Strictosidine synthase: Mechanism of a Pictet-Spengler catalyzing enzyme

Journal of the American Chemical Society

Volumn 130, Issue 2, 2008, Pages 710-723

  Maresh, Justin J ^a   Giddings, Lesley Ann ^a   Friedrich, Anne ^a   Loris, Elke A ^b,c   Panjikar, Santosh ^d   Trout, Bernhardt L ^e   Stöckigt, Joachim ^b,c   Peters, Baron ^f   O'Connor, Sarah E ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b ZHEJIANG UNIVERSITY   (China)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^e Massachusetts Institute of Technology Cambridge   (United States)

^f University of California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PICTET-SPENGLER CATALYZING ENZYME; STRICTOSIDINE SYNTHASE;

ALDEHYDES; AMINES; BIOSYNTHESIS; CATALYST ACTIVITY; PH EFFECTS;

ENZYME ACTIVITY;

AMINE; BETA CARBOLINE; ENZYME; METHANOLAMINE; STRICTOSIDINE SYNTHASE; UNCLASSIFIED DRUG; CARBOLINE DERIVATIVE; ENZYME INHIBITOR; LYASE; STRICTOSIDINE SYNTHETASE;

ANALYTIC METHOD; ARTICLE; BIOSYNTHESIS; CATALYSIS; CYCLIZATION; ENZYME KINETICS; ENZYME STRUCTURE; PH; PICTET SPENGLER REACTION; STEREOCHEMISTRY; BINDING SITE; CHEMISTRY; CRYSTALLIZATION; DRUG ANTAGONISM; KINETICS; METABOLISM; STEREOISOMERISM;

BINDING SITES; CARBOLINES; CARBON-NITROGEN LYASES; CATALYSIS; CRYSTALLIZATION; ENZYME INHIBITORS; KINETICS; STEREOISOMERISM;

EID: 40149083317     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja077190z     Document Type: Article

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