A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 19, 2012, Pages 8429-8439

  Selig, Roland ^a   Goettert, Marcia ^a   Schattel, Verena ^a   Schollmeyer, Dieter ^b   Albrecht, Wolfgang ^c   Laufer, Stefan ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c C a i r Biosciences GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZYL 4 [4 (4 FLUOROPHENYL) 2 PHENYL 1H IMIDAZOL 5 YL] 1H PYRROLO[2,3 B]PYRIDINE; 2 CYCLOHEXYL 4 [4 (4 FLUOROPHENYL) 2 PHENYL 1H IMIDAZOL 5 YL] 1H PYRROLO[2,3 B]PYRIDINE; 4 (4 (4 FLUOROPHENYL) 2 [4 (METHYLSULFINYL)PHENYL] 1H IMIDAZOL 5 YL] 2 PHENYL 1H PYRROLO[2,3 B]PYRIDINE; 4 [4 (4 FLUOROPHENYL) 1 (METHOXYMETHYL) 2 PHENYL 1H IMIDAZOL 5 YL] 7H PYRROLO[2,3 D]PYRIMIDINE; 4 [4 (4 FLUOROPHENYL) 1 (METHOXYMETHYL) 2 PHENYL 1H IMIDZOL 5 YL] 1H PYRROLO[2,3 B]PYRIDINE; 4 [4 (4 FLUOROPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL) 1H IMIDADAZOL 5 YL] 2 PHENYL 1H PYRROLO[2,3 B]PYRIDINE; 4 [4 (4 FLUOROPHENYL) 2 (4 METHOXYPHENYL) 1H IMIDAZOL 5 YL] 2 PHENYL 1H PYRROLO[2,3 B]PYRIDINE; 4 [4 (4 FLUOROPHENYL) 2 [4 (METHYLSULFONYL)PHENYL] 1H IMIDAZOL 5 YL] 2 PHENYL 1H PYRROLO[2,3 B]PYRIDINE; 4 [4 (4 FLUOROPHENYL) 2 [4 (METHYLTHIO)PHENYL] 1H IMIDAZOL 5 YL] 2 PHENYL 1H PYRROLO[2,3 B]PYRIDINE; 4 [4 (4 FLUOROPHENYL) 2 PHENYL 1H IMIDAZOL 5 YL] 1H PYRROLO[2,3 B]PYRIDINE; 4 [4 (4 FLUOROPHENYL) 2 PHENYL 1H IMIDAZOL 5 YL] 2 PHENYL 1H PYRROLO[2,3 B]PYRIDINE; 4 [4 (4 FLUOROPHENYL) 2 PHENYL 1H IMIDAZOL 5 YL] 7H PYRROLOL[2,3 D]PYRIMIDINE; 4 [4 (4 FLUOROPHENYL) 2 PHENYL 1H IMIDAZOL 5 YL] 9H PYRIDOL[2,3 B]INDOLE; 4 [4 (4 FLUOROPHENYL) 5 (2 PHENYL 1H PYRROLO[2,3 B]PYRIDIN 4 YL) 1H IMIDAZOL 2 YL]PHENOL; 6 [4 (4 FLUOROPHENYL) 1 (METHOXYMETHYL) 2 PHENYL 1H IMIDAZOL 5 YL] 9H PURINE; 6 [4 (4 FLUOROPHENYL) 2 PHENYL 1H IMIDAZOL 5 YL] 9H PURINE; AMINOPYRIDINYLIMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CROSS COUPLING REACTION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION;

DRUG DESIGN; ENTROPY; IMIDAZOLES; MOLECULAR CONFORMATION; MOLECULAR DOCKING SIMULATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PURINES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867368167     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300852w     Document Type: Article

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