Diallyl trisulfide inhibits phorbol ester-induced tumor promotion, activation of AP-1, and expression of COX-2 in mouse skin by blocking JNK and AKT signaling

Cancer Research

Volumn 70, Issue 5, 2010, Pages 1932-1940

  Shrotriya, Sangeeta ^a   Kundu, Joydeb Kumar ^a   Na, Hye Kyung ^c   Surh, Young Joon ^a,b,d  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Sungshin Women's University   (South Korea)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 7,12 DIMETHYLBENZ[A]ANTHRACENE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYCLOOXYGENASE 2; DIALLYL TRISULFIDE; HYBRID PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN C FOS; PROTEIN C JUN; PROTEIN KINASE B; SP 100625; STRESS ACTIVATED PROTEIN KINASE; SYNAPSIN I; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA BINDING; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GENE EXPRESSION REGULATION; GENE REPRESSION; MOUSE; NONHUMAN; PAPILLOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SKIN CARCINOGENESIS; SKIN TUMOR; TUMOR PROMOTION;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ALLYL COMPOUNDS; ANIMALS; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DOWN-REGULATION; DRUG INTERACTIONS; ENZYME ACTIVATION; ENZYME INDUCTION; FEMALE; HUMANS; MAP KINASE KINASE 4; MICE; MICE, INBRED ICR; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SKIN; SKIN NEOPLASMS; SULFIDES; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1;

EID: 77950280661     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-3501     Document Type: Article

References (42)

1. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002;420:860-867
2. Kundu JK, Surh Y-J. Inflammation: gearing the journey to cancer. Mutat Res 2008;659:15-30.
3. Surh Y-J, Kundu JK. Cancer preventive phytochemicals as speed breakers in inflammatory signaling involved in aberrant COX-2 expression. Curr Cancer Drug Targets 2007;7:447-458
4. Chun K-S, Surh Y-J. Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. Biochem Pharmacol 2004;68:1089-1100
5. Muller-Decker K, Neufang G, Berger I, Neumann M, Marks F, Furstenberger G. Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis. Proc Natl Acad Sci U S A 2002;99:12483-12488
6. Tiano HF, Loftin CD, Akunda J, et al. Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res 2002;62:3395-3401
7. Surh Y-J, Kundu JK. Signal transduction network leading to COX-2 induction: a road map in search of cancer chemopreventives. Arch Pharm Res 2005;28:1-15.
8. Chun KS, Keum YS, Han SS, Song YS, Kim SH, Surh Y-J. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-κB activation. Carcinogenesis 2003;24:1515-1524
9. Chun KS, Kim SH, Song YS, Surh Y-J. Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin. Carcinogenesis 2004;25:713-722
10. Kim SO, Kundu JK, Shin YK, et al. [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin. Oncogene 2005;24:2558-2567
11. Kundu JK, Shin YK, Kim SH, Surh Y-J. Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-κB in mouse skin by blocking IκB kinase activity. Carcinogenesis 2006;27:1465-1474
12. Kundu JK, Shin YK, Surh Y-J. Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-κB and AP-1 as prime targets. Biochem Pharmacol 2006;72:1506-1515
13. Kang YJ, Wingerd BA, Arakawa T, Smith WL. Cyclooxygenase-2 gene transcription in a macrophage model of inflammation. J Immunol 2006;177:8111-8122
14. Lee JC, Kundu JK, Hwang DM, Na HK, Surh Y-J. Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-κB and AP-1: IκB kinase and c-Jun-N-terminal kinase as respective potential upstream targets. Carcinogenesis 2007;28:1491-1498
15. Hwang DM, Kundu JK, Shin JW, Lee JC, Lee HJ, Surh Y-J. cis-9, trans-11-conjugated linoleic acid down-regulates phorbol ester-induced NF-κB activation and subsequent COX-2 expression in hairless mouse skin by targeting IκB kinase and PI3K-Akt. Carcinogenesis 2007;28:363-371
16. Powolny AA, Singh SV. Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds. Cancer Lett 2008;269:305-314
17. Shukla Y, Kalra N. Cancer chemoprevention with garlic and its constituents. Cancer Lett 2007;247:167-181
18. Elango EM, Asita H, Nidhi G, Seema P, Banerji A, Kuriakose MA. Inhibition of cyclooxygenase-2 by diallyl sulfides (DAS) in HEK 293T cells. J Appl Genet 2004;45:469-471
19. Dwivedi C, Rohlfs S, Jarvis D, Engineer FN. Chemoprevention of chemically induced skin tumor development by diallyl sulfide and diallyl disulfide. Pharm Res 1992;9:1668-1670
20. Ramsay RG, Ciznadija D, Vanevski M, Mantamadiotis T. Transcriptional regulation of cyclo-oxygenase expression: three pillars of control. Int J Immunopathol Pharmacol 2003;16:59-67.
21. Surh Y-J. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003;3:768-780
22. Fukao T, Hosono T, Misawa S, Seki T, Ariga T. The effects of allyl sulfides on the induction of phase II detoxification enzymes and liver injury by carbon tetrachloride. Food Chem Toxicol 2004;42:743-749
23. Jakubikova J, Sedlak J. Garlic-derived organosulfides induce cytotoxicity, apoptosis, cell cycle arrest and oxidative stress in human colon carcinoma cell lines. Neoplasma 2006;53:191-199
24. Liu KL, Chen HW, Wang RY, Lei YP, Sheen LY, Lii CK. DATS reduces LPS-induced iNOS expression, NO production, oxidative stress, and NF-κB activation in RAW 264.7 macrophages. J Agric Food Chem 2006;54:3472-3478
25. Wu CC, Sheen LY, Chen HW, Kuo WW, Tsai SJ, Lii CK. Differential effects of garlic oil and its three major organosulfur components on the hepatic detoxification system in rats. J Agric Food Chem 2002;50:378-383
26. Dannenberg AJ, Altorki NK, Boyle JO, et al. Cyclooxygenase 2: a pharmacological target for the prevention of cancer. Lancet Oncol 2001;2:544-551
27. Baldwin AS, Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-683
28. Harnish DC, Scicchitano MS, Adelman SJ, Lyttle CR, Karathanasis SK. The role of CBP in estrogen receptor cross-talk with nuclear factor-κB in HepG2 cells. Endocrinology 2000;141:3403-3411
29. Takahashi N, Tetsuka T, Uranishi H, Okamoto T. Inhibition of the NF-κB transcriptional activity by protein kinase A. Eur J Biochem 2002;269:4559-4565
30. Ghosh S, Karin M. Missing pieces in the NF-κB puzzle. Cell 2002;109:S81-96.
31. Bianchini F, Vainio H. Allium vegetables and organosulfur compounds: do they help prevent cancer? Environ Health Perspect 2001;109:893-902.
32. Wu XJ, Hu Y, Lamy E, Mersch-Sundermann V. Apoptosis induction in human lung adenocarcinoma cells by oil-soluble allyl sulfides: triggers, pathways, and modulators. Environ Mol Mutagen 2009;50:266-275
33. Xiao D, Choi S, Johnson DE, et al. Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2. Oncogene 2004;23:5594-5606
34. Bachelor MA, Cooper SJ, Sikorski ET, Bowden GT. Inhibition of p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase decreases UVB-induced activator protein-1 and cyclooxygenase-2 in a SKH-1 hairless mouse model. Mol Cancer Res 2005;3:90-99
35. Liao SL, Ou YC, Chen SY, Chiang AN, Chen CJ. Induction of cyclooxygenase-2 expression by manganese in cultured astrocytes. Neurochem Int 2007;50:905-915
36. Xiao D, Singh SV. Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells. Carcinogenesis 2006;27:533-540
37. Lee JY, Shin JW, Chun KS, et al. Antitumor promotional effects of a novel intestinal bacterial metabolite (IH-901) derived from the protopanaxadiol-type ginsenosides in mouse skin. Carcinogenesis 2005;26:359-367
38. Kikuchi J, Kinoshita I, Shimizu Y, et al. Simultaneous blockade of AP-1 and phosphatidylinositol 3-kinase pathway in non-small cell lung cancer cells. Br J Cancer 2008;99:2013-2019
39. Ma C, Bower KA, Lin H, et al. The role of epidermal growth factor receptor in ethanol-mediated inhibition of activator protein-1 transactivation. Biochem Pharmacol 2005;69:1785-1794
40. Yu X, Luo A, Zhou C, et al. Differentiation-associated genes regulated by TPA-induced c-Jun expression via a PKC/JNK pathway in KYSE450 cells. Biochem Biophys Res Commun 2006;342:286-292
41. Funakoshi-Tago M, Tago K, Sonoda Y, Tominaga S, Kasahara T. TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway. Eur J Biochem 2003;270:1257-1268
42. Beales IL, Ogunwobi O. Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways. Mol Cell Endocrinol 2006;247:140-149