CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells

Blood

Volumn 113, Issue 18, 2009, Pages 4309-4318

  Tai, Yu Tzu ^a   Soydan, Ender ^a   Song, Weihua ^a   Fulciniti, Mariateresa ^a   Kim, Kihyun ^a,b   Hong, Fangxin ^c   Li, Xian Feng ^a   Burger, Peter ^a   Rumizen, Matthew J ^a   Nahar, Sabikun ^a   Podar, Klaus ^a   Hideshima, Teru ^a   Munshi, Nikhil C ^a   Tonon, Giovanni ^a,d   Carrasco, Ruben D ^a,e   Afar, Daniel E H ^f   Anderson, Kenneth C ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b Sungkyunkwan University School of Medicine   (South Korea)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d SAN RAFFAELE HOSPITAL   (Italy)

^e HARVARD MEDICAL SCHOOL   (United States)

^f Oncology Programs   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTEGRIN; BETA7 INTEGRIN; CARRIER PROTEINS AND BINDING PROTEINS; CASPASE; ELOTUZUMAB; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCLONAL ANTIBODY; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BIK; PROTEIN BNIP3; PROTEIN CS1; PROTEIN KINASE B; SMALL INTERFERING RNA; STAT3 PROTEIN; TRANSCRIPTION FACTOR C MAF; UNCLASSIFIED DRUG; VASCULOTROPIN; MAF PROTEIN, HUMAN; MEMBRANE ANTIGEN; SSFA2 PROTEIN, HUMAN; TUMOR MARKER; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARCINOGENICITY; CELL ADHESION; CELL GROWTH; CELL INTERACTION; CELL PROLIFERATION; CELL SURVIVAL; CLONOGENESIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; GENE CONTROL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MOUSE; MULTIPLE MYELOMA; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TUMOR GROWTH; UPREGULATION; ANIMAL; BONE MARROW; CELL MEMBRANE; CHEMISTRY; CLONOGENIC ASSAY; CULTURE MEDIUM; DNA MICROARRAY; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; GENETICS; IMMUNOBLOTTING; LENTIVIRINAE; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; STROMA CELL; TRANSCRIPTION INITIATION; TUMOR CELL CULTURE;

ANIMALS; ANTIGENS, SURFACE; BONE MARROW; CELL ADHESION; CELL MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; COLONY-FORMING UNITS ASSAY; CULTURE MEDIA, SERUM-FREE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMANS; IMMUNOBLOTTING; LENTIVIRUS; MICE; MICE, SCID; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MULTIPLE MYELOMA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MAF; RNA, SMALL INTERFERING; STAT3 TRANSCRIPTION FACTOR; STROMAL CELLS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 66149133630     PISSN: 00064971     EISSN: 15280020     Source Type: None    
DOI: 10.1182/blood-2008-10-183772     Document Type: Article

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