1037/0033-2909.120.1.3